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    • 7. 发明授权
    • High density cast-in-place sample preparation card
    • 高密度现场样品制备卡
    • US06869572B1
    • 2005-03-22
    • US09659241
    • 2000-09-11
    • William KopaciewiczCheryl Brucato
    • William KopaciewiczCheryl Brucato
    • B01J20/28B01L3/00G01N30/02B01D29/05
    • B01L3/50255B01J20/28026B01L2200/141B01L2300/0829B01L2400/049G01N30/02Y10T436/25375Y10T436/255B01D15/3804
    • A card or insert having a plurality of recesses for a sample preparation device, the card containing cast-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular card size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a plurality of recesses in an insert for a multi-well sample preparation device, thereby providing an effective platform for high throughput micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted in multiplicity, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. Manufacturing flexibility and high throughput is achieved. The card can be configured for direct analysis of bound sample without elution.
    • 具有用于样品制备装置的多个凹部的卡或插入件,该卡包含可用作吸附或反应性介质或基于尺寸的分离的现浇复合材料和/或非填充结构。 可以使用任何特定的卡尺寸或构型,并且在保持膜三维结构的同时实现在聚合物中包含大量吸附颗粒。 在第一优选实施方案中,复合结构包括捕获在多孔聚合物基质内的颗粒,并且在多孔样品制备装置的插入物中就地浇铸成多个凹槽,从而为高通量微孔提供了有效的平台 处理。 通过适当选择的颗粒化学,几乎任何分离或纯化操作都可以进行多重性,包括选择性结合/洗脱色谱操作,样品质量负载小于1微克体积的几微升,以及较大的质量负载, 卷。 实现了制造灵活性和高吞吐量。 该卡可以配置为直接分析结合的样品而不洗脱。
    • 8. 发明授权
    • Cast membrane structures for sample preparation
    • 用于样品制备的铸膜结构
    • US06635201B1
    • 2003-10-21
    • US09291355
    • 1999-04-14
    • William KopaciewiczDonald G. SheerTodd E. ArnoldVinay Goel
    • William KopaciewiczDonald G. SheerTodd E. ArnoldVinay Goel
    • B29C6500
    • B01J20/28033B01D61/00B01D61/007B01D61/18B01D63/16B01D69/10B01D69/141B01J20/28004B01J20/28019B01J20/28026B01J20/28028B01J20/2803B01J2220/64B01L3/0275G01N30/466G01N30/6004G01N30/6052G01N30/6065G01N2030/528G01N2035/1053G01N2035/1055
    • A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
    • 用于现浇复合和/或非填充结构的方法,其可用作吸附或反应介质或基于尺寸的分离。 可以使用任何特定的壳体尺寸或构型,并且在保持膜三维结构的同时实现在聚合物中包含大量吸附颗粒。 在第一优选实施方案中,复合结构包括捕获在多孔聚合物基底内的颗粒,并且被放置在诸如移液管尖端的壳体中,从而为微粒处理提供有效的平台。 通过适当的颗粒化学选择,可以进行任何分离或纯化操作,包括选择性结合/洗脱色谱操作,样品质量负载小于1微克体积的几微升,以及较大的质量负载和体积。 本发明还包括复合结构以及含有该结构的样品制备装置。 在第二结构中,在合适的壳体中原位铸造,并且可以用于基于尺寸的间隔,其中铸造结构用作半渗透屏障。 本发明还包括这些结构以及包含这些结构的壳体。