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1. 发明申请

US20060035786A1 Saccarose-6-phosphate phosphatase as a target for herbicides 失效
标题翻译： Saccarose-6-磷酸磷酸酶作为除草剂的靶标
公开(公告)号：US20060035786A1
公开(公告)日：2006-02-16
申请号：US10522096
申请日：2003-07-16
申请人： Thomas Ehrhardt , Uwe Sonnewald , Frederik Bornke , Shuai Chen
发明人： Thomas Ehrhardt , Uwe Sonnewald , Frederik Bornke , Shuai Chen
IPC分类号： A01N25/00 , C12Q1/68 , C12Q1/42 , C12P21/06 , C12N9/16 , C40B30/04
CPC分类号： C12N9/16 , C12N15/8274
摘要： The present invention relates to the use of a polypeptide with the biological activity of a sucrose-6-phosphate phosphatase which, if not present, brings about growth retardation symptoms and chlorotic leaves and which is encoded by the nucleic acid sequences SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5 or by a functional equivalent of SEQ ID NO:1, SEQ ID NO:3 or SEQ ID NO:5 as target for herbicides. Moreover, the present invention relates to the use of the abovementioned polypeptides in a method for identifying herbicidal or growth-regulatory compounds which inhibit sucrose-6-phosphate phosphatase. Moreover, the invention relates to the use of these compounds which have been identified via the method as herbicides or growth regulators.
摘要翻译：本发明涉及具有蔗糖-6-磷酸磷酸酶的生物学活性的多肽的用途，如果不存在，则会导致生长迟缓症状和褪绿叶，并由核酸序列SEQ ID NO：1编码，SEQ ID NO：3，SEQ ID NO：5或功能等同物为SEQ ID NO：1，SEQ ID NO：3或SEQ ID NO：5作为除草剂的靶标。此外，本发明涉及上述多肽在鉴定抑制蔗糖-6-磷酸磷酸酶的除草或生长调节化合物的方法中的用途。此外，本发明涉及通过该方法鉴定的这些化合物作为除草剂或生长调节剂的用途。

2. 发明申请

US20070113300A1 Clp-protease as target for herbicides 审中-公开
标题翻译： Clp蛋白酶作为除草剂的靶标
公开(公告)号：US20070113300A1
公开(公告)日：2007-05-17
申请号：US10581293
申请日：2004-11-30
申请人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke , Kirsten Deist
发明人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke , Kirsten Deist
IPC分类号： A01H1/00 , C12Q1/37 , C12P21/06 , A01N25/00 , C12N9/48 , C12N5/04 , C12N15/82 , C07H21/04
CPC分类号： C12N9/14 , C12N15/8261 , C12Q1/37 , G01N33/56961 , G01N33/573 , Y02A40/146
摘要： The present invention relates to Clp-protease, which, when absent, brings about reduced growth and chlorotic leaves as target for herbicides. For this purpose, novel nucleic acid sequences encompassing SEQ ID NO:3, SEQ ID NO:11 and SEQ ID NO: 17 and functional equivalents of SEQ ID NO:3, SEQ ID NO:11 and SEQ ID NO: 17 are provided. Moreover, the present invention relates to the use of Clp-protease in a method for identifying compounds with herbicidal or growth-regulatory activity, and to the use of the compounds identified by this method as herbicides or growth regulators.
摘要翻译：本发明涉及Clp-蛋白酶，当不存在时，会产生减少的生长和褪绿叶作为除草剂的靶标。为此，提供包含SEQ ID NO：3，SEQ ID NO：11和SEQ ID NO：17的新型核酸序列和SEQ ID NO：3，SEQ ID NO：11和SEQ ID NO：17的功能等同物。此外，本发明涉及Clp-蛋白酶在鉴定具有除草或生长调节活性的化合物的方法中的用途，以及通过该方法鉴定的化合物作为除草剂或生长调节剂的用途。

3. 发明申请

US20070042451A1 Glycine decarboxylase complex as a herbicidal target 审中-公开
标题翻译：甘氨酸脱羧酶复合物作为除草靶
公开(公告)号：US20070042451A1
公开(公告)日：2007-02-22
申请号：US10578637
申请日：2004-10-27
申请人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke , Kirsten Deist
发明人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke , Kirsten Deist
IPC分类号： C12Q1/48 , A01N63/00
CPC分类号： C12N15/8274 , C12N9/00
摘要： The invention relates to the use of glycine decarboxylase complex, which is used as a target for herbicides in the absence of growth retardations and chlorotic leaves. Novel nucleic acid sequences comprising SEQ ID NO:1 and functional equivalents of SEQ ID NO:1 are thus disclosed. The invention also relates to the use of glycine decarboxylase complex and the functional equivalents thereof in a method for identifying compounds having a herbicidal or growth-regulatory effect, in addition to the use of said compounds identified via said method as herbicides or growth regulators.
摘要翻译：本发明涉及甘氨酸脱羧酶复合物的使用，其在不存在生长迟缓和褪绿叶的情况下用作除草剂的靶标。因此，公开了包含SEQ ID NO：1和SEQ ID NO：1的功能等同物的新型核酸序列。本发明还涉及除用于通过所述方法鉴定的所述化合物作为除草剂或生长调节剂之外，甘氨酸脱羧酶复合物及其功能等同物用于鉴定具有除草或生长调节作用的化合物的方法中。

4. 发明申请

US20070003934A1 2-Methyl-6-solanylbenzoquinone methyltransferase as target for herbicides 审中-公开
标题翻译： 2-甲基-6-苯基苯甲酮甲基转移酶作为除草剂的靶标
公开(公告)号：US20070003934A1
公开(公告)日：2007-01-04
申请号：US10581223
申请日：2004-11-30
申请人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke
发明人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke
IPC分类号： C12Q1/68 , C12Q1/48 , C12P19/34 , A01N25/00
CPC分类号： A01N61/00 , C12N9/1007 , C12N15/8274 , G01N2333/91011 , G01N2500/00
摘要： The present invention relates to the use of 2-methyl-6-solanylbenzoquinone methyltransferase which, when absent, brings about retarded growth and chlorotic leaves, as target for herbicides. In this context, there are provided novel nucleic acid sequences comprising SEQ ID NO:5 and SEQ ID NO:7 and corresponding functional equivalents. Moreover, the present invention relates to the use of 2-methyl-6-solanylbenzoquinone methyltransferase and its functional equivalents in a method for identifying herbicidal or growth-regulatory compounds, and to the use of the compounds identifed via the method as herbicides or growth regulators.
摘要翻译：本发明涉及2-甲基-6-苯甲酰基苯并醌甲基转移酶的用途，当不存在时，会导致延迟生长和褪绿叶作为除草剂的靶标。在本文中，提供了包含SEQ ID NO：5和SEQ ID NO：7的新型核酸序列和相应的功能等同物。此外，本发明涉及2-甲基-6-苯基苯醌基甲基转移酶及其功能等同物在鉴定除草或生长调节化合物的方法中的用途，以及通过该方法鉴定的化合物作为除草剂或生长调节剂的用途。

5. 发明申请

US20060058190A1 Malate dehydrogenase as a target for herbicides 审中-公开
标题翻译：苹果酸脱氢酶作为除草剂的靶标
公开(公告)号：US20060058190A1
公开(公告)日：2006-03-16
申请号：US10538544
申请日：2003-12-17
申请人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Kirsten Deist , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke
发明人： Thomas Ehrhardt , Andreas Reindl , Annette Freund , Ralf-Michael Schmidt , Kirsten Deist , Uwe Sonnewald , Marc Nigel , Wolfgang Lein , Frederik Bornke
IPC分类号： A01N25/00 , C12Q1/48
CPC分类号： C12N9/0006 , C12N15/8274 , C12Q1/32
摘要： The present invention relates to malate dehydrogenase, which, when absent, brings about reduced growth and chlorotic leaves and is encoded by the nucleic acid sequence SEQ ID NO:2 or by a functional equivalent of this nucleic acid sequence, as target for herbicides. For this purpose, novel nucleic acid sequences encompassing SEQ ID NO:2 and functional equivalents of SEQ ID NO:2 are provided. Moreover, the present invention relates to the use of the abovementioned malate dehydrogenase and its functional equivalents in a method for identifying compounds with herbicidal or growth-regulatory activity, and to the use of the compounds identified by this method as herbicides or growth regulators.
摘要翻译：本发明涉及苹果酸脱氢酶，当不存在时，其产生减少的生长和褪绿叶，并由核酸序列SEQ ID NO：2编码，或通过该核酸序列的功能等同物作为除草剂的靶标。为此，提供了包含SEQ ID NO：2和SEQ ID NO：2的功能等同物的新型核酸序列。此外，本发明涉及上述苹果酸脱氢酶及其功能等同物在鉴定具有除草或生长调节活性的化合物的方法中的用途，以及通过该方法鉴定的化合物作为除草剂或生长调节剂的用途。

6. 发明申请

US20050142553A1 Serine hydroxymethyltransferase as a target for herbicides 失效
标题翻译：丝氨酸羟甲基转移酶作为除草剂的靶标
公开(公告)号：US20050142553A1
公开(公告)日：2005-06-30
申请号：US10507989
申请日：2003-03-13
申请人： Uwe Sonnewald , Frederik Bornke , Kirsten Deist , Marc Nigel , Wolfgang Lein , Thomas Ehrhardt , Andreas Reindl , Ralf-Michael Schmidt , Annette Freund
发明人： Uwe Sonnewald , Frederik Bornke , Kirsten Deist , Marc Nigel , Wolfgang Lein , Thomas Ehrhardt , Andreas Reindl , Ralf-Michael Schmidt , Annette Freund
IPC分类号： A01H1/00 , A01H5/00 , A01K67/027 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/09 , C12N15/82 , C12Q1/02 , C12Q1/48 , C12Q1/68 , A01N25/00 , C12N9/24 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12N9/1014 , C12N15/8274
摘要： The present invention relates to serine hydroxymethyltransferase (E.C. 2.1.2.1) as novel target for herbicides, and to nucleic acid sequences encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase, which, when not present, bring about growth retardation symptoms and chlorotic leaves, comprising the nucleic acid sequence SEQ ID No:3, and functional equivalents of the abovementioned nucleic acid sequence or the nucleic acid sequence SEQ ID NO:7 and functional equivalents of the abovementioned nucleic acid sequence. Moreover, the present invention relates to the use of the abovementioned nucleic acid sequences, of functional analogs of the SEQ ID NO:3 or SEQ ID NO:7 or of polypeptides encoded by one of the abovementioned nucleic acid sequences in a method for identifying herbicidally active compounds which inhibit serine hydroxymethyltransferases, and to the use of these compounds which have been identified by the method as herbicides.
摘要翻译：本发明涉及丝氨酸羟甲基转移酶（EC 2.1.2.1）作为除草剂的新靶标，以及编码具有丝氨酸羟甲基转移酶生物活性的多肽的核酸序列，当不存在时，其产生生长迟缓症状和褪绿叶包括核酸序列SEQ ID No：3和上述核酸序列或核酸序列SEQ ID NO：7的功能等同物和上述核酸序列的功能等同物。此外，本发明涉及上述核酸序列，SEQ ID NO：3或SEQ ID NO：7的功能类似物或由上述核酸序列之一编码的多肽在除草方法中的用途抑制丝氨酸羟甲基转移酶的活性化合物，以及通过该方法鉴定的这些化合物作为除草剂的用途。

7. 发明授权

US07374899B2 Sucrose-6-phosphate phosphatase as target for herbicides 失效
标题翻译：蔗糖-6-磷酸酯酶作为除草剂的靶标
公开(公告)号：US07374899B2
公开(公告)日：2008-05-20
申请号：US10522096
申请日：2003-07-16
申请人： Thomas Ehrhardt , Uwe Sonnewald , Frederik Börnke , Shuai Chen
发明人： Thomas Ehrhardt , Uwe Sonnewald , Frederik Börnke , Shuai Chen
IPC分类号： C12Q1/42
CPC分类号： C12N9/16 , C12N15/8274
摘要： The present invention relates to the use of a polypeptide with the biological activity of a sucrose-6-phosphate phosphatase which, if not present, brings about growth retardation symptoms and chlorotic leaves and which is encoded by the nucleic acid sequences SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5 or by a functional equivalent of SEQ ID NO:1, SEQ ID NO:3 or SEQ ID NO:5 as target for herbicides. Moreover, the present invention relates to the use of the abovementioned polypeptides in a method for identifying herbicidal or growth-regulatory compounds which inhibit sucrose-6-phosphate phosphatase. Moreover, the invention relates to the use of these compounds which have been identified via the method as herbicides or growth regulators.
摘要翻译：本发明涉及具有蔗糖-6-磷酸磷酸酶的生物学活性的多肽的用途，如果不存在，则会导致生长迟缓症状和褪绿叶，并由核酸序列SEQ ID NO：1编码，SEQ ID NO：3，SEQ ID NO：5或功能等同物为SEQ ID NO：1，SEQ ID NO：3或SEQ ID NO：5作为除草剂的靶标。此外，本发明涉及上述多肽在鉴定抑制蔗糖-6-磷酸磷酸酶的除草或生长调节化合物的方法中的用途。此外，本发明涉及通过该方法鉴定的这些化合物作为除草剂或生长调节剂的用途。

8. 发明授权

US07662603B2 Nucleic acid encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase 失效
标题翻译：编码具有丝氨酸羟甲基转移酶生物活性的多肽的核酸
公开(公告)号：US07662603B2
公开(公告)日：2010-02-16
申请号：US11949874
申请日：2007-12-04
申请人： Uwe Sonnewald , Frederik Boernke , Kirsten Deist , Marc Stitt Nigel , Wolfgang Lein , Thomas Ehrhardt , Andreas Reindl , Ralf-Michael Schmidt , Annette Freund
发明人： Uwe Sonnewald , Frederik Boernke , Kirsten Deist , Marc Stitt Nigel , Wolfgang Lein , Thomas Ehrhardt , Andreas Reindl , Ralf-Michael Schmidt , Annette Freund
IPC分类号： C12N9/00 , C12N9/10 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/1014 , C12N15/8274
摘要： The present invention relates to serine hydroxymethyltransferase (E.C. 2.1.2.1) as novel target for herbicides, and to nucleic acid sequences encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase, which, when not present, bring about growth retardation symptoms and chlorotic leaves, comprising the nucleic acid sequence SEQ ID No:3, and functional equivalents of the abovementioned nucleic acid sequence or the nucleic acid sequence SEQ ID NO:7 and functional equivalents of the abovementioned nucleic acid sequence. Moreover, the present invention relates to the use of the abovementioned nucleic acid sequences, of functional analogs of the SEQ ID NO:3 or SEQ ID NO:7 or of polypeptides encoded by one of the abovementioned nucleic acid sequences in a method for identifying herbicidally active compounds which inhibit serine hydroxymethyltransferases, and to the use of these compounds which have been identified by the method as herbicides.
摘要翻译：本发明涉及丝氨酸羟甲基转移酶（EC 2.1.2.1）作为除草剂的新靶标，以及编码具有丝氨酸羟甲基转移酶生物活性的多肽的核酸序列，当不存在时，其产生生长迟缓症状和褪绿叶包括核酸序列SEQ ID No：3和上述核酸序列或核酸序列SEQ ID NO：7的功能等同物和上述核酸序列的功能等同物。此外，本发明涉及上述核酸序列，SEQ ID NO：3或SEQ ID NO：7的功能类似物或由上述核酸序列之一编码的多肽在除草方法中的用途抑制丝氨酸羟甲基转移酶的活性化合物，以及通过该方法鉴定的这些化合物作为除草剂的用途。

9. 发明授权

US07319013B2 Serine hydroxymethyltransferase as a target for herbicides 失效
标题翻译：丝氨酸羟甲基转移酶作为除草剂的靶标
公开(公告)号：US07319013B2
公开(公告)日：2008-01-15
申请号：US10507989
申请日：2003-03-13
申请人： Uwe Sonnewald , Frederik Börnke , Kirsten Deist , Marc Stitt Nigel , Wolfgang Lein , Thomas Ehrhardt , Andreas Reindl , Ralf-Michael Schmidt , Annette Freund
发明人： Uwe Sonnewald , Frederik Börnke , Kirsten Deist , Marc Stitt Nigel , Wolfgang Lein , Thomas Ehrhardt , Andreas Reindl , Ralf-Michael Schmidt , Annette Freund
IPC分类号： C12Q1/48 , C12N9/10 , C12N5/04 , C12N5/14 , C07H21/04
CPC分类号： C12N9/1014 , C12N15/8274
摘要： The present invention relates to serine hydroxymethyltransferase (E.C. 2.1.2.1) as novel target for herbicides, and to nucleic acid sequences encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase, which, when not present, bring about growth retardation symptoms and chlorotic leaves, comprising the nucleic acid sequence SEQ ID No:3, and functional equivalents of the abovementioned nucleic acid sequence or the nucleic acid sequence SEQ ID NO:7 and functional equivalents of the abovementioned nucleic acid sequence. Moreover, the present invention relates to the use of the abovementioned nucleic acid sequences, of functional analogs of the SEQ ID NO:3 or SEQ ID NO:7 or of polypeptides encoded by one of the abovementioned nucleic acid sequences in a method for identifying herbicidally active compounds which inhibit serine hydroxymethyltransferases, and to the use of these compounds which have been identified by the method as herbicides.
摘要翻译：本发明涉及丝氨酸羟甲基转移酶（EC 2.1.2.1）作为除草剂的新靶标，以及编码具有丝氨酸羟甲基转移酶生物活性的多肽的核酸序列，当不存在时，其产生生长迟缓症状和褪绿叶包括核酸序列SEQ ID No：3和上述核酸序列或核酸序列SEQ ID NO：7的功能等同物和上述核酸序列的功能等同物。此外，本发明涉及上述核酸序列，SEQ ID NO：3或SEQ ID NO：7的功能类似物或由上述核酸序列之一编码的多肽在除草方法中的用途抑制丝氨酸羟甲基转移酶的活性化合物，以及通过该方法鉴定的这些化合物作为除草剂的用途。

10. 发明申请

US20110113494A1 Serine Hydroxymethyltransferase as Target for Herbicides 审中-公开
标题翻译：丝氨酸羟甲基转移酶作为除草剂的靶标
公开(公告)号：US20110113494A1
公开(公告)日：2011-05-12
申请号：US12645976
申请日：2009-12-23
申请人： Uwe Sonnewald , Frederik Börnke , Kirsten Deist , Marc Stitt Nigel , Wolfgang Lein , Thomas Ehrhardt , Andreas Reindl , Ralf-Michael Schmidt , Annette Freund
发明人： Uwe Sonnewald , Frederik Börnke , Kirsten Deist , Marc Stitt Nigel , Wolfgang Lein , Thomas Ehrhardt , Andreas Reindl , Ralf-Michael Schmidt , Annette Freund
IPC分类号： A61K49/00 , C40B30/04 , A01H5/00 , A01K67/00 , C12N1/19 , C12N1/15 , C12N1/21 , C12Q1/68 , G01N33/573 , C12Q1/02 , C40B30/06 , A01H1/06
CPC分类号： C12N9/1014 , C12N15/8274
摘要： The present invention relates to serine hydroxymethyltransferase (E.C. 2.1.2.1) as novel target for herbicides, and to nucleic acid sequences encoding a polypeptide with the biological activity of a serine hydroxymethyltransferase, which, when not present, bring about growth retardation symptoms and chlorotic leaves, comprising the nucleic acid sequence SEQ ID No:3, and functional equivalents of the abovementioned nucleic acid sequence or the nucleic acid sequence SEQ ID NO:7 and functional equivalents of the abovementioned nucleic acid sequence. Moreover, the present invention relates to the use of the abovementioned nucleic acid sequences, of functional analogs of the SEQ ID NO:3 or SEQ ID NO:7 or of polypeptides encoded by one of the abovementioned nucleic acid sequences in a method for identifying herbicidally active compounds which inhibit serine hydroxymethyltransferases, and to the use of these compounds which have been identified by the method as herbicides.
摘要翻译：本发明涉及丝氨酸羟甲基转移酶（EC 2.1.2.1）作为除草剂的新靶标，以及编码具有丝氨酸羟甲基转移酶生物活性的多肽的核酸序列，当不存在时，其产生生长迟缓症状和褪绿叶包括核酸序列SEQ ID No：3和上述核酸序列或核酸序列SEQ ID NO：7的功能等同物和上述核酸序列的功能等同物。此外，本发明涉及上述核酸序列，SEQ ID NO：3或SEQ ID NO：7的功能类似物或由上述核酸序列之一编码的多肽在除草方法中的用途抑制丝氨酸羟甲基转移酶的活性化合物，以及通过该方法鉴定的这些化合物作为除草剂的用途。

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