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1. 发明授权

EP2012833B1 Radiolabeled dihydrotrabenazine derivatives and their use as imaging agents 有权转让
标题翻译：放射性标记的二氢丁苯那嗪衍生物和它们作为成像剂的用途
公开(公告)号：EP2012833B1
公开(公告)日：2014-10-29
申请号：EP07776522.0
申请日：2007-05-01
申请人： The Trustees Of The University Of Pennsylvania , The Regents of the University of Michigan , AVID Radiopharmaceuticals Inc.
发明人： KUNG, Hank F. , KUNG, Mei-Ping , KILBOURN, Michael , SKOVRONSKY, Daniel M.
IPC分类号： A61K51/00 , A61P43/00 , C07D455/06
CPC分类号： A61K51/0455

2. 发明申请

WO2006029303A2 DIPHENYL ETHER DERIVATIVES AND THEIR USE FOR IMAGING SEROTONIN TRANSPORTERS 审中-公开
标题翻译：二苯基醚衍生物及其用于成像血清素转运蛋白的用途
公开(公告)号：WO2006029303A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/032131
申请日：2005-09-09
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , KUNG, Hank F.
发明人： KUNG, Hank F.
IPC分类号： A61K51/00 , C07C217/54
CPC分类号： A61K51/04 , C07C217/58 , C07C217/90
摘要： This invention relates to diphenyl ether derivatives and their use in imaging of Serotonin Transporters (SERTS). The present invention also provides diagnostic compositions comprising the compounds of the present invention, and a pharmaceutically acceptable carrier or diluent. The invention further provides a method of imaging SERTS, comprising introducing into a patient a detectable quantity of a labeled compound of the present invention, or a pharmaceutically acceptable salt, ester, amide or prodrug thereof, allowing sufficient time for the labeled compound to associate with one or more SERTs, and detecting the labeled compound. The present invention can also be used to follow the progression of a disease associated with SERTs or a therapy that targets SERTs.
摘要翻译：本发明涉及二苯醚衍生物及其在血清素转运蛋白（SERTS）成像中的用途。本发明还提供了包含本发明化合物和药学上可接受的载体或稀释剂的诊断组合物。本发明进一步提供了对SERTS成像的方法，包括向患者中引入可检测量的本发明的标记化合物或其药学上可接受的盐，酯，酰胺或前药，允许标记化合物足够的时间与一个或多个SERT，并检测标记的化合物。本发明还可以用于跟踪与SERT相关的疾病或靶向SERT的疗法的进展。

3. 发明公开

EP1838298A2 STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES 审中-公开
标题翻译：茋衍生物和它们用于结合和成像淀粉样蛋白斑的使用
公开(公告)号：EP1838298A2
公开(公告)日：2007-10-03
申请号：EP05857100.1
申请日：2005-12-19
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： KUNG, Hank F. , KUNG, Mei-Ping , ZHUANG, Zhi-Ping
IPC分类号： A61K31/135
CPC分类号： A61K51/04 , C07B59/001 , C07C217/80
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

4. 发明公开

EP1893245A2 RADIOLABELED-PEGYLATION OF LIGANDS FOR USE AS IMAGING AGENTS 审中-公开
标题翻译：放射性注明配体的PEG化用作造影剂
公开(公告)号：EP1893245A2
公开(公告)日：2008-03-05
申请号：EP06785541.1
申请日：2006-06-26
申请人： The Trustees of the University of Pennsylvania
发明人： KUNG, Hank F.
IPC分类号： A61K51/00 , A61K36/14 , A61K9/14
CPC分类号： C07C213/08 , A61K47/60 , A61K51/04 , A61K51/0453 , A61K51/0455 , C07B2200/05 , C07D213/64 , C07D277/66 , C07D471/04
摘要： The present invention is directed to a method of using radiolabeled ethylene glycol (n = 1) (EG) or polyethylene glycol (n = from 2 to 10) (PEG) as a labeling group moiety on compounds that can be useful for imaging tissues. Specifically, the EG or PEG moiety preferably contains a radiofluorine (18F), and is covalently bonded to a ligand (L). The L portion of the molecule can be any molecule appropriate for covalently bonding with the radiolabeled EG or PEG moiety and subsequent use as an imaging agent. In particular, the imaging agent is preferably an agent suitable for administering to a mammal and detecting by PET or SPECT imaging.

5. 发明公开

EP0751790A1 SEROTONIN (5-HT 1A) RECEPTOR LIGANDS AND IMAGING AGENTS 失效
标题翻译：血清素（5-HT 1A）受体配体和造影剂
公开(公告)号：EP0751790A1
公开(公告)日：1997-01-08
申请号：EP95914702.0
申请日：1995-03-10
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： KUNG, Hank F.
IPC分类号： C07D213 , C07D239 , C07F7
CPC分类号： C07D213/74 , C07D213/75 , C07D239/42 , C07F7/2212
摘要： Compounds such as 4-(2'-methoxy)phenyl-[2'-(N-2'-pyridinyl)-p-iodobenzamido]ethylpiperazine have affinity and specificity for serotonin 5-HT1A receptors.

6. 发明公开

EP1999109A2 STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES 有权
标题翻译： STYRYLPYRIDINDERIVATE及其用于绑定和淀粉样斑块的图片
公开(公告)号：EP1999109A2
公开(公告)日：2008-12-10
申请号：EP07753982.3
申请日：2007-03-26
申请人： The Trustees Of The University Of Pennsylvania
发明人： KUNG, Hank F. , KUNG, Mei-Ping
IPC分类号： C07D213/16 , A61K51/04
CPC分类号： C07D211/94 , A61K51/0455 , C07D213/16
摘要： This invention relates to a method of imaging amyloid deposits and to styrylpyridine compounds, and methods of making radiolabeled styrylpyridine compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

7. 发明授权

EP1999109B1 STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES 有权
标题翻译： STYRYLPYRIDINDERIVATE及其用于绑定和淀粉样斑块的图片
公开(公告)号：EP1999109B1
公开(公告)日：2011-12-28
申请号：EP07753982.3
申请日：2007-03-26
申请人： The Trustees Of The University Of Pennsylvania
发明人： KUNG, Hank F. , KUNG, Mei-Ping
IPC分类号： C07D213/16 , A61K51/04
CPC分类号： C07D211/94 , A61K51/0455 , C07D213/16
摘要： This invention relates to a method of imaging amyloid deposits and to styrylpyridine compounds, and methods of making radiolabeled styrylpyridine compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

8. 发明公开

EP2089110A2 ACETYLENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES 审中-公开
标题翻译：乙炔及其用于绑定和淀粉样斑块的图片
公开(公告)号：EP2089110A2
公开(公告)日：2009-08-19
申请号：EP07862676.9
申请日：2007-12-07
申请人： The Trustees of the University of Pennsylvania
发明人： KUNG, Hank F. , KUNG, Mei Ping
IPC分类号： A61P25/28 , A61K31/36 , C07C43/178 , C07C43/225 , C07C219/34 , C07D213/64
CPC分类号： C07B59/002 , C07B2200/05 , C07C43/23 , C07C217/80 , C07D213/64 , C07D213/74 , C07D213/75
摘要： The invention relates to radiolabeled compounds and their use in methods of imaging amyloid deposits, as well as to methods of their manufacture. The invention also relates to compounds for inhibiting the aggregation of amyloid proteins that form amyloid deposits, methods for delivering therapeutic agents to amyloid deposits, as well as methods of making compounds that inhibit the aggregation of amyloid proteins.

9. 发明授权

EP1381604B1 AMYLOID PLAQUE AGGREGATION INHIBITORS AND DIAGNOSTIC IMAGING AGENTS 有权
标题翻译：淀粉样斑块聚集抑制剂和诊断显像剂
公开(公告)号：EP1381604B1
公开(公告)日：2006-12-27
申请号：EP02728893.5
申请日：2002-04-23
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： KUNG, Hank F. , KUNG, Mei-Ping , ZHUANG, Zhi-Ping
IPC分类号： C07D471/04 , C07F7/22 , C07F13/00 , A61K49/00 , A61K51/00 , A61K31/437 , A61P25/28
CPC分类号： C07F13/005 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0468 , A61K51/0478 , A61K51/0497 , C07D471/04 , C07F7/2212
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

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