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1. 发明授权

US07803400B2 Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier 有权
公开(公告)号：US07803400B2
公开(公告)日：2010-09-28
申请号：US11802727
申请日：2007-05-24
申请人： Thomas J. Nelson , Daniel L. Alkon , Alessandro Quattrone
发明人： Thomas J. Nelson , Daniel L. Alkon , Alessandro Quattrone
IPC分类号： A61K9/14 , A61K31/195 , A61K38/02 , A61P43/00
CPC分类号： A61K9/127 , A61K9/1275 , A61K31/195 , A61K31/56 , A61K31/70 , A61K31/704 , A61K31/7088 , A61K38/1709
摘要： This invention relates to a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery therapeutic agents across the blood-brain barrier (BBB). In particular, this invention relates to artificial LDL particles comprised of three lipid elements: phosphatidyl choline, fatty-acyl-cholesterol esters, and at least one apolipoprotein. The present invention further relates to compositions, methods and kits comprising artificial LDL particles for targeting drugs to and across the BBB for the prevention and treatment of brain diseases.

2. 发明申请

US20100022645A1 PKC-Activating Compounds for the Treatment of Neurodegenerative Diseases 有权
标题翻译：用于治疗神经退行性疾病的PKC-活化化合物
公开(公告)号：US20100022645A1
公开(公告)日：2010-01-28
申请号：US12510681
申请日：2009-07-28
申请人： Thomas J. Nelson , Daniel L. Alkon
发明人： Thomas J. Nelson , Daniel L. Alkon
IPC分类号： A61K31/202 , C12N9/12 , A61K31/201 , A61P25/28
CPC分类号： C07D303/42 , A61K31/045 , A61K31/201 , A61K31/23 , A61K31/231 , A61K31/335 , C07C31/13 , C07C31/1333 , C07C53/134 , C07C69/608 , C07D303/40 , C12N9/12 , C12Y207/11013
摘要： The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.
摘要翻译：本发明涉及使用单和多不饱和脂肪酸的环丙烷化或环氧化衍生物来激活蛋白激酶C（PKC）的同种型以治疗包括阿尔茨海默氏病和中风的神经疾病的方法。本发明还涉及使用单和多不饱和脂肪酸的环丙烷化或环氧化衍生物降低神经变性的方法。

3. 发明授权

US09119825B2 PKC-activating compounds for the treatment of neurodegenerative diseases 有权
标题翻译：用于治疗神经变性疾病的PKC活化化合物
公开(公告)号：US09119825B2
公开(公告)日：2015-09-01
申请号：US13401459
申请日：2012-02-21
申请人： Thomas J. Nelson , Daniel L. Alkon
发明人： Thomas J. Nelson , Daniel L. Alkon
IPC分类号： A61K31/045 , A61K31/201 , A61K31/335 , A61K31/231 , A61K31/23
CPC分类号： C07D303/42 , A61K31/045 , A61K31/201 , A61K31/23 , A61K31/231 , A61K31/335 , C07C31/13 , C07C31/1333 , C07C53/134 , C07C69/608 , C07D303/40 , C12N9/12 , C12Y207/11013
摘要： The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.
摘要翻译：本发明涉及使用单和多不饱和脂肪酸的环丙烷化或环氧化衍生物来激活蛋白激酶C（PKC）的同种型用于治疗包括阿尔茨海默氏病和中风的神经疾病的方法。本发明还涉及使用单和多不饱和脂肪酸的环丙烷化或环氧化衍生物减少神经变性的方法。

4. 发明申请

US20120149768A1 PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权
标题翻译：用于治疗神经损伤性疾病的PKC-活化化合物
公开(公告)号：US20120149768A1
公开(公告)日：2012-06-14
申请号：US13401459
申请日：2012-02-21
申请人： Thomas J. Nelson , Daniel L. Alkon
发明人： Thomas J. Nelson , Daniel L. Alkon
IPC分类号： A61K31/336 , A61K31/20 , C07C53/134 , C07C69/608 , C07D303/38 , A61P25/24 , C07C31/13 , A61K31/045 , A61K31/215 , A61K31/19 , A61P25/28 , C12N9/12 , C07C53/132
CPC分类号： C07D303/42 , A61K31/045 , A61K31/201 , A61K31/23 , A61K31/231 , A61K31/335 , C07C31/13 , C07C31/1333 , C07C53/134 , C07C69/608 , C07D303/40 , C12N9/12 , C12Y207/11013
摘要： The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.
摘要翻译：本发明涉及使用单和多不饱和脂肪酸的环丙烷化或环氧化衍生物来激活蛋白激酶C（PKC）的同种型以治疗包括阿尔茨海默氏病和中风的神经疾病的方法。本发明还涉及使用单和多不饱和脂肪酸的环丙烷化或环氧化衍生物减少神经变性的方法。

5. 发明授权

US07977377B2 Treatment of depressive disorders 有权
标题翻译：治疗抑郁症
公开(公告)号：US07977377B2
公开(公告)日：2011-07-12
申请号：US11802724
申请日：2007-05-24
申请人： Miao-Kun Sun , Daniel L. Alkon , Thomas J. Nelson
发明人： Miao-Kun Sun , Daniel L. Alkon , Thomas J. Nelson
IPC分类号： A61K31/335 , A61K31/351 , A61P25/24
CPC分类号： A61K38/1825 , A61K31/045 , A61K31/05 , A61K31/192 , A61K31/196 , A61K31/365 , A61K31/366 , A61K31/4164 , A61K31/4172
摘要： The invention provides for the use of carbonic anhydrase activators; protein kinase C activators and FGF-18 to treat depressive disorders. The invention also relates to improved animal models and methods for screening and identifying compounds the treatment of depressive disorders.
摘要翻译：本发明提供了使用碳酸酐酶活化剂; 蛋白激酶C激活剂和FGF-18治疗抑郁障碍。本发明还涉及用于筛选和鉴定化合物治疗抑郁症的改进的动物模型和方法。

6. 发明授权

US08163800B2 PKC-activating compounds for the treatment of neurodegenerative diseases 有权
标题翻译：用于治疗神经变性疾病的PKC活化化合物
公开(公告)号：US08163800B2
公开(公告)日：2012-04-24
申请号：US12510681
申请日：2009-07-28
申请人： Thomas J. Nelson , Daniel L. Alkon
发明人： Thomas J. Nelson , Daniel L. Alkon
IPC分类号： A61K31/19 , A61K31/20
CPC分类号： C07D303/42 , A61K31/045 , A61K31/201 , A61K31/23 , A61K31/231 , A61K31/335 , C07C31/13 , C07C31/1333 , C07C53/134 , C07C69/608 , C07D303/40 , C12N9/12 , C12Y207/11013
摘要： The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.
摘要翻译：本发明涉及使用单和多不饱和脂肪酸的环丙烷化或环氧化衍生物来激活蛋白激酶C（PKC）的同种型以治疗包括阿尔茨海默氏病和中风的神经疾病的方法。本发明还涉及使用单和多不饱和脂肪酸的环丙烷化或环氧化衍生物减少神经变性的方法。

7. 发明授权

US09567422B2 Acetoacetoxy and enamine compounds and coatings therefrom 有权
标题翻译：乙酰乙酰氧基和烯胺化合物及其涂料
公开(公告)号：US09567422B2
公开(公告)日：2017-02-14
申请号：US13577039
申请日：2011-02-04
申请人： Dean C. Webster , Thomas J. Nelson , Xiao Pan
发明人： Dean C. Webster , Thomas J. Nelson , Xiao Pan
IPC分类号： C07C229/30 , C07H15/04 , C09D105/00 , C08G16/02 , C08G2/12 , C08G12/06 , C09D161/00
CPC分类号： C08G16/0212 , C08G2/12 , C08G12/06 , C09D161/00
摘要： The invention relates to enamine resins which are the reaction products of a) an acetoacetylated resin, and a C1-C20 alkyl amine or a mixture of C1-C20 alkyl amines. The acetoacetylated resin is the reaction product of a polyol having 4 or more hydroxyl groups; and at least one acetoacetate. The invention also relates to an acetoacetylated resin which is the reaction product of a polyol having 4 or more hydroxyl groups and at least one acetoacetate, where a portion of the hydroxyl groups of the polyol are replaced by acetoacetate groups and the remaining hydroxyl groups are replaced by a saturated monofunctional carboxylic acid ester, unsaturated monofunctional carboxylic acid ester, or a mixture thereof; as well as to enamine resins prepared from these acetoacetylated resins. The invention also relates to curable coating compositions containing such resins or a mixture of those resins, at least one metallic drier compound; and optionally one or more solvents.
摘要翻译：本发明涉及烯胺树脂，其是a）乙酰乙酰化树脂和C 1 -C 20烷基胺或C 1 -C 20烷基胺的混合物的反应产物。乙酰乙酰化树脂是具有4个以上羟基的多元醇的反应产物; 和至少一种乙酰乙酸酯。本发明还涉及乙酰乙酰化树脂，其是具有4个或更多个羟基和至少一个乙酰乙酸酯的多元醇的反应产物，其中多羟基的一部分羟基被乙酰乙酸酯基团取代并且剩余的羟基被替换饱和单官能羧酸酯，不饱和单官能羧酸酯或其混合物; 以及烯化由这些乙酰乙酰化树脂制备的树脂。本发明还涉及含有这些树脂的可固化涂料组合物或这些树脂的混合物，至少一种金属干燥剂化合物; 和任选的一种或多种溶剂。

8. 发明授权

US06631686B2 Insert injection molded laminate work surface 失效
标题翻译：插入注塑层压板工作面
公开(公告)号：US06631686B2
公开(公告)日：2003-10-14
申请号：US09810332
申请日：2001-03-19
申请人： Thomas J. Nelson , Mark T. Krejchi , Jon M. Patterson , Frank Villari , Phil LoPresti , James P. Nelson , Mark D. Bauer , Peter Malcolm Green
发明人： Thomas J. Nelson , Mark T. Krejchi , Jon M. Patterson , Frank Villari , Phil LoPresti , James P. Nelson , Mark D. Bauer , Peter Malcolm Green
IPC分类号： A47B1308
CPC分类号： D06F39/12 , A47B77/022 , B29C45/14 , B29C45/14688 , B29C2045/0093 , B29C2045/14868
摘要： An injection molded work surface for use in conjunction with a portable clothes washer includes a decorative laminate top surface and an underlying injection molded substrate. The substrate is provided with a connecting structure facilitating convenient attachment to the upper surface of the clothes washer.
摘要翻译：与便携式洗衣机一起使用的注塑工作表面包括装饰层压板顶表面和下面的注塑底物。该基板设置有便于连接到洗衣机上表面的连接结构

9. 发明授权

US06553878B2 Rotary torsion cutting apparatus 有权
标题翻译：旋转扭转切割装置
公开(公告)号：US06553878B2
公开(公告)日：2003-04-29
申请号：US09682515
申请日：2001-09-13
申请人： Anatoly Gosis , Lee A. Sheridan , G. Michael Velan , Thomas J. Nelson
发明人： Anatoly Gosis , Lee A. Sheridan , G. Michael Velan , Thomas J. Nelson
IPC分类号： B26D100
CPC分类号： B26D3/169 , B23D23/04 , Y10T83/04 , Y10T83/416 , Y10T83/8809
摘要： Disclosed herein is a unique torsional cutting apparatus. Two plates, referred to as a stationary and rotating plate member, are positioned and held in place next to each other using any convention means such as spring tensioned bolts. There is a zero gap between the two plate members. A hole in the general shape of the object to be cut is fashioned through the two plate members so that the object to be cut can be placed into and through the hole. The hole is tapered towards the center of the rotary torsion cutting apparatus thereby allowing ease of insertion, a more precise cut, and the elimination of burring.
摘要翻译：这里公开了一种独特的扭转切割装置。称为固定和旋转板构件的两个板使用诸如弹簧张紧螺栓的任何常规手段彼此相对定位和保持就位。两个板构件之间存在零间隙。要切割的物体的大致形状的孔通过两个板构件形成，使得待切割的物体可以放置在孔中并穿过孔。孔朝向旋转扭转切割装置的中心逐渐变细，从而允许插入方便，切割更精确，并且消除毛刺。

10. 发明授权

US06335091B1 Adhesive tape and products made therefrom 有权
公开(公告)号：US06335091B1
公开(公告)日：2002-01-01
申请号：US09749776
申请日：2000-12-28
申请人： Thomas J. Nelson , Robert R. Krebs
发明人： Thomas J. Nelson , Robert R. Krebs
IPC分类号： B32B712
摘要： A polymeric adhesive tape including a first polymeric adhesive layer which is a heat activated film and a second polymeric adhesive layer which is a heat activated film is disclosed. The tape is designed for use in the fabrication of articles wherein the polymeric adhesive tape secures a first member to a support surface. A method for bonding adjacent sheets to a substrate is also disclosed. In accordance with the disclosed method, a substrate is prepared for application of a first sheet and a second sheet, a polymeric adhesive tape is positioned on the substrate at a position along which the seam between the first sheet and the second sheet will be located, the first sheet and the second sheet are laid on the substrate such that the seam between the first sheet and the second sheet lies along the polymeric adhesive tape, and the adhesive tape is heated along the seam to bond the substrate, adhesive tape, first laminate and second laminate.

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