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1. 发明申请

US20050064038A1 Active agent delivery systems including a single layer of a miscible polymer blend, medical devices, and methods 审中-公开
标题翻译：活性剂递送系统，包括单层可混溶聚合物共混物，医疗装置和方法
公开(公告)号：US20050064038A1
公开(公告)日：2005-03-24
申请号：US10916159
申请日：2004-08-11
申请人： Thomas Dinh , Randall Sparer , SuPing Lyu , Kiem Dang , Christopher Hobot
发明人： Thomas Dinh , Randall Sparer , SuPing Lyu , Kiem Dang , Christopher Hobot
IPC分类号： A61K9/00 , A61K47/34 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61K9/14
CPC分类号： A61K9/0024 , A61K47/34 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/45 , A61L2300/602
摘要： An active agent delivery system that includes two or more active agents in a layer of a miscible polymer blend having at least two miscible polymers; wherein delivery of at least one of the active agents occurs predominantly under permeation control; and further wherein the permeability of the active agent that is to be released faster is greater than the permeability of the other one or more active agents.
摘要翻译：一种活性剂递送系统，其包含在具有至少两种可混溶聚合物的可混溶聚合物共混物层中的两种或更多种活性剂; 其中至少一种活性剂的递送主要在渗透控制下发生; 并且其中待释放的活性剂的渗透性比其它一种或多种活性剂的渗透性大。

2. 发明申请

US20050064005A1 Active agent delivery systems including a miscible polymer blend, medical devices, and methods 审中-公开
标题翻译：包括可混溶聚合物共混物，医疗装置和方法的活性剂递送系统
公开(公告)号：US20050064005A1
公开(公告)日：2005-03-24
申请号：US10916162
申请日：2004-08-11
申请人： Thomas Dinh , Randall Sparer , SuPing Lyu , Kiem Dang , Christopher Hobot
发明人： Thomas Dinh , Randall Sparer , SuPing Lyu , Kiem Dang , Christopher Hobot
IPC分类号： A61F2/00 , A61F2/82 , A61K9/00 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , A61K9/14
CPC分类号： A61L31/16 , A61F2/07 , A61F2/82 , A61F2250/0067 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61L2300/602 , A61L2300/61
摘要： An active agent delivery system that includes two or more active agents and two or more layers of polymers; wherein at least one layer includes miscible polymer blend comprising two or more miscible polymers; and further wherein delivery of at least one active agent occurs predominantly under permeation control.
摘要翻译：包含两种或更多种活性剂和两层或多层聚合物的活性剂递送系统; 其中至少一层包括包含两种或更多种可混溶聚合物的混溶性聚合物共混物; 并且其中至少一种活性剂的递送主要在渗透控制下进行。

3. 发明申请

US20070276504A1 Medical device exhibiting improved adhesion between polymeric coating and substrate 审中-公开
标题翻译：具有改善聚合物涂层和基底之间粘附性的医疗装置
公开(公告)号：US20070276504A1
公开(公告)日：2007-11-29
申请号：US11890416
申请日：2007-08-06
申请人： Randall Sparer , Christopher Hobot , SuPing Lyu
发明人： Randall Sparer , Christopher Hobot , SuPing Lyu
IPC分类号： A61F2/04
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/608 , A61L2420/08 , C08L75/04
摘要： Polymer-coated medical devices having improved structural integrity and drug elution profile, and related methods. Treatment of a polymeric undercoat layer to reflow the undercoat polymer results in a substrate/coating interface with improved adhesion.
摘要翻译：具有改进的结构完整性和药物洗脱曲线的聚合物涂覆的医疗装置及相关方法。处理聚合物底涂层以回流底涂层聚合物导致具有改善的粘附性的基底/涂层界面。

4. 发明申请

US20130199998A1 HEMODIALYSIS SYSTEM HAVING A FLOW PATH WITH A CONTROLLED COMPLIANT VOLUME 审中-公开
标题翻译：具有控制合格体积的流路的血液透析系统
公开(公告)号：US20130199998A1
公开(公告)日：2013-08-08
申请号：US13565733
申请日：2012-08-02
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
IPC分类号： A61M1/16
CPC分类号： A61M1/3482 , A61M1/1696 , A61M2202/0021 , A61M2202/0413
摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
摘要翻译：公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制组件，吸附剂盒和流体储存器，其被配置为适于被需要治疗的个体穿戴或携带的重量和尺寸。用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。透析电路和用于循环血液的体外循环通过透析膜流体连通。在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。

5. 发明申请

US20120289881A1 System and Implantable Device for Treating Chronic Kidney Disease 审中-公开
标题翻译：用于治疗慢性肾脏疾病的系统和植入装置
公开(公告)号：US20120289881A1
公开(公告)日：2012-11-15
申请号：US13462190
申请日：2012-05-02
申请人： SuPing Lyu , Thomas Edward Meyer , Mark Fredrick Daniels , Bryant J. Pudil
发明人： SuPing Lyu , Thomas Edward Meyer , Mark Fredrick Daniels , Bryant J. Pudil
IPC分类号： A61M1/16
CPC分类号： A61M1/1678 , B01D61/18 , B01D61/28 , B01D63/084 , B01D2313/105
摘要： An implantable dialysis device with a related medical system for intracorporeal dialysis and ultrafiltration of blood, and methods of use are described. The medical system includes an extracorporeal module, a cutaneous module, and an implantable module. Features of the implantable module facilitate delivery and flow of blood and dialysate through the medical system. A filter pack within the implantable module performs dialysis and ultrafiltration of blood. System cleansing is also described.
摘要翻译：描述了具有用于体内透析和血液超滤的相关医疗系统的植入式透析装置及其使用方法。医疗系统包括体外模块，皮肤模块和可植入模块。可植入模块的特征便于血液和透析液通过医疗系统的输送和流动。可植入模块内的过滤器组件执行血液的透析和超滤。还描述了系统清洁。

6. 发明申请

US20080069856A1 Compression molding method for making biomaterial composites 有权
标题翻译：制备生物材料复合材料的压制成型方法
公开(公告)号：US20080069856A1
公开(公告)日：2008-03-20
申请号：US11523841
申请日：2006-09-20
申请人： SuPing Lyu , Christopher M. Hobot , Sean M. Haddock , Brian Loy , Randall V. Sparer , K. Matthew Kinnane , Jeffrey M. Gross
发明人： SuPing Lyu , Christopher M. Hobot , Sean M. Haddock , Brian Loy , Randall V. Sparer , K. Matthew Kinnane , Jeffrey M. Gross
IPC分类号： A61K35/12 , A61F2/02 , B27N3/00
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/3683 , A61L27/58 , C08L67/04
摘要： A process for making an implantable material comprising a composite of a biocompatible polymer and a bioactive agent. The composite combines desirable mechanical properties of polymers and the bioactivity of tissue or one or more component of tissue. More particularly, but not exclusively, the invention relates to methods for the manufacture of implantable materials, devices and components via a powder molding process.
摘要翻译：一种用于制造可植入材料的方法，其包括生物相容性聚合物和生物活性剂的复合物。该复合物结合聚合物的所需机械性能和组织的生物活性或组织的一种或多种组分。更具体地但不排他地，本发明涉及通过粉末成型工艺制造可植入材料，装置和部件的方法。

7. 发明授权

US10695481B2 Hemodialysis system having a flow path with a controlled compliant volume 有权
公开(公告)号：US10695481B2
公开(公告)日：2020-06-30
申请号：US13565733
申请日：2012-08-02
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
IPC分类号： A61M1/34 , A61M1/16
摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.

8. 发明申请

US20130256227A1 POLYSTYRENE SULFONATE RESIN FOR USE WITH A HEMODIALYSIS SYSTEM HAVING A CONTROLLED COMPLIANCE DIALYSIS CIRCUIT 审中-公开
标题翻译：聚苯乙烯磺酸酯树脂与具有控制的合规性透析电路的血液透析系统一起使用
公开(公告)号：US20130256227A1
公开(公告)日：2013-10-03
申请号：US13612701
申请日：2012-09-12
申请人： Thomas D. Kelly , SuPing Lyu
发明人： Thomas D. Kelly , SuPing Lyu
IPC分类号： A61M1/36
CPC分类号： A61M1/3621 , A61M1/1696
摘要： Sorbent cartridges having a polystyrene sulfonate resin saturated with calcium ions for the performance of kidney replacement therapy are disclosed. Systems and methods having or using a sorbent cartridge, a dialyzer, control components, a cartridge having a polystyrene sulfonate resin, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. A system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to quantify or monitor the removal of urea by the sorbent cartridge.
摘要翻译：公开了具有用钙离子饱和的聚苯乙烯磺酸盐树脂进行肾脏替代疗法的吸收性药筒。公开了具有或使用吸附剂药筒，透析器，控制组件，具有聚苯乙烯磺酸酯树脂的药筒和被配置为具有适于由需要治疗的个体佩戴或携带的重量和尺寸的流体储存器的系统和方法。用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。该系统提供对吸附剂盒的入口和出口导电性的监测，以量化或监测吸附剂盒的尿素去除。

9. 发明授权

US07064168B2 AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods 有权
标题翻译：含有聚（乙烯基吡咯烷酮）单元的AnB嵌段共聚物，医疗装置和方法
公开(公告)号：US07064168B2
公开(公告)日：2006-06-20
申请号：US10842176
申请日：2004-05-10
申请人： Michael Eric Benz , Julie A Alkatout , SuPing Lyu
发明人： Michael Eric Benz , Julie A Alkatout , SuPing Lyu
IPC分类号： C08F126/10 , A61K31/79
CPC分类号： C09D175/04 , A61L29/085 , A61L29/14 , C08F293/005 , C08G18/10 , C08G18/4238 , C08G18/4854 , C08G18/5024 , C08G18/6283 , C08G18/7812 , C08G18/797 , C08L53/00 , C09D153/00 , C08L39/06 , C08G18/62 , C08L2666/02
摘要： AnB block copolymers, wherein n is at least two, that include A blocks with poly(vinyl pyrrolidone) units and B blocks with urethane groups, urea groups, imide groups, amide groups, ether groups, ester groups, or combinations thereof, as well as medical devices and methods.
摘要翻译：其中n为至少两个，其包括具有聚（乙烯基吡咯烷酮）单元的A嵌段和具有氨基甲酸酯基团的B嵌段，脲基，酰亚胺基，酰胺基，醚基，酯基团或其组合，以及医疗装置和方法。

10. 发明授权

US06756449B2 AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods 有权
标题翻译：含有聚（乙烯基吡咯烷酮）单元的AnB嵌段共聚物，医疗器械和方法
公开(公告)号：US06756449B2
公开(公告)日：2004-06-29
申请号：US10246806
申请日：2002-09-17
申请人： Michael Eric Benz , Julie A. Alkatout , SuPing Lyu
发明人： Michael Eric Benz , Julie A. Alkatout , SuPing Lyu
IPC分类号： C08L7500
CPC分类号： C09D175/04 , A61L29/085 , A61L29/14 , C08F293/005 , C08G18/10 , C08G18/4238 , C08G18/4854 , C08G18/5024 , C08G18/6283 , C08G18/7812 , C08G18/797 , C08L53/00 , C09D153/00 , C08L39/06 , C08G18/62 , C08L2666/02
摘要： AnB block copolymers, wherein n is at least two, that include A blocks with poly(vinyl pyrrolidone) units and B blocks with urethane groups, urea groups, imide groups, amide groups, ether groups, ester groups, or combinations thereof, as well as medical devices and methods.
摘要翻译： AnB嵌段共聚物，其中n为至少两个，其包含具有聚（乙烯基吡咯烷酮）单元的A嵌段和具有氨基甲酸酯基团，脲基团，酰亚胺基团，酰胺基团，醚基团，酯基团或其组合的B嵌段作为医疗器械和方法。

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