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    • 4. 发明申请
    • METHOD FOR THE DETECTION AND/OR ENRICHMENT OF ANALYTE PROTEINS AND/OR ANALYTE PEPTIDES FROM A COMPLEX PROTEIN MIXTURE
    • 检测和/或分析分析蛋白和/或从复合蛋白混合物分析肽的方法
    • US20100331199A1
    • 2010-12-30
    • US12294854
    • 2007-03-29
    • Dieter StollThomas JoosMarkus TemplinOliver Poetz
    • Dieter StollThomas JoosMarkus TemplinOliver Poetz
    • C40B30/04G01N33/53G01N27/26
    • G01N33/6842C07K16/44
    • The present invention relates to a method for the detection and/or enrichment of a large number of different analyte proteins and/or analyte peptides from a sample mixture which includes proteins and/or peptides. The method includes the following steps: a) provision of the sample mixture and, where appropriate, fragmentation of the proteins contained therein into defined peptides, b) provision of first binding molecules which are specific for a peptide epitope of at least one of the various analyte proteins and/or analyte peptides, whereby the peptide epitope includes up to a maximum of five, preferably two to three, amino acids, c) incubation of the first binding molecules with the sample mixture, and d) detection and/or enrichment of the analyte proteins and/or analyte peptides bound to the first binding molecules. The invention also relates to binding molecules which are specific for the terminal peptide epitope of various peptide analytes, whereby the terminal peptide epitope includes the free NH2 group or the free COOH group, one or more than one amino acid defined by the protease specificity, and in each case up to a maximum of three further terminal amino acids.
    • 本发明涉及从包括蛋白质和/或肽的样品混合物中检测和/或富集大量不同分析物蛋白质和/或分析物肽的方法。 该方法包括以下步骤:a)提供样品混合物,并在适当情况下将其中包含的蛋白质碎裂成定义的肽,b)提供对多种抗原决定簇中的至少一种的肽表位是特异性的第一结合分子 分析物蛋白质和/或分析物肽,其中肽表位包含最多5个,优选2至3个氨基酸,c)将第一结合分子与样品混合物孵育,以及d)检测和/或富集 分析物蛋白和/或与第一结合分子结合的分析物肽。 本发明还涉及对各种肽分析物的末端肽表位特异的结合分子,其中末端肽表位包括游离NH 2基团或游离COOH基团,由蛋白酶特异性定义的一个或多于一个氨基酸,以及 在每种情况下,最多三个其他末端氨基酸。
    • 8. 发明申请
    • METHOD AND APPARATUS FOR CONTROLLING INFORMATION AVAILABLE FROM CONTENT DISTRIBUTION POINTS
    • 用于控制内容分发点信息的方法和装置
    • US20080115167A1
    • 2008-05-15
    • US11554122
    • 2006-10-30
    • Christian Thomas HermsmeyerDieter StollWolfgang Thomas
    • Christian Thomas HermsmeyerDieter StollWolfgang Thomas
    • H04N5/445G06F3/00G06F13/00
    • H04L67/1095H04L67/2847H04L67/2885H04L67/322H04L67/325
    • The invention includes a method and apparatus for controlling information available at a network element located at a first hierarchical level in a content distribution network. A method includes determining a subset of content using content forecast information, comparing the determined subset of content to a subset of content available to the network element located at the first hierarchical level, generating a request adapted for modifying the available subset of content in response to a difference between the determined and available subsets of content, and propagating the request toward a network element at a second hierarchical level in the content distribution network, where the first and second hierarchical levels are different. The content may include any information adapted for being distributed from a server to a subscriber terminal (e.g., broadcast multimedia content, content-on-demand, non-streaming content such as files and software patches, and the like, as well as various combinations thereof).
    • 本发明包括一种用于控制在内容分发网络中位于第一层级的网元的可用信息的方法和装置。 一种方法包括使用内容预测信息来确定内容的子集,将确定的内容子集与可用于位于第一层级的网络元素的内容的子集进行比较,产生适于修改内容的可用子集以响应于 所确定的和可用的内容子集之间的差异,以及在第一和第二层级不同的内容分发网络中向第二层级的网元传播请求。 内容可以包括适于从服务器分发给用户终端的任何信息(例如,广播多媒体内容,按需内容,诸如文件和软件补丁等非流式传输内容等,以及各种组合 )。
    • 9. 发明授权
    • Method and apparatus for controlling information available from content distribution points
    • 用于控制从内容分发点获得的信息的方法和装置
    • US08763062B2
    • 2014-06-24
    • US11554122
    • 2006-10-30
    • Christian Thomas HermsmeyerDieter StollWolfgang Thomas
    • Christian Thomas HermsmeyerDieter StollWolfgang Thomas
    • H04N21/20H04N21/266
    • H04L67/1095H04L67/2847H04L67/2885H04L67/322H04L67/325
    • The invention includes a method and apparatus for controlling information available at a network element located at a first hierarchical level in a content distribution network. A method includes determining a subset of content using content forecast information, comparing the determined subset of content to a subset of content available to the network element located at the first hierarchical level, generating a request adapted for modifying the available subset of content in response to a difference between the determined and available subsets of content, and propagating the request toward a network element at a second hierarchical level in the content distribution network, where the first and second hierarchical levels are different. The content may include any information adapted for being distributed from a server to a subscriber terminal (e.g., broadcast multimedia content, content-on-demand, non-streaming content such as files and software patches, and the like, as well as various combinations thereof).
    • 本发明包括一种用于控制在内容分发网络中位于第一层级的网元的可用信息的方法和装置。 一种方法包括使用内容预测信息来确定内容的子集,将确定的内容子集与可用于位于第一层级的网络元素的内容的子集进行比较,产生适于修改内容的可用子集以响应于 所确定的和可用的内容子集之间的差异,以及在第一和第二层级不同的内容分发网络中向第二层级的网元传播请求。 内容可以包括适于从服务器分发给用户终端的任何信息(例如,广播多媒体内容,按需内容,诸如文件和软件补丁等非流式传输内容等,以及各种组合 )。