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    • 2. 发明授权
    • Pharmaceutical compositions
    • 药物组合物
    • US5364628A
    • 1994-11-15
    • US141832
    • 1993-10-22
    • Thomas KisselHenriette SchrankHans-Rainer Hoffmann
    • Thomas KisselHenriette SchrankHans-Rainer Hoffmann
    • A61K9/70A61K31/40A61F13/02
    • A61K9/7061A61K31/40A61K9/7084
    • The present invention provides a pharmaceutical composition for the transdermal systemic administration of an active agent characterized in that the active agent is bopindolol or methysergide. Also the present invention provides a pharmaceutical composition for the transdermal systemic administration of a pharmacologically active agent characterized in that it contains bopindolol, tizanidine, clemastine, ketotifen or methysergide as active agent in a reservoir comprising a hydrophilic polymer. Furthermore a pharmaceutical composition for the transdermal systemic administration of pharmacologically active agents characterised in that the pharmacologically active agent is in a reservoir comprising a polyacrylate polymer containing cationic ester groups.
    • 本发明提供了一种用于经皮全身给药活性剂的药物组合物,其特征在于活性剂是苯吲哚洛尔或甲基麦角苷。 本发明还提供了一种药物组合物,其用于药理学活性剂的经皮系统性给药,其特征在于在包含亲水性聚合物的储库中含有苯妥萘洛,替扎尼定,克立马斯酮,酮替芬或甲基麦角苷作为活性剂。 此外,用于经皮系统施用药理活性剂的药物组合物,其特征在于药理活性剂在包含含有阳离子酯基的聚丙烯酸酯聚合物的储库中。
    • 3. 发明授权
    • Pharmaceutical compositions
    • 药物组合物
    • US5593686A
    • 1997-01-14
    • US314167
    • 1994-09-28
    • Thomas KisselHenriette SchrankHans-Rainer Hoffmann
    • Thomas KisselHenriette SchrankHans-Rainer Hoffmann
    • A61K9/70A61K31/40A61F13/02
    • A61K9/7061A61K31/40A61K9/7084
    • The present invention provides a pharmaceutical composition for the transdermal systemic administration of an active agent characterized in that the active agent is bopindolol or methysergide. Also the present invention provides a pharmaceutical composition for the transdermal systemic administration of a pharmacologically active agent characterized in that it contains bopindolol, tizanidine, clemastine, ketotifen or methysergide as active agent in a reservoir comprising a hydrophilic polymer. Furthermore a pharmaceutical composition for the transdermal systemic administration of pharmacologically active agents characterized in that the pharmacologically active agent is in a reservoir comprising a polyacrylate polymer containing cationic ester groups.
    • 本发明提供了一种用于经皮全身给药活性剂的药物组合物,其特征在于活性剂是苯吲哚洛尔或甲基麦角苷。 本发明还提供了一种药物组合物,其用于药理学活性剂的经皮系统性给药,其特征在于在包含亲水性聚合物的储库中含有苯妥萘洛,替扎尼定,克立马斯酮,酮替芬或甲基麦角苷作为活性剂。 此外,用于经皮系统施用药理活性剂的药物组合物,其特征在于药理活性剂在包含含有阳离子酯基的聚丙烯酸酯聚合物的储库中。