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1. 发明授权

US08923588B2 Method and system for improved TOF PET reconstruction 有权
标题翻译：改进TOF PET重建的方法和系统
公开(公告)号：US08923588B2
公开(公告)日：2014-12-30
申请号：US12374374
申请日：2007-07-18
申请人： Thomas Laurence , Jerome J. Griesmer , Jeffrey A. Kolthammer , Andreas Thon , Ralph Brinks , Carsten Degenhardt
发明人： Thomas Laurence , Jerome J. Griesmer , Jeffrey A. Kolthammer , Andreas Thon , Ralph Brinks , Carsten Degenhardt
IPC分类号： G06K9/00 , G01T1/29
CPC分类号： G01T1/2985
摘要： A time of flight positron emission tomography apparatus (100) includes a detector (106), a data acquisition system (120), a coincidence system (122) and a reconstructor (129). Various elements of an imaging chain influence the temporal resolution of the system (100) so that positron data collected along different lines of response is characterized by different temporal resolutions. The different temporal resolutions are used to estimate the positions of detected events along their respective lines of response.
摘要翻译：飞行时间正电子发射断层摄影装置（100）包括检测器（106），数据采集系统（120），符合系统（122）和重构器（129）。成像链的各种元素影响系统（100）的时间分辨率，使得沿不同响应线收集的正电子数据由不同的时间分辨率表征。使用不同的时间分辨率来估计检测到的事件沿其各自的响应行的位置。

2. 发明申请

US20090324042A1 METHOD AND SYSTEM FOR IMPROVED TOF PET RECONSTRUCTION 有权
标题翻译：改进TOF PET重建的方法和系统
公开(公告)号：US20090324042A1
公开(公告)日：2009-12-31
申请号：US12374374
申请日：2007-07-18
申请人： Thomas Laurence , Jerome J. Griesmer , Jeffrey A. Kolthammer , Andreas Thon , Ralph Brinks , Carsten Degenhardt
发明人： Thomas Laurence , Jerome J. Griesmer , Jeffrey A. Kolthammer , Andreas Thon , Ralph Brinks , Carsten Degenhardt
IPC分类号： G06K9/00
CPC分类号： G01T1/2985
摘要： A time of flight positron emission tomography apparatus (100) includes a detector (106), a data acquisition system (120), a coincidence system (122) and a reconstructor (129). Various elements of an imaging chain influence the temporal resolution of the system (100) so that positron data collected along different lines of response is characterized by different temporal resolutions. The different temporal resolutions are used to estimate the positions of detected events along their respective lines of response.
摘要翻译：飞行时间正电子发射断层摄影装置（100）包括检测器（106），数据采集系统（120），符合系统（122）和重构器（129）。成像链的各种元素影响系统（100）的时间分辨率，使得沿不同响应线收集的正电子数据由不同的时间分辨率表征。使用不同的时间分辨率来估计检测到的事件沿其各自的响应行的位置。

3. 发明申请

US20110017916A1 REFLECTOR AND LIGHT COLLIMATOR ARRANGEMENT FOR IMPROVED LIGHT COLLECTION IN SCINTILLATION DETECTORS 有权
标题翻译：反射器和光收缩装置改进光学检测器中的光收集
公开(公告)号：US20110017916A1
公开(公告)日：2011-01-27
申请号：US12673774
申请日：2008-08-12
申请人： Volkmar Schulz , Carsten Degenhardt , Jerome J. Griesmer , Steven E. Cooke
发明人： Volkmar Schulz , Carsten Degenhardt , Jerome J. Griesmer , Steven E. Cooke
IPC分类号： G01T1/202 , G01T1/20
CPC分类号： G01T1/2002 , G01T1/202
摘要： In nuclear imaging, when a gamma ray strikes a scintillator, a burst of visible light is created. That light is detected by a photodetector and processed by downstream electronics. It is desirable to harness as much of the burst of light as possible and get it to the photodetector. In a detector element (18), a first reflective layer (44) partially envelops a scintillation crystal (34). The first reflective layer (44) diffuses the scintillated light. A second reflective layer (46) and a support component reflective layer (48) prevent the light from leaving the scintillation crystal (34) by any route except a light emitting face (36) of the scintillator (34). In another embodiment, a light concentrator (50) is coupled to the scintillator (34) and channels the diffuse light onto a light sensitive portion of a photodetector (38). The reflective layers (44, 46, 48) and the concentrator (50) ensure that all or nearly all of the light emitted by the scintillator (34) is received by the photodetector (38).
摘要翻译：在核成像中，当伽马射线撞击闪烁体时，产生可见光的突发。该光被光检测器检测并由下游电子器件处理。最好利用尽可能多的光线，并将其送到光检测器。在检测器元件（18）中，第一反射层（44）部分地包围闪烁晶体（34）。第一反射层（44）扩散闪烁的光。第二反射层（46）和支撑部件反射层（48）通过除了闪烁体（34）的发光面（36）之外的任何路线防止光离开闪烁晶体（34）。在另一个实施例中，聚光器（50）耦合到闪烁体（34），并将漫射光通过光电检测器（38）的光敏部分。反射层（44,46,48）和聚光器（50）确保由闪烁体（34）发射的全部或几乎全部的光被光电检测器（38）接收。

4. 发明授权

US08426823B2 Reflector and light collimator arrangement for improved light collection in scintillation detectors 有权
标题翻译：反射器和光准直器布置，用于改善闪烁探测器中的光采集
公开(公告)号：US08426823B2
公开(公告)日：2013-04-23
申请号：US12673774
申请日：2008-08-12
申请人： Volkmar Schulz , Carsten Degenhardt , Jerome J. Griesmer , Steven E. Cooke
发明人： Volkmar Schulz , Carsten Degenhardt , Jerome J. Griesmer , Steven E. Cooke
IPC分类号： G01T1/20
CPC分类号： G01T1/2002 , G01T1/202
摘要： In nuclear imaging, when a gamma ray strikes a scintillator, a burst of visible light is created. That light is detected by a photodetector and processed by downstream electronics. It is desirable to harness as much of the burst of light as possible and get it to the photodetector. In a detector element (18), a first reflective layer (44) partially envelops a scintillation crystal (34). The first reflective layer (44) diffuses the scintillated light. A second reflective layer (46) and a support component reflective layer (48) prevent the light from leaving the scintillation crystal (34) by any route except a light emitting face (36) of the scintillator (34). In another embodiment, a light concentrator (50) is coupled to the scintillator (34) and channels the diffuse light onto a light sensitive portion of a photodetector (38). The reflective layers (44, 46, 48) and the concentrator (50) ensure that all or nearly all of the light emitted by the scintillator (34) is received by the photodetector (38).
摘要翻译：在核成像中，当伽马射线撞击闪烁体时，产生可见光的突发。该光被光检测器检测并由下游电子器件处理。最好利用尽可能多的光线，并将其送到光检测器。在检测器元件（18）中，第一反射层（44）部分地包围闪烁晶体（34）。第一反射层（44）扩散闪烁的光。第二反射层（46）和支撑部件反射层（48）通过除了闪烁体（34）的发光面（36）之外的任何路线防止光离开闪烁晶体（34）。在另一个实施例中，聚光器（50）耦合到闪烁体（34），并将漫射光通过光电检测器（38）的光敏部分。反射层（44,46,48）和聚光器（50）确保由闪烁体（34）发射的全部或几乎全部的光被光电检测器（38）接收。

5. 发明授权

US08476593B2 PET detector system with improved capabilities for quantification 有权
标题翻译： PET检测器系统具有改进的量化能力
公开(公告)号：US08476593B2
公开(公告)日：2013-07-02
申请号：US13319153
申请日：2010-05-03
申请人： Carsten Degenhardt , Andrew Buckler
发明人： Carsten Degenhardt , Andrew Buckler
IPC分类号： G01T1/10
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/2018 , G01T1/249
摘要： A nuclear medical imaging system employing radiation detection modules with pixelated scintillator crystals includes a scatter detector (46) configured to detect and label scattered and non-scattered detected radiation events stored in a list mode memory (44). Coincident pairs of both scattered and non-scattered radiation events are detected and the corresponding lines of response (LOR) are determined. A first image representation of the examination region can be reconstructed using the LORs corresponding to both scattered and non-scattered detected radiation events to generate a lower resolution image (60) with good noise statistics. A second higher resolution image (62) of all or a subvolume of the examination region can be generated using LORs that correspond to non-scattered detected radiation events. A quantification processor is configured to extract at least one metric, e.g. volume, count rate, standard uptake value (SUV), or the like, from at least one of the lower resolution image, the higher resolution image, or a combined image (64).
摘要翻译：采用具有像素化闪烁体晶体的放射线检测模块的核医学成像系统包括：散射检测器（46），被配置为检测并标记存储在列表模式存储器（44）中的散射和非散射的检测到的辐射事件。检测到散射和非散射辐射事件的重合对，并确定相应的响应行（LOR）。可以使用对应于散射和非散射检测的辐射事件的LOR来重建检查区域的第一图像表示，以生成具有良好噪声统计的较低分辨率图像（60）。可以使用对应于非散射检测到的辐射事件的LOR来生成检查区域的全部或子体积的第二较高分辨率图像（62）。量化处理器被配置为提取至少一个度量，例如，从较低分辨率图像，较高分辨率图像或组合图像（64）中的至少一个获取体积，计数率，标准摄取值（SUV）等。

6. 发明申请

US20120061576A1 PET DETECTOR SYSTEM WITH IMPROVED CAPABILITIES FOR QUANTIFICATION 有权
标题翻译：具有改进的量化能力的PET检测器系统
公开(公告)号：US20120061576A1
公开(公告)日：2012-03-15
申请号：US13319153
申请日：2010-05-03
申请人： Carsten Degenhardt , Andrew Buckler
发明人： Carsten Degenhardt , Andrew Buckler
IPC分类号： G01T1/202 , G01T1/16
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/2018 , G01T1/249
摘要： A nuclear medical imaging system employing radiation detection modules with pixelated scintillator crystals includes a scatter detector (46) configured to detect and label scattered and non-scattered detected radiation events stored in a list mode memory (44). Coincident pairs of both scattered and non-scattered radiation events are detected and the corresponding lines of response (LOR) are determined. A first image representation of the examination region can be reconstructed using the LORs corresponding to both scattered and non-scattered detected radiation events to generate a lower resolution image (60) with good noise statistics. A second higher resolution image (62) of all or a subvolume of the examination region can be generated using LORs that correspond to non-scattered detected radiation events. A quantification processor is configured to extract at least one metric, e.g. volume, count rate, standard uptake value (SUV), or the like, from at least one of the lower resolution image, the higher resolution image, or a combined image (64).
摘要翻译：采用具有像素化闪烁体晶体的放射线检测模块的核医学成像系统包括：散射检测器（46），被配置为检测并标记存储在列表模式存储器（44）中的散射和非散射的检测到的辐射事件。检测到散射和非散射辐射事件的重合对，并确定相应的响应行（LOR）。可以使用对应于散射和非散射检测的辐射事件的LOR来重建检查区域的第一图像表示，以生成具有良好噪声统计的较低分辨率图像（60）。可以使用对应于非散射检测到的辐射事件的LOR来生成检查区域的全部或子体积的第二较高分辨率图像（62）。量化处理器被配置为提取至少一个度量，例如，从较低分辨率图像，较高分辨率图像或组合图像（64）中的至少一个获取体积，计数率，标准摄取值（SUV）等。

7. 发明授权

US09995829B2 Autonomous detector module as a building block for scalable PET and SPECT systems 有权
公开(公告)号：US09995829B2
公开(公告)日：2018-06-12
申请号：US13132934
申请日：2009-11-16
申请人： Carsten Degenhardt , Thomas Frach , Gordian Prescher
发明人： Carsten Degenhardt , Thomas Frach , Gordian Prescher
IPC分类号： G01T1/20 , G01T1/164 , G01T1/00 , A61B6/03
CPC分类号： G01T1/1644 , A61B6/037 , G01T1/00
摘要： When detecting scintillation events in a nuclear imaging system, time-stamping and energy-gating processing is incorporated into autonomous detection modules (ADM) (14) to reduce downstream processing. Each ADM (14) is removably coupled to a detector fixture (13), and comprises a scintillation crystal array (66) and associated light detect or (s) (64), such as a silicon photomultiplier or the like. The light detector(s) (64) is coupled to a processing module (62) in or on the ADM (14), which performs the energy gating and time-stamping.

8. 发明授权

US08610808B2 Color CMOS imager with single photon counting capability 有权
标题翻译：彩色CMOS成像器具有单光子计数能力
公开(公告)号：US08610808B2
公开(公告)日：2013-12-17
申请号：US13139626
申请日：2009-11-19
申请人： Gordian Prescher , Carsten Degenhardt , Rob Ballizany , Anja Schmitz , Thomas Frach
发明人： Gordian Prescher , Carsten Degenhardt , Rob Ballizany , Anja Schmitz , Thomas Frach
IPC分类号： H04N9/083 , H04N3/14 , H04N5/335 , H04N9/04 , H01L31/107
CPC分类号： H04N9/045 , G01S17/023 , G01S17/10 , G01S17/89 , H04N5/3696
摘要： A color imaging device comprises: one or more arrays (10, RA, GA, BA) of color selective photodetectors (R, G, B) configured to acquire a color image of a subject; a set of avalanche photodiode photodetectors (APD) arranged to acquire a luminance image of the subject; and digital image processing circuitry (30) configured to process the acquired color image and the acquired luminance image to generate an output image of the subject. In some embodiments the avalanche photodiode photodetectors are configured to perform photon counting. In some embodiments, the one or more arrays comprise an imaging array (10) including the color-selective photodetectors (R, G, B) distributed across the imaging array with the set of avalanche photodiode photodetectors (APD) interspersed amongst the color-selective photodetectors.
摘要翻译：彩色成像装置包括：被配置为获取被摄体的彩色图像的彩色选择光电检测器（R，G，B）的一个或多个阵列（10，RA，GA，BA）布置成获取被摄体的亮度图像的一组雪崩光电二极管光电检测器（APD）以及数字图像处理电路（30），被配置为处理所获取的彩色图像和所获取的亮度图像以生成被摄体的输出图像。在一些实施例中，雪崩光电二极管光电探测器被配置为执行光子计数。在一些实施例中，一个或多个阵列包括成像阵列（10），该成像阵列包括分布在成像阵列上的颜色选择性光电检测器（R，G，B），其中所述一组雪崩光电二极管光电检测器（APD）散布在颜色选择性光电探测器

9. 发明申请

US20110248175A1 TEMPERATURE COMPENSATION CIRCUIT FOR SILICON PHOTOMULTIPLIERS AND OTHER SINGLE PHOTON COUNTERS 有权
标题翻译：硅光电子器件和其他单光子计数器的温度补偿电路
公开(公告)号：US20110248175A1
公开(公告)日：2011-10-13
申请号：US13139307
申请日：2009-11-19
申请人： Thomas Frach , Gordian Prescher , Carsten Degenhardt
发明人： Thomas Frach , Gordian Prescher , Carsten Degenhardt
IPC分类号： G01T1/164 , G01T1/166 , H01L31/18 , G01T1/20
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/2018
摘要： A PET scanner (8) includes a ring of detector modules (10) encircling an imaging region (12). Each of the detector modules includes at least one detector pixel (24,34). Each detector pixel includes a scintillator (20, 30) optically coupled to one or more sensor APDs (54) that are biased in a breakdown region in a Geiger mode. The sensor APDs output a pulse in response to the light from the scintillator corresponding to a single incident radiation photon. A reference APD (26, 36) also biased in a break-down down region in a Geiger mode is optically shielded from light and outputs a temperature dependent signal. At least one temperature compensation circuit (40) adjusts a bias voltage applied to the sensor APDs based on the temperature dependent signal.
摘要翻译： PET扫描器（8）包括围绕成像区域（12）的检测器模块环（10）。每个检测器模块包括至少一个检测器像素（24,34）。每个检测器像素包括光学耦合到以盖革模式偏置在击穿区域中的一个或多个传感器APD（54）的闪烁体（20,30）。传感器APD响应于来自闪烁体的对应于单个入射辐射光子的光输出脉冲。参考APD（26,36）也在Geiger模式的偏压下降区域偏压光学屏蔽光并输出温度依赖信号。至少一个温度补偿电路（40）根据温度依赖信号来调节施加到传感器APD的偏置电压。

10. 发明申请

US20110240864A1 AUTONOMOUS DETECTOR MODULE AS A BUILDING BLOCK FOR SCALABLE PET AND SPECT SYSTEMS 有权
标题翻译：自动检测模块作为可扩展PET和SPECT系统的建筑块
公开(公告)号：US20110240864A1
公开(公告)日：2011-10-06
申请号：US13132934
申请日：2009-11-16
申请人： Carsten Degenhardt , Thomas Frach , Gordian Prescher
发明人： Carsten Degenhardt , Thomas Frach , Gordian Prescher
IPC分类号： G01T1/164 , G01T1/20
CPC分类号： G01T1/1644 , A61B6/037 , G01T1/00
摘要： When detecting scintillation events in a nuclear imaging system, time-stamping and energy-gating processing is incorporated into autonomous detection modules (ADM) (14) to reduce downstream processing. Each ADM (14) is removably coupled to a detector fixture (13), and comprises a scintillation crystal array (66) and associated light detect or (s) (64), such as a silicon photomultiplier or the like. The light detector(s) (64) is coupled to a processing module (62) in or on the ADM (14), which performs the energy gating and time-stamping.
摘要翻译：当检测核成像系统中的闪烁事件时，时间戳和能量门控处理被并入到自主检测模块（ADM）（14）中以减少下游处理。每个ADM（14）可移除地耦合到检测器夹具（13），并且包括闪烁晶体阵列（66）和相关联的光检测（64），例如硅光电倍增管等。光检测器（64）耦合到ADM（14）中或其上的处理模块（62），其执行能量门控和时间戳。

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