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1. 发明申请

US20060264609A1 Use of heat shock proteins 审中-公开
标题翻译：使用热休克蛋白
公开(公告)号：US20060264609A1
公开(公告)日：2006-11-23
申请号：US10491679
申请日：2002-10-03
申请人： Thomas Lehner , Charles Kelly , Yufei Wang , Mahavir Singh
发明人： Thomas Lehner , Charles Kelly , Yufei Wang , Mahavir Singh
IPC分类号： C07K14/47 , C07H21/04 , C12P21/06 , A61K39/00
CPC分类号： C07K14/35 , A61K39/00 , C07K14/47
摘要： The present invention relates to a fragment of heat shock protein that can increase the level of one or more cytokines and/or one or more CC chemokines and/or NO produced by a cell, above that caused by the corresponding full length heat shock protein. The invention also relates to the use of that fragment in the treatment or prophylaxis of a disease.
摘要翻译：本发明涉及一种热休克蛋白的片段，其可以增加由相应的全长热休克蛋白引起的一种或多种细胞因子和/或由细胞产生的一种或多种CC趋化因子和/或NO的水平。本发明还涉及该片段在治疗或预防疾病中的用途。

2. 发明授权

US6024958A Polypeptide fragments capable of competition with Streptococcus mutans antigen I/II 失效
标题翻译：能够与变形链球菌抗原I / II竞争的多肽片段
公开(公告)号：US6024958A
公开(公告)日：2000-02-15
申请号：US894017
申请日：1997-10-20
申请人： Thomas Lehner , Charles Kelly
发明人： Thomas Lehner , Charles Kelly
IPC分类号： A61K39/00 , A61P1/02 , C07K14/315 , C12N15/31 , A61K39/02 , A61K39/09 , C07K5/00
CPC分类号： C07K14/315 , A61K2039/51 , A61K39/00 , C07K2319/00
摘要： Defined peptide subunits of Streptococcus mutans antigen I/II are useful as agents to prevent and treat dental caries either by eliciting an immunological response or by preventing adhesion of S. mutans to the tooth.
摘要翻译： PCT No.PCT / GB96 / 00207 Sec。 371日期：1997年10月20日 102（e）日期1997年10月20日PCT 1996年1月31日PCT PCT。公开号WO96 / 23886 日期1996年8月8日变形链球菌抗原I / II的定义肽亚基可用作预防和治疗龋齿的药剂，通过引发免疫应答或通过防止变形链球菌粘附到牙齿上。

3. 发明授权

US06500433B1 Polypeptide fragments capable of competition with Streptococcus mutans antigen I/II 失效
标题翻译：能够与变形链球菌抗原I / II竞争的多肽片段
公开(公告)号：US06500433B1
公开(公告)日：2002-12-31
申请号：US09456474
申请日：1999-12-09
申请人： Thomas Lehner , Charles Kelly
发明人： Thomas Lehner , Charles Kelly
IPC分类号： A61K3900
CPC分类号： C07K14/315 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Defined peptide subunits of Streptococcus mutans antigen I/II (SAI/II) are useful as agents to prevent and treat dental caries either by eliciting an immunological response or by preventing adhesion of S. mutans to the tooth.
摘要翻译：变异链球菌抗原I / II（SAI / II）的定义肽亚基可用作预防和治疗龋齿的药剂，通过引发免疫应答或通过防止变形链球菌粘附到牙齿上。

4. 发明申请

US20120255638A1 HYDRAULIC CONTROL VALVE HAVING A PILOT PISTON ARRANGED INSIDE THE HOLLOW SPOOL 审中-公开
标题翻译：液压控制阀具有安装在中空阀座内的导柱活塞
公开(公告)号：US20120255638A1
公开(公告)日：2012-10-11
申请号：US13288230
申请日：2011-11-03
申请人： Thomas Lehner , Frank Baumanns , Viktor Vogel , Walter Krips
发明人： Thomas Lehner , Frank Baumanns , Viktor Vogel , Walter Krips
IPC分类号： F15B13/042 , F16K11/07
CPC分类号： F16K11/0716 , Y10T137/86582 , Y10T137/8671
摘要： A hydraulic control valve with a main stage, having spool valves movable in a valve housing having at least four ports and provided with control edges formed on piston collars. A hydraulic pilot stage is provided to control the spool valve of the main stage, and is characterized by the fact that the spool valve of the main stage is designed hollow to form the hydraulic pilot stage. The wall of the hollow spool valve has at least one opening, to which a piston collar formed on the pilot valve is assigned with two control edges arranged on the outside, and in which the pilot valve penetrates a thrust plate inserted into the valve housing, enclosing the spool valve and creating a front pressure chamber for the spool valve to form a defined constant outflow path for the hydraulic fluid introduced into the annular space between spool and pilot valves.
摘要翻译：一种具有主级的液压控制阀，具有可在具有至少四个端口的阀壳体中移动的滑阀，并且具有形成在活塞套环上的控制边缘。提供液压先导级以控制主级的滑阀，其特征在于主级的滑阀被设计成中空以形成液压先导级。中空滑阀的壁具有至少一个开口，形成在先导阀上的活塞套环被分配有设置在外部的两个控制边缘，并且其中先导阀穿过插入到阀壳体中的止推板，封闭滑阀并创建用于滑阀的前压力室，以形成用于引入到阀芯和先导阀之间的环形空间中的液压流体的限定的恒定流出路径。

5. 发明申请

US20080115244A1 Method for producing immunoglobulins containing protection proteins and their use 审中-公开
标题翻译：用于生产含有保护性蛋白质的免疫球蛋白的方法及其用途
公开(公告)号：US20080115244A1
公开(公告)日：2008-05-15
申请号：US11605720
申请日：2006-11-28
申请人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner
发明人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner
IPC分类号： C12N15/82 , C07K16/18 , C12N9/14 , C12P21/04
CPC分类号： C07K16/1278 , C07K14/705 , C07K16/00 , C07K2317/13 , C07K2318/10 , C12N15/8242 , C12N15/8258
摘要： The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment.The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules.The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.
摘要翻译：本发明的免疫球蛋白是针对粘膜病原体如变形链球菌的有用的治疗性免疫球蛋白。免疫球蛋白含有保护蛋白质，其保护粘膜环境中的免疫球蛋白。本发明还包括通过在与免疫球蛋白的其它组分相同的细胞中产生保护性蛋白质来大大改进在植物中产生免疫球蛋白的方法。以非常改进的效率组装免疫球蛋白的组分。本发明的方法允许这种复合分子的组装和高效生产。本发明还考虑在多种细胞（包括植物细胞）中产生含有保护性蛋白质的免疫球蛋白，其可以选择用于有用的附加性质。还考虑使用含有保护性蛋白质的免疫球蛋白作为针对粘膜和其它病原体的治疗性抗体。

6. 发明授权

US08662261B2 Brake pad holder and brake pad of a disc brake 失效
标题翻译：刹车片刹车片和制动盘
公开(公告)号：US08662261B2
公开(公告)日：2014-03-04
申请号：US12750878
申请日：2010-03-31
申请人： Christian Raffin , Markus Gruber , Wlodzimierz Macke , Thomas Lehner
发明人： Christian Raffin , Markus Gruber , Wlodzimierz Macke , Thomas Lehner
IPC分类号： F16D55/00
CPC分类号： F16D65/0978 , F16D66/02 , F16D2055/007
摘要： A brake pad holder of a disc brake, in particular for a commercial vehicle is provided, wherein brake pads assigned to both sides of a brake disc are held by a respective pad-holding spring in a spring-loaded manner in a pad shaft of a positionally fixed brake anchor plate or of a brake caliper. A pad-holding clip, which extends in the axial direction of the brake disc and is fastened to the brake caliper, is supported on the brake pads. The brake pad holder is designed such that the pad-holding clip has at least one limb which extends approximately radially with respect to the brake disc and enters into a recess of at least one brake pad.
摘要翻译：特别是用于商用车辆的盘式制动器的制动衬块支架，其中分配到制动盘两侧的制动衬块由相应的衬垫固定弹簧以弹簧加载的方式保持在位置固定的制动器锚板或制动钳。在制动盘的轴向延伸并固定在制动钳上的垫保持夹被支撑在制动片上。制动衬块保持器被设计成使得垫保持夹具具有至少一个相对于制动盘大致径向延伸并且进入至少一个制动衬块的凹部中的一个肢体。

7. 发明授权

US06303341B1 Method for producing immunoglobulins containing protection proteins in plants and their use 失效
标题翻译：在植物中产生含有保护性蛋白质的免疫球蛋白的方法及其用途
公开(公告)号：US06303341B1
公开(公告)日：2001-10-16
申请号：US09312157
申请日：1999-05-14
申请人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
发明人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
IPC分类号： C12M1500
CPC分类号： C12N15/8258 , C07K14/705 , C07K16/00 , C12N15/8242
摘要： The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.
摘要翻译：本发明的免疫球蛋白是针对粘膜病原体如变形链球菌的有用的治疗性免疫球蛋白。免疫球蛋白含有保护粘膜环境中的免疫球蛋白的保护蛋白。本发明还包括通过在与免疫球蛋白的其它成分相同的细胞中产生保护性蛋白质而在植物中产生免疫球蛋白的极大改进的方法。以非常改进的效率组装免疫球蛋白的组分。本发明的方法允许组装和高效生产这样的复合分子。本发明还考虑在多种细胞（包括植物细胞）中产生含有保护性蛋白质的免疫球蛋白，其可以选择用于有用的附加性质。还考虑使用含有保护性蛋白质的免疫球蛋白作为针对粘膜和其它病原体的治疗性抗体。

8. 发明申请

US20100258409A1 RAILING GUIDE 有权
标题翻译：铁路指导
公开(公告)号：US20100258409A1
公开(公告)日：2010-10-14
申请号：US12741190
申请日：2008-11-04
申请人： Roland Käs , Thomeas Wollny , Thomas Lehner , Robert Wagner
发明人： Roland Käs , Thomeas Wollny , Thomas Lehner , Robert Wagner
IPC分类号： B65G21/20
CPC分类号： B65G21/2054 , B65G21/2072
摘要： The invention relates to a guide arrangement for guiding moving containers, comprising at least one guide element (4) which extends in a predefined extension direction (E) at least in some sections along the transport path of the containers, and at least one holding device (10) which holds the guide element (4) at a predetermined position relative to the transport path. According to the invention, the holding device (10) has a clamp element (6) which clamps the guide element (4), wherein the clamp element (6) bears against the guide element (4) in a direction perpendicular to the extension direction (E), and the guide element (4) has in its cross-section two holding sections (9a, 9b) and a wall section (8) which is formed between these holding sections (9a, 9b) and in one piece with these holding sections (9a, 9b), wherein these holding sections (9a, 9b) are curved at least by 90° and an outer circumference of the holding sections (9a, 9b) is in contact with the clamp element (6) at least in some sections, and the guide element (4) has a recess (18) which is formed by the wall section (8) and the holding sections (9a, 9b) and by which a further guide device (12) can be held.
摘要翻译：本发明涉及一种用于引导移动容器的引导装置，包括至少一个引导元件（4），所述至少一个引导元件（4）至少沿着容器的传送路径的一些部分沿预定的延伸方向（E）延伸，以及至少一个保持装置（10），其将引导元件（4）保持在相对于输送路径的预定位置。根据本发明，保持装置（10）具有夹紧引导元件（4）的夹紧元件（6），其中夹紧元件（6）沿垂直于延伸方向的方向抵靠引导元件（4）（E），并且导向元件（4）的横截面具有两个保持部（9a，9b）和形成在这些保持部（9a，9b）之间的一个壁部（8）保持部分（9a，9b），其中这些保持部分（9a，9b）至少弯曲90°，并且保持部分（9a，9b）的外周与夹紧元件（6）至少在一些部分，并且引导元件（4）具有由壁部（8）和保持部（9a，9b）形成的凹部（18），并且可以保持另外的引导装置（12）。

9. 发明授权

US07211389B2 Method for producing immunoglobulins containing protection proteins and their use 失效
标题翻译：用于生产含有保护性蛋白质的免疫球蛋白的方法及其用途
公开(公告)号：US07211389B2
公开(公告)日：2007-05-01
申请号：US10781989
申请日：2004-02-18
申请人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
发明人： Andrew C. Hiatt , Julian K.-C. Ma , Thomas Lehner , Keith E. Mostov
IPC分类号： C12Q1/68
CPC分类号： C07K16/1278 , C07K14/705 , C07K16/00 , C07K2317/13 , C07K2318/10 , C12N15/8242 , C12N15/8258
摘要： The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.
摘要翻译：本发明的免疫球蛋白是针对粘膜病原体如变形链球菌的有用的治疗性免疫球蛋白。免疫球蛋白含有保护蛋白质，其保护粘膜环境中的免疫球蛋白。本发明还包括通过在与免疫球蛋白的其它组分相同的细胞中产生保护性蛋白质来大大改进在植物中产生免疫球蛋白的方法。以非常改进的效率组装免疫球蛋白的组分。本发明的方法允许这种复合分子的组装和高效生产。本发明还考虑在多种细胞（包括植物细胞）中产生含有保护性蛋白质的免疫球蛋白，其可以选择用于有用的附加性质。还考虑使用含有保护性蛋白质的免疫球蛋白作为针对粘膜和其它病原体的治疗性抗体。

10. 发明申请

US20070006056A1 Method and apparatus for enabling multipoint bus access 审中-公开
标题翻译：用于启用多点总线访问的方法和装置
公开(公告)号：US20070006056A1
公开(公告)日：2007-01-04
申请号：US11172002
申请日：2005-06-30
申请人： Thomas Lehner , Hans-Joachim Goetz
发明人： Thomas Lehner , Hans-Joachim Goetz
IPC分类号： G01R31/28
CPC分类号： G01R31/318536 , G01R31/318538
摘要： The invention includes a method and apparatus for enabling multipoint bus access. In one example, the open ring-architecture bus includes a boundary scan bus including a plurality of bus access points adapted for interfacing with a plurality of circuit packs, a first termination circuit coupled to a first end of the bus, and a second termination circuit coupled to a second end of the bus. The first termination circuit and second termination circuit are adapted for terminating signaling on the boundary scan bus. The open-ring architecture bus provides a master circuit pack a multipoint access capability such that the master circuit pack may be disposed at any of the plurality of bus access points. In one example, signaling includes signaling operable for performing hierarchical system testing, including boundary scan testing. In another example, signaling includes upgrade signaling operable for performing firmware upgrades, software upgrades, and like circuit pack upgrades.
摘要翻译：本发明包括用于实现多点总线访问的方法和装置。在一个示例中，开放环形架构总线包括边界扫描总线，其包括适于与多个电路板接口连接的多个总线接入点，耦合到总线第一端的第一终端电路和第二终端电路连接到公共汽车的第二端。第一终端电路和第二终端电路适用于在边界扫描总线上终止信令。开环架构总线为主电路板提供多点访问能力，使得主电路板可以设置在多个总线接入点中的任一个处。在一个示例中，信令包括用于执行分级系统测试的信令，包括边界扫描测试。在另一示例中，信令包括用于执行固件升级，软件升级和类似的电路板升级的升级信号。

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