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1. 发明申请

US20100125241A1 Prandial Blood Glucose Excursion Optimization Method Via Computation of Time-Varying Optimal Insulin Profiles and System Thereof 有权
标题翻译：膳食血糖偏移优化方法通过计算时变最优胰岛素谱及其系统
公开(公告)号：US20100125241A1
公开(公告)日：2010-05-20
申请号：US12272155
申请日：2008-11-17
申请人： Thierry Prud'homme , Catalin Cris
发明人： Thierry Prud'homme , Catalin Cris
IPC分类号： A61M5/142 , A61B5/00
CPC分类号： G06F19/3468 , G06F19/00 , G16H50/20
摘要： A method and system for optimizing post prandial blood glucose excursions for persons with diabetes via computation of time-varying optimal insulin profiles are disclosed. The method builds upon a mathematical model based on the physiologic description of the human glucoregulatory system. Model parameter values are specific for each patient and meal type, and are determined from measured data by minimizing differences between both measurements and model predictions, and which are used to provide the optimal insulin profiles that are useful to diabetics in managing their chronic disease.
摘要翻译：公开了一种通过计算时变最佳胰岛素分布来优化糖尿病患者餐后血糖偏移的方法和系统。该方法建立在基于人体葡萄糖调节系统的生理描述的数学模型的基础上。模型参数值对于每个患者和膳食类型是特异性的，并且通过最小化测量和模型预测之间的差异从测量数据确定，并且其用于提供对糖尿病患者管理其慢性疾病有用的最佳胰岛素特征。

2. 发明授权

US08527208B2 Prandial blood glucose excursion optimization method via computation of time-varying optimal insulin profiles and system thereof 有权
标题翻译：通过计算时变最优胰岛素曲线及其系统的餐饮血糖偏移优化方法
公开(公告)号：US08527208B2
公开(公告)日：2013-09-03
申请号：US12272155
申请日：2008-11-17
申请人： Thierry Prud'homme , Catalin Cris
发明人： Thierry Prud'homme , Catalin Cris
IPC分类号： G01N33/48 , G01N31/00 , G06G7/48 , G06G7/58
CPC分类号： G06F19/3468 , G06F19/00 , G16H50/20
摘要： A method and system for optimizing post prandial blood glucose excursions for persons with diabetes via computation of time-varying optimal insulin profiles are disclosed. The method builds upon a mathematical model based on the physiologic description of the human glucoregulatory system. Model parameter values are specific for each patient and meal type, and are determined from measured data by minimizing differences between both measurements and model predictions, and which are used to provide the optimal insulin profiles that are useful to diabetics in managing their chronic disease.
摘要翻译：公开了一种通过计算时变最佳胰岛素分布来优化糖尿病患者餐后血糖偏移的方法和系统。该方法建立在基于人体葡萄糖调节系统的生理描述的数学模型的基础上。模型参数值对于每个患者和膳食类型是特异性的，并且通过最小化测量和模型预测之间的差异从测量数据确定，并且其用于提供对糖尿病患者管理其慢性疾病有用的最佳胰岛素特征。

3. 发明申请

US20120029833A1 ASSESSMENT METHOD TO PROCESS A GLUCOSE CONCENTRATION SIGNAL AND DEVICES THEREOF 有权
标题翻译：葡萄糖浓度信号处理的评估方法及其装置
公开(公告)号：US20120029833A1
公开(公告)日：2012-02-02
申请号：US13267436
申请日：2011-10-06
申请人： Thomas Vering , Florian Kuhnl , Lucas Kalt , Catalin Cris , Caroline Patte
发明人： Thomas Vering , Florian Kuhnl , Lucas Kalt , Catalin Cris , Caroline Patte
IPC分类号： G06F19/26 , G01N33/50
CPC分类号： A61B5/14532 , A61B5/7275 , A61B5/7285 , G06F19/00 , G06F19/324 , G06F19/3456 , G16H50/20
摘要： Embodiments of an assessment method for processing a signal corresponding to a glucose concentration and performing a retrospective analysis comprises the steps of: a) initiating a first trigger, wherein the first trigger defines the beginning of a segment of a continuous measurement of glucose concentration or defines the first of a series of spot measurements of glucose concentration; b) collecting data of the continuous measurement or the series of spot measurements of glucose concentration to be analyzed, wherein the collected data relates to a glucose concentration excursion corresponding to a reaction to a relevant event such as a meal or physical activity; c) analyzing the collected data initiated by a second trigger, wherein the second trigger defines the end of the collected data to be analyzed, wherein a measure for a grading of the excursion is determined from the collected data, and d) displaying the results of the analysis.
摘要翻译：用于处理对应于葡萄糖浓度并进行回顾性分析的信号的评估方法的实施方案包括以下步骤：a）启动第一触发，其中第一触发器定义连续测量葡萄糖浓度的段的开始或定义首先对葡萄糖浓度进行一系列点测量; b）收集要分析的葡萄糖浓度的连续测量或点测量的数据，其中所收集的数据涉及对应于对诸如膳食或身体活动的相关事件的反应的葡萄糖浓度偏移; c）分析由第二触发器发起的所收集的数据，其中所述第二触发器定义所述被分析数据的结束，其中根据所收集的数据确定所述偏移的分级的度量，以及d）显示所述数据的结果分析。

4. 发明授权

US08060318B2 Assessment method to process a glucose concentration signal and devices thereof 有权
标题翻译：用于处理葡萄糖浓度信号的评估方法及其装置
公开(公告)号：US08060318B2
公开(公告)日：2011-11-15
申请号：US12511190
申请日：2009-07-29
申请人： Thomas Vering , Florian Kuhni , Lucas Kalt , Catalin Cris , Caroline Patte
发明人： Thomas Vering , Florian Kuhni , Lucas Kalt , Catalin Cris , Caroline Patte
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/7275 , A61B5/7285 , G06F19/00 , G06F19/324 , G06F19/3456 , G16H50/20
摘要： Embodiments of an assessment method for processing a signal corresponding to a glucose concentration and performing a retrospective analysis comprises the steps of: a) initiating a first trigger, wherein the first trigger defines the beginning of a segment of a continuous measurement of glucose concentration or defines the first of a series of spot measurements of glucose concentration; b) collecting data of the continuous measurement or the series of spot measurements of glucose concentration to be analyzed, wherein the collected data relates to a glucose concentration excursion corresponding to a reaction to a relevant event such as a meal or physical activity; c) analyzing the collected data initiated by a second trigger, wherein the second trigger defines the end of the collected data to be analyzed, wherein a measure for a grading of the excursion is determined from the collected data, and d) displaying the results of the analysis.
摘要翻译：用于处理对应于葡萄糖浓度并进行回顾性分析的信号的评估方法的实施方案包括以下步骤：a）启动第一触发，其中第一触发器定义连续测量葡萄糖浓度的段的开始或定义首先对葡萄糖浓度进行一系列点测量; b）收集要分析的葡萄糖浓度的连续测量或点测量的数据，其中所收集的数据涉及对应于对诸如膳食或身体活动的相关事件的反应的葡萄糖浓度偏移; c）分析由第二触发器发起的所收集的数据，其中所述第二触发器定义所述被分析数据的结束，其中根据所收集的数据确定所述偏移的分级的度量，以及d）显示所述数据的结果分析。

5. 发明授权

US08684996B2 Method and apparatus for setting a basal rate profile for an insulin pump 有权
标题翻译：用于设置胰岛素泵的基础速率曲线的方法和装置
公开(公告)号：US08684996B2
公开(公告)日：2014-04-01
申请号：US13038635
申请日：2011-03-02
申请人： Ulrich Haueter , Daniel Von Buren , Catalin Cris , Stephan Marcin
发明人： Ulrich Haueter , Daniel Von Buren , Catalin Cris , Stephan Marcin
IPC分类号： A61M31/00 , A61K9/22 , A61M37/00
CPC分类号： G06T11/203 , A61M5/14244 , A61M5/172 , G06F3/03545 , G06F3/0412 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： Methods for setting a basal rate profile for an insulin pump, wherein the basal rate profile defines a basal rate delivery for a selected time interval and has a pre-defined number of profile segments each of which define the basal rate delivery for a subset of the selected time interval, include providing a curve representing the basal rate as a continuous function of time as an input for an input unit and generating the basal rate profile from the curve by a calculation unit by assigning curve values at selected time instances to the pre-defined number of profile segments.
摘要翻译：用于设置胰岛素泵的基本速率曲线的方法，其中所述基本速率曲线定义了所选择的时间间隔的基础速率递送，并且具有预定义数量的轮廓区段，每个轮廓区段定义了所述基础速率递送的基本速率递送选择的时间间隔包括提供表示基础速率的曲线作为时间的连续函数作为输入单元的输入，并且通过计算单元从所述曲线生成基本速率曲线，通过将所选择的时间实例的曲线值分配给预设的时间间隔，定义数量的配置文件段。

6. 发明申请

US20100030483A1 ASSESSMENT METHOD TO PROCESS A GLUCOSE CONCENTRATION SIGNAL AND DEVICES THEREOF 有权
标题翻译：葡萄糖浓度信号处理的评估方法及其装置
公开(公告)号：US20100030483A1
公开(公告)日：2010-02-04
申请号：US12511190
申请日：2009-07-29
申请人： Thomas Vering , Florian Kuhni , Lucas Kalt , Catalin Cris , Caroline Patte
发明人： Thomas Vering , Florian Kuhni , Lucas Kalt , Catalin Cris , Caroline Patte
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： A61B5/14532 , A61B5/7275 , A61B5/7285 , G06F19/00 , G06F19/324 , G06F19/3456 , G16H50/20
摘要： Embodiments of an assessment method for processing a signal corresponding to a glucose concentration and performing a retrospective analysis comprises the steps of: a) initiating a first trigger, wherein the first trigger defines the beginning of a segment of a continuous measurement of glucose concentration or defines the first of a series of spot measurements of glucose concentration; b) collecting data of the continuous measurement or the series of spot measurements of glucose concentration to be analyzed, wherein the collected data relates to a glucose concentration excursion corresponding to a reaction to a relevant event such as a meal or physical activity; c) analyzing the collected data initiated by a second trigger, wherein the second trigger defines the end of the collected data to be analyzed, wherein a measure for a grading of the excursion is determined from the collected data, and d) displaying the results of the analysis.
摘要翻译：用于处理对应于葡萄糖浓度并进行回顾性分析的信号的评估方法的实施方案包括以下步骤：a）启动第一触发，其中第一触发器定义连续测量葡萄糖浓度的段的开始或定义首先对葡萄糖浓度进行一系列点测量; b）收集要分析的葡萄糖浓度的连续测量或点测量的数据，其中所收集的数据涉及对应于对诸如膳食或身体活动的相关事件的反应的葡萄糖浓度偏移; c）分析由第二触发器发起的所收集的数据，其中所述第二触发器定义所述被分析数据的结束，其中根据所收集的数据确定所述偏移的分级的度量，以及d）显示所述数据的结果分析。

7. 发明授权

US07419484B2 Administering device with an osmotic drive 失效
标题翻译：使用渗透驱动器管理设备
公开(公告)号：US07419484B2
公开(公告)日：2008-09-02
申请号：US11041913
申请日：2005-01-24
申请人： Gilbert Schiltges , Axel Remde , Simone Geiser , Catalin Cris
发明人： Gilbert Schiltges , Axel Remde , Simone Geiser , Catalin Cris
IPC分类号： A61K9/22
CPC分类号： A61M5/14526 , A61M5/14228 , A61M5/14244 , A61M5/14276 , A61M5/1454 , A61M5/14566 , A61M5/16877 , A61M5/16881 , A61M2005/14513 , A61M2230/201
摘要： An administering device with an osmotic drive for administering an injectable product includes a housing with a first chamber containing a solvent, a second chamber containing a solution and a product chamber for accommodating the product. A semi-permeable membrane is disposed between the first chamber and the second chamber. The second chamber is adjoined by a delivery means for delivering product out of the product chamber. A triggering device for triggering the osmotic drive includes an impermeable separating means between the first chamber and the second chamber. The delivery means is slidable relative to the housing along a longitudinal axis of the housing.
摘要翻译：具有用于施用可注射产品的渗透驱动器的施用装置包括具有包含溶剂的第一室的壳体，容纳溶液的第二室和用于容纳产品的产品室。半透膜设置在第一室和第二室之间。第二腔室由用于将产品输出产品室的输送装置相邻。用于触发渗透驱动器的触发装置包括在第一腔室和第二腔室之间的不可渗透分离装置。输送装置可沿着壳体的纵向轴线相对于壳体滑动。

8. 发明授权

US08352196B2 Assessment method to process a glucose concentration signal and devices thereof 有权
标题翻译：用于处理葡萄糖浓度信号的评估方法及其装置
公开(公告)号：US08352196B2
公开(公告)日：2013-01-08
申请号：US13267436
申请日：2011-10-06
申请人： Thomas Vering , Florian Kuhnl , Lucas Kalt , Catalin Cris , Caroline Patte
发明人： Thomas Vering , Florian Kuhnl , Lucas Kalt , Catalin Cris , Caroline Patte
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/7275 , A61B5/7285 , G06F19/00 , G06F19/324 , G06F19/3456 , G16H50/20
摘要： Embodiments of an assessment method for processing a signal corresponding to a glucose concentration and performing a retrospective analysis includes the steps of: a) initiating a first trigger, wherein the first trigger defines the beginning of a segment of a continuous measurement of glucose concentration or define the first of a series of spot measurements of glucose concentration; b) collecting data of the continuous measurement or the series of spot measurements of glucose concentration to be analyzed, wherein the collected data relates to a glucose concentration excursion corresponding to a reaction to a relevant event such as a meal or physical activity; c) analyzing the collected data initiated by a second trigger, wherein the second trigger defines the end of the collected data to be analyzed, wherein a measure for a grading of the excursion is determined from the collected data, and d) displaying the result of the analysis.
摘要翻译：用于处理对应于葡萄糖浓度并进行回顾性分析的信号的评估方法的实施方案包括以下步骤：a）启动第一触发，其中第一触发器定义葡萄糖浓度的连续测量段的开始或定义首先对葡萄糖浓度进行一系列点测量; b）收集要分析的葡萄糖浓度的连续测量或点测量的数据，其中所收集的数据涉及对应于对诸如膳食或身体活动的相关事件的反应的葡萄糖浓度偏移; c）分析由第二触发器发起的所收集的数据，其中所述第二触发器定义所述被分析数据的结束，其中根据所收集的数据确定所述偏移的分级的度量，以及d）显示所述数据的结果分析。

9. 发明申请

US20050182391A1 Administering device with an osmotic drive 失效
标题翻译：使用渗透驱动器管理设备
公开(公告)号：US20050182391A1
公开(公告)日：2005-08-18
申请号：US11041913
申请日：2005-01-24
申请人： Gilbert Schiltges , Axel Remde , Simone Geiser , Catalin Cris
发明人： Gilbert Schiltges , Axel Remde , Simone Geiser , Catalin Cris
IPC分类号： A61K9/22 , A61M1/36 , A61M5/142 , A61M5/145 , A61M5/168
CPC分类号： A61M5/14526 , A61M5/14228 , A61M5/14244 , A61M5/14276 , A61M5/1454 , A61M5/14566 , A61M5/16877 , A61M5/16881 , A61M2005/14513 , A61M2230/201
摘要： An administering device with an osmotic drive for administering an injectable product includes a housing with a first chamber containing a solvent, a second chamber containing a solution and a product chamber for accommodating the product. A semi-permeable membrane is disposed between the first chamber and the second chamber. The second chamber is adjoined by a delivery means for delivering product out of the product chamber. A triggering device for triggering the osmotic drive includes an impermeable separating means between the first chamber and the second chamber. The delivery means is slidable relative to the housing along a longitudinal axis of the housing.
摘要翻译：具有用于施用可注射产品的渗透驱动器的施用装置包括具有包含溶剂的第一室的壳体，容纳溶液的第二室和用于容纳产品的产品室。半透膜设置在第一室和第二室之间。第二腔室由用于将产品输出产品室的输送装置相邻。用于触发渗透驱动器的触发装置包括在第一腔室和第二腔室之间的不可渗透分离装置。输送装置可沿着壳体的纵向轴线相对于壳体滑动。

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