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1. 发明申请

US20130280775A1 Recombinant N-propanol and Isopropanol Production 审中-公开
标题翻译：重组N-丙醇和异丙醇生产
公开(公告)号：US20130280775A1
公开(公告)日：2013-10-24
申请号：US13882336
申请日：2011-10-28
申请人： Thomas Grotkjaer , Bjarke Christensen , Torsten Bak Regueira , Steen Troels Joergensen , Alan Berry
发明人： Thomas Grotkjaer , Bjarke Christensen , Torsten Bak Regueira , Steen Troels Joergensen , Alan Berry
IPC分类号： C12P7/04
CPC分类号： C12P7/04 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/90 , C12N15/746 , C12P7/02 , C12Y101/01001 , C12Y101/0108 , C12Y102/01003 , C12Y203/01009 , C12Y208/03005 , C12Y208/03009 , C12Y301/02011 , C12Y401/01004 , C12Y401/01041 , C12Y501/99001 , C12Y504/99002
摘要： The present invention relates to methods of producing n-propanol, isopropanol, and coproducing n-propanol with isopropanol. The present invention also relates to methods for producing propylene, as well as host cells capable of n-propanol and isopropanol production.
摘要翻译：本发明涉及用异丙醇生产正丙醇，异丙醇和共同生产正丙醇的方法。本发明还涉及生产丙烯的方法，以及能够进行正丙醇和异丙醇生产的宿主细胞。

2. 发明申请

US20130295644A1 Polypeptides Having Succinyl-CoA: Acetoacetate Transferase Activity and Polynucleotides Encoding Same 有权
标题翻译：具有琥珀酰辅酶A的多肽：乙酰乙酸转移酶活性和编码相同的多核苷酸
公开(公告)号：US20130295644A1
公开(公告)日：2013-11-07
申请号：US13882343
申请日：2011-10-28
申请人： Bjarke Christensen , Peter Bjarke Olsen , Torsten Bak Regueira , Steen Troels Joergensen , Alan Berry
发明人： Bjarke Christensen , Peter Bjarke Olsen , Torsten Bak Regueira , Steen Troels Joergensen , Alan Berry
IPC分类号： C12N9/10
CPC分类号： C12N9/13 , C12Y208/03005
摘要： The present invention relates to isolated protein complexes having succinyl-CoA:acetoacetate transferase activity, isolated polypeptide subunits thereof, and isolated polynucleotides encoding the subunits. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and protein complexes.
摘要翻译：本发明涉及具有琥珀酰-CoA：乙酰乙酸转移酶活性的分离的蛋白复合物，其分离的多肽亚基，以及编码亚基的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽和蛋白质复合物的方法。

3. 发明授权

US08728804B2 Polypeptides having succinyl-CoA: acetoacetate transferase activity and polynucleotides encoding same 有权
标题翻译：具有琥珀酰-CoA：乙酰乙酸转移酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：US08728804B2
公开(公告)日：2014-05-20
申请号：US13882343
申请日：2011-10-28
申请人： Bjarke Christensen , Peter Bjarke Olsen , Torsten Bak Regueira , Steen Troels Joergensen , Alan Berry
发明人： Bjarke Christensen , Peter Bjarke Olsen , Torsten Bak Regueira , Steen Troels Joergensen , Alan Berry
IPC分类号： C12N15/00 , C07H21/04
CPC分类号： C12N9/13 , C12Y208/03005
摘要： The present invention relates to isolated protein complexes having succinyl-CoA:acetoacetate transferase activity, isolated polypeptide subunits thereof, and isolated polynucleotides encoding the subunits. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and protein complexes.
摘要翻译：本发明涉及具有琥珀酰-CoA：乙酰乙酸转移酶活性的分离的蛋白复合物，其分离的多肽亚基，以及编码亚基的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽和蛋白质复合物的方法。

4. 发明申请

US20090280534A1 Recombinant Production of Serum Albumin 审中-公开
标题翻译：重组血清白蛋白的生产
公开(公告)号：US20090280534A1
公开(公告)日：2009-11-12
申请号：US11721813
申请日：2005-12-22
申请人： Bjarke Christensen , Carsten Hjort , Thomas Agersten Poulsen , Poul Bach
发明人： Bjarke Christensen , Carsten Hjort , Thomas Agersten Poulsen , Poul Bach
IPC分类号： C12P21/02 , C12N15/11
CPC分类号： C07K14/765 , A61K9/16 , A61K38/38 , C12N15/67
摘要： The present invention relates to modified nucleotide sequences encoding serum albumin, wherein the mRNA sequence has been codon optimized for expression in a filamentous host cell. Furthermore the present invention relates to serum albumin produced in filamentous fungi or loaded by contacting serum albumin with an extract of a filamentous fungi culture. In an-other aspect the present invention relates to the use of said serum albumin in serum free cell culture media and also to a method of drying and agglomerating serum albumin thereby im-proving wettability and dispersability.
摘要翻译：本发明涉及编码血清白蛋白的修饰的核苷酸序列，其中mRNA序列已被密码子优化用于在丝状宿主细胞中表达。此外，本发明涉及在丝状真菌中产生的血清白蛋白或通过使血清白蛋白与丝状真菌培养物的提取物接触来加载。另一方面，本发明涉及所述血清白蛋白在无血清细胞培养基中的用途，还涉及一种干燥和附聚血清白蛋白从而提高润湿性和分散性的方法。

5. 发明申请

US20090239757A1 Control Sequences Responding to AMP and Uses Thereof 审中-公开
标题翻译：控制序列响应AMP及其用途
公开(公告)号：US20090239757A1
公开(公告)日：2009-09-24
申请号：US11722249
申请日：2005-12-20
申请人： Jesper Duus Nielsen , Allan Kent Nielsen , Bjarke Christensen , Poul Erik Pedersen , Hans-Henrik Kristensen Hoegenhaug
发明人： Jesper Duus Nielsen , Allan Kent Nielsen , Bjarke Christensen , Poul Erik Pedersen , Hans-Henrik Kristensen Hoegenhaug
IPC分类号： C40B30/04 , C12Q1/68 , C12N1/21 , C40B30/06
CPC分类号： C12N15/1086 , C12Q1/6809 , C12Q1/6897 , C12Q2565/501
摘要： The present invention relates to a method of identifying control sequences responding to antimicrobial peptides (AMPs), to host cells expressing an AMP and comprising a control sequence of the invention operable linked to a reporter, and to a method of screening for novel AMPs or AMP-variants having improved antimicrobial activity. Particularly the present invention relates to DNA control sequences, wherein the transcriptional profiles of said control sequences are regulated by the presence of an antimicrobial polypeptide expressed inside the host cell.
摘要翻译：本发明涉及一种鉴定对抗微生物肽（AMP）作出反应的控制序列的方法，宿主表达AMP的细胞并包含可操作地连接到报道分子的本发明的对照序列的方法，以及筛选新的AMP或AMP的方法变体具有改善的抗微生物活性。特别地，本发明涉及DNA控制序列，其中所述控制序列的转录谱通过在宿主细胞内表达的抗微生物多肽的存在来调节。

6. 发明申请

US20120329090A1 Methods for Producing Heterologous Polypeptides in Thiol-Disulfide Oxidoreductase-Deficient Bacterial Mutant Cells 审中-公开
标题翻译：在硫代二硫化物氧化还原酶缺陷型细菌突变体细胞中产生异源多肽的方法
公开(公告)号：US20120329090A1
公开(公告)日：2012-12-27
申请号：US13516475
申请日：2010-12-17
申请人： William Widner , Bjarke Christensen
发明人： William Widner , Bjarke Christensen
IPC分类号： C12N1/21 , C12N15/87 , C12P21/00
CPC分类号： C12N15/75 , C12N9/0036 , C12N9/0051 , C12Y108/04002
摘要： The present invention relates to methods of producing a heterologous polypeptide, comprising: (a) cultivating a mutant of a parent bacterial cell in a medium for the production of the heterologous polypeptide, wherein (i) the mutant cell comprises a first polynucleotide encoding the heterologous polypeptide which comprises two or more (several) cysteines, and a second polynucleotide comprising a modification of a gene encoding a thiol-disulfide oxidoreductase that incorrectly catalyzes the formation of one or more (several) disulfide bonds between the two or more (several) cysteines of the heterologous polypeptide, and (ii) the mutant cell is deficient in production of the thiol-disulfide oxidoreductase compared to the parent bacterial cell when cultivated under the same conditions; and (b) recovering the heterologous polypeptide from the cultivation medium. The present invention also relates to such bacterial mutants and methods for producing such bacterial mutants.
摘要翻译：本发明涉及产生异源多肽的方法，其包括：（a）在用于产生异源多肽的培养基中培养母细菌细胞的突变体，其中（i）突变细胞包含编码异源多肽的第一个多核苷酸包括两个或多个（几个）半胱氨酸的多肽，以及第二多核苷酸，其包含编码硫醇 - 二硫键氧化还原酶的基因的修饰，其不正确地催化两个或多个（几个）半胱氨酸之间的一个或多个（几个）二硫键的形成的异源多肽，和（ii）当在相同条件下培养时，与母体细菌细胞相比，突变细胞缺乏硫醇 - 二硫键氧化还原酶的产生; 和（b）从培养基中回收异源多肽。本发明还涉及这种细菌突变体及其生产方法。

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