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1. 发明授权

US09944950B2 Methods and compositions for producing induced airway tissue progenitor cells 有权
公开(公告)号：US09944950B2
公开(公告)日：2018-04-17
申请号：US14295004
申请日：2014-06-03
申请人： Thomas K. Waddell , Li Guo , Andras Nagy
发明人： Thomas K. Waddell , Li Guo , Andras Nagy
IPC分类号： C12N5/00 , C12N15/00 , C12N15/85 , C12N5/074 , A61K35/42
CPC分类号： C12N15/85 , A61K35/42 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2506/27 , C12N2830/003
摘要： A method of generating an induced progenitor population (iPP) of cells and/or induced population of cells from somatic cells, comprising the steps: a) obtaining a starting cell population, wherein cells of the starting cell population comprise, or are contacted with, a nucleic acid molecule encoding four reprogramming factors under the control of a control element, wherein the four reprogramming factors are optionally Oct4, Klf4, Sox2 and c-Myc, and wherein the control element prevents or stops expression of the reprogramming factors under its control in the absence of induction by an inducing agent; and b) transiently inducing expression of the reprogramming factors in the starting cell population to obtain an iPP, c) optionally isolating the iPP, and d) terminating the transient induction while the proliferative capacity of the iPP remains under the control of the one or more exogenous reprogramming factors to produce an induced population of cells.

2. 发明申请

US20150004612A1 METHODS AND COMPOSITIONS FOR PRODUCING INDUCED AIRWAY TISSUE PROGENITOR CELLS 审中-公开
标题翻译：用于生产诱导性气道组织原核细胞的方法和组合物
公开(公告)号：US20150004612A1
公开(公告)日：2015-01-01
申请号：US14295004
申请日：2014-06-03
申请人： Thomas K. Waddell , Li Guo , Andras Nagy
发明人： Thomas K. Waddell , Li Guo , Andras Nagy
IPC分类号： C12N15/85 , G01N33/569 , G01N33/50
CPC分类号： C12N15/85 , A61K35/42 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2506/27 , C12N2830/003
摘要： A method of generating an induced progenitor population (iPP) of cells and/or induced population of cells from somatic cells, comprising the steps: a) obtaining a starting cell population, wherein cells of the starting cell population comprise, or are contacted with, a nucleic acid molecule encoding four reprogramming factors under the control of a control element, wherein the four reprogramming factors are optionally Oct4, Klf4, Sox2 and c-Myc, and wherein the control element prevents or stops expression of the reprogramming factors under its control in the absence of induction by an inducing agent; and b) transiently inducing expression of the reprogramming factors in the starting cell population to obtain an iPP, c) optionally isolating the iPP, and d) terminating the transient induction while the proliferative capacity of the iPP remains under the control of the one or more exogenous reprogramming factors to produce an induced population of cells.
摘要翻译：产生来自体细胞的细胞和/或诱导的细胞群的诱导祖细胞群体（iPP）的方法，包括以下步骤：a）获得起始细胞群体，其中起始细胞群体的细胞包含或与其接触，编码在控制元件控制下的四个重编程因子的核酸分子，其中四个重编程因子任选为Oct4，Klf4，Sox2和c-Myc，并且其中控制元件防止或停止其控制下的重编程因子的表达诱导剂不诱导; 和b）在起始细胞群体中瞬时诱导重编程因子的表达以获得iPP，c）任选分离iPP，以及d）终止瞬时诱导，而iPP的增殖能力保持在一个或多个外源性重编程因子产生诱导的细胞群体。

3. 发明授权

US08637696B2 Methods for preparing amides and amino acids 有权
标题翻译：制备酰胺和氨基酸的方法
公开(公告)号：US08637696B2
公开(公告)日：2014-01-28
申请号：US13621553
申请日：2012-09-17
申请人： Samuel Helmer Gellman , Yonggui Chi , Li Guo
发明人： Samuel Helmer Gellman , Yonggui Chi , Li Guo
IPC分类号： C07C231/04 , C07C269/04 , C07C227/12 , C07C271/22 , C07C227/02 , C07C269/00
CPC分类号： C07C269/00 , C07C205/15 , C07C205/37 , C07C205/44 , C07C205/51 , C07C205/57 , C07C227/02 , C07C233/47 , C07C271/22
摘要： The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide α-substituted-γ-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96-99% e.e.). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected γ2-amino acids, which are essential for systematic conformational studies of γ-peptide foldamers.
摘要翻译：本发明提供了新的化合物和方法，用于通过脯氨酸衍生物进行有机催化迈克尔加成醛到硝基亚乙基以提供α-取代的γ-硝基醛。当使用手性吡咯烷催化剂时，反应可以呈现为对映选择性，允许以几乎光学纯的形式（例如96-99％e.e。）的迈克尔加合物。迈克尔加合物可以承受单个取代基或与羰基相邻的双取代基。迈克尔加合物可以有效地转化为受保护的γ2-氨基酸，这对于γ-肽折叠物的系统构象研究至关重要。

4. 发明授权

US08494073B2 Beamforming weight estimation using wideband multipath direction of arrival analysis 有权
标题翻译：使用宽带多径方向到达分析的波束成形权重估计
公开(公告)号：US08494073B2
公开(公告)日：2013-07-23
申请号：US12502607
申请日：2009-07-14
申请人： Genyuan Wang , Li Guo , Ahmadreza Hedayat , Hang Jin
发明人： Genyuan Wang , Li Guo , Ahmadreza Hedayat , Hang Jin
IPC分类号： H04L1/02 , H04M1/00
CPC分类号： H04B7/0617 , H04B7/0439 , H04B7/086
摘要： Techniques are provided for computing downlink beamforming weights based on the received data at a base station from a mobile station in a MIMO communication system. An uplink transmission is received at a plurality of antennas at a first communication device from a second communication device, where the uplink transmission comprises a plurality of uplink subbands. The uplink spatial signature is estimated for each of the plurality of uplink subbands. The uplink spatial signature is decomposed into a plurality of direction of arrival (DOA) components for each uplink subband using a transform. Data representing multiple propagation paths between the first communication device and the second communication device is computed for each DOA component. A plurality of direction of departure (DOD) components for each of a plurality of downlink subbands is computed based on the data representing the multiple propagation paths. A downlink spatial signature for each downlink subband from the plurality of DOD components is computed using an inverse of the transform. Downlink beamforming weights are computed for each of the plurality of downlink subbands based on the downlink spatial signature, where the downlink beamforming weights are for use by the first communication device when beamforming a downlink transmission via the plurality of antennas of the first communication device to the second communication device.
摘要翻译：提供了用于基于MIMO通信系统中的移动台在基站处接收到的数据来计算下行链路波束成形权重的技术。在来自第二通信设备的第一通信设备的多个天线处接收上行链路传输，其中上行链路传输包括多个上行链路子带。针对多个上行链路子带中的每一个估计上行链路空间特征。使用变换将上行链路空间特征分解为每个上行链路子带的多个到达方向（DOA）分量。针对每个DOA分量计算代表第一通信设备和第二通信设备之间的多个传播路径的数据。基于表示多个传播路径的数据来计算多个下行链路子带中的每一个的多个出发方向（DOD）分量。使用变换的倒数来计算来自多个DOD分量的每个下行链路子带的下行链路空间特征。基于下行链路空间特征，针对多个下行链路子带中的每一个计算下行链路波束形成权重，其中下行链路波束赋形权重由第一通信设备使用时，当波束成形通过第一通信设备的多个天线的下行链路传输到第二通信设备。

5. 发明申请

US20130062049A1 SHAPED MEMORY POLYPHENYLENE SULFIDE (PPS) FOR DOWNHOLE PACKER APPLICATIONS 有权
标题翻译：用于卧式包装机应用的形状记忆聚苯乙烯（PPS）
公开(公告)号：US20130062049A1
公开(公告)日：2013-03-14
申请号：US13229923
申请日：2011-09-12
申请人： Jiaxiang Ren , David P. Gerrard , James E. Goodson , Li Guo , Ping Duan
发明人： Jiaxiang Ren , David P. Gerrard , James E. Goodson , Li Guo , Ping Duan
IPC分类号： E21B33/12 , B29C44/12
CPC分类号： B29C44/5636 , E21B33/1208
摘要： A downhole element to isolate or complete a wellbore includes a shape memory material including polyphenylene sulfide. The polyphenylene sulfide is the cure product of being cured at a temperature of about 200° C. to about 400° C., for a total time of less than or equal to 200 hours. The shape memory material is thermally activated between an actuated and unactuated shape, and the polyphenylene sulfide in the shape memory material is a closed cell foam, open cell foam, or solid.
摘要翻译：用于隔离或完成井孔的井下元件包括包含聚苯硫醚的形状记忆材料。聚苯硫醚是在约200℃至约400℃的温度下固化的固化产物，总时间小于或等于200小时。形状记忆材料在致动和未致动形状之间被热活化，并且形状记忆材料中的聚苯硫醚是闭孔泡沫，开孔泡沫或固体。

6. 发明申请

US20130003564A1 Link Adaptation for Retransmission Schemes 有权
标题翻译：链接适应重传方案
公开(公告)号：US20130003564A1
公开(公告)日：2013-01-03
申请号：US13616066
申请日：2012-09-14
申请人： Hang Jin , Li Guo , Hanqing Lou
发明人： Hang Jin , Li Guo , Hanqing Lou
IPC分类号： H04W24/00
CPC分类号： H04L1/0034 , H04L1/0035
摘要： Link adaptive retransmission techniques are provided for use in connection with wireless communications between a first wireless communication device and a second wireless communication device. The first wireless communication device generates M packet error information values for the transmit session of a packet based on whether an acknowledgment message or a non-acknowledgment message is received from the second wireless communication device for a transmission and for previously sent transmissions even if less than M transmissions are sent by the first wireless communication device to the second wireless communication device upon completion of the transmit session. The first wireless communication device computes a retransmission fading margin based on the M packet error information values, from which an effective carrier-to-interference-plus-noise ratio is derived for selection of a modulation scheme.
摘要翻译：链路自适应重传技术被提供用于结合第一无线通信设备和第二无线通信设备之间的无线通信。第一无线通信设备基于是否从第二无线通信设备接收到用于传输的确认消息或非确认消息，以及对于先前发送的传输，即使小于等于，也产生用于分组的发送会话的M个分组错误信息值在发送会话完成时，M个传输由第一无线通信设备发送到第二无线通信设备。第一无线通信设备基于M个分组误差信息值来计算重发衰落余量，从而从其导出用于选择调制方案的有效载波干扰加噪声比。

7. 发明申请

US20120276855A1 WIRELESS LINK BACKUP SYSTEM 审中-公开
标题翻译：无线链路备份系统
公开(公告)号：US20120276855A1
公开(公告)日：2012-11-01
申请号：US13133579
申请日：2010-06-22
申请人： Xiaogang Yi , Xiang Zhou , Li Guo , Gaoshang Yao , Xiaoqi Mo
发明人： Xiaogang Yi , Xiang Zhou , Li Guo , Gaoshang Yao , Xiaoqi Mo
IPC分类号： H04B1/38
CPC分类号： H04B1/74
摘要： A wireless link backup system, including a first device and a second device, wherein the first device comprises a first controller and at least two first wireless transceivers; the at least two first wireless transceivers have the same working parameters; and the first controller is adapted to control such that only one of the first wireless transceivers is working at a time; the second device comprises a second controller and at least two second wireless transceivers; the at least two second wireless transceivers have the same working parameters; and the second controller is adapted to control such that only one of the second wireless transceivers is working at a time; and the working parameter of the first wireless transceiver match the working parameter of the second wireless transceiver, so that wireless connection between the first wireless transceiver and the second wireless transceiver can be established.
摘要翻译：一种无线链路备份系统，包括第一设备和第二设备，其中所述第一设备包括第一控制器和至少两个第一无线收发器; 所述至少两个第一无线收发器具有相同的工作参数; 并且第一控制器适于控制使得一次只有一个第一无线收发器正在工作; 所述第二设备包括第二控制器和至少两个第二无线收发器; 所述至少两个第二无线收发器具有相同的工作参数; 并且第二控制器适于控制使得仅一个第二无线收发器一次正在工作; 并且第一无线收发器的工作参数与第二无线收发器的工作参数匹配，从而可以建立第一无线收发器与第二无线收发器之间的无线连接。

8. 发明申请

US20110124290A1 MIMO Mode Switch Management for Beamformed MIMO Systems 有权
标题翻译：用于波束形成MIMO系统的MIMO模式切换管理
公开(公告)号：US20110124290A1
公开(公告)日：2011-05-26
申请号：US12623932
申请日：2009-11-23
申请人： Hanqing Lou , Li Guo , Genyuan Wang , Hang Jin , Yanxin Na
发明人： Hanqing Lou , Li Guo , Genyuan Wang , Hang Jin , Yanxin Na
IPC分类号： H04B15/00
CPC分类号： H04B7/0689
摘要： Techniques are provided herein for improving multiple-input multiple-output (MIMO) wireless communications, and in particular to dynamically determining when to switch MIMO transmission modes on a communication link between two devices that are capable of supporting multiple MIMO transmission modes. A base station receives from a client device one or more signals containing information representing a first signal-to-noise ratio (SNR) measurement and a second SNR measurement made by the client device. The first SNR measurement is associated with a first MIMO transmission mode and the second SNR measurement is associated with a second MIMO transmission mode. The base station computes a MIMO channel quality indicator from the first SNR measurement and the second SNR measurement, and evaluates the MIMO channel quality indicator to determine whether to switch MIMO transmission modes for transmissions to the client device.
摘要翻译：本文提供了用于改进多输入多输出（MIMO）无线通信的技术，特别是动态地确定何时在能够支持多个MIMO传输模式的两个设备之间的通信链路上切换MIMO传输模式。基站从客户端设备接收包含表示第一信噪比（SNR）测量的信息的一个或多个信号和由客户端设备进行的第二SNR测量。第一SNR测量与第一MIMO传输模式相关联，并且第二SNR测量与第二MIMO传输模式相关联。基站从第一SNR测量和第二SNR测量计算MIMO信道质量指示符，并且评估MIMO信道质量指示符，以确定是否将用于传输的MIMO传输模式切换到客户端设备。

9. 发明授权

US07876715B1 Beamforming multiple-input multiple-output wireless techniques using spatial decomposition for frequency division duplex systems 有权
标题翻译：使用分频双工系统的空间分解对多输入多输出无线技术进行波束成形
公开(公告)号：US07876715B1
公开(公告)日：2011-01-25
申请号：US12204867
申请日：2008-09-05
申请人： Hang Jin , Yanxin Na , Li Guo , John Grabner
发明人： Hang Jin , Yanxin Na , Li Guo , John Grabner
IPC分类号： H04B7/005
CPC分类号： H04B7/043 , H04B7/0452
摘要： Techniques are provided herein to combine the advantages of beamforming with the advantages of multiple-input multiple output (MIMO) technology in a frequency division duplex (FDD) communication system, even when the uplink and downlink frequency separation exceeds the coherent bandwidth of the over-the-air-channels. At a first wireless communication device having M plurality of antennas, a wireless transmission is received that is sent from a second wireless communication device having P plurality of antennas. The first device computes spatial components associated with the transmission received at the M plurality of antennas. The first device selects the N strongest spatial components among the computed spatial components. The first device computes N beamforming weight vectors based on the N strongest spatial components. The first device then computes N MIMO beamforming weight vectors based on the N beamforming weight vectors. The N MIMO beamforming weight vectors are applied to N signal streams to be transmitted via the plurality of antennas of the first device to the plurality of antennas of the second device.
摘要翻译：本文提供了技术，即使当上行链路和下行链路频率间隔超过超分辨率的相干带宽时，波束成形的优点与频分双工（FDD）通信系统中的多输入多输出（MIMO）技术的优点相结合，空中通道。在具有M个多个天线的第一无线通信装置中，接收从具有多个天线的第二无线通信装置发送的无线传输。第一设备计算与在M个多个天线处接收的传输相关联的空间分量。第一个装置在计算的空间分量中选择N个最强的空间分量。第一个设备基于N个最强的空间分量来计算N个波束成形权重向量。然后，第一设备基于N个波束形成权重向量来计算N个MIMO波束成形加权向量。 N个MIMO波束成形加权矢量被施加到要经由第一设备的多个天线发送到第二设备的多个天线的N个信号流。

10. 发明授权

US07697654B1 Determining effective carrier-to-interference plus noise ratio in OFDMA systems 有权
标题翻译：确定OFDMA系统中有效的载波与干扰加噪声比
公开(公告)号：US07697654B1
公开(公告)日：2010-04-13
申请号：US12473801
申请日：2009-05-28
申请人： Hang Jin , John Grabner , Li Guo
发明人： Hang Jin , John Grabner , Li Guo
IPC分类号： H04L23/00 , H04L27/36
CPC分类号： H04L27/2647 , H04L5/0007 , H04L25/022
摘要： Techniques are provided to determine a more realistic measure of a physical carrier-to-interference plus noise radio (pCINR) associated with a wireless channel between first and second wireless communication devices. Channel conditions are used to derive a channel margin quantity that is in turn used “discount” the pCINR. The discounted pCINR is then used to determine a modulation and encoding scheme that can be used on the wireless channel for communications between the first and second wireless communication devices.
摘要翻译：提供技术来确定与第一和第二无线通信设备之间的无线信道相关联的物理载波对干扰加噪声无线电（pCINR）的更实际的测量。通道条件用于导出通道边际数量，反过来使用“折扣”pCINR。然后使用打折的pCINR来确定可以在无线信道上用于第一和第二无线通信设备之间的通信的调制和编码方案。

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