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1. 发明授权

US08118779B2 Collagen delivery device 有权
标题翻译：胶原递送装置
公开(公告)号：US08118779B2
公开(公告)日：2012-02-21
申请号：US11479916
申请日：2006-06-30
申请人： Thomas A. Simonton , Jeffrey M. Gross , Sean M. Haddock , Hai H. Trieu
发明人： Thomas A. Simonton , Jeffrey M. Gross , Sean M. Haddock , Hai H. Trieu
IPC分类号： A61M37/00
CPC分类号： A61K47/42 , A61K9/0024 , A61K38/00 , A61M5/3158 , A61M5/31586 , A61M5/31595
摘要： A collagen delivery device is disclosed and can include a barrel having a syringe chamber. Further, a syringe can be disposed within the syringe chamber. The syringe can include a collagen material therein. Additionally, the collagen delivery device can include a plunger within the barrel. The plunger can be moved to expel the collagen material from the syringe.
摘要翻译：公开了胶原递送装置，并且可以包括具有注射器室的筒体。此外，注射器可以设置在注射器室内。注射器可以在其中包括胶原材料。另外，胶原递送装置可以包括筒内的柱塞。可以移动柱塞以从注射器排出胶原材料。

2. 发明申请

US20080004431A1 Method of manufacturing an injectable collagen material 审中-公开
标题翻译：可注射胶原材料的制造方法
公开(公告)号：US20080004431A1
公开(公告)日：2008-01-03
申请号：US11479758
申请日：2006-06-30
申请人： Keith M. Kinnane , Jeffrey M. Gross , Sean M. Haddock , Thomas A. Simonton , Hai H. Trieu
发明人： Keith M. Kinnane , Jeffrey M. Gross , Sean M. Haddock , Thomas A. Simonton , Hai H. Trieu
IPC分类号： C07K14/78
CPC分类号： A61L27/3691 , A61L27/24 , A61L27/3604 , A61L2400/06 , A61L2430/40
摘要： A method of manufacturing a ground collagen material from fascia is disclosed and includes mixing the fascia with a freezing agent to yield a fascia/freezing agent mixture and grinding the fascia/freezing agent mixture to yield the ground collagen.
摘要翻译：公开了一种从面板制造研磨胶原材料的方法，包括将筋膜与冷冻剂混合以产生筋膜/冷冻剂混合物，并研磨筋膜/冷冻剂混合物以产生研磨胶原蛋白。

3. 发明申请

US20080004570A1 Collagen delivery device 有权
标题翻译：胶原递送装置
公开(公告)号：US20080004570A1
公开(公告)日：2008-01-03
申请号：US11479916
申请日：2006-06-30
申请人： Thomas A. Simonton , Jeffrey M. Gross , Sean M. Haddock , Hai H. Trieu
发明人： Thomas A. Simonton , Jeffrey M. Gross , Sean M. Haddock , Hai H. Trieu
IPC分类号： A61M37/00
CPC分类号： A61K47/42 , A61K9/0024 , A61K38/00 , A61M5/3158 , A61M5/31586 , A61M5/31595
摘要： A collagen delivery device is disclosed and can include a barrel having a syringe chamber. Further, a syringe can be disposed within the syringe chamber. The syringe can include a collagen material therein. Additionally, the collagen delivery device can include a plunger within the barrel. The plunger can be moved to expel the collagen material from the syringe.
摘要翻译：公开了胶原递送装置，并且可以包括具有注射器室的筒体。此外，注射器可以设置在注射器室内。注射器可以在其中包括胶原材料。另外，胶原递送装置可以包括筒内的柱塞。可以移动柱塞以从注射器排出胶原材料。

4. 发明申请

US20080004214A1 Injectable collagen material 有权
标题翻译：注射胶原材料
公开(公告)号：US20080004214A1
公开(公告)日：2008-01-03
申请号：US11480067
申请日：2006-06-30
申请人： Hai H. Trieu , Jeffrey M. Gross , Sean M. Haddock , Keith M. Kinnane , Thomas A. Simonton
发明人： Hai H. Trieu , Jeffrey M. Gross , Sean M. Haddock , Keith M. Kinnane , Thomas A. Simonton
IPC分类号： A61K38/39 , A61K31/728
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/00 , A61K31/728 , A61L27/24 , A61L2400/06 , A61L2430/38
摘要： A collagen material is disclosed and can include a plurality of particles. Each particle can include an elongated, thin body having one or more arcuate portions and one or more straight portions. Further, each particle can include one or more fibers extending from the body. One or more fibers of one particle can engage the one or more fibers of one or more other particles to establish a matrix of material.
摘要翻译：公开了胶原材料，并且可以包括多个颗粒。每个颗粒可以包括具有一个或多个弓形部分和一个或多个直线部分的细长薄体。此外，每个颗粒可以包括从身体延伸的一个或多个纤维。一个颗粒的一个或多个纤维可以与一个或多个其它颗粒的一个或多个纤维接合以建立材料基质。

5. 发明授权

US08399619B2 Injectable collagen material 有权
标题翻译：注射胶原材料
公开(公告)号：US08399619B2
公开(公告)日：2013-03-19
申请号：US11480067
申请日：2006-06-30
申请人： Hai H. Trieu , Jeffrey M. Gross , Sean M. Haddock , Keith M. Kinnane , Thomas A. Simonton
发明人： Hai H. Trieu , Jeffrey M. Gross , Sean M. Haddock , Keith M. Kinnane , Thomas A. Simonton
IPC分类号： A61K38/39 , A61F2/24 , A61F2/30
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/00 , A61K31/728 , A61L27/24 , A61L2400/06 , A61L2430/38
摘要： A collagen material is disclosed and can include a plurality of particles. Each particle can include an elongated, thin body having one or more arcuate portions and one or more straight portions. Further, each particle can include one or more fibers extending from the body. One or more fibers of one particle can engage the one or more fibers of one or more other particles to establish a matrix of material, where a cross-linking agent may be added in the collagen material. Furthermore, an additive including a radiocontrast medium, a drug, a cellular matter, a biological factor, or a combination thereof may be added to the collagen mixture.
摘要翻译：公开了胶原材料，并且可以包括多个颗粒。每个颗粒可以包括具有一个或多个弓形部分和一个或多个直线部分的细长薄体。此外，每个颗粒可以包括从身体延伸的一个或多个纤维。一个颗粒的一个或多个纤维可以与一个或多个其它颗粒的一个或多个纤维接合以建立材料基质，其中交联剂可以添加到胶原材料中。此外，可以向胶原混合物中添加包括放射性对照培养基，药物，细胞物质，生物因子或其组合的添加剂。

6. 发明申请

US20080004703A1 Method of treating a patient using a collagen material 审中-公开
标题翻译：使用胶原材料治疗患者的方法
公开(公告)号：US20080004703A1
公开(公告)日：2008-01-03
申请号：US11480116
申请日：2006-06-30
申请人： Hai H. Trieu , Jeffrey M. Gross , Sean M. Haddock , Keith M. Kinnane , Thomas A. Simonton
发明人： Hai H. Trieu , Jeffrey M. Gross , Sean M. Haddock , Keith M. Kinnane , Thomas A. Simonton
IPC分类号： A61F2/44 , A61F2/30
CPC分类号： A61F2/4618 , A61F2/30756 , A61F2/4611 , A61F2002/2817 , A61F2002/444 , A61F2002/4627 , A61F2002/4628 , A61F2310/00365 , A61L27/24 , A61L27/3654 , A61L27/50 , A61L2430/38
摘要： A method of treating an intervertebral disc having an annulus fibrosis and a nucleus pulposus is disclosed. The method can include inserting a guide needle to the annulus fibrosis, inserting an injection needle through the guide needle, penetrating the annulus fibrosis within the injection needle, and injecting collagen material into the intervertebral disc.
摘要翻译：公开了一种治疗具有环状纤维化和髓核的椎间盘的方法。该方法可以包括将引导针插入到环状纤维化中，通过引导针插入注射针，穿过注射针内的环状纤维化，以及将胶原材料注射到椎间盘中。

7. 发明授权

US08128591B2 Multiple component mixing and delivery system 有权
标题翻译：多组分混合和输送系统
公开(公告)号：US08128591B2
公开(公告)日：2012-03-06
申请号：US12268075
申请日：2008-11-10
申请人： Thomas A. Simonton , Sean M. Haddock , Lehmann K. Li
发明人： Thomas A. Simonton , Sean M. Haddock , Lehmann K. Li
IPC分类号： A61M37/00
CPC分类号： B01F15/0205 , B01F7/00075 , B01F11/0082 , B01F11/0091 , B01F13/002 , B01F13/0023 , B01F15/0215 , B01F15/0223 , B01F15/0279 , B01F2215/0027 , B01F2215/0029
摘要： A multiple component cartridge includes a barrel defining a chamber and a longitudinal axis. A first plunger is disposed within the chamber and in sealing engagement with the barrel. The first plunger includes at least one member and is movable relative to the barrel such that the at least one member is configured for movement relative to the first plunger to facilitate passage of at least a first component through the first plunger. A second plunger is disposed within the chamber and in sealing engagement with the barrel. The second plunger includes at least one member and is movable relative to the barrel such that the at least one member of the second plunger is configured for movement relative to the second plunger to facilitate passage of at least a second component through the second plunger.
摘要翻译：多部件盒包括限定腔室和纵向轴线的筒体。第一柱塞设置在室内并与筒密封接合。所述第一柱塞包括至少一个构件并且可相对于所述筒移动，使得所述至少一个构件被构造成相对于所述第一柱塞运动，以促进至少第一构件通过所述第一柱塞。第二柱塞设置在腔室内并与枪管密封接合。所述第二柱塞包括至少一个构件并且可相对于所述筒移动，使得所述第二柱塞的所述至少一个构件被构造成相对于所述第二柱塞移动以便于至少第二构件通过所述第二柱塞。

8. 发明授权

US08702677B2 Device and method for directional delivery of a drug depot 有权
标题翻译：用于定向递送药物库的装置和方法
公开(公告)号：US08702677B2
公开(公告)日：2014-04-22
申请号：US12262823
申请日：2008-10-31
申请人： Thomas A. Simonton , Sean M. Haddock , John Myers Zanella , William F. McKay
发明人： Thomas A. Simonton , Sean M. Haddock , John Myers Zanella , William F. McKay
IPC分类号： A61M31/00 , A61M5/00 , A61M5/178 , A61M25/00
CPC分类号： A61M25/00 , A61B5/04001 , A61B5/4893 , A61M25/007 , A61M25/0084
摘要： Drug depot delivery devices and methods are provided for delivering one or more drug depots to one or more sites beneath the skin of a patient with or without repositioning the cannula. The device has a cannula capable of insertion to the site beneath the skin of the patient and one or more side port openings for delivering a drug depot. The side port openings are spaced a distance from the blunt tip, which will allow the user to implant at a set distance from a nerve. The device may also include an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot at or near the nerve.
摘要翻译：提供药物库递送装置和方法用于将一个或多个药物储存器递送到具有或不具有重新定位插管的患者皮肤下方的一个或多个部位。该装置具有能够插入到患者皮肤下方的部位的插管和用于递送药物库的一个或多个侧口开口。侧端口与钝头间隔开一段距离，这将允许使用者以距离神经一定距离植入。该装置还可以包括用于检测套管尖端与神经的接近的电子监视器。在一些实施方案中，通过检测神经并将药物贮存库输送到神经中或附近来提供递送药物库的方法。

9. 发明申请

US20100106137A1 Drug Delivery System 审中-公开
标题翻译：药物输送系统
公开(公告)号：US20100106137A1
公开(公告)日：2010-04-29
申请号：US12260683
申请日：2008-10-29
申请人： Thomas A. Simonton , William F. McKay
发明人： Thomas A. Simonton , William F. McKay
IPC分类号： A61M5/315
CPC分类号： A61M31/007 , A61B17/3468 , A61M37/0069
摘要： Drug depot delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments, a device for delivering a drug depot to a site beneath the skin of patient is provided, the device comprising: a cannula capable of insertion to the site beneath the skin of the patient and having an opening for passage of the drug depot; a drug cartridge comprising at least two chambers, wherein each chamber is configured to store and release a drug depot into the cannula when the cannula is aligned with a first chamber and the plunger. In some embodiments, the drug depot delivery device and methods provide dial-a-dose technology for delivering the drug depot to the target tissue site.
摘要翻译：提供了用于将药剂库递送到患者皮肤下方的部位的药物库递送装置和方法。在各种实施例中，提供了一种用于将药物储存器递送到患者皮肤下方的部位的装置，该装置包括：能够插入到患者皮肤下方的位置并具有用于药物库的通过的开口的套管 ; 药筒，其包括至少两个腔室，其中每个腔室配置成当所述插管与第一腔室和所述柱塞对准时，将药物储存器储存并释放到所述套管中。在一些实施方案中，药物贮库递送装置和方法提供用于将药物贮库递送至目标组织部位的拨号技术。

10. 发明授权

US09352137B2 Drug cartridge for delivering a drug depot comprising a bulking agent and/or cover 有权
标题翻译：用于递送包含填充剂和/或盖的药物贮库的药筒
公开(公告)号：US09352137B2
公开(公告)日：2016-05-31
申请号：US12260876
申请日：2008-10-29
申请人： Thomas A. Simonton , John M. Zanella , Vanja King
发明人： Thomas A. Simonton , John M. Zanella , Vanja King
IPC分类号： A61M37/00 , A61M31/00
CPC分类号： A61M37/0069 , A61M31/007
摘要： A drug cartridge is provided for delivering a drug pellet to a site beneath the skin of a patient, the drug cartridge comprising: two or more chambers, each chamber holding a drug pellet and having a proximal end and a distal end, the proximal end of the chamber having an opening to receive the drug pellet and a plunger, the distal end of the chamber having an opening for receiving the plunger and passage of the drug pellet, a bulking agent disposed within at least a portion of each chamber, wherein movement of the plunger to an extended position moves the drug pellet within the chamber of the cartridge out the distal end of the chamber and out of the drug cartridge. In some embodiments, instead or with the bulking agent pierceable superior and inferior covers are used to contain the drug pellets.
摘要翻译：提供了药物盒，用于将药物丸粒输送到患者皮肤下方的部位，药物盒包括：两个或更多个腔室，每个腔室容纳药物丸粒并具有近端和远端，近端所述腔室具有用于接收药物丸粒的开口和柱塞，所述腔室的远端具有用于接收柱塞和药物丸粒通道的开口，设置在每个腔室的至少一部分内的填充剂，其中，柱塞到延伸位置将药筒内的药丸从药筒的远端移出药物盒。在一些实施方案中，替代地或与填充剂可刺穿的上下盖用于容纳药物颗粒。

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