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1. 发明申请

WO2014182824A2 SYSTEM AND METHOD FOR 3D POSITION AND GESTURE SENSING OF HUMAN HAND 审中-公开
标题翻译：人体三维位置和姿态感觉的系统与方法
公开(公告)号：WO2014182824A2
公开(公告)日：2014-11-13
申请号：PCT/US2014/037163
申请日：2014-05-07
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , HU, Yingzhe , HUANG, Liechao , RIEUTORT-LOUIS, Warren , SANZ-ROBINSON, Josue , VERMA, Naveen , WAGNER, Sigurd , STURM, James, C.
发明人： HU, Yingzhe , HUANG, Liechao , RIEUTORT-LOUIS, Warren , SANZ-ROBINSON, Josue , VERMA, Naveen , WAGNER, Sigurd , STURM, James, C.
IPC分类号： G06F3/041
CPC分类号： G06F3/0416 , G06F3/017 , G06F3/0346 , G06F3/0412 , G06F3/044 , G06F2203/04101 , G06F2203/04104 , G06F2203/04107 , G06F2203/04108 , G06F2203/04112 , G06K9/00201 , G06K9/00355 , G06K9/00375
摘要： A three dimensional touch sensing system having a touch surface configured to detect a touch input located above the touch surface is disclosed. The system includes a plurality of capacitive touch sensing electrodes disposed on the touch surface, each electrode having a baseline capacitance and a touch capacitance based on the touch input. An oscillating plane is disposed below the touch surface. A touch detector is configured to drive one of the touch sensing electrodes with an AC signal having a frequency that shifts from a baseline frequency to a touch frequency based on the change in electrode capacitance from the baseline capacitance to the touch capacitance. The touch detector is configured to drive the oscillating plane to the touch frequency.
摘要翻译：公开了具有被配置为检测位于触摸表面上方的触摸输入的触摸表面的三维触摸感测系统。该系统包括设置在触摸表面上的多个电容式触摸感测电极，每个电极具有基于触摸输入的基线电容和触摸电容。摆动平面设置在触摸面下方。触摸检测器被配置为基于从基线电容到触摸电容的电极电容的变化的具有从基线频率向触摸频率偏移的AC信号来驱动触摸感测电极之一。触摸检测器被配置为将振荡平面驱动到触摸频率。

2. 发明公开

EP2994817A2 SYSTEM AND METHOD FOR 3D POSITION AND GESTURE SENSING OF HUMAN HAND 无效
标题翻译：系统在VERFAHREN ZUR 3D-位置 - 在GESTENERFASSUNG DER MENSCHLICHEN手
公开(公告)号：EP2994817A2
公开(公告)日：2016-03-16
申请号：EP14795467.1
申请日：2014-05-07
申请人： The Trustees of Princeton University , Rieutort-Louis, Warren
发明人： RIEUTORT-LOUIS, Warren , HU, Yingzhe , HUANG, Liechao , SANZ-ROBINSON, Josue , VERMA, Naveen , WAGNER, Sigurd , STURM, James, C.
IPC分类号： G06F3/044
CPC分类号： G06F3/0416 , G06F3/017 , G06F3/0346 , G06F3/0412 , G06F3/044 , G06F2203/04101 , G06F2203/04104 , G06F2203/04107 , G06F2203/04108 , G06F2203/04112 , G06K9/00201 , G06K9/00355 , G06K9/00375
摘要： A three dimensional touch sensing system having a touch surface configured to detect a touch input located above the touch surface is disclosed. The system includes a plurality of capacitive touch sensing electrodes disposed on the touch surface, each electrode having a baseline capacitance and a touch capacitance based on the touch input. An oscillating plane is disposed below the touch surface. A touch detector is configured to drive one of the touch sensing electrodes with an AC signal having a frequency that shifts from a baseline frequency to a touch frequency based on the change in electrode capacitance from the baseline capacitance to the touch capacitance. The touch detector is configured to drive the oscillating plane to the touch frequency.
摘要翻译：公开了具有被配置为检测位于触摸表面上方的触摸输入的触摸表面的三维触摸感测系统。该系统包括设置在触摸表面上的多个电容式触摸感测电极，每个电极具有基于触摸输入的基线电容和触摸电容。摆动平面设置在触摸面下方。触摸检测器被配置为基于从基线电容到触摸电容的电极电容的变化，以具有从基线频率向触摸频率移动的频率的AC信号来驱动触摸感测电极之一。触摸检测器被配置为将振荡平面驱动到触摸频率。

3. 发明申请

WO2010011934A2 BUMP ARRAY DEVICE HAVING ASYMMETRIC GAPS FOR SEGREGATION OF PARTICLES 审中-公开
标题翻译：具有不对称GAPS的BUG阵列设备用于分离颗粒
公开(公告)号：WO2010011934A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051704
申请日：2009-07-24
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , STURM, James, C. , AUSTIN, Robert , LOUTHERBACK, Kevin , MORTON, Keith , PUCHALLA, Jason
发明人： STURM, James, C. , AUSTIN, Robert , LOUTHERBACK, Kevin , MORTON, Keith , PUCHALLA, Jason
IPC分类号： G01N27/00
CPC分类号： B03B5/00 , B01L3/502753 , G01N27/44791 , G01N30/0005 , G01N30/6069 , G01N30/6095 , G01N2030/528
摘要： The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ.
摘要翻译：本公开涉及用于按尺寸分离颗粒群的障碍物阵列装置（也称为凸块阵列装置）。通过使跨越障碍物之间的间隙的流体速度分布相对于平分该间隙并且平行于体积流体流动方向的平面不对称来实现对先前障碍物阵列装置的改进。这种不对称性可以通过选择围绕间隙的障碍物的形状来实现，使得障碍物的上游，下游或桥接最窄部分的障碍物的部分相对于该平面是不对称的。通过使用具有边界限制边界的障碍物来实现改进。通过选择障碍物形状来实现其他改进，使得由两个不同流体流动方向上的间隙限定的临界粒子尺寸不同。

4. 发明申请

WO2003047316A1 INCREASED EMISSION EFFICIENCY IN ORGANIC LIGHT-EMITTING DEVICES ON HIGH-INDEX SUBSTRATES 审中-公开
标题翻译：有机发光装置在高指数基板上的发射效率提高
公开(公告)号：WO2003047316A1
公开(公告)日：2003-06-05
申请号：PCT/US2002/038181
申请日：2002-11-27
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , UNIVERSAL DISPLAY CORPORATION , LU, Min-Hao, Michael , STURM, James, C. , MADIGAN, Conor, Francis , KWONG, Raymond
发明人： LU, Min-Hao, Michael , STURM, James, C. , MADIGAN, Conor, Francis , KWONG, Raymond
IPC分类号： H05B33/14
CPC分类号： H01L51/5275 , H01L51/52 , H01L51/5262 , H01L2251/558
摘要： A device is provided. The device includes a substrate, a first electrode disposed over the substrate, a small molecule organic emissive layer disposed over the first electrode, and a second electrode disposed over the organic emissive layer. The substrate has a first index of refraction, and the organic emissive layer has a second index or refraction. The first index of refraction is higher than the second index or refraction. The device may have an external electroluminescent efficiency of at least about 56%. Bulky substituents or dopants may be used to decrease the index of refraction and/or the density of the organic emissive layer.
摘要翻译：提供了一种设备。该器件包括衬底，设置在衬底上的第一电极，设置在第一电极上方的小分子有机发射层和设置在有机发射层上的第二电极。衬底具有第一折射率，并且有机发射层具有第二折射率或折射率。第一折射率高于第二折射率或折射率。该器件可具有至少约56％的外部电致发光效率。可以使用大体积的取代基或掺杂剂来降低折射率和/或有机发光层的密度。

5. 发明申请

WO2011149850A2 PHOTOVOLTAIC DEVICE AND METHOD OF MAKING SAME 审中-公开
标题翻译：光电器件及其制造方法
公开(公告)号：WO2011149850A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/037597
申请日：2011-05-23
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , AVASTHI, Sushobhan , STURM, James, C. , SCHWARTZ, Jeffrey
发明人： AVASTHI, Sushobhan , STURM, James, C. , SCHWARTZ, Jeffrey
IPC分类号： H01L51/42
CPC分类号： H01L51/4213 , H01L51/0052 , H01L51/4273 , Y02E10/549 , Y02P70/521
摘要： A photovoltaic device and method of manufacturing is disclosed. In one embodiment, the device includes a silicon layer and first and second organic layers. The silicon layer has a first face and a second face. First and second electrodes electrically are coupled to the first and second organic layers. A first heterojunction is formed at a junction between the one of the faces of the silicon layer and the first organic layer. A second heterojunction is formed at a junction between one of the faces of the silicon layer and the second organic layer. The silicon layer may be formed without a p-n junction. At least one organic layer may be configured as an electron-blocking layer or a hole-blocking layer. At least one organic layer may be comprised of phenanthrenequinone (PQ). A passivating layer may be disposed between at least one of the organic layers and the silicon layer. The passivating layer may be organic. At least one of the organic layers may passivate a surface of the silicon layer. The device may also include at least one transparent electrode layer coupled to at least one of the electrodes.
摘要翻译：公开了一种光电器件及其制造方法。在一个实施例中，该器件包括硅层和第一和第二有机层。硅层具有第一面和第二面。第一和第二电极电连接到第一和第二有机层。在硅层和第一有机层的一个表面之间的接合处形成第一异质结。在硅层和第二有机层的一个面之间的接合处形成第二异质结。可以在没有p-n结的情况下形成硅层。至少一个有机层可以被构造为电子阻挡层或空穴阻挡层。至少一个有机层可以由菲醌（PQ）组成。钝化层可以设置在至少一个有机层和硅层之间。钝化层可以是有机的。有机层中的至少一个可以钝化硅层的表面。该装置还可以包括耦合到至少一个电极的至少一个透明电极层。

6. 发明申请

WO2003001569A3 ORGANIC LIGHT-EMITTING DEVICES WITH BLOCKING AND TRANSPORT LAYERS 审中-公开
公开(公告)号：WO2003001569A3
公开(公告)日：2003-01-03
申请号：PCT/US2002/020189
申请日：2002-06-21
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： LONG, Ke , STURM, James, C. , LU, Min-Hao, Michael
IPC分类号： H05B33/18
摘要： The present invention relates to an organic light emitting device (OLED) for producing electroluminescence having, in order, for example, an anode, a hole transporting layer (HTL), a blocking layer, an electron transporting layer (ETL), and a cathode. In the devices of the present invention, the hole transporting layer comprises a polymeric material, which material may be emissive or may be doped with an emissive dopant. The blocking layer and the electron transporting layer are small-molecule materials. The presence of a blocking layer confines the emission of light to the polymer layer, which may be HTL or a separate emitting layer (EL). The devices of the present invention are suitable for use in single color, multi-color and full-color, passive or active matrix OLED displays.

7. 发明申请

WO2016019393A1 METHODS AND SYSTEMS FOR PROCESSING PARTICLES 审中-公开
标题翻译：处理颗粒的方法和系统
公开(公告)号：WO2016019393A1
公开(公告)日：2016-02-04
申请号：PCT/US2015/043500
申请日：2015-08-03
申请人： GPB SCIENTIFIC, LLC , THE TRUSTEES OF PRINCETON UNIVERSITY , UNIVERSITY OF MARYLAND, BALTIMORE
发明人： GRISHAM, Michael , CIVIN, Curt, I. , STURM, James, C. , AUSTIN, Robert, H. , D'SILVA, Joseph , CHEN, Yu
IPC分类号： C12N9/00 , G01N30/00 , G01N30/50
CPC分类号： C12N9/00 , G01N27/447 , G01N30/60
摘要： Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.
摘要翻译：本文描述了用于处理可改善细胞质量，简化工作流程和降低成本的细胞的改进的微流体装置和方法。应用包括癌症，传染病和炎性疾病等疾病领域的研究和临床诊断。

8. 发明申请

WO2021202892A1 DETERMINISTIC LATERAL DISPLACEMENT ARRAY WITH A SINGLE COLUMN OF BUMPING OBSTACLES 审中-公开
公开(公告)号：WO2021202892A1
公开(公告)日：2021-10-07
申请号：PCT/US2021/025407
申请日：2021-04-01
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , LIANG, Weibin , STURM, James, C.
发明人： LIANG, Weibin , STURM, James, C.
IPC分类号： B01L3/00
摘要： Provided are microfluidic sorting devices comprising: a sample inlet, a single column comprising a plurality of bumping features configured for lateral displacement situated in a microfluidic channel, and a plurality of outlets, wherein the single column creates a main channel and a secondary channel in the microfluidic channel, wherein the sample inlet, the plurality of outlets, and the main channel and secondary channel are in fluid connection.

9. 发明申请

WO2019046052A1 METHODS FOR PREPARING THERAPEUTICALLY ACTIVE CELLS USING MICROFLUIDICS 审中-公开
公开(公告)号：WO2019046052A1
公开(公告)日：2019-03-07
申请号：PCT/US2018/047426
申请日：2018-08-22
申请人： GPB SCIENTIFIC, LLC , THE TRUSTEES OF PRINCETON UNIVERSITY , UNIVERSITY OF MARYLAND, BALTIMORE
发明人： WARD, Anthony , CAMPOS-GONZALEZ, Roberto , SKELLEY, Alison , GANDHI, Khushroo , GRISHAM, Michael , CIVIN, Curt , STURM, James, C.
IPC分类号： A61K35/12 , A61K35/17 , A61P35/00 , C07K14/725 , C12N5/00 , C12N5/0783
摘要： The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses. In its first aspect, the invention is directed to a method of genetically engineering a population of target cells. This is done by isolating the target cells from a crude fluid composition by performing Deterministic Lateral Displacement (DLD) on a microfluidic device. The invention includes a method of producing CAR T cells by obtaining a crude fluid composition comprising T cells and performing DLD on the composition using a microfluidic device. In another aspect, the invention is directed to a method of treating a patient for cancer, an autoimmune disease or an infectious disease by administering CAR T cells engineered according to the method.

10. 发明申请

WO2018080997A1 DETERMINISTIC LATERAL DISPLACEMENT IN THE PREPARATION OF CELLS AND COMPOSITIONS FOR THERAPEUTIC USES 审中-公开
标题翻译：细胞制剂中的确定性横向位移和用于治疗的组合物
公开(公告)号：WO2018080997A1
公开(公告)日：2018-05-03
申请号：PCT/US2017/057876
申请日：2017-10-23
申请人： GPB SCIENTIFIC, LLC , THE TRUSTEES OF PRINCETON UNIVERSITY , UNIVERSITY OF MARYLAND, BALTIMORE
发明人： WARD, Anthony , CAMPOS-GONZALEZ, Roberto , SKELLEY, Alison , GANDHI, Khushroo , GRISHAM, Michael , CIVIN, Curt , STURM, James, C.
IPC分类号： A61K35/12 , A61K35/17 , A61P35/00 , C07K14/725 , C12N5/00 , C12N5/0783
摘要： The present invention is directed to the use of Deterministic Lateral Displacement (DLD) in the preparation of cells and compositions for therapeutic uses. The present invention is directed, inter alia, to methods of collecting and rapidly processing cells, particularly cells that have therapeutic uses. The invention is directed to a method of genetically engineering a population of target cells comprising isolating target cells from a crude fluid composition by performing DLD using a microfluidic device. The invention includes a method of producing CAR T cells by obtaining a crude fluid composition comprising T cells.
摘要翻译：本发明涉及确定性横向置换（DLD）在制备用于治疗用途的细胞和组合物中的用途。本发明尤其涉及收集和快速处理细胞，特别是具有治疗用途的细胞的方法。本发明涉及遗传改造靶细胞群的方法，其包括通过使用微流体装置进行DLD从粗制流体组合物中分离靶细胞。本发明包括通过获得包含T细胞的粗制流体组合物生产CAR T细胞的方法。

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