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1. 发明授权

US07322360B2 Device for accurately marking tissue 有权
标题翻译：用于准确标记组织的装置
公开(公告)号：US07322360B2
公开(公告)日：2008-01-29
申请号：US10798776
申请日：2004-03-10
申请人： Thomas J. Fogarty , David Willis , Thomas A. Howell , George D. Hermann , Peter M. Wilson , Elizabeth M. Bush , Steven W. Kim , Roman Turovskiy
发明人： Thomas J. Fogarty , David Willis , Thomas A. Howell , George D. Hermann , Peter M. Wilson , Elizabeth M. Bush , Steven W. Kim , Roman Turovskiy
IPC分类号： A61B19/00
CPC分类号： A61B90/39 , A61B17/221 , A61B17/320016 , A61B17/320068 , A61B17/3211 , A61B17/34 , A61B17/3401 , A61B17/3403 , A61B17/3421 , A61B17/3468 , A61B17/3476 , A61B18/14 , A61B18/1477 , A61B18/149 , A61B2017/008 , A61B2017/00849 , A61B2017/00853 , A61B2017/00867 , A61B2017/00929 , A61B2018/1425 , A61B2090/3908
摘要： This invention is an improved tissue localizing device for fixedly yet removably marking a volume of tissue containing a suspect region for excision. This invention also encompasses methods for deployment of the localizing device and its excision along with the marked tissue volume. At least one locator element is deployed into tissue and assumes a predetermined curvilinear shape to define a tissue border containing a suspect tissue region along a path. The locator element path preferably encompasses the distalmost portion of the tissue volume without penetrating that volume. Multiple locator elements may be deployed to further define the tissue volume along additional paths defining the tissue volume border that do not penetrate the volume. Other localization wire embodiments of the invention are disclosed in which the tissue volume may be penetrated by a portion of the device. Polar and tangential deployment configurations as well as a locator element that may be cold-formed by a die in the distal portion of the deployment tube into a permanent arcuate shape are also disclosed.
摘要翻译：本发明是一种改进的组织定位装置，用于固定地可移除地标记包含可疑区域的组织的体积用于切除。本发明还包括用于部署定位装置及其切除以及标记的组织体积的方法。至少一个定位元件被部署到组织中并且呈现预定的曲线形状以限定沿着路径包含可疑组织区域的组织边界。定位元件路径优选地包围组织体积的最远部分而不穿透该体积。可以部署多个定位器元件以进一步沿着限定不穿透该体积的组织体积边界的附加路径限定组织体积。公开了本发明的其它定位线实施例，其中组织体积可以被装置的一部分穿透。还公开了极性和切向部署构造以及可以由展开管的远侧部分中的模具冷成形为永久弓形形状的定位元件。

2. 发明授权

US06752154B2 Device for accurately marking tissue 有权
标题翻译：用于准确标记组织的装置
公开(公告)号：US06752154B2
公开(公告)日：2004-06-22
申请号：US09935477
申请日：2001-08-22
申请人： Thomas J. Fogarty , David B. Willis , Thomas A. Howell , George D. Hermann , Peter M. Wilson , Elizabeth M. Bush , Steven W. Kim , Roman Turovskiy
发明人： Thomas J. Fogarty , David B. Willis , Thomas A. Howell , George D. Hermann , Peter M. Wilson , Elizabeth M. Bush , Steven W. Kim , Roman Turovskiy
IPC分类号： A61B1900
CPC分类号： A61B90/39 , A61B17/221 , A61B17/320016 , A61B17/320068 , A61B17/3211 , A61B17/34 , A61B17/3401 , A61B17/3403 , A61B17/3421 , A61B17/3468 , A61B17/3476 , A61B18/14 , A61B18/1477 , A61B18/149 , A61B2017/008 , A61B2017/00849 , A61B2017/00853 , A61B2017/00867 , A61B2017/00929 , A61B2018/1425 , A61B2090/3908
摘要： This invention is an improved tissue localizing device for fixedly yet removably marking a volume of tissue containing a suspect region for excision. This invention also encompasses methods for deployment of the localizing device and its excision along with the marked tissue volume. At least one locator element is deployed into tissue and assumes a predetermined curvilinear shape to define a tissue border containing a suspect tissue region along a path. The locator element path preferably encompasses the distalmost portion of the tissue volume without penetrating that volume. Multiple locator elements may be deployed to further define the tissue volume along additional paths defining the tissue volume border that do not penetrate the volume. Other localization wire embodiments of the invention are disclosed in which the tissue volume may be penetrated by a portion of the device. Polar and tangential deployment configurations as well as a locator element that may be cold-formed by a die in the distal portion of the deployment tube into a permanent arcuate shape are also disclosed.
摘要翻译：本发明是一种改进的组织定位装置，用于固定地可移除地标记包含可疑区域的组织的体积用于切除。本发明还包括用于部署定位装置及其切除以及标记的组织体积的方法。至少一个定位元件被部署到组织中并且呈现预定的曲线形状以限定沿着路径包含可疑组织区域的组织边界。定位元件路径优选地包围组织体积的最远部分而不穿透该体积。可以部署多个定位器元件以进一步沿着限定不穿透该体积的组织体积边界的附加路径限定组织体积。公开了本发明的其它定位线实施例，其中组织体积可以被装置的一部分穿透。还公开了极性和切向部署构造以及可以由展开管的远侧部分中的模具冷成形为永久弓形形状的定位元件。

3. 发明申请

US20120232619A1 Reinforced High Strength Microwave Antenna 有权
标题翻译：强化高强度微波天线
公开(公告)号：US20120232619A1
公开(公告)日：2012-09-13
申请号：US13479588
申请日：2012-05-24
申请人： Roman Turovskiy , Ted Su , Mani Prakash , Steven Kim
发明人： Roman Turovskiy , Ted Su , Mani Prakash , Steven Kim
IPC分类号： A61N5/02
CPC分类号： A61B18/1815 , A61B18/18 , A61B2018/00011 , A61B2018/00577 , A61B2018/00589 , A61B2018/00642 , A61B2018/00702 , A61B2018/00791 , A61B2018/1838 , A61B2018/1846 , A61B2018/1853 , H01Q9/22
摘要： High-strength microwave antenna assemblies and methods of use are described herein. The microwave antenna has a radiating portion connected by a feedline to a power generating source, e.g., a generator. Proximal and distal radiating portions of the antenna assembly are separated by a junction member. A reinforcing member is disposed within the junction member to increase structural rigidity.
摘要翻译：这里描述了高强度微波天线组件和使用方法。微波天线具有通过馈线连接到发电源（例如发电机）的辐射部分。天线组件的近端和远端辐射部分由连接部件分开。加强构件设置在接合构件内以增加结构刚度。

4. 发明申请

US20120136417A1 NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS 有权
公开(公告)号：US20120136417A1
公开(公告)日：2012-05-31
申请号：US13279327
申请日：2011-10-23
申请人： Naomi Buckley , Benjamin J. Clark , Michael Cummins , Danny Donovan , Luke Hughes , Brian Kelly , Gary Kelly , Grace Kelly , John Kelly , Seamus Ledwith , Gwenda McMullin , Karun D. Naga , Stephen Nash , Francesco Piccagli , Eric Ryba , Fiachra Sweeney , Vincenzo Tilotta , Roman Turovskiy , Lana Woolley , Denise Zarins , Mark Gelfand , Mark S. Leung , Barry Mullins
发明人： Naomi Buckley , Benjamin J. Clark , Michael Cummins , Danny Donovan , Luke Hughes , Brian Kelly , Gary Kelly , Grace Kelly , John Kelly , Seamus Ledwith , Gwenda McMullin , Karun D. Naga , Stephen Nash , Francesco Piccagli , Eric Ryba , Fiachra Sweeney , Vincenzo Tilotta , Roman Turovskiy , Lana Woolley , Denise Zarins , Mark Gelfand , Mark S. Leung , Barry Mullins
IPC分类号： A61F7/12
CPC分类号： A61B18/02 , A61B2017/22054 , A61B2017/22067 , A61B2018/00023 , A61B2018/00166 , A61B2018/0022 , A61B2018/00232 , A61B2018/0025 , A61B2018/00261 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262
摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

5. 发明授权

US07875024B2 Devices and methods for cooling microwave antennas 有权
标题翻译：用于冷却微波天线的设备和方法
公开(公告)号：US07875024B2
公开(公告)日：2011-01-25
申请号：US11053987
申请日：2005-02-08
申请人： Roman Turovskiy , Steven Kim , Mani Prakash , Francesca Rossetto
发明人： Roman Turovskiy , Steven Kim , Mani Prakash , Francesca Rossetto
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B18/18 , A61B2017/00084 , A61B2018/00017 , A61B2018/00023 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00791 , A61B2018/00863 , A61B2018/00875 , A61B2018/1838 , A61N5/045
摘要： Devices and methods for cooling microwave antennas are disclosed herein. The cooling systems can be used with various types of microwave antennas. One variation generally comprises a handle portion with an elongate outer jacket extending from the handle portion. A microwave antenna is positioned within the handle and outer jacket such that cooling fluid pumped into the handle comes into contact directly along a portion of the length, or a majority of the length, or the entire length of the antenna to allow for direct convective cooling. Other variations include cooling sheaths which form defined cooling channels around a portion of the antenna. Yet another variation includes passively-cooled systems which utilize expandable balloons to urge tissue away from the surface of the microwave antenna as well as cooling sheaths which are cooled through endothermic chemical reactions. Furthermore, the microwave antennas themselves can have cooling lumens integrated directly therethrough.
摘要翻译：本文公开了用于冷却微波天线的装置和方法。冷却系统可用于各种类型的微波天线。一个变型通常包括具有从手柄部分延伸的细长外护套的手柄部分。微波天线位于手柄和外护套内，使得泵送到手柄中的冷却液体沿着长度的一部分，或长度的大部分或天线的整个长度直接接触以允许直接对流冷却。其他变型包括在天线的一部分周围形成限定的冷却通道的冷却护套。另一个变型包括被动冷却的系统，其利用可膨胀的气囊来促使组织远离微波天线的表面，以及通过吸热化学反应冷却的冷却鞘。此外，微波天线本身可以具有直接集成在其中的冷却管道。

6. 发明授权

US07846108B2 Localization element with energized tip 有权
标题翻译：带通电尖端的本地化元件
公开(公告)号：US07846108B2
公开(公告)日：2010-12-07
申请号：US12331663
申请日：2008-12-10
申请人： Roman Turovskiy , Ted Su , Steven Kim , Mani N. Prakash
发明人： Roman Turovskiy , Ted Su , Steven Kim , Mani N. Prakash
IPC分类号： A61B10/00 , A61B18/18
CPC分类号： A61B90/39 , A61B18/1477 , A61B18/1815 , A61B2018/1425 , A61B2018/1435 , A61B2018/1475 , A61B2018/183 , A61B2090/3908
摘要： This invention is an improved tissue-localizing device with an electrically energized locator element for fixedly yet removal marking a volume of tissue containing a suspect region for excision. The electrical energizing of the locator element facilitates the penetration of the locator element in to subject's tissue and minimizes resistance due to dense or calcified tissues. At least one locator element is deployed into tissue and assumes a predetermined curvilinear shape to define a tissue border containing a suspect tissue region along a path. Multiple locator elements may be deployed to further define the tissue volume along additional paths defining the tissue volume border that do not penetrate the volume. Delivery of electric cut-rent may be achieved through monopolar or bipolar electronic configuration depending on design needs. Various energy sources, e.g, radio frequency, microwave or ultrasound, may be implemented in this energized tissue-localizing device.
摘要翻译：本发明是一种改进的组织定位装置，其具有电激励定位元件，用于固定地除去标记包含用于切除的可疑区域的体积的组织。定位器元件的电能激励定位元件穿透到受试者的组织中并使由于致密或钙化组织引起的阻力最小化。至少一个定位元件被部署到组织中并且呈现预定的曲线形状以限定沿着路径包含可疑组织区域的组织边界。可以部署多个定位器元件以进一步沿着限定不穿透该体积的组织体积边界的附加路径限定组织体积。根据设计需要，可以通过单极或双极电子配置实现电力租赁的交付。各种能量源，例如射频，微波或超声可以在这种激活的组织定位装置中实现。

7. 发明申请

US20080135217A1 Devices and Methods for Cooling Microwave Antennas 有权
标题翻译：冷却微波天线的设备和方法
公开(公告)号：US20080135217A1
公开(公告)日：2008-06-12
申请号：US11940738
申请日：2007-11-15
申请人： Roman Turovskiy , Steven Kim
发明人： Roman Turovskiy , Steven Kim
IPC分类号： F28D15/00
CPC分类号： A61B18/1815 , A61B18/18 , A61B2017/00084 , A61B2018/00017 , A61B2018/00023 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00791 , A61B2018/00863 , A61B2018/00875 , A61B2018/1838 , A61N5/045
摘要： Devices and methods for cooling microwave antennas are disclosed herein. The cooling systems can be used with various types of microwave antennas. One variation generally comprises a handle portion with an elongate outer jacket extending from the handle portion. A microwave antenna is positioned within the handle and outer jacket such that cooling fluid pumped into the handle comes into contact directly along a portion of the length, or a majority of the length, or the entire length of the antenna to allow for direct convective cooling. Other variations include cooling sheaths which form defined cooling channels around a portion of the antenna. Yet another variation includes passively-cooled systems which utilize expandable balloons to urge tissue away from the surface of the microwave antenna as well as cooling sheaths which are cooled through endothermic chemical reactions. Furthermore, the microwave antennas themselves can have cooling lumens integrated directly therethrough.
摘要翻译：本文公开了用于冷却微波天线的装置和方法。冷却系统可用于各种类型的微波天线。一个变型通常包括具有从手柄部分延伸的细长外护套的手柄部分。微波天线位于手柄和外护套内，使得泵送到手柄中的冷却液体沿着长度的一部分，或长度的大部分或天线的整个长度直接接触以允许直接对流冷却。其他变型包括在天线的一部分周围形成限定的冷却通道的冷却护套。另一个变型包括被动冷却的系统，其利用可膨胀的气囊来促使组织远离微波天线的表面，以及通过吸热化学反应冷却的冷却鞘。此外，微波天线本身可以具有直接集成在其中的冷却管道。

8. 发明授权

US07311703B2 Devices and methods for cooling microwave antennas 有权
标题翻译：用于冷却微波天线的设备和方法
公开(公告)号：US07311703B2
公开(公告)日：2007-12-25
申请号：US10622800
申请日：2003-07-18
申请人： Roman Turovskiy , Steven Kim , Mani Prakash , Francesca Rossetto
发明人： Roman Turovskiy , Steven Kim , Mani Prakash , Francesca Rossetto
IPC分类号： A61B18/04
CPC分类号： A61B18/1815 , A61B18/18 , A61B2017/00084 , A61B2018/00017 , A61B2018/00023 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00791 , A61B2018/00863 , A61B2018/00875 , A61B2018/1838 , A61N5/045
摘要： Devices and methods for cooling microwave antennas are disclosed herein. The cooling systems can be used with various types of microwave antennas. One variation generally comprises a handle portion with an elongate outer jacket extending from the handle portion. A microwave antenna is positioned within the handle and outer jacket such that cooling fluid pumped into the handle comes into contact directly along a portion of the length, or a majority of the length, or the entire length of the antenna to allow for direct convective cooling. Other variations include cooling sheaths which form defined cooling channels around a portion of the antenna. Yet another variation includes passively-cooled systems which utilize expandable balloons to urge tissue away from the surface of the microwave antenna as well as cooling sheaths which are cooled through endothermic chemical reactions. Furthermore, the microwave antennas themselves can have cooling lumens integrated directly therethrough.
摘要翻译：本文公开了用于冷却微波天线的装置和方法。冷却系统可以与各种类型的微波天线一起使用。一个变型通常包括具有从手柄部分延伸的细长外护套的手柄部分。微波天线位于手柄和外护套内，使得泵送到手柄中的冷却液体沿着长度的一部分，或长度的大部分或天线的整个长度直接接触以允许直接对流冷却。其他变型包括在天线的一部分周围形成限定的冷却通道的冷却护套。另一个变型包括被动冷却的系统，其利用可膨胀的气囊来促使组织远离微波天线的表面，以及通过吸热化学反应冷却的冷却鞘。此外，微波天线本身可以具有直接集成在其中的冷却管道。

9. 发明授权

US06752767B2 Localization element with energized tip 有权
标题翻译：带通电尖端的本地化元件
公开(公告)号：US06752767B2
公开(公告)日：2004-06-22
申请号：US10271850
申请日：2002-10-15
申请人： Roman Turovskiy , Ted Su , Steven Kim , Mani Prakash
发明人： Roman Turovskiy , Ted Su , Steven Kim , Mani Prakash
IPC分类号： A61B1050
CPC分类号： A61B90/39 , A61B18/1477 , A61B18/1815 , A61B2018/1425 , A61B2018/1435 , A61B2018/1475 , A61B2018/183 , A61B2090/3908
摘要： This invention is an improved tissue-localizing device with an electrically energized locator element for fixedly yet removably marking a volume of tissue containing a suspect region for excision. The electrical energizing of the locator element facilitates the penetration of the locator element in to subject's tissue and minimizes resistance due to dense or calcified tissues. At least one locator element is deployed into tissue and assumes a predetermined curvilinear shape to define a tissue border containing a suspect tissue region along a path. Multiple locator elements may be deployed to further define the tissue volume along additional paths defining the tissue volume border that do not penetrate the volume. Delivery of electric current may be achieved through monopolar or bipolar electronic configuration depending on design needs. Various energy sources, e.g. radio frequency, microwave or ultrasound, may be implemented in this energized tissue-localizing device.
摘要翻译：本发明是一种改进的组织定位装置，其具有用于固定地可移除地标记包含可疑区域的组织的体积的用于切除的电激励定位元件。定位器元件的电能激励定位元件穿透到受试者的组织中并使由于致密或钙化组织引起的阻力最小化。至少一个定位元件被部署到组织中并且呈现预定的曲线形状以限定沿着路径包含可疑组织区域的组织边界。可以部署多个定位器元件以进一步沿着限定不穿透该体积的组织体积边界的附加路径限定组织体积。根据设计需要，可以通过单极或双极电子配置实现电流传递。各种能量源射频，微波或超声可以在这种激活的组织定位装置中实现。

10. 发明授权

US06666846B1 Medical device introducer and obturator and methods of use 有权
公开(公告)号：US06666846B1
公开(公告)日：2003-12-23
申请号：US09439646
申请日：1999-11-12
申请人： Roman Turovskiy , Richard O. Murphy
发明人： Roman Turovskiy , Richard O. Murphy
IPC分类号： A61M5178
CPC分类号： A61B17/3421 , A61B17/3417 , A61B2017/00243 , A61B2017/3445 , A61B2017/3447 , A61F2002/011
摘要： An introducer having an elongate tubular member and a device connector releasably attached to a proximal end of the tubular member. The introducer allows exchange of medical instruments, such as a blood filter and cardioplegia catheter, through a single lumen. An obturator having a retractable blade for making incision on a tissue is insertable through the lumen of the introducer. Methods of using the obturator and the introducer for introducing medical device(s) into body cavity, such as a vessel or cardiac tissue, are also disclosed.

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