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    • 7. 发明授权
    • 5-arylpyrimidines as anticancer agents
    • 5-芳基嘧啶作为抗癌剂
    • US07524849B2
    • 2009-04-28
    • US10950375
    • 2004-09-24
    • Nan ZhangSemiramis Ayral-KaloustianThai Nguyen
    • Nan ZhangSemiramis Ayral-KaloustianThai Nguyen
    • C07D239/42C07D239/48A61K31/505
    • C07D239/42A61K31/505A61K31/506C07D239/48C07D401/04C07D403/04C07D405/04C07D409/04
    • This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof.More specifically, the present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
    • 本发明涉及某些5-芳基嘧啶化合物或其药学上可接受的盐,以及含有所述化合物或其药学上可接受的盐的组合物,其中所述化合物是可用于治疗哺乳动物癌症的抗癌剂。 本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法,并进一步提供了治疗或预防表达多重耐药性(MDR)或耐多药耐药性的癌性肿瘤的方法 在需要的哺乳动物中,所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。 更具体地,本发明涉及通过促进微管聚合来治疗或抑制有需要的哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法,其包括向所述哺乳动物施用有效量的所述化合物和药学上可接受的盐 其中。
    • 8. 发明申请
    • 5-arylpyrimidines as anticancer agents
    • 5-芳基嘧啶作为抗癌剂
    • US20050075357A1
    • 2005-04-07
    • US10950375
    • 2004-09-24
    • Nan ZhangSemiramis Ayral-KaloustianThai Nguyen
    • Nan ZhangSemiramis Ayral-KaloustianThai Nguyen
    • A61K31/505A61K31/506A61P35/00C07D239/42C07D239/48C07D401/04C07D403/04C07D405/04C07D409/04A61K31/513C07D43/02
    • C07D239/42A61K31/505A61K31/506C07D239/48C07D401/04C07D403/04C07D405/04C07D409/04
    • This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof. More specifically, the present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
    • 本发明涉及某些5-芳基嘧啶化合物或其药学上可接受的盐,以及含有所述化合物或其药学上可接受的盐的组合物,其中所述化合物是可用于治疗哺乳动物癌症的抗癌剂。 本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法,并进一步提供了治疗或预防表达多重耐药性(MDR)或耐多药耐药性的癌性肿瘤的方法 在需要的哺乳动物中,所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。 更具体地,本发明涉及通过促进微管聚合来治疗或抑制有需要的哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法,其包括向所述哺乳动物施用有效量的所述化合物和药学上可接受的盐 其中。
    • 9. 发明授权
    • Network attached virtual data storage subsystem
    • 网络连接的虚拟数据存储子系统
    • US06658526B2
    • 2003-12-02
    • US09421916
    • 1999-10-20
    • Thai NguyenRobert M. RaymondMichael L. Leonhardt
    • Thai NguyenRobert M. RaymondMichael L. Leonhardt
    • G06F1200
    • G06F3/0613G06F3/0664G06F3/067G06F3/0686
    • This data storage subsystem creates multiple virtual storage devices on demand, which are available to any and all of the system's host data processors. The subsystem utilizes a plurality of tape devices and automated tape libraries with the tape devices connected to a plurality of data processors via a high-speed network. A set of software components, the Network Storage Manager (NSM) controls all system operations. Depending upon the requested storage performance, one or more tape devices are assigned to a virtual device. Data stripping across multiple tape devices allows the storage bandwidth of a virtual device to be changed on demand. The overall capacity and performance of the subsystem is scalable by adding or removing storage devices. The NSM system controller contains a plurality of software elements including: Resource Allocation, Resource Configuration, Resource Management, and Security Management modules. The use of a networked storage manager enables the storage devices to be managed as a pool and yet be attached directly to the network as individual resources. The NSM also provides the mechanism for the enterprise management to control tape device allocation and configuration as well as other functions, such as tape cartridge movement, data migration and data security.
    • 该数据存储子系统根据需要创建多个虚拟存储设备,可用于任何和所有系统的主机数据处理器。 子系统利用多个磁带设备和自动磁带库,磁带设备经由高速网络连接到多个数据处理器。 一组软件组件,网络存储管理器(NSM)控制所有系统操作。 根据请求的存储性能,将一个或多个磁带设备分配给虚拟设备。 跨多个磁带设备的数据剥离允许虚拟设备的存储带宽根据需求进行更改。 通过添加或删除存储设备可以扩展子系统的整体容量和性能。 NSM系统控制器包含多个软件元素,包括:资源分配,资源配置,资源管理和安全管理模块。 使用网络存储管理器可以将存储设备作为池进行管理,并将其作为个别资源直接连接到网络。 NSM还提供了企业管理控制磁带设备分配和配置以及其他功能(如磁带盒移动,数据迁移和数据安全性)的机制。
    • 10. 发明授权
    • Network attached virtual tape data storage subsystem
    • 网络连接的虚拟磁带数据存储子系统
    • US06529996B1
    • 2003-03-04
    • US09343512
    • 1999-06-30
    • Thai NguyenRobert Michael RaymondMichael Lawrence Leonhardt
    • Thai NguyenRobert Michael RaymondMichael Lawrence Leonhardt
    • G06F1200
    • G11B15/68G06F3/0626G06F3/0664G06F3/067
    • The network attached virtual tape storage subsystem interconnects a plurality of tape devices with a plurality of data processors via a high bandwidth switching network to implement a virtual, distributed tape data storage subsystem. The virtual, distributed tape data storage system realizes multiple virtual devices, which are available to any of the data processors and the bandwidth of the system is scalable and can be changed on demand. The virtual tape storage subsystem is managed by a system controller which contains a plurality of software elements including: resource allocation, resource configuration, and resource management. The use of a networked storage manager enables the tape devices to be managed as a pool and yet attach the tape devices directly to the network as individual resources. The networked storage manager must provide the mechanism for the enterprise management to control tape device allocation and configuration as well as other functions, such as tape cartridge movement and data migration.
    • 网络连接的虚拟磁带存储子系统通过高带宽交换网络将多个磁带设备与多个数据处理器互连,以实现虚拟的分布式磁带数据存储子系统。 虚拟分布式磁带数据存储系统实现多个虚拟设备,这些虚拟设备可用于任何数据处理器,并且系统的带宽是可扩展的,可以根据需要进行更改。 虚拟磁带存储子系统由包含多个软件元素的系统控制器管理,包括:资源分配,资源配置和资源管理。 使用网络存储管理器可以将磁带设备作为池进行管理,并将磁带设备作为个别资源直接附加到网络。 网络存储管理器必须提供企业管理机制来控制磁带设备分配和配置以及其他功能,如磁带盒移动和数据迁移。