会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明授权
    • Aralkyl and aralkenyl glycosides as inhibitors of antigen-specific
T-cell proliferation
    • 芳烷基和芳烯基糖苷作为抗原特异性T细胞增殖的抑制剂
    • US4554349A
    • 1985-11-19
    • US540594
    • 1983-10-11
    • Mitree M. PonpipomTsung-Ying ShenRobert L. Bugianesi
    • Mitree M. PonpipomTsung-Ying ShenRobert L. Bugianesi
    • C07H15/18C07H5/06
    • C07H15/18
    • The invention disclosed herein relates to novel 1-deoxyglycosides, preferably 1-deoxy-D-mannopyranosides and 1-deoxy-L-rhamnopyranosides, having in the 1-position of the pyranose ring an aralkylthio/aralkenylthio, aralkyloxy/aralkenyloxy or aralkanoylamino/aralkenoylamino substituent; and to novel processes for preparing these 1-substituted-1-deoxyglycosides starting with the corresponding tetra-O-acetylglycopyranosyl bromide or amine. The 6-hydroxy group of 1-substituted-1 deoxyglycopyranosides can also be replaced by other functional groups. These aralkylthio/aralkenylthio, aralkyloxy/aralkenyloxy and aralkanoylamino/aralkenoylamino 1-deoxyglycosides are potent inhibitors of antigen-specific T-cell proliferation and are also useful as inhibitors of delayed-type hypersensitivity reactions.
    • 本文公开的本发明涉及新的1-脱氧糖苷,优选1-脱氧-D-甘露吡喃糖苷和1-脱氧-L-鼠李糖吡喃糖苷,其在吡喃糖环的1-位具有芳烷硫基/芳烯基硫基,芳烷氧基/芳烯基氧基或芳烷酰氨基/芳烯基酰氨基 取代基; 以及由相应的四-O-乙酰基吡喃葡糖基溴或胺开始制备这些1-取代-1-脱氧糖苷的新方法。 1-取代-1脱氧吡喃糖苷的6-羟基也可以被其它官能团取代。 这些芳烷硫基/芳烯基硫基,芳烷氧基/芳烯基氧基和芳烷酰氨基/芳烯酰氨基-1-脱氧糖苷是抗原特异性T细胞增殖的有效抑制剂,也可用作延迟型超敏反应的抑制剂。