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1. 发明授权

US08114680B2 Buffy coat separator float system and method 有权
标题翻译：水雾分离器浮法系统及方法
公开(公告)号：US08114680B2
公开(公告)日：2012-02-14
申请号：US13052172
申请日：2011-03-21
申请人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
发明人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
IPC分类号： G01N1/18 , G01N33/48 , C12M1/34
CPC分类号： G01N33/5094 , B01L3/50215 , G01N33/491 , Y10T436/111666 , Y10T436/25 , Y10T436/25375
摘要： A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.
摘要翻译：用于血沉棕黄层的分离和轴向膨胀的管和浮子系统包括透明或半透明的柔性样品管和具有红细胞和血浆的比重中间体的刚性分离器浮子。浮子包括直径减小的主体部分，以在样品管的内壁和浮子之间提供间隙。主体部分上的一个或多个突起用于支撑柔性管。在离心过程中，离心力使柔性管的直径膨胀并允许管中的浮子的基于密度的轴向运动。浮子还包括一个压力释放系统，以减轻在浮子下面的被捕获的红细胞血液部分中的压力增加，从而防止红细胞被迫进入含有血沉棕黄层的环形间隙。

2. 发明申请

US20110165672A1 BUFFY COAT SEPARATOR FLOAT SYSTEM AND METHOD 有权
标题翻译： BUFFY COAT SEPATATOR FLOAT SYSTEM AND METHOD
公开(公告)号：US20110165672A1
公开(公告)日：2011-07-07
申请号：US13052172
申请日：2011-03-21
申请人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
发明人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
IPC分类号： C12N5/078 , C12M1/34
CPC分类号： G01N33/5094 , B01L3/50215 , G01N33/491 , Y10T436/111666 , Y10T436/25 , Y10T436/25375
摘要： A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.
摘要翻译：用于血沉棕黄层的分离和轴向膨胀的管和浮子系统包括透明或半透明的柔性样品管和具有红细胞和血浆的比重中间体的刚性分离器浮子。浮子包括直径减小的主体部分，以在样品管的内壁和浮子之间提供间隙。主体部分上的一个或多个突起用于支撑柔性管。在离心过程中，离心力使柔性管的直径膨胀并允许管中的浮子的基于密度的轴向运动。浮子还包括一个压力释放系统，以减轻在浮子下面的被捕获的红细胞血液部分中的压力增加，从而防止红细胞被迫进入含有血沉棕黄层的环形间隙。

3. 发明申请

US20100074803A1 BUFFY COAT SEPARATOR FLOAT SYSTEM AND METHOD 有权
标题翻译： BUFFY COAT SEPATATOR FLOAT SYSTEM AND METHOD
公开(公告)号：US20100074803A1
公开(公告)日：2010-03-25
申请号：US12614602
申请日：2009-11-09
申请人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
发明人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
IPC分类号： G01N1/18 , G01N33/48
CPC分类号： G01N33/5094 , B01L3/50215 , G01N33/491 , Y10T436/111666 , Y10T436/25 , Y10T436/25375
摘要： A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.
摘要翻译：用于血沉棕黄层的分离和轴向膨胀的管和浮子系统包括透明或半透明的柔性样品管和具有红细胞和血浆的比重中间体的刚性分离器浮子。浮子包括直径减小的主体部分，以在样品管的内壁和浮子之间提供间隙。主体部分上的一个或多个突起用于支撑柔性管。在离心过程中，离心力使柔性管的直径膨胀并允许管中的浮子的基于密度的轴向运动。浮子还包括一个压力释放系统，以减轻在浮子下面的被捕获的红细胞血液部分中的压力增加，从而防止红细胞被迫进入含有血沉棕黄层的环形间隙。

4. 发明授权

US07629176B2 Buffy coat separator float system and method 失效
标题翻译：水雾分离器浮法系统及方法
公开(公告)号：US07629176B2
公开(公告)日：2009-12-08
申请号：US12029289
申请日：2008-02-11
申请人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
发明人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
IPC分类号： G01N1/18 , G01N33/48
CPC分类号： G01N33/5094 , B01L3/50215 , G01N33/491 , Y10T436/111666 , Y10T436/25 , Y10T436/25375
摘要： A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.
摘要翻译：用于血沉棕黄层的分离和轴向膨胀的管和浮子系统包括透明或半透明的柔性样品管和具有红细胞和血浆的比重中间体的刚性分离器浮子。浮子包括直径减小的主体部分，以在样品管的内壁和浮子之间提供间隙。主体部分上的一个或多个突起用于支撑柔性管。在离心过程中，离心力使柔性管的直径膨胀并允许管中的浮子的基于密度的轴向运动。浮子还包括一个压力释放系统，以减轻在浮子下面的被捕获的红细胞血液部分中的压力增加，从而防止红细胞被迫进入含有血沉棕黄层的环形间隙。

5. 发明授权

US08415169B2 Buffy coat separator float system and method 失效
公开(公告)号：US08415169B2
公开(公告)日：2013-04-09
申请号：US13371761
申请日：2012-02-13
申请人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
发明人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
IPC分类号： G01N1/18 , G01N33/48 , C12M1/34
CPC分类号： B01L3/50215 , Y10T436/111666 , Y10T436/25375
摘要： A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.

6. 发明申请

US20120164683A1 BUFFY COAT SEPARATOR FLOAT SYSTEM AND METHOD 失效
标题翻译： BUFFY COAT SEPATATOR FLOAT SYSTEM AND METHOD
公开(公告)号：US20120164683A1
公开(公告)日：2012-06-28
申请号：US13371761
申请日：2012-02-13
申请人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
发明人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
IPC分类号： C12Q1/04 , B29C45/00 , C12M1/34
CPC分类号： B01L3/50215 , Y10T436/111666 , Y10T436/25375
摘要： A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.
摘要翻译：用于血沉棕黄层的分离和轴向膨胀的管和浮子系统包括透明或半透明的柔性样品管和具有红细胞和血浆的比重中间体的刚性分离器浮子。浮子包括直径减小的主体部分，以在样品管的内壁和浮子之间提供间隙。主体部分上的一个或多个突起用于支撑柔性管。在离心过程中，离心力使柔性管的直径膨胀并允许管中的浮子的基于密度的轴向运动。浮子还包括一个压力释放系统，以减轻在浮子下面的被捕获的红细胞血液部分中的压力增加，从而防止红细胞被迫进入含有血沉棕黄层的环形间隙。

7. 发明申请

US20080131868A1 BUFFY COAT SEPARATOR FLOAT SYSTEM AND METHOD 失效
标题翻译： BUFFY COAT SEPATATOR FLOAT SYSTEM AND METHOD
公开(公告)号：US20080131868A1
公开(公告)日：2008-06-05
申请号：US12029289
申请日：2008-02-11
申请人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
发明人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
IPC分类号： A01N1/02 , C12M1/24
CPC分类号： G01N33/5094 , B01L3/50215 , G01N33/491 , Y10T436/111666 , Y10T436/25 , Y10T436/25375
摘要： A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.
摘要翻译：用于血沉棕黄层的分离和轴向膨胀的管和浮子系统包括透明或半透明的柔性样品管和具有红细胞和血浆的比重中间体的刚性分离器浮子。浮子包括直径减小的主体部分，以在样品管的内壁和浮子之间提供间隙。主体部分上的一个或多个突起用于支撑柔性管。在离心过程中，离心力使柔性管的直径膨胀并允许管中的浮子的基于密度的轴向运动。浮子还包括一个压力释放系统，以减轻在浮子下面的被捕获的红细胞血液部分中的压力增加，从而防止红细胞被迫进入含有血沉棕黄层的环形间隙。

8. 发明授权

US07919049B2 Buffy Coat separator float system and method 有权
标题翻译： Buffy Coat分离器浮子系统和方法
公开(公告)号：US07919049B2
公开(公告)日：2011-04-05
申请号：US12614602
申请日：2009-11-09
申请人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
发明人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
IPC分类号： G01N1/18 , G01N33/48
CPC分类号： G01N33/5094 , B01L3/50215 , G01N33/491 , Y10T436/111666 , Y10T436/25 , Y10T436/25375
摘要： A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.
摘要翻译：用于血沉棕黄层的分离和轴向膨胀的管和浮子系统包括透明或半透明的柔性样品管和具有红细胞和血浆的比重中间体的刚性分离器浮子。浮子包括直径减小的主体部分，以在样品管的内壁和浮子之间提供间隙。主体部分上的一个或多个突起用于支撑柔性管。在离心过程中，离心力使柔性管的直径膨胀并允许管中的浮子的基于密度的轴向运动。浮子还包括一个压力释放系统，以减轻在浮子下面的被捕获的红细胞血液部分中的压力增加，从而防止红细胞被迫进入含有血沉棕黄层的环形间隙。

9. 发明授权

US07358095B2 Buffy coat separator float system and method 有权
标题翻译：水雾分离器浮法系统及方法
公开(公告)号：US07358095B2
公开(公告)日：2008-04-15
申请号：US11609186
申请日：2006-12-11
申请人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
发明人： Thomas Haubert , Vince Contini , Steve Grimes , Randy Jones , Stephen C. Wardlaw
IPC分类号： G01N1/18 , G01N33/48
CPC分类号： G01N33/5094 , B01L3/50215 , G01N33/491 , Y10T436/111666 , Y10T436/25 , Y10T436/25375
摘要： A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.
摘要翻译：用于血沉棕黄层的分离和轴向膨胀的管和浮子系统包括透明或半透明的柔性样品管和具有红细胞和血浆的比重中间体的刚性分离器浮子。浮子包括直径减小的主体部分，以在样品管的内壁和浮子之间提供间隙。主体部分上的一个或多个突起用于支撑柔性管。在离心过程中，离心力使柔性管的直径膨胀并允许管中的浮子的基于密度的轴向运动。浮子还包括一个压力释放系统，以减轻在浮子下面的被捕获的红细胞血液部分中的压力增加，从而防止红细胞被迫进入含有血沉棕黄层的环形间隙。

10. 发明申请

US20080128340A1 BUFFY COAT TUBE AND FLOAT SYSTEM AND METHOD 有权
公开(公告)号：US20080128340A1
公开(公告)日：2008-06-05
申请号：US12029274
申请日：2008-02-11
申请人： Thomas Haubert , Stephen C. Wardlaw
发明人： Thomas Haubert , Stephen C. Wardlaw
IPC分类号： B01D35/05
CPC分类号： B01L3/505 , B01L3/50215 , B01L2400/0409 , G01N33/49 , Y10S435/81 , Y10S436/81
摘要： A tube and float system for use in separation and axial expansion of the buffy coat is provided. The system includes a transparent, or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The sample tube has an elongated sidewall having a first cross-sectional inner diameter. The float consists of a main body portion and one or more support members protruding from the main body portion to engage and support the sidewall of the sample tube. The main body portion and the support members of the float have a cross-sectional diameter less than that of the first cross-sectional inner diameter of the tube when the sample tube is expanded, such as by centrifugation. The main body portion of the float together with an axially aligned portion of the sidewall define an annular volume therebetween. The support members protruding from the main body portion of the float traverse said annular volume to produce one or more analysis areas. During centrifugation, the centrifugal force enlarges the diameter of the tube to permit density-based axial movement of the float in the tube. Thereafter, the centrifugal force is reduced to cause the tube sidewall to return to its first diameter, thereby capturing the float and trapping the buffy coat constituents in the analysis area. The buffy coat constituents can then be evaluated or measured.
摘要翻译：提供了用于分离和轴向膨胀血沉棕黄层的管和浮子系统。该系统包括透明或半透明的柔性样品管和具有红细胞和血浆的比重中间体的刚性分离器浮子。样品管具有具有第一横截面内径的细长侧壁。浮子包括主体部分和从主体部分突出的一个或多个支撑构件，以接合和支撑样品管的侧壁。例如通过离心，浮体的主体部分和支撑构件的横截面直径小于管的第一截面内径的横截面直径。浮子的主体部分与侧壁的轴向对准部分在其间限定了环形体积。从浮子的主体部分突出的支撑构件穿过所述环形体积以产生一个或多个分析区域。在离心过程中，离心力扩大了管的直径，以允许管中的浮子的基于密度的轴向运动。此后，减小离心力使管侧壁回到其第一直径，从而捕获浮子并将分析区域中的血沉棕黄层成分捕获。然后可以评估或测量血沉棕质成分。

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