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1. 发明公开

EP0381514A3 Use of N-methyl-sphingosine as inhibitor of cell growth 失效
标题翻译：作为细胞生长抑制剂的丝氨酸和N-甲基 - 丝胶蛋白
公开(公告)号：EP0381514A3
公开(公告)日：1991-07-17
申请号：EP90301099.9
申请日：1990-02-02
申请人： The Biomembrane Institute , CORNELL RESEARCH FOUNDATION, INC. , MECT CORPORATION
发明人： Igarashi, Yasuyuki , Toyokuni, Tatsushi , Hakomori, Sen-itiroh , Racker, Efraim, Department of Biochemistry , Fujita, Shuji , Sugimoto, Mamoru , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
IPC分类号： A61K31/13
CPC分类号： A61K31/13
摘要： A medicament for inhibiting growth of human and animal cells comprising: (1) a cell growth inhibitory amount of a one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method for inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof. A medicament for inhibiting growth of human and animal cells comprising: (1) A cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method of inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof.

2. 发明授权

EP0381514B1 Use of N-methyl-sphingosine as inhibitor of cell growth 失效
标题翻译：使用N-甲基 - 鞘氨醇作为细胞生长抑制剂。
公开(公告)号：EP0381514B1
公开(公告)日：1995-05-17
申请号：EP90301099.9
申请日：1990-02-02
申请人： The Biomembrane Institute , CORNELL RESEARCH FOUNDATION, INC. , MECT CORPORATION
发明人： Igarashi, Yasuyuki , Toyokuni, Tatsushi , Hakomori, Sen-itiroh , Racker, Efraim, Department of Biochemistry , Fujita, Shuji , Sugimoto, Mamoru , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
IPC分类号： A61K31/13
CPC分类号： A61K31/13

3. 发明公开

EP0381514A2 Use of N-methyl-sphingosine as inhibitor of cell growth 失效
标题翻译： Verwendung von Sphingosin und N-Methyl-Sphingosin als Zell-Wachstums-Inhibitor。
公开(公告)号：EP0381514A2
公开(公告)日：1990-08-08
申请号：EP90301099.9
申请日：1990-02-02
申请人： The Biomembrane Institute , CORNELL RESEARCH FOUNDATION, INC. , MECT CORPORATION
发明人： Igarashi, Yasuyuki , Toyokuni, Tatsushi , Hakomori, Sen-itiroh , Racker, Efraim, Department of Biochemistry , Fujita, Shuji , Sugimoto, Mamoru , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
IPC分类号： A61K31/13
CPC分类号： A61K31/13
摘要： A medicament for inhibiting growth of human and animal cells comprising: (1) a cell growth inhibitory amount of a one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method for inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof. A medicament for inhibiting growth of human and animal cells comprising: (1) A cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method of inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof.
摘要翻译：一种用于抑制人和动物细胞生长的药物，包括：（1）细胞生长抑制量的一种或多种生长抑制剂，其包含合成制备的鞘氨醇，合成制备的N-甲基 - 鞘氨醇或其药学上可接受的盐; 和（2）药学上可接受的载体，稀释剂或赋形剂。一种用于抑制体内人和动物细胞生长的方法，包括使所述细胞与细胞生长抑制量的一种或多种生长抑制剂接触，所述生长抑制剂包括合成制备的鞘氨醇，合成制备的N-甲基 - 鞘氨醇或其药学上可接受的盐。一种用于抑制人和动物细胞生长的药物，包括：（1）细胞生长抑制量的一种或多种生长抑制剂，其包含由天然存在的鞘脂制备的鞘氨醇，由天然存在的鞘脂制备的N-甲基 - 鞘氨醇或其药学上可接受的盐; 和（2）药学上可接受的载体，稀释剂或赋形剂。一种在体内抑制人和动物细胞生长的方法，其包括使所述细胞与细胞生长抑制量的一种或多种生长抑制剂接触，所述生长抑制剂包含由天然存在的鞘脂制备的鞘氨醇，由天然存在的鞘脂制备的N-甲基 - 鞘氨醇或药学上可接受的盐它们。

4. 发明公开

EP0256485A3 Process for preparing sialic acid derivatives 失效
标题翻译：制备酸性衍生物的方法
公开(公告)号：EP0256485A3
公开(公告)日：1990-06-13
申请号：EP87111579.6
申请日：1987-08-10
申请人： MECT CORPORATION
发明人： Yoshimura, Shoji , Tani, Yoichiro , Matsuzaki, Youzi , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
IPC分类号： C07H15/04 , A61K31/70
CPC分类号： C07H15/04
摘要： The present invention relates to a new process for preparing 3-O-(sodium(5-acetamide-3,5-dideoxy-alpha-D-glycero-D-galacto-2-noneuro pyranosyl)onate-1,2-di-O-tetradecyl-Sn-glycerol (3).

5. 发明公开

EP0315973A3 Sialocylglycerolipids and method for preparing the same 失效
标题翻译：唾液酸甘油酯及其制备方法
公开(公告)号：EP0315973A3
公开(公告)日：1990-05-16
申请号：EP88118659.7
申请日：1988-11-09
申请人： MECT CORPORATION
发明人： Yoshimura, Shoji , Matsuzaki, Yuzi , Sugimoto, Mamoru , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
IPC分类号： C07H15/06 , A61K31/70 , C07H15/04
CPC分类号： C07H15/06
摘要： Sialocylglycerolipids represented by the following general formula:
wherein R 1 represents a hydrogen atom or a group CH 3 CO-; R 2 represents an alkali metal, a hydrogen atom or a lower alkyl group; R 3 represents a hydrogen atom or a group C n H 2n+1 - (n is an integer ranging from 1 to 30); and R 4 represents a group C m H 2m+1 - (m is an integer ranging from 1 to 30) are herein disclosed. They are prepared by treating a corresponding compound in an alkaline aqueous solvent. The method makes it possible to provide these compounds in a high yield by a simple processes.
摘要翻译：由以下通式表示的唾液酸酯甘油脂：其中R 1表示氢原子或基团CH 3 CO-; R2代表碱金属，氢原子或低级烷基; R3代表氢原子或基团CnH2n + 1-（n是1-30的整数）; 和R4代表基团CmH2m + 1-（m是1-30的整数）。它们通过在碱性含水溶剂中处理相应的化合物来制备。该方法可以通过简单的方法以高收率提供这些化合物。

6. 发明公开

EP0332191A2 Sialosyl glyceride and process for producing the same 失效
标题翻译：唾液酸甘油和Verfahren zu dessen Herstellung。
公开(公告)号：EP0332191A2
公开(公告)日：1989-09-13
申请号：EP89104199.8
申请日：1989-03-09
申请人： MECT CORPORATION
发明人： Yoshimura, Shoji , Matsuzaki, Yuzi , Sugimoto, Mamoru , Ito, Masayoshi , Ogawa, Tomoya
IPC分类号： C07H5/06 , A61K31/70
CPC分类号： C07H15/06
摘要： The present application discloses a new sialosyl glyceride having the following formula, which compound is useful as a remedy for nervous diseases, has an excellent compatibility with the living bodies, and is easily producible.
wherein R¹ represents a hydrogen atom or XCH₂CO- (X being a halogen atom), R² represents an alkali metal, a hydrogen atom or a lower alkyl group, R³ represents a hydrogen atom or -CO(CH₂)mCH₃, R⁴ represents -CO(CH₂)mCH₃ and m and n each represents a number of 0 to 30.
摘要翻译：本申请公开了具有下式的新的唾液酸甘油酯，该化合物可用作神经疾病的补救剂，与活体具有优异的相容性，并且易于生产。其中R 1表示氢原子或XCH 2 CO-（X为卤素原子），R 2表示碱金属，氢原子或低级烷基，R 3表示氢原子或 -CO（CH 2）m CH 3，R 4表示-CO（CH 2）m CH 3，m和n各自表示0〜30的数。

7. 发明公开

EP0315973A2 Sialocylglycerolipids and method for preparing the same 失效
标题翻译：唾液酸甘油脂和Verfahren zu ihrer Herstellung。
公开(公告)号：EP0315973A2
公开(公告)日：1989-05-17
申请号：EP88118659.7
申请日：1988-11-09
申请人： MECT CORPORATION
发明人： Yoshimura, Shoji , Matsuzaki, Yuzi , Sugimoto, Mamoru , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
IPC分类号： C07H15/06 , A61K31/70 , C07H15/04
CPC分类号： C07H15/06
摘要： Sialocylglycerolipids represented by the following general formula:
wherein R 1 represents a hydrogen atom or a group CH 3 CO-; R 2 represents an alkali metal, a hydrogen atom or a lower alkyl group; R 3 represents a hydrogen atom or a group C n H 2n+1 - (n is an integer ranging from 1 to 30); and R 4 represents a group C m H 2m+1 - (m is an integer ranging from 1 to 30) are herein disclosed. They are prepared by treating a corresponding compound in an alkaline aqueous solvent. The method makes it possible to provide these compounds in a high yield by a simple processes.
摘要翻译：由以下通式表示的唾液酸甘油脂：其中R 1表示氢原子或基团CH 3 CO-; R 2表示碱金属，氢原子或低级烷基; R 3表示氢原子或C n H 2n + 1-（n为1〜30的整数）的基团。并且R 4表示基团C m H 2n + 1 - （m为1至30的整数）。它们通过在碱性水溶剂中处理相应的化合物来制备。该方法可以通过简单的方法以高产率提供这些化合物。

8. 发明公开

EP0273388A3 Sialic acid derivatives having active carbonyl group 失效
标题翻译：具有活性碳基团的酸性衍生物
公开(公告)号：EP0273388A3
公开(公告)日：1989-04-26
申请号：EP87119132.6
申请日：1987-12-23
申请人： MECT CORPORATION
发明人： Yoshimura, Shoji , Shibayama, Shohei , Numata, Masaaki , Ito, Masayoshi , Shitori, Yoshiyasu , Ogawa, Tomoya
IPC分类号： C07H15/04 , C07H15/26 , A61K31/70 , B01J20/26
CPC分类号： C07H15/04 , A61K47/26
摘要： A sialic acid derivative having an active carbonyl group represented by the formula [I]:
(wherein R' represents hydrogen or acetyl group; R 2 represents hydrogen, a metal or a lower alkyl group; R 3 represents hydrogen, hydroxyl group, or a residue removed hydrogen from an alcohol portion of an active ester; Ac represents acetyl group; and n is 1 to 20, respectively). This sialic acid derivative [I] can be utilized as a starting material for various complex having a sialic acid in the molecule since it has an active carbonyl group in the molecule so that it shows high reactivity.

9. 发明公开

EP0260606A2 Medicament for curing neurotic disturbance or disorder comprising sialocylglycerolipid 失效
标题翻译： Sialocylglycerolipid药可治神经症性障碍或疾病。
公开(公告)号：EP0260606A2
公开(公告)日：1988-03-23
申请号：EP87113263.5
申请日：1987-09-10
申请人： MECT CORPORATION , MITSUI TOATSU CHEMICALS, Inc.
发明人： Nagai, Yoshitaka , Awaya, Akira , Horikomi, Kazutoshi , Kobayashi, Hisashi , Mizuchi, Akira , Shitori, Yoshiyasu , Ito, Masayoshi , Ogawa, Tomoya
IPC分类号： A61K31/70
CPC分类号： A61K31/7004 , C07H15/04
摘要： A medicament composition for curing neurotic disturbance or disorder comprising a compound represented by the following formula (I) of:
摘要翻译： D：固化神经质扰动或紊乱，其包括由下式（I）表示的化合物的药物组合物

10. 发明公开

EP0255717A2 Ganglioside related compounds and method of producing the same 失效
标题翻译：神经节苷脂衍生物和Verfahren zur Herstellung davon。
公开(公告)号：EP0255717A2
公开(公告)日：1988-02-10
申请号：EP87111254.6
申请日：1987-08-04
申请人： MECT CORPORATION
发明人： Ogawa, Tomoya , Sugimoto, Mamoru , Numata, Masaaki , Ito, Masayoshi , Shitori, Yoshiyasu , Nunomura, Shigeki
IPC分类号： C07H15/10 , C07H13/04 , A61K31/70
CPC分类号： C07H15/10 , C07H3/06
摘要： The present invention relates to ganglioside related compounds having. for example. the following formula:
where R 1 represents H or COCH 3 (hereinafter abbreviated to "Ac"); R 2 represents H or CH 3 ; and R 3 represents -OH,

or

These ganglioside related compounds are useful as membrane receptors, tumor markers, cell growth controlling substances, etc., and useful for immunotherapy for cancer, etc.
摘要翻译：本发明涉及具有例如下式的神经节苷脂相关化合物：其中R 1表示H或COCH 3（以下简称为“Ac”）的CHEM> R2表示H或CH3; R3表示-OH，这些神经节苷脂相关化合物可用作膜受体，肿瘤标志物，细胞生长控制物质等，可用于癌症免疫治疗等。

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