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1. 发明公开

EP2296627A2 MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：胶束的治疗剂的细胞内输送
公开(公告)号：EP2296627A2
公开(公告)日：2011-03-23
申请号：EP09747515.6
申请日：2009-05-13
申请人： The University of Washington , Phaserx, Inc.
发明人： JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , CONVERTINE, Anthony, J. , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
IPC分类号： A61K9/127 , A61K48/00 , A61K47/38 , A61K31/7105
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/7105 , A61K47/551 , A61K47/58 , A61K47/60 , A61K47/6907 , A61K48/0041 , C08F293/005 , C08F2438/03 , C12N15/111 , C12N2320/32
摘要： Composition comprising a polymeric micelle and an associated polynucleotide.

2. 发明公开

EP1108015A1 STREPTAVIDIN MUTANTS HAVING SECONDARY FUNCTIONAL DOMAINS 审中-公开
标题翻译： SEKONDÄRE功能域含STREPTAVIDIN突变体
公开(公告)号：EP1108015A1
公开(公告)日：2001-06-20
申请号：EP99945205.5
申请日：1999-08-25
申请人： BOARD OF REGENTSOF THE UNIVERSITY OF WASHINGTON
发明人： STAYTON, Patrick, S. , MCDEVITT, Todd C. , NELSON, Kjell, E.
IPC分类号： C12N15/00 , C07K14/36 , G01N33/48 , G01N33/531 , G01N33/58 , A61K38/16 , A61L27/34 , C12N11/02
CPC分类号： G01N33/58 , A61F2/0077 , A61F2/30767 , A61K38/164 , A61K38/50 , A61L27/227 , A61L27/34 , C07K14/36 , C07K2319/00 , C12N11/02 , G01N33/531 , C08L89/00
摘要： Streptavidin molecules are disclosed that contain a secondary functional domain. In preferred embodiments, the secondary domain is a cell adhesion peptide incorporated in the streptavidin amino acid sequence at a site not interfering with biotin binding. In a preferred embodiment, the cell adhesion peptide is arginine-glycine-aspartate (Arg-Gly-Asp) (RGD). The peptide is preferably placed on an exposed loop of the streptavidin molecule, such as within the loop defined by residues 63 to 69. The mutant streptavidin molecule can have other characteristics such as reduced biotin binding due to a modification of an amino acid at the biotin binding site. Preferred uses for the disclosed streptavidin molecules are as adaptors to bring, via a streptavidin/biotin interaction, the secondary functional domain into proximity with a cell or molecule to be affected and as a coating for substrates such as vascular devices or prostheses.

3. 发明公开

EP1066322A1 CIRCULARLY PERMUTED BIOTIN BINDING PROTEINS 审中-公开
标题翻译：环形排列的生物素结合蛋白
公开(公告)号：EP1066322A1
公开(公告)日：2001-01-10
申请号：EP99915242.4
申请日：1999-04-02
申请人： The University of Washington
发明人： STAYTON, Patrick, S.
IPC分类号： C07K14/36 , C12N15/62
CPC分类号： C07K14/36 , C07K2299/00 , C07K2319/00 , C07K2319/22 , C12N15/62 , Y10S530/825
摘要： Circularly permuted proteins are described wherein the natural termini of the polypeptide are joined and the resulting circular protein is opened at another point to create new C- and N-termini. The resulting protein exhibits some altered characteristic such as reduced substrate binding, for example. Fusion proteins can be made from the circularly permuted protein by attaching the second polypeptide to these newly created termini. These fusion proteins will have altered properties from a fusion protein made by attaching the second polypeptide to the natural termini. For example, the second peptide or protein can be attached at a position where it is more accessible to its substrate or intended target. In the preferred embodiment, the base polypeptide is streptavidin. Circular permutation of streptavidin results in a circularly permuted biotin binding protein. In one embodiment, a flexible polypeptide loop important for the binding of biotin was opened by creation of the circularly permuted protein. The original termini (residues 13 and 139 of Sequence ID NO:1) were joined by a linker. The biotin association constant was reduced approximately six orders of magnitude below that of wild type streptavidin to 107 M-1. Fusion proteins of the circularly permuted streptavidin can be made with secondary peptides/proteins such as IgG binding protein A or single-chain antibodies.

4. 发明授权

EP2281011B1 DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS 有权转让
标题翻译：二段和POLYNUKLEOTIDKOMPLEXE及其用于输运细胞
公开(公告)号：EP2281011B1
公开(公告)日：2013-02-27
申请号：EP09747510.7
申请日：2009-05-13
申请人： University of Washington , PhaseRx, Inc.
发明人： STAYTON, Patrick, S. , HOFFMAN, Allan, S. , CONVERTINE, Anthony, J. , BENOIT, Danielle , DUVALL, Craig, L. , JOHNSON, Paul , GALL, Anna
IPC分类号： C08F293/00 , C12N15/87 , A61K48/00
CPC分类号： C08F293/005 , A61K31/713 , A61K47/32 , A61K47/58 , C07K2319/10 , C08F293/00 , C12N15/111 , C12N15/113 , C12N15/87 , C12N2310/14 , C12N2310/315 , C12N2310/351 , C12N2320/32
摘要： Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.

5. 发明申请

WO2010021770A1 HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY 审中-公开
标题翻译：异源聚合物细胞用于细胞内递送
公开(公告)号：WO2010021770A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/043859
申请日：2009-05-13
申请人： UNIVERSITY OF WASHINGTON , PHASERX, INC. , JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
发明人： JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
IPC分类号： A61K9/127 , A61K48/00 , A61K47/34 , A61K31/7088 , A61K31/7105
CPC分类号： A61K9/0019 , A61K9/1075 , A61K47/58 , C08L53/00 , C12N15/88 , C08L2666/24
摘要： Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.
摘要翻译：公开了包含非均相聚合物胶束和与胶束相关联的试剂（例如，多核苷酸）的组合物，以及用于细胞内递送该试剂的方法。

6. 发明申请

WO2010054266A3 MULTIBLOCK COPOLYMERS 审中-公开
公开(公告)号：WO2010054266A3
公开(公告)日：2010-05-14
申请号：PCT/US2009/063648
申请日：2009-11-06
申请人： UNIVERSITY OF WASHINGTON , PHASERX, INC. , PRIEVE, Mary, G. , JOHNSON, Paul, H. , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , OVERELL, Robert, W. , GALL, Anna, S. , PASCHAL, Amber, E. E. , DIAB, Charbel , DE, Priyadarsi , DECLUE, Michael, S. , MONAHAN, Sean, D.
发明人： PRIEVE, Mary, G. , JOHNSON, Paul, H. , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , OVERELL, Robert, W. , GALL, Anna, S. , PASCHAL, Amber, E. E. , DIAB, Charbel , DE, Priyadarsi , DECLUE, Michael, S. , MONAHAN, Sean, D.
IPC分类号： C08F297/00 , C08F220/18 , C08F220/56 , C08F212/06 , A61K48/00
摘要： Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.

7. 发明申请

WO2009140421A2 POLYMERIC CARRIER 审中-公开
标题翻译：聚合载体
公开(公告)号：WO2009140421A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/043837
申请日：2009-05-13
申请人： UNIVERSITY OF WASHINGTON , PHASERX, INC. , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , CONVERTINE, Anthony, J. , DUVALL, Craig, L. , BENOIT, Danielle , OVERELL, Robert , JOHNSON, Paul , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
发明人： STAYTON, Patrick, S. , HOFFMAN, Allan, S. , CONVERTINE, Anthony, J. , DUVALL, Craig, L. , BENOIT, Danielle , OVERELL, Robert , JOHNSON, Paul , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
IPC分类号： A61K47/34 , A61K48/00 , A61K31/7088
CPC分类号： A61K47/488 , A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907 , C08F293/005 , C12N15/113 , C12N15/87 , C12N2310/11 , C12N2310/14
摘要： Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.
摘要翻译：本文提供适合于将多核苷酸（例如寡核苷酸）和/或其它治疗剂递送至活细胞的聚合物载体。

8. 发明申请

WO2011062965A2 TARGETING MONOMERS AND POLYMERS HAVING TARGETING BLOCKS 审中-公开
标题翻译：瞄准具有目标块的单体和聚合物
公开(公告)号：WO2011062965A2
公开(公告)日：2011-05-26
申请号：PCT/US2010/056993
申请日：2010-11-17
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION , PHASERX, INC. , MONAHAN, Sean, D. , JOHNSON, Paul, H. , DECLUE, Michael, S. , DE, Priyadarsi , GALL, Anna, S. , STAYTON, Patrick, S. , HOFFMAN, Allan, S.
发明人： MONAHAN, Sean, D. , JOHNSON, Paul, H. , DECLUE, Michael, S. , DE, Priyadarsi , GALL, Anna, S. , STAYTON, Patrick, S. , HOFFMAN, Allan, S.
IPC分类号： A61K47/48
CPC分类号： A61K47/48176 , A61K47/551 , A61K47/557 , A61K47/58 , A61K47/62
摘要： Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof.
摘要翻译：本文提供了含有叶酸盐或其它靶向剂的单体，由其制备的聚合物，由其制备的具有共价偶联于其上的治疗剂的聚合物，以及胶束和其治疗组合物。

9. 发明申请

WO2009140432A2 MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于细胞内递送治疗药物的细胞
公开(公告)号：WO2009140432A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/043853
申请日：2009-05-13
申请人： UNIVERSITY OF WASHINGTON , PhaseRx, Inc. , JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , CONVERTINE, Anthony, J. , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
发明人： JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , CONVERTINE, Anthony, J. , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
IPC分类号： A61K9/127 , A61K48/00 , A61K47/38 , A61K31/7105
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/7105 , A61K47/551 , A61K47/58 , A61K47/60 , A61K47/6907 , A61K48/0041 , C08F293/005 , C08F2438/03 , C12N15/111 , C12N2320/32
摘要： Composition comprising a polymeric micelle and an associated polynucleotide.
摘要翻译：包含聚合胶束和相关多核苷酸的组合物。

10. 发明授权

EP2364330B1 MULTIBLOCK COPOLYMERS 有权
标题翻译： MULTIBLOCKPOLYMERE
公开(公告)号：EP2364330B1
公开(公告)日：2015-03-25
申请号：EP09825524.3
申请日：2009-11-06
申请人： University of Washington , PhaseRx, Inc.
发明人： PRIEVE, Mary, G. , JOHNSON, Paul, H. , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , OVERELL, Robert, W. , GALL, Anna, S. , PASCHAL, Amber, E. E. , DIAB, Charbel , DE, Priyadarsi , DECLUE, Michael, S. , MONAHAN, Sean, D.
IPC分类号： C12N15/87 , C08F220/28 , C08F293/00 , A61K48/00 , A61K31/713
CPC分类号： A61K31/713 , A61K47/545 , A61K47/58 , A61K47/6907 , A61K48/00 , C08F293/005 , C08F2220/286 , C08F2438/03 , C12N15/113 , C12N15/87 , C12N2310/14 , Y02A50/411 , C08F220/34
摘要： Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.
摘要翻译：本文提供多嵌段共聚物，以及胶束和其治疗组合物。

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