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1. 发明公开

EP3365441A1 TYPE VI-B CRISPR ENZYMES AND SYSTEMS 审中-实审转让
公开(公告)号：EP3365441A1
公开(公告)日：2018-08-29
申请号：EP16791741.8
申请日：2016-10-21
申请人： The Broad Institute Inc. , Massachusetts Institute of Technology , Zhang, Feng , Smargon, Aaron , Pyzocha, Neena , Cox, David Benjamin Turitz , Lander, Eric, S.
发明人： ZHANG, Feng , SMARGON, Aaron , PYZOCHA, Neena , COX, David Benjamin Turitz , LANDER, Eric S.
IPC分类号： C12N9/22 , C12N15/55 , C12N15/113
CPC分类号： C12Q1/6876 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/113 , C12N15/63 , C12N2310/20 , C12Q2600/156 , G06F19/20 , G06F19/22
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

2. 发明申请

WO2017070605A1 TYPE VI-B CRISPR ENZYMES AND SYSTEMS 审中-公开
标题翻译： VI-B型CRISPR酶和系统
公开(公告)号：WO2017070605A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058302
申请日：2016-10-21
申请人： THE BROAD INSTITUTE INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ZHANG, Feng , SMARGON, Aaron , PYZOCHA, Neena , COX, David Benjamin Turitz , LANDER, Eric S.
发明人： ZHANG, Feng , SMARGON, Aaron , PYZOCHA, Neena , COX, David Benjamin Turitz , LANDER, Eric S.
IPC分类号： C12N9/22 , C12N15/55 , C12N15/113
CPC分类号： C12Q1/6876 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/113 , C12N15/63 , C12N2310/20 , C12Q2600/156 , G06F19/20 , G06F19/22
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA- targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
摘要翻译：本发明提供了用于靶向核酸的系统，方法和组合物。特别地，本发明提供了非天然存在的或工程化的DNA或RNA-靶向系统，其包含新型DNA或RNA-靶向CRISPR效应蛋白和至少一种靶向核酸组分如引导RNA。

3. 发明公开

EP4159856A1 NOVEL CRISPR ENZYMES AND SYSTEMS 审中-实审转让
公开(公告)号：EP4159856A1
公开(公告)日：2023-04-05
申请号：EP22196333.3
申请日：2016-06-17
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , Rutgers, the State University of New Jersey , Skolkovo Institute of Science and Technology (SKOLTECH) , The United States of America, as Represented by the Secretary, Department of Health and Human Services , Severinov, Konstantin , Zhang, Feng , Wolf, Yuri I. , Shmakov, Sergey , Semenova, Ekaterina , Minakhin, Leonid , Makarova, Kira , Koonin, Eugene , Konermann, Silvana , Joung, Julia , Gootenberg, Jonathan S. , Abudayyeh, Omar O. , Lander, Eric S.
发明人： SEVERINOV, Konstantin , ZHANG, Feng , WOLF, Yuri I. , SHMAKOV, Sergey , SEMENOVA, Ekaterina , MINAKHIN, Leonid , MAKAROVA, Kira S. , KOONIN, Eugene , KONERMANN, Silvana , JOUNG, Julia , GOOTENBERG, Jonathan , ABUDAYYEH, Omar O. , LANDER, Eric S.
IPC分类号： C12N15/10 , C12N9/22 , C12N15/63
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting C2c2 CRISPR effector protein with two HEPN domains and at least one targeting nucleic acid component like a guide RNA. The effector protein is linked to a heterologous functional domain and the HEPN domain(s) may be inactivated.

4. 发明申请

WO2018170340A1 CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS FOR VIRUS DETECTION 审中-公开
公开(公告)号：WO2018170340A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022764
申请日：2018-03-15
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , ABUDAYYEH, Omar , GOOTENBERG, Jonathan , LANDER, Eric S. , SABETI, Pardis , FREIJE, Catherine Amanda , MYHRVOLD, Cameron
发明人： ABUDAYYEH, Omar , GOOTENBERG, Jonathan , LANDER, Eric S. , SABETI, Pardis , FREIJE, Catherine Amanda , MYHRVOLD, Cameron , COLLINS, James, Joseph , ZHANG, Feng
IPC分类号： C12N15/11 , C12N15/15 , C12Q1/68
摘要： Provided herein is a nucleic acid detection system comprising: a CRISPR system comprising an effector protein and one or more guide RNAs designed to bind to corresponding target molecules; an RNA-based masking construct; and optionally, nucleic acid amplification reagents to amplify target RNA molecules in a sample. In another aspect, the embodiments provide a polypeptide detection system comprising: a CRISPR system comprising an effector protein and one or more guide RNAs designed to bind a trigger RNA, an RNA-based masking construct; and one or more detection aptamers comprising a masked RNA polymerase promoter binding site or a masked primer binding site. In some embodiments, the system may be used to detect viruses in samples.

5. 发明申请

WO2018064208A1 SYSTEMATIC SCREENING AND MAPPING OF REGULATORY ELEMENTS IN NON-CODING GENOMIC REGIONS, METHODS, COMPOSITIONS, AND APPLICATIONS THEREOF 审中-公开
标题翻译：非编码基因组区域的调控元件的系统筛选和图谱，方法，组合物及其应用
公开(公告)号：WO2018064208A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/053795
申请日：2017-09-27
申请人： ENGREITZ, Jesse , LANDER, Eric S. , FULCO, Charles , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： ENGREITZ, Jesse , LANDER, Eric S. , FULCO, Charles
IPC分类号： A61K48/00 , C12N15/10
摘要： The application relates to methods for identifying putative regulatory elements that regulates a gene, comprising: obtaining a measure of intrinsic activity of a plurality of genomic elements; obtaining a measure of proximity between each of the genomic elements and the gene; scoring a predicted impact of each of the genomic elements on the gene as a function of the measure of intrinsic activity and the measure of proximity, wherein a plurality of predicted impacts scored are ranked to identify at least one genomic element as a putative regulatory element that regulates the gene; and optionally, training, optimizing, and/or validating the scoring of predicted impact using experimental or computational data describing functional interactions between the genomic elements and the gene. The application also relates to methods for identification of transcriptional enhancers and repressors regulating a gene associated with an agricultural trait of interest in plants or a disease phenotype in mammalians.
摘要翻译：本申请涉及用于鉴定调控基因的推定调节元件的方法，其包括：获得多种基因组元件的内在活性的量度; 获得每个基因组元件与基因之间的接近度量度; 对作为内在活性度量和邻近性度量的函数的基因组中的每个基因组元素的预测影响进行评分，其中对多个预测的影响评分进行排序以将至少一个基因组元件鉴定为推定的调控元件，调节基因; 并且可选地，使用描述基因组元件和基因之间的功能性相互作用的实验或计算数据来训练，优化和/或验证对预测影响的评分。本申请还涉及用于鉴定转录增强子和阻遏物的方法，所述转录增强子和阻遏物调节与哺乳动物中植物感兴趣的农业性状或哺乳动物疾病表型相关的基因。

6. 发明申请

WO2017075292A1 SYSTEMS AND METHODS FOR DETERMINING RELATIVE ABUNDANCES OF BIOMOLECULES 审中-公开
标题翻译：确定生物分子相对丰度的系统和方法
公开(公告)号：WO2017075292A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/059230
申请日：2016-10-27
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： REGEV, Aviv , LANDER, Eric S. , CLEARY, Brian , CONG, Le
IPC分类号： G06F19/24 , G06N3/08 , G06F15/18
CPC分类号： G06N3/08 , G06F19/20 , G06F19/24
摘要： The present invention relates to genomic informatics and gene-expression profiling. Gene-expression profiles provide complex molecular fingerprints regarding the relative state of a cell or tissue. Similarities in gene-expression profiles between organic states provide molecular taxonomies, classification, and diagnostics. Similarities in gene-expression profiles resulting from various external perturbations reveal functional similarities between these perturbagens, of value in pathway and mechanism-of-action elucidation. Similarities in gene-expression profiles between organic and induced states may identify clinically-effective therapies. Systems and methods herein provide for the measurement of relative gene abundances, including unbiased selection of and construction of probes and targets designed and methods for using known properties of sparsity of measurements to reach gene abundances.
摘要翻译：本发明涉及基因组信息学和基因表达谱。基因表达谱提供关于细胞或组织的相对状态的复杂分子指纹。基因表达谱在有机状态之间的相似性提供了分子分类，分类和诊断。由各种外部扰动引起的基因表达谱的相似性揭示了这些干扰因子之间的功能相似性，通路中的价值和作用机制阐明。有机状态和诱导状态之间的基因表达谱的相似性可以确定临床上有效的治疗方法。本文中的系统和方法提供了相对基因丰度的测量，包括设计的探针和靶的无偏选择和构建以及使用测量的稀疏性的已知性质以达到基因丰度的方法。

7. 发明申请

WO2019060450A1 METHODS AND SYSTEMS FOR RECONSTRUCTION OF DEVELOPMENTAL LANDSCAPES BY OPTIMAL TRANSPORT ANALYSIS 审中-公开
公开(公告)号：WO2019060450A1
公开(公告)日：2019-03-28
申请号：PCT/US2018/051808
申请日：2018-09-19
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , RIGOLLET, Philippe
发明人： RIGOLLET, Philippe , SCHIEBINGER, Geoffrey , SHU, Jian , TABAKA, Marcin , CLEARY, Brian , REGEV, Aviv , LANDER, Eric S.
IPC分类号： C12N5/07 , C12N15/63 , C12N15/85
摘要： Methods and compositions for producing induced pluripotent stem cell by introducing nucleic acids encoding one or more transcription factors including Obox6 into a target cell.

8. 发明申请

WO2018204777A3 METHODS FOR IDENTIFICATION AND MODIFICATION OF LNCRNA ASSOCIATED WITH TARGET GENOTYPES AND PHENOTYPES 审中-公开
公开(公告)号：WO2018204777A3
公开(公告)日：2018-11-08
申请号：PCT/US2018/031075
申请日：2018-05-04
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： JOUNG, Julia , ENGREITZ, Jesse , LANDER, Eric S. , ZHANG, Feng
IPC分类号： A61P35/00
摘要： The application relates to methods for compositions for identifying IncRNA loci associated with target genotypes or phenotypes, including desirable plant genotypes or phenotype. The application also relates to regulatory regions and genes associated with drug resistance, such as resistance to BRAF-inhibitors. Such regulatory regions and genes form the basis for methods for identifying resistance to BRAF-inhibitors, which is useful for improving disease prognosis, treatment, and likely outcomes. The regulatory regions and genes are also suitable targets for therapy in melanoma that is resistant to BRAF-inhibitors.

9. 发明申请

WO2018204777A2 METHODS FOR IDENTIFICATION AND MODIFICATION OF LNCRNA ASSOCIATED WITH TARGET GENOTYPES AND PHENOTYPES 审中-公开
公开(公告)号：WO2018204777A2
公开(公告)日：2018-11-08
申请号：PCT/US2018/031075
申请日：2018-05-04
申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： JOUNG, Julia , ENGREITZ, Jesse , LANDER, Eric S. , ZHANG, Feng
IPC分类号： A61P35/00
CPC分类号： A61P35/00
摘要： The application relates to methods for compositions for identifying IncRNA loci associated with target genotypes or phenotypes, including desirable plant genotypes or phenotype. The application also relates to regulatory regions and genes associated with drug resistance, such as resistance to BRAF-inhibitors. Such regulatory regions and genes form the basis for methods for identifying resistance to BRAF-inhibitors, which is useful for improving disease prognosis, treatment, and likely outcomes. The regulatory regions and genes are also suitable targets for therapy in melanoma that is resistant to BRAF-inhibitors.

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