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1. 发明申请

WO2015006590A1 GENERATION OF MALE GERM CELLS 审中-公开
标题翻译：男性细胞的产生
公开(公告)号：WO2015006590A1
公开(公告)日：2015-01-15
申请号：PCT/US2014/046200
申请日：2014-07-10
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY . , UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： RAMATHAL, Cyril Yeshwant , DURRUTHY-DURRUTHY, Jens , REIJO PERA, Renee A. , ORWIG, Kyle E.
IPC分类号： C12N5/076
CPC分类号： C12N5/061 , A61K9/0034 , A61K35/52 , A61K35/545 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2506/02 , C12N2506/1307 , C12N2506/45 , C12N2510/00
摘要： Methods are provided for the generation of male germ cells from somatic cells. Included are methods of non-integrative reprogramming for germ cell differentiation with a reduced risk of neoplasia during in vivo differentiation by the inclusion of VASA with the reprogramming factors. Also included are methods of generating male germ cells from reprogrammed pluripotent cells by direct injection of the reprogrammed cells into the seminiferous tubules. In some embodiments the somatic cells are derived from a male with oligospermia or azoospermia, which may be the result of a genetic abnormality in Azoospermia Factor (AZF) region.
摘要翻译：提供用于从体细胞产生雄性生殖细胞的方法。包括生物细胞分化的非综合重编程方法，通过包含VASA与重编程因子在体内分化过程中瘤形成风险降低。还包括通过将重编程细胞直接注射到生精小管中从重编程的多能细胞产生雄性生殖细胞的方法。在一些实施方案中，体细胞源自具有精子不足或无精子症的雄性，这可能是无精症因子（AZF）区域的遗传异常的结果。

2. 发明申请

WO2016138289A1 METHODS OF GENERATING CELLS OF THE SMOOTH MUSCLE LINEAGE AND USES THEREOF 审中-公开
标题翻译：产生平滑肌细胞系的细胞的方法及其用途
公开(公告)号：WO2016138289A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/019605
申请日：2016-02-25
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： REIJO PERA, Renee A. , CHEN, Bertha , BAER, Thomas M. , PHADNIS, Smruti , WEN, Yan
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/0661 , C12N2501/727 , C12N2506/02 , C12N2506/45
摘要： Methods are provided for generating a homogenous population of smooth muscle progenitor cells from pluripotent progenitor cells and treating a subject having a smooth muscle defect, deficiency or disease through the use of such cells. Methods are also provided for treating a subject for a smooth muscle deficiency, defect, and/or disease with cellular therapy using homogenous populations of smooth muscle precursors and/or differentiated smooth muscle cells derived according to the methods described herein. Some aspects of the treatment include methods of generating homogenous populations of smooth muscle precursor cells and/or differentiated smooth muscle cells from pluripotent progenitor cells using non-invasive automated identification of cell types based on cellular behavior parameters of cultured pluripotent progenitor cells and removal and/or isolation of the identified cell types. Also provided are systems, compositions, and kits for practicing the methods of the disclosure.
摘要翻译：提供了用于从多能祖细胞产生平滑肌祖细胞的均质群体并通过使用这样的细胞治疗具有平滑肌缺陷，缺陷或疾病的受试者的方法。还提供了使用根据本文所述的方法衍生的平滑肌前体和/或分化的平滑肌细胞的均质群体用细胞疗法治疗受试者平滑肌缺乏，缺陷和/或疾病的方法。治疗的一些方面包括使用基于培养的多能祖细胞的细胞行为参数的非侵入性自动鉴定细胞类型从多能祖细胞产生平滑肌前体细胞和/或分化的平滑肌细胞的均质群的方法，以及去除和/ 或分离所识别的细胞类型。还提供了用于实施本公开的方法的系统，组合物和试剂盒。

3. 发明申请

WO2012116185A1 METHODS OF DETECTING ANEUPLOIDY IN HUMAN EMBRYOS 审中-公开
标题翻译：在人类胚胎中检测异常的方法
公开(公告)号：WO2012116185A1
公开(公告)日：2012-08-30
申请号：PCT/US2012/026328
申请日：2012-02-23
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , CHAVEZ, Shawn L. , LOEWKE, Kevin E. , BEHR, Barry , REIJO PERA, Renee A.
发明人： CHAVEZ, Shawn L. , LOEWKE, Kevin E. , BEHR, Barry , REIJO PERA, Renee A.
IPC分类号： G01N33/48 , A61K35/48 , A61K35/54
CPC分类号： C12Q1/68 , C12Q1/6876 , C12Q2600/158 , G01N2800/385 , G01N2800/387
摘要： Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
摘要翻译：提供了用于确定一个或多个胚胎或多能细胞的发育潜力和/或在一个或多个胚胎或多能细胞中存在染色体异常的方法，组合物和试剂盒。这些方法，组合物和试剂盒可用于鉴定体外最有用的治疗人类不育症的胚胎和卵母细胞。

4. 发明申请

WO2011022507A1 ENHANCED EFFICIENCY OF INDUCED PLURIPOTENT STEM CELL GENERATION FROM HUMAN SOMATIC CELLS 审中-公开
标题翻译：诱导人肺癌细胞产生的细胞因子增强效能
公开(公告)号：WO2011022507A1
公开(公告)日：2011-02-24
申请号：PCT/US2010/045933
申请日：2010-08-18
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , REIJO PERA, Renee A. , BYRNE, James
发明人： REIJO PERA, Renee A. , BYRNE, James
IPC分类号： C12N5/071
CPC分类号： C12N5/0696 , C12N2500/44 , C12N2501/115 , C12N2501/119 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/13
摘要： A substantially pure population of human somatic cells that have enhanced potential to become induced pluripotent stem cells (iPS cells) is provided. Also provided are methods for generating this population of cells and methods for generating iPS cells from this population of cells.
摘要翻译：提供了具有增强潜力成为诱导多能干细胞（iPS细胞）的基本上纯的人类体细胞群体。还提供了用于产生该细胞群的方法和用于从该细胞群体产生iPS细胞的方法。

5. 发明授权

EP2678675B1 METHODS OF DETECTING ANEUPLOIDY IN HUMAN EMBRYOS 有权转让
标题翻译：检测人胚胎中抗体的方法
公开(公告)号：EP2678675B1
公开(公告)日：2017-10-11
申请号：EP12749372.4
申请日：2012-02-23
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： CHAVEZ, Shawn L. , LOEWKE, Kevin E. , BEHR, Barry , REIJO PERA, Renee A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6876 , C12Q2600/158 , G01N2800/385 , G01N2800/387
摘要： Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.

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