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1. 发明申请

US20150224128A1 IMINOSUGARS AND METHODS OF TREATING VIRAL DISEASES 有权
标题翻译：麻醉药和治疗病毒的方法
公开(公告)号：US20150224128A1
公开(公告)日：2015-08-13
申请号：US14696686
申请日：2015-04-27
申请人： United Therapeutics Corporation , The Chancellor, Masters and Scholars of the University of Oxford
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
摘要翻译：提供了使用亚氨基二糖治疗或预防由登革热病毒引起或与登革热病毒有关的病毒感染的方法。

2. 发明授权

US09044470B2 Iminosugars and methods of treating viral diseases 有权
标题翻译：伊莫诺斯和治疗病毒性疾病的方法
公开(公告)号：US09044470B2
公开(公告)日：2015-06-02
申请号：US13870341
申请日：2013-04-25
申请人： United Therapeutics Corporation , The Chancellor, Masters and Scholars of the University of Oxford
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/20 , A61K31/665
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
摘要翻译：提供了使用亚氨基二糖治疗或预防由登革热病毒引起或与登革热病毒有关的病毒感染的方法。

3. 发明授权

US09579334B2 Iminosugars and methods of treating viral diseases 有权
标题翻译：伊莫诺斯和治疗病毒性疾病的方法
公开(公告)号：US09579334B2
公开(公告)日：2017-02-28
申请号：US14696686
申请日：2015-04-27
申请人： Emergent Virology LLC , The Chancellor, Masters and Scholars of the University of Oxford
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/20 , A61K31/70 , A61K31/665
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
摘要翻译：提供了使用亚氨基二糖治疗或预防由登革热病毒引起或与登革热病毒有关的病毒感染的方法。

4. 发明申请

US20160077109A1 CLINICAL DIAGNOSIS OF HEPATIC FIBROSIS USING A NOVEL PANEL OF HUMAN SERUM PROTEIN BIOMARKERS 审中-公开
标题翻译：使用人类血清蛋白生物标志物的新面板进行的肝脏纤维化的临床诊断
公开(公告)号：US20160077109A1
公开(公告)日：2016-03-17
申请号：US14690539
申请日：2015-04-20
申请人： The Chancellor, Masters and Scholars of The University of Oxford
发明人： Bevin Gangadharan , Nicole Zitzmann , Raymond A. Dwek
IPC分类号： G01N33/68 , G01N33/576
CPC分类号： G01N33/6893 , G01N33/576 , G01N33/5767 , G01N2333/775 , G01N2800/085 , Y10S436/811
摘要： The inventors have proposed a novel panel of human serum protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Serum from patients with varying degrees of hepatic scarring induced by infection with the hepatitis C virus (HCV) was analysed. Several proteins associated with liver scarring and/or viral infection were identified. These proteins include the inter-α-trypsin inhibitor heavy chain H4 fragments, complement factor H-related protein 1, CD5L, Apo L1, and β2GPI. Increased and decreased thiolester cleavage of a2M and Complement C3, respectively, was also detected. The concentrations of these novel biomarkers can be determined using an immunoassay where the concentrations would reflect the extent of fibrosis. A fibrosis scoring scale for each of the novel biomarkers is proposed. The additive result from the scores of all the novel biomarkers would give a more reliable indication of the degree of fibrosis rather than examining individual biomarkers.
摘要翻译：本发明人提出了用于诊断肝纤维化和肝硬化的人类血清蛋白生物标志物的新颖小组。目前尚无可靠的非侵入性肝纤维化评估方法。使用基于2D-PAGE的蛋白质组学研究来鉴定潜在的纤维化生物标志物。分析了丙型肝炎病毒（HCV）感染引起肝脏瘢痕形成程度不同的患者血清。鉴定了与肝脏瘢痕形成和/或病毒感染相关的几种蛋白质。这些蛋白质包括α-间胰蛋白酶抑制剂重链H4片段，补体因子H相关蛋白1，CD5L，Apo L1和＆bgr; 2GPI。还检测到了分别增加和减少的a2M和补体C3的硫醇裂解。这些新型生物标志物的浓度可以使用免疫测定来确定，其中浓度将反映纤维化程度。提出了每种新型生物标志物的纤维化评分量表。所有新生物标志物的得分的添加剂结果将给出更可靠的纤维化程度的指示，而不是检查个体生物标志物。

5. 发明授权

US08921568B2 Iminosugars and their applications 有权
标题翻译： Iminosugars及其应用
公开(公告)号：US08921568B2
公开(公告)日：2014-12-30
申请号：US13910564
申请日：2013-06-05
申请人： Unither Virology, LLC , The Chancellor, Masters and Scholars of the University of Oxford
发明人： J. L. Kiappes , Peter Laing , Raymond Dwek , Nicole Zitzmann , Stephanie Pollock
IPC分类号： C07D401/12 , C07D211/46 , C07D405/12 , A61K31/575 , A61K31/445 , A61P31/12 , A61K31/335 , C07J43/00
CPC分类号： C07D405/12 , C07D211/46 , C07D401/12 , C07J43/003
摘要： Iminosugar compounds are described that have inbuilt delivery features by virtue of covalent incorporation of a tocopherol moiety, or alternative moieties that are analogs of tocopherol or select analogs of cholesterol, or its antagonist “Ezitimibe”; and are likely to have broad spectrum antiviral activity. The compounds differ from previous iminosugar compounds, even lipophillic ones, being more hydrophobic and resembling fats and oils in their partition behavior in vivo into lipid phases of lipoproteins, cellular lipid droplet organelles and biological membranes. These features confer a number of unique delivery attributes in vivo, favorable to the therapy of virus infections involving cells of the lymphoid system and the liver, in particular, but these features are also favorable in general for the treatment of virus infections of man and animals.
摘要翻译：描述了通过共价引入生育酚部分或作为生育酚类型或胆固醇的选择性类似物或其拮抗剂“依泽替米贝”的替代部分具有内含递送特征的亚氨基缩寡核苷酸化合物; 并且可能具有广谱抗病毒活性。这些化合物与以前的亚氨基硫糖化合物不同，甚至是脂肪细胞的化合物，更疏水，并且类似于脂肪和油在体内分泌体内成脂蛋白，细胞脂滴细胞器和生物膜的脂质相的类似物。这些特征在体内赋予许多独特的递送属性，特别是有助于涉及淋巴系统和肝细胞的病毒感染的治疗，但是这些特征对于治疗人和动物的病毒感染也是有利的。

6. 发明授权

US08748460B2 Iminosugars and methods of treating togaviral diseases 有权
标题翻译：伊米诺糖和治疗披膜病毒疾病的方法
公开(公告)号：US08748460B2
公开(公告)日：2014-06-10
申请号：US13761583
申请日：2013-02-07
申请人： United Therapeutics Corporation , The Chancellor, Masters and Scholars of the University of Oxford
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , Y02A50/382 , Y02A50/397 , Y02A50/409
摘要： Provided are novel methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Togaviridae family using iminosugars, such as DNJ derivatives.
摘要翻译：提供治疗和/或预防使用亚氨基二糖（例如DNJ衍生物）的属于披膜病毒科的病毒引起或与之相关的疾病或病症的新方法。

7. 发明申请

US20130331578A1 NOVEL IMINOSUGARS AND THEIR APPLICATIONS 有权
标题翻译：新型药物及其应用
公开(公告)号：US20130331578A1
公开(公告)日：2013-12-12
申请号：US13910564
申请日：2013-06-05
申请人： The Chancellor, Masters and Scholars of the University of Oxford , Unither Virology, LLC
发明人： J. L. Kiappes , Peter Laing , Raymond Dwek , Nicole Zitzmann , Stephanie Pollock
IPC分类号： C07D405/12 , C07J43/00 , C07D401/12 , C07D211/46
CPC分类号： C07D405/12 , C07D211/46 , C07D401/12 , C07J43/003
摘要： Iminosugar compounds are described that have inbuilt delivery features by virtue of covalent incorporation of a tocopherol moiety, or alternative moieties that are analogues of tocopherol or select analogues of cholesterol, or its antagonist “Ezitimibe”; and are likely to have broad spectrum antiviral activity. The compounds differ from previous iminosugar compounds, even lipophillic ones, being more hydrophobic and resembling fats and oils in their partition behavior in vivo into lipid phases of lipoproteins, cellular lipid droplet organelles and biological membranes. These features confer a number of unique delivery attributes in vivo, favorable to the therapy of virus infections involving cells of the lymphoid system and the liver, in particular, but these features are also favorable in general for the treatment of virus infections of man and animals.
摘要翻译：描述了通过共价引入生育酚部分或作为生育酚或胆固醇的选择性类似物或其拮抗剂“依泽替米贝”的类似物的替代部分具有内含递送特征的亚氨基缩寡核苷酸化合物; 并且可能具有广谱抗病毒活性。这些化合物与以前的亚氨基硫糖化合物不同，甚至是脂肪细胞的化合物，更疏水，并且类似于脂肪和油在体内分泌体内成脂蛋白，细胞脂滴细胞器和生物膜的脂质相的类似物。这些特征在体内赋予许多独特的递送属性，特别是有助于涉及淋巴系统和肝细胞的病毒感染的治疗，但是这些特征对于治疗人和动物的病毒感染也是有利的。

8. 发明授权

US09943532B2 Iminosugars and methods of treating viral diseases 有权
公开(公告)号：US09943532B2
公开(公告)日：2018-04-17
申请号：US15399213
申请日：2017-01-05
申请人： Emergent Virology LLC , THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
发明人： Urban Ramstedt , Brennan Klose , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/445 , A61P31/20 , A61K31/70 , A61K31/665
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.

9. 发明申请

US20160202274A1 CLINICAL DIAGNOSIS OF HEPATIC FIBROSIS USING A NOVEL PANEL OF LOW ABUNDANT HUMAN PLASMA PROTEIN BIOMARKERS 审中-公开
标题翻译：使用低等离子人血浆蛋白生物标志物的新面板进行的皮肤纤维化临床诊断
公开(公告)号：US20160202274A1
公开(公告)日：2016-07-14
申请号：US15076894
申请日：2016-03-22
申请人： The Chancellor, Masters and Scholars of the University of Oxford
发明人： Bevin Gangadharan , Nicole Zitzmann , Raymond A. Dwek
IPC分类号： G01N33/68
CPC分类号： G01N33/5767 , G01N33/57438 , G01N33/6893 , G01N2333/47 , G01N2333/4728 , G01N2333/775 , G01N2333/924 , G01N2500/00 , G01N2800/085 , G01N2800/52 , G01N2800/54 , G01N2800/56 , G01N2800/7057
摘要： The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Plasma from patients with hepatic cirrhosis induced by infection with the hepatitis C virus (HCV) were analysed. Several proteins associated with liver scarring and potentially also related to viral infection were identified. These proteins include 14-3-3 protein zeta/delta, adiponectin, afamin, alpha-1-antitrypsin, alpha-2-HS-glycoprotein, apolipoprotein C-III, apolipoprotein E, C4b-binding protein beta chain, intact/cleaved complement C3dg, corticosteroid-binding globulin, fibrinogen gamma chain, beta haptoglobin at pH 5.46-5.49, haptoglobin-related protein, hemopexin, immunoglobulin J chain, leucine-rich alpha-2-glycoprotein, lipid transfer inhibitor protein, retinol-binding protein 4, serum paraoxonase/arylesterase 1, sex hormone-binding globulin and zinc-alpha-2-glycoprotein.
摘要翻译：本发明人提出了用于诊断肝纤维化和肝硬化的人血浆蛋白生物标志物的新颖小组。目前尚无可靠的非侵入性肝纤维化评估方法。使用基于2D-PAGE的蛋白质组学研究来鉴定潜在的纤维化生物标志物。对丙型肝炎病毒（HCV）感染引起的肝硬化患者血浆进行了分析。鉴定了与肝脏瘢痕形成相关并且潜在地也与病毒感染相关的几种蛋白质。这些蛋白质包括14-3-3蛋白ζ/δ，脂连蛋白，afamin，α-1-抗胰蛋白酶，α-2-HS-糖蛋白，载脂蛋白C-III，载脂蛋白E，C4b结合蛋白β链，完整/切割补体 C3dg，皮质类固醇结合球蛋白，纤维蛋白原γ链，β接触珠蛋白，pH 5.46-5.49，触珠蛋白相关蛋白，血红蛋白，免疫球蛋白J链，富含亮氨酸的α-2-糖蛋白，脂质转移抑制蛋白，视黄醇结合蛋白4，血清对氧磷酶/芳基酯酶1，性激素结合球蛋白和锌-α-2-糖蛋白。

10. 发明申请

US20170304333A1 IMINOSUGARS AND METHODS OF TREATING VIRAL DISEASES 有权
公开(公告)号：US20170304333A1
公开(公告)日：2017-10-26
申请号：US15399213
申请日：2017-01-05
申请人： Emergent Virology LLC , THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
发明人： Urban RAMSTEDT , Brennan KLOSE , Nicole Zitzmann , Raymond A. Dwek , Terry D. Butters
IPC分类号： A61K31/70 , A61K31/665 , A61K31/445
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.

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