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1. 发明授权

US08262726B2 Ocular implant with stiffness qualities, methods of implantation and system 有权
标题翻译：具有刚度品质的眼植入物，植入方法和系统
公开(公告)号：US08262726B2
公开(公告)日：2012-09-11
申请号：US12898630
申请日：2010-10-05
申请人： Thomas A. Silvestrini , Eugene de Juan, Jr.
发明人： Thomas A. Silvestrini , Eugene de Juan, Jr.
IPC分类号： A61F2/14
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
摘要翻译：本文描述了用于治疗眼睛状况的装置和方法。描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路，当细长成员植入眼睛。细长构件具有赋予细长构件刚性的壁材料。选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。

2. 发明授权

US08574294B2 Ocular implant with stiffness qualities, methods of implantation and system 有权
标题翻译：具有刚度质量的眼植入物，植入方法和系统
公开(公告)号：US08574294B2
公开(公告)日：2013-11-05
申请号：US12970567
申请日：2010-12-16
申请人： Thomas A. Silvestrini , Eugene de Juan, Jr.
发明人： Thomas A. Silvestrini , Eugene de Juan, Jr.
IPC分类号： A61F2/14
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
摘要翻译：本文描述了用于治疗眼睛状况的装置和方法。描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路，当细长成员植入眼睛。细长构件具有赋予细长构件刚性的壁材料。选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。

3. 发明授权

US08377122B2 Ocular implant with stiffness qualities, methods of implantation and system 有权
公开(公告)号：US08377122B2
公开(公告)日：2013-02-19
申请号：US12694691
申请日：2010-01-27
申请人： Thomas A. Silvestrini , Eugene de Juan, Jr.
发明人： Thomas A. Silvestrini , Eugene de Juan, Jr.
IPC分类号： A61F2/14
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.

4. 发明授权

US08167939B2 Ocular implant with stiffness qualities, methods of implantation and system 有权
公开(公告)号：US08167939B2
公开(公告)日：2012-05-01
申请号：US13245802
申请日：2011-09-26
申请人： Thomas A. Silvestrini , Eugene de Juan, Jr.
发明人： Thomas A. Silvestrini , Eugene de Juan, Jr.
IPC分类号： A61F2/14
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.

5. 发明授权

US08535333B2 Ocular implant applier and methods of use 有权
标题翻译：眼部植入物施加器和使用方法
公开(公告)号：US08535333B2
公开(公告)日：2013-09-17
申请号：US12846201
申请日：2010-07-29
申请人： Eugene de Juan, Jr. , Steven John , Jose Garcia , Richard S. Lilly , Thomas A. Silvestrini
发明人： Eugene de Juan, Jr. , Steven John , Jose Garcia , Richard S. Lilly , Thomas A. Silvestrini
IPC分类号： A61F11/00
CPC分类号： A61F9/0017 , A61B2090/061 , A61B2090/062 , A61F9/0026 , A61F9/007 , A61F9/00781
摘要： Described herein is a delivery device and methods for delivering an ocular implant into an eye. The delivery device includes a proximal handle portion; a distal delivery portion coupled to a distal end of the handle portion and configured to releasably hold an ocular implant and includes a sheath positioned axially over a guidewire; and a metering system configured to provide visual guidance regarding depth of advancement of an implant positioned on the guidewire into an anatomic region of the eye. Also disclosed is a device and method for loading an implant onto the delivery device.
摘要翻译：本文描述了用于将眼部植入物递送到眼睛中的递送装置和方法。输送装置包括近端手柄部分; 远端传送部分，其联接到所述手柄部分的远端并且构造成可释放地保持眼睛植入物并且包括轴向地定位在导丝上的护套; 以及计量系统，其被配置为提供关于定位在所述导丝上的植入物的进展深度到所述眼睛的解剖区域中的视觉指导。还公开了一种用于将植入物装载到输送装置上的装置和方法。

6. 发明授权

US08172899B2 Ocular implant with stiffness qualities, methods of implantation and system 有权
公开(公告)号：US08172899B2
公开(公告)日：2012-05-08
申请号：US13245772
申请日：2011-09-26
申请人： Thomas A. Silvestrini , Eugene de Juan, Jr.
发明人： Thomas A. Silvestrini , Eugene de Juan, Jr.
IPC分类号： A61F2/14
CPC分类号： A61F9/00781 , A61F2210/0019
摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.

7. 发明授权

US06866142B2 Pre-filled package containing unit dose of medical gas and method of making the same 有权
标题翻译：预装包装单位剂量的医用气体及其制造方法
公开(公告)号：US06866142B2
公开(公告)日：2005-03-15
申请号：US10290093
申请日：2002-11-07
申请人： Andrew N. Lamborne , Eugene de Juan, Jr.
发明人： Andrew N. Lamborne , Eugene de Juan, Jr.
IPC分类号： A61M5/178 , A61J1/00 , A61J1/20 , A61M5/00 , A61M13/00 , A61M31/00 , B65D81/20
CPC分类号： A61M5/002 , A61F9/0017 , A61J1/20 , A61J1/201 , A61J1/2082 , A61J1/2096 , A61M13/003 , A61M2209/06 , A61M2210/0612
摘要： A unit dose, gas-filled syringe is provided which is filled with gas and packaged in a gas barrier material prior to use to increase shelf-life, that is, to minimize gas leakage and dilution of the contents of the syringe. The syringe is filled with a selected gas and sealed inside a container made from a high gas barrier material. The container is also filled with the selected gas. The container material is selected to have a gas transmission rate sufficient to prevent the selected gas from diffusing out of the container into the atmosphere. The volume of gas in the container is greater that atmospheric pressure to prevent atmospheric contaminants from entering the container and syringe.
摘要翻译：提供了单位剂量的充气注射器，其在使用之前填充有气体并封装在阻气材料中以增加保质期，即使气体泄漏和注射器内容物的稀释最小化。注射器填充有选定的气体并密封在由高阻气材料制成的容器内。容器还装有选定的气体。容器材料被选择为具有足以防止选定气体从容器扩散进入大气中的气体透过率。容器中的气体体积大于大气压，以防止大气污染物进入容器和注射器。

8. 发明授权

US06309419B1 Tympanic membrane prosthesis with mechanical fixation 有权
标题翻译：鼓膜假体与机械固定
公开(公告)号：US06309419B1
公开(公告)日：2001-10-30
申请号：US09276710
申请日：1999-03-26
申请人： Eugene de Juan, Jr. , R. Scott Rader , Terry H. Shelley , Andrew N. Lamborne , Alexander C. Walsh , John K. Niparko
发明人： Eugene de Juan, Jr. , R. Scott Rader , Terry H. Shelley , Andrew N. Lamborne , Alexander C. Walsh , John K. Niparko
IPC分类号： A61F218
CPC分类号： A61F2/18 , A61F2002/183
摘要： A tympanic membrane prosthesis is provided that includes, in combination, a generally flat, planar membrane sized to overlay a tear or perforation in the tympanic membrane and having at least one preformed perforation, and at least one mechanical fixation device for fixing the membrane to the tympanic membrane of a patient. Each mechanical fixation device is a tack component including a sharp, piercing distal end, an enlarged proximal end and a shaft extending therebetween. A tack insertion device is provided to guide the tack to and through the tear covering membrane.
摘要翻译：提供了一种鼓膜假体，其组合包括大致平坦的平面膜，其大小适于覆盖鼓膜中的泪液或穿孔并且具有至少一个预成形穿孔，以及至少一个机械固定装置，用于将膜固定到患者的鼓膜。每个机械固定装置是一种粘性部件，包括尖锐的，穿刺的远端，扩大的近端和在它们之间延伸的轴。提供一种定位插入装置，用于将粘性物引导并穿过泪膜覆盖膜。

9. 发明授权

US5993072A Adapter assembly for connecting multiple optic fiber illuminated microsurgical instruments to a single light source 失效
标题翻译：用于将多个光纤照明的显微外科器械连接到单个光源的适配器组件
公开(公告)号：US5993072A
公开(公告)日：1999-11-30
申请号：US633428
申请日：1996-04-17
申请人： Eugene de Juan, Jr. , Gregg D. Scheller , Michael D. Auld , Dyson Hickingbotham
发明人： Eugene de Juan, Jr. , Gregg D. Scheller , Michael D. Auld , Dyson Hickingbotham
IPC分类号： A61B5/00 , G02B6/24 , G02B6/38 , G02B6/36
CPC分类号： A61B5/0084 , G02B6/241 , G02B6/3833 , A61B2562/228 , G02B6/3834 , Y10S385/902
摘要： An assembly of connectors adapt multiple optic fiber illuminators of microsurgical instruments for use with a variety of different available light sources.
摘要翻译：连接器的组件适应于用于各种不同可用光源的显微外科器械的多个光纤照明器。

10. 发明授权

US09883968B2 Fluid exchange apparatus and methods 有权
公开(公告)号：US09883968B2
公开(公告)日：2018-02-06
申请号：US13615229
申请日：2012-09-13
申请人： Darren Doud , Randolph E. Campbell , Signe Erickson , K. Angela MacFarlane , Mike Barrett , Christina Skieller , David Batten , Greg Stine , Eugene de Juan, Jr. , Douglas Sutton , Kathleen Cogan Farinas
发明人： Darren Doud , Randolph E. Campbell , Signe Erickson , K. Angela MacFarlane , Mike Barrett , Christina Skieller , David Batten , Greg Stine , Eugene de Juan, Jr. , Douglas Sutton , Kathleen Cogan Farinas
IPC分类号： A61F9/00 , A61M25/00 , A61M39/02 , A61M5/14 , A61M5/32 , A61M5/46 , A61M39/00 , A61M5/142
CPC分类号： A61F9/0008 , A61F9/0017 , A61M5/141 , A61M5/14276 , A61M5/3202 , A61M5/3291 , A61M5/46 , A61M25/007 , A61M39/0247 , A61M2025/0031 , A61M2025/0039 , A61M2039/0081 , A61M2039/009 , A61M2039/027 , A61M2039/0276 , A61M2039/0294 , A61M2205/6045 , A61M2205/6054 , A61M2209/045 , A61M2210/0612
摘要： An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.

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