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1. 发明授权

US08211463B2 Use of glycolipids as adjuvants 有权
标题翻译：使用糖脂作为佐剂
公开(公告)号：US08211463B2
公开(公告)日：2012-07-03
申请号：US12440315
申请日：2007-09-06
申请人： Thomas Ebensen , Michael Morr , Carlos Guzman , Goetz Milkereit
发明人： Thomas Ebensen , Michael Morr , Carlos Guzman , Goetz Milkereit
IPC分类号： A61K9/127
CPC分类号： A61K39/39 , A61K2039/55511
摘要： The present invention relates to adjuvants of the glycolipid type and their uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new uses of compounds useful as adjuvants for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumors and allergies. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants.
摘要翻译：本发明涉及糖脂类型的佐剂及其在药物组合物中的用途，如疫苗中。特别地，本发明提供了用作治疗感染性疾病，炎性疾病，自身免疫性疾病，肿瘤和过敏症中的预防和/或治疗性疫苗的辅助剂的新用途。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。

2. 发明授权

US08053417B2 Hexosylceramides as adjuvants and their uses in pharmaceutical compositions 有权
标题翻译：二十二烷酰胆碱作为佐剂及其在药物组合物中的用途
公开(公告)号：US08053417B2
公开(公告)日：2011-11-08
申请号：US12090279
申请日：2006-10-19
申请人： Thomas Ebensen , Michael Morr , Carlos Guzman
发明人： Thomas Ebensen , Michael Morr , Carlos Guzman
IPC分类号： A61K31/70 , A61K31/7028 , C07H15/04
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/0043 , A61K39/39 , A61K2039/55511 , C07H15/04 , C07H15/08 , Y02A50/412
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.
摘要翻译：本发明涉及新的佐剂和药物组合物中的用途，如疫苗。特别地，本发明提供了新的化合物，其可用作治疗感染性疾病，炎性疾病，自身免疫性疾病，肿瘤，过敏症以及用于控制人或动物群体中的生育力的预防和/或治疗性疫苗的佐剂。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。此外，本发明涉及其作为药物组合物中的活性成分的用途。

3. 发明申请

US20090017106A1 ADJUVANTS ON THE BASIS OF BISACYLOXYPROPYLCYSTENE CONJUGATES AND DERIVATIVES AND THEIR USES IN PHARMACEUTICAL COMPOSITIONS 有权
标题翻译：基于双歧杆菌脂蛋白结合物和衍生物的研究进展及其在药物组合物中的应用
公开(公告)号：US20090017106A1
公开(公告)日：2009-01-15
申请号：US12093865
申请日：2006-11-22
申请人： Thomas Ebensen , Michael Morr , Carlos Guzman
发明人： Thomas Ebensen , Michael Morr , Carlos Guzman
IPC分类号： A61K31/225 , A61K9/127 , A61K9/14 , A61K47/20 , A61K39/00 , A61P31/00 , A61P37/00 , A61P35/00 , A61K39/395 , C07C321/04 , C12N5/06
CPC分类号： A61K47/60
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new conjugates of the bisacyloxycysteine type useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.
摘要翻译：本发明涉及新的佐剂和药物组合物中的用途，如疫苗。特别地，本发明提供了用作治疗感染性疾病，炎症性疾病，自身免疫性疾病，肿瘤，过敏症以及用于治疗性疾病的预防和/或治疗性接种疫苗的辅助剂和/或免疫调节剂的双酰氧基半胱氨酸类型的新缀合物人或动物种群的生育力。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。此外，本发明涉及其作为药物组合物中的活性成分的用途。

4. 发明授权

US08119689B2 Adjuvants on the basis of bisacyloxypropylcystene conjugates and derivatives and their uses in pharmaceutical compositions 有权
标题翻译：基于双酰氧基丙基胱氨酸共轭物和衍生物的佐剂及其在药物组合物中的用途
公开(公告)号：US08119689B2
公开(公告)日：2012-02-21
申请号：US12093865
申请日：2006-11-22
申请人： Thomas Ebensen , Michael Morr , Carlos Guzman
发明人： Thomas Ebensen , Michael Morr , Carlos Guzman
IPC分类号： A01N37/02 , A01N37/06 , A61K31/225 , A61K51/00 , A61K45/00 , C07C321/00 , C07C323/00 , C07C381/00 , A61M36/14
CPC分类号： A61K47/60
摘要： Bisacyloxycysteine type conjugates have been found to be useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumors, and allergies, as well as in the control of fertility in human or animal populations. The compounds can be administered by system or mucosal routes and are particularly useful as mucosal adjuvants. These compounds can function as active ingredients in pharmaceutical compositions.
摘要翻译：已经发现双酰氧基半胱氨酸型缀合物可用作治疗感染性疾病，炎症性疾病，自身免疫性疾病，肿瘤和过敏以及在人类的生育能力的控制中用于预防和/或治疗性接种的佐剂和/或免疫调节剂或动物种群。化合物可以通过系统或粘膜途径施用，并且特别可用作粘膜佐剂。这些化合物可以用作药物组合物中的活性成分。

5. 发明申请

US20080206319A1 Hexosylceramides as Adjuvants and Their Uses in Pharmaceutical Compositions 有权
标题翻译：作为佐剂的二十二烷酰胆碱及其在药物组合物中的应用
公开(公告)号：US20080206319A1
公开(公告)日：2008-08-28
申请号：US12090279
申请日：2006-10-19
申请人： Thomas Ebensen , Michael Morr , Carlos A. Guzman
发明人： Thomas Ebensen , Michael Morr , Carlos A. Guzman
IPC分类号： A61K9/127 , C07H15/04 , A61K31/7028 , A61P37/04 , A61K39/35 , A61K39/00
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/0043 , A61K39/39 , A61K2039/55511 , C07H15/04 , C07H15/08 , Y02A50/412
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.
摘要翻译：本发明涉及新的佐剂和药物组合物中的用途，如疫苗。特别地，本发明提供了新的化合物，其可用作治疗感染性疾病，炎性疾病，自身免疫性疾病，肿瘤，过敏症以及用于控制人或动物群体中的生育力的预防和/或治疗性疫苗的佐剂。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。此外，本发明涉及其作为药物组合物中的活性成分的用途。

6. 发明授权

US08257734B2 PQS and its conjugates as adjuvants and their uses in pharmaceutical compositions 有权
标题翻译： PQS及其缀合物作为佐剂及其在药物组合物中的用途
公开(公告)号：US08257734B2
公开(公告)日：2012-09-04
申请号：US12092518
申请日：2006-11-08
申请人： Thomas Ebensen , Michael Morr , Carlos A. Guzman
发明人： Thomas Ebensen , Michael Morr , Carlos A. Guzman
IPC分类号： A61K9/127 , A61K39/00 , A61K47/22 , C07D215/233
CPC分类号： A61K39/39 , A61K31/7076 , A61K31/7084 , A61K2039/55511 , Y02A50/412
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumors, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.
摘要翻译：本发明涉及新的佐剂和药物组合物中的用途，如疫苗。特别地，本发明提供了新的化合物，其可用作治疗感染性疾病，炎症性疾病，自身免疫性疾病，肿瘤，过敏症以及控制人类生育能力的预防和/或治疗性疫苗的佐剂和/或免疫调节剂动物种群。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。此外，本发明涉及其作为药物组合物中的活性成分的用途。

7. 发明申请

US20080286296A1 Cyclic-Dinucleotides and Its Conjugates as Adjuvants and Their Uses in Pharmaceutical Compositions 有权
标题翻译：循环二核苷酸及其缀合物作为佐剂及其在药物组合物中的用途
公开(公告)号：US20080286296A1
公开(公告)日：2008-11-20
申请号：US12092747
申请日：2006-11-08
申请人： Thomas Ebensen , Michael Morr , Carlos A. Guzman
发明人： Thomas Ebensen , Michael Morr , Carlos A. Guzman
IPC分类号： A61K39/39 , A61K39/00 , A61P35/00 , A61P31/00 , A61P37/00 , A61P29/00 , A61P15/00
CPC分类号： A61K39/39 , A61K31/7076 , A61K31/7084 , A61K2039/55511 , Y02A50/412
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumors, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.
摘要翻译：本发明涉及新的佐剂和药物组合物中的用途，如疫苗。特别地，本发明提供了新的化合物，其可用作治疗感染性疾病，炎症性疾病，自身免疫性疾病，肿瘤，过敏症以及控制人类生育能力的预防和/或治疗性疫苗的佐剂和/或免疫调节剂动物种群。所述化合物不仅特别适用于全身，而且优选作为粘膜佐剂。此外，本发明涉及其作为药物组合物中的活性成分的用途。

8. 发明授权

US10918733B2 Lipopeptide- and lipoprotein-conjugates and its use 有权
公开(公告)号：US10918733B2
公开(公告)日：2021-02-16
申请号：US13519336
申请日：2010-12-28
申请人： Thomas Ebensen , Carlos Alberto Guzman , Michael Morr , Werner Tegge
发明人： Thomas Ebensen , Carlos Alberto Guzman , Michael Morr , Werner Tegge
IPC分类号： A61K47/60 , A61K47/64 , A61K47/54
摘要： The present invention relates to new lipopeptide- and lipoprotein molecules and lipopeptide- and lipoprotein-conjugates. In particular, the present invention relates to new lipopeptide- and lipoprotein molecules and lipopeptide- and lipoprotein-conjugates comprising a lipid-containing moiety representing an adjuvant moiety, a peptide or protein moiety whereby said peptide or protein moiety represents at least one antigenic structure, the antigen-moiety, and, optionally, a conjugate moiety, preferably a monodisperse polyethyleneglycol unit.
Said compounds are particularly useful for therapeutic or prophylactic vaccination by mucosal or systemic administration, preferably mucosal and systemic vaccination. That is, the present invention relates in another aspect to pharmaceutical compositions comprising the compounds according to the present invention, in particular, said pharmaceutical compositions are vaccines. In addition, said pharmaceutical compositions are useful for the prophylaxis or treatment of infectious diseases, inflammatory and autoimmune diseases, cancer, allergies or for the control of fertility in human or animal populations.

9. 发明授权

US09597391B2 Cyclic-dinucleotides and its conjugates as adjuvants and their uses in pharmaceutical compositions 有权
公开(公告)号：US09597391B2
公开(公告)日：2017-03-21
申请号：US12092747
申请日：2006-11-08
申请人： Thomas Ebensen , Michael Morr , Carlos A. Guzman
发明人： Thomas Ebensen , Michael Morr , Carlos A. Guzman
IPC分类号： A61K39/39 , A61K39/00 , A61P37/00 , A61K31/7084 , A61K31/7076
CPC分类号： A61K39/39 , A61K31/7076 , A61K31/7084 , A61K2039/55511 , Y02A50/412
摘要： The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumors, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

10. 发明申请

US20130039939A1 LIPOPEPTIDE- AND LIPOPROTEIN-CONJUGATES AND ITS USE 审中-公开
标题翻译： LIPOPEPTIDE-和LIPOPROTEIN-CONJUGATES及其用途
公开(公告)号：US20130039939A1
公开(公告)日：2013-02-14
申请号：US13519336
申请日：2009-12-12
申请人： Thomas Ebensen , Carlos Alberto Guzman , Michael Morr , Werner Tegge
发明人： Thomas Ebensen , Carlos Alberto Guzman , Michael Morr , Werner Tegge
IPC分类号： A61K39/385 , A61K38/10 , A61K38/16 , A61P35/00 , A61P33/06 , A61P31/14 , A61P31/18 , A61P31/04 , A61P31/06 , A61P31/08 , C07K17/02 , A61P31/12
CPC分类号： A61K47/646 , A61K47/543 , A61K47/60
摘要： The present invention relates to new lipopeptide- and lipoprotein molecules and lipopeptide- and lipoprotein-conjugates. In particular, the present invention relates to new lipopeptide- and lipoprotein molecules and lipopeptide- and lipoprotein-conjugates comprising a lipid-containing moiety representing an adjuvant moiety, a peptide or protein moiety whereby said peptide or protein moiety represents at least one antigenic structure, the antigen-moiety, and, optionally, a conjugate moiety, preferably a monodisperse polyethyleneglycol unit.Said compounds are particularly useful for therapeutic or prophylactic vaccination by mucosal or systemic administration, preferably mucosal and systemic vaccination. That is, the present invention relates in another aspect to pharmaceutical compositions comprising the compounds according to the present invention, in particular, said pharmaceutical compositions are vaccines. In addition, said pharmaceutical compositions are useful for the prophylaxis or treatment of infectious diseases, inflammatory and autoimmune diseases, cancer, allergies or for the control of fertility in human or animal populations.
摘要翻译：本发明涉及新的脂肽和脂蛋白分子和脂肽和脂蛋白共轭物。特别地，本发明涉及新的脂肽和脂蛋白分子和脂肽和脂蛋白 - 缀合物，其包含代表佐剂部分的脂质部分，肽或蛋白质部分，由此所述肽或蛋白质部分代表至少一种抗原结构，抗原部分和任选的缀合物部分，优选单分散聚乙二醇单元。所述化合物特别可用于通过粘膜或全身给药进行治疗或预防性接种，优选粘膜和全身性接种疫苗。也就是说，本发明在另一方面涉及包含根据本发明的化合物的药物组合物，特别是所述药物组合物是疫苗。此外，所述药物组合物可用于预防或治疗感染性疾病，炎性和自身免疫性疾病，癌症，过敏或用于控制人或动物群体的生育力。

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