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1. 发明申请

US20070269486A1 Methods and Devices for Reducing Tissue Damage After Ischemic Injury 审中-公开
标题翻译：缺血性损伤后减少组织损伤的方法和装置
公开(公告)号：US20070269486A1
公开(公告)日：2007-11-22
申请号：US11696360
申请日：2007-04-04
申请人： Theodore Parker , Thai Nguyen , John Shanley , Frank Litvack
发明人： Theodore Parker , Thai Nguyen , John Shanley , Frank Litvack
IPC分类号： A61F2/06 , A61K31/337 , A61K31/4353 , A61K38/28 , A61P9/00
CPC分类号： A61K31/337 , A61F2/91 , A61F2250/003 , A61F2250/0068 , A61K38/28 , A61L31/16 , A61L2300/416 , A61L2300/45
摘要： Methods and devices are provided for the delivery of therapeutic agents which reduce myocardial tissue damage due to ischemia and anti-restenotic agents which inhibit restenosis following a cardiac procedure such as stent implantation. The anti-ischemia agents are delivered to the myocardial tissue over an administration period sufficient to achieve reduction in ischemic or reperfusion injury of the myocardial tissue. The anti-restenotic agents are delivered over an administration period sufficient to reduce the re-narrowing of a blood vessel following a cardiac procedure such as implantation of a device. Preferred anti-restenotic drugs are those that do not reduce the beneficial effects provided by the anti-ischemic drug, such as drugs that do not act on the mammalian target of rapamycin (mTOR).
摘要翻译：提供了用于递送治疗剂的方法和装置，其减少由于局部缺血引起的心肌组织损伤和在心脏手术如支架植入之后抑制再狭窄的抗再狭窄剂。在足以实现心肌组织的缺血或再灌注损伤减少的给药期间将抗缺血剂递送至心肌组织。抗再狭窄剂在足以减少心脏手术如植入装置后的血管再狭窄的给药期内递送。优选的抗再狭窄药物是不减少由抗缺血药物提供的有益效果的那些，例如不作用于雷帕霉素哺乳动物靶标（mTOR）的药物。

2. 发明申请

US20060122697A1 Expandable medical device with openings for delivery of multiple beneficial agents 有权
标题翻译：具有用于输送多种有益剂的开口的可扩展医疗装置
公开(公告)号：US20060122697A1
公开(公告)日：2006-06-08
申请号：US11079967
申请日：2005-03-14
申请人： John Shanley , Frank Litvack , Theodore Parker , Thai Nguyen
发明人： John Shanley , Frank Litvack , Theodore Parker , Thai Nguyen
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2250/0035 , A61F2250/0068 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/45 , A61L2300/602
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. A plurality of different beneficial agents can be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different beneficial agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different beneficial agents may also be used to address different diseases, such as restenosis and acute myocardial infarction from the same drug delivery device.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成基本上圆柱形的装置，其可从具有第一直径的圆柱体扩展到具有第二直径的圆柱体。多个不同的有益剂可以被装载到支柱内的不同的开口中以便递送到组织。为了治疗诸如再狭窄的病症，将不同的有益药物装入装置的不同开口中以解决与再狭窄有关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的有益药物也可用于解决来自同一药物递送装置的不同疾病，例如再狭窄和急性心肌梗塞。

3. 发明申请

US20060204547A1 Drug delivery stent with extended in vivo release of anti-inflammatory 审中-公开
标题翻译：药物输送支架具有延长体内释放的抗炎作用
公开(公告)号：US20060204547A1
公开(公告)日：2006-09-14
申请号：US11375595
申请日：2006-03-14
申请人： Thai Nguyen , John Shanley , Frank Litvack , Theodore Parker
发明人： Thai Nguyen , John Shanley , Frank Litvack , Theodore Parker
IPC分类号： A61K31/4745 , A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91541 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L2300/416
摘要： A method for decreasing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an anti-restenotic agent, such as Pimecrolimus, from the stent to vascular tissue in need of treatment in a controlled and extended drug release profile for a period of at least 45 days in vivo. The in vivo release profile is determined by in vivo animal experiments involving implanting a series of stents in animals, explanting the stents from the animals at selected time points, and extracting remaining drug from the explanted stents.
摘要翻译：用于降低支架放置医疗干预后再狭窄水平的方法包括将需要在受控和延长的药物释放曲线中进行治疗的支架到维管组织连续施用一定剂量的抗再狭窄剂如吡美莫司，从支架到血管组织在体内至少45天的时间。通过体内动物实验确定体内释放曲线，包括在动物中植入一系列支架，在选定的时间点从动物外植体支架，以及从移植的支架中提取剩余的药物。

4. 发明申请

US20060204546A1 Methods and systems for delivering immunosuppressant and anti-inflammatory agents from a stent 审中-公开
标题翻译：从支架输送免疫抑制剂和抗炎剂的方法和系统
公开(公告)号：US20060204546A1
公开(公告)日：2006-09-14
申请号：US11375454
申请日：2006-03-14
申请人： Thai Nguyen , John Shanley , Frank Litvack , Theodore Parker
发明人： Thai Nguyen , John Shanley , Frank Litvack , Theodore Parker
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91541 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L2300/416
摘要： A method for decreasing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an immunosuppressant or anti-inflammatory agent from reservoirs in a stent to vascular tissue in need of treatment in a controlled, two phase drug release profile. It is envisioned that the vascular tissue in need of treatment is arterial tissue, specifically coronary arterial tissue. The agent or drug can be the calcineurin inhibitor Pimecrolimus. The drug can be held within reservoirs in the stent in a drug delivery matrix comprised of the drug and a bioresorbable polymeric material and optionally additives to regulate the drug release.
摘要翻译：用于降低支架置入医疗干预后再狭窄水平的方法包括将需要在受控的两相药物释放曲线中进行治疗的支架中的血管中的一个剂量的免疫抑制剂或抗炎药剂的剂量连续施用于血管组织。可以想象，需要治疗的血管组织是动脉组织，特别是冠状动脉组织。该药物或药物可以是钙调神经磷酸酶抑制剂Pimecrolimus。该药物可以在由药物和生物可再吸收的聚合物材料和任选的调节药物释放的添加剂的药物递送基质中的支架内的储存器中保持。

5. 发明申请

US20070065477A1 Composition, system, and method for modulating release kinetics in implantable drug delivery devices by modifying drug solubility 审中-公开
标题翻译：通过改变药物溶解度来调节可植入药物递送装置中的释放动力学的组成，系统和方法
公开(公告)号：US20070065477A1
公开(公告)日：2007-03-22
申请号：US11520470
申请日：2006-09-12
申请人： Theodore Parker , Stephen Diaz , John Shanley , Diane Dang , Thai Nguyen
发明人： Theodore Parker , Stephen Diaz , John Shanley , Diane Dang , Thai Nguyen
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0068 , A61K9/0024 , A61L31/022 , A61L2300/416 , A61L2300/63
摘要： An implantable drug delivery device loaded with a beneficial agent is provided, wherein the beneficial agent is in two different forms, a first form having a higher solubility and a second form having a lower solubility, and wherein the two different forms are present in a proportion which is selected to achieve a desired release rate.
摘要翻译：提供了一种装载有益剂的可植入药物递送装置，其中有益剂是两种不同形式，具有较高溶解度的第一形式和具有较低溶解度的第二种形式，并且其中两种不同形式以一定比例存在其被选择以实现期望的释放速率。

6. 发明申请

US20060229713A1 Implantable medical device with openings for delivery of beneficial agents with combination release kinetics 有权
标题翻译：具有开口的植入式医疗装置，用于递送具有组合释放动力学的有益剂
公开(公告)号：US20060229713A1
公开(公告)日：2006-10-12
申请号：US11448319
申请日：2006-06-06
申请人： John Shanley , Theodore Parker , Thai Nguyen , Micheline Markey , Gary Steese-Bradley
发明人： John Shanley , Theodore Parker , Thai Nguyen , Micheline Markey , Gary Steese-Bradley
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2250/0035 , A61F2250/0068
摘要： A method and system for delivering drug includes a first set of holes filled with a first formulation of the drug and a second set of holes filled with a second formulation of the same drug. This dual formulation or dual release kinetic system allows the creation of specifically tailored release kinetics by summation of multiple release kinetics.
摘要翻译：用于递送药物的方法和系统包括填充有药物的第一制剂的第一组孔和填充有相同药物的第二制剂的第二组孔。这种双重配方或双重释放动力学系统允许通过多次释放动力学的求和来创建专门定制的释放动力学。

7. 发明授权

US07524849B2 5-arylpyrimidines as anticancer agents 有权
标题翻译： 5-芳基嘧啶作为抗癌剂
公开(公告)号：US07524849B2
公开(公告)日：2009-04-28
申请号：US10950375
申请日：2004-09-24
申请人： Nan Zhang , Semiramis Ayral-Kaloustian , Thai Nguyen
发明人： Nan Zhang , Semiramis Ayral-Kaloustian , Thai Nguyen
IPC分类号： C07D239/42 , C07D239/48 , A61K31/505
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D239/48 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof.More specifically, the present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及某些5-芳基嘧啶化合物或其药学上可接受的盐，以及含有所述化合物或其药学上可接受的盐的组合物，其中所述化合物是可用于治疗哺乳动物癌症的抗癌剂。本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，并进一步提供了治疗或预防表达多重耐药性（MDR）或耐多药耐药性的癌性肿瘤的方法在需要的哺乳动物中，所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。更具体地，本发明涉及通过促进微管聚合来治疗或抑制有需要的哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，其包括向所述哺乳动物施用有效量的所述化合物和药学上可接受的盐其中。

8. 发明授权

US07350101B1 Simultaneous writing and reconstruction of a redundant array of independent limited performance storage devices 有权
标题翻译：同时编写和重建独立有限性能存储设备的冗余阵列
公开(公告)号：US07350101B1
公开(公告)日：2008-03-25
申请号：US10329222
申请日：2002-12-23
申请人： Thai Nguyen , Charles A. Milligan , Michael L. Leonhardt , Stephen S. Selkirk , Gerald O'Nions , James P. Hughes
发明人： Thai Nguyen , Charles A. Milligan , Michael L. Leonhardt , Stephen S. Selkirk , Gerald O'Nions , James P. Hughes
IPC分类号： G06F11/00
CPC分类号： G06F11/1084 , G06F2211/108
摘要： A method, computer program product, and data processing system for continuously writing new data to a redundant array of independent storage devices without interrupting the writing of new data to the array to reconstruct missing data from a failed device or failed media is disclosed. A fault-tolerance scheme using multiple independent parity values is used to record data to the array. In the event that one of the volumes in the array fails, the remaining volumes continue being written to, but with fewer data or parity values being employed. The failed volume can then be reconstructed following the completion of writing the media set currently being written.
摘要翻译：公开了一种方法，计算机程序产品和数据处理系统，用于将新数据连续地写入独立存储设备的冗余阵列，而不会中断将数据写入阵列以从故障设备或故障介质重新构建丢失的数据。使用多个独立奇偶校验值的容错方案用于将数据记录到阵列。如果阵列中的一个卷失败，剩余的卷将继续写入，但采用的数据或奇偶校验值较少。完成写入当前正在写入的媒体集之后，可以重构失败的音量。

9. 发明申请

US20050075357A1 5-arylpyrimidines as anticancer agents 有权
标题翻译： 5-芳基嘧啶作为抗癌剂
公开(公告)号：US20050075357A1
公开(公告)日：2005-04-07
申请号：US10950375
申请日：2004-09-24
申请人： Nan Zhang , Semiramis Ayral-Kaloustian , Thai Nguyen
发明人： Nan Zhang , Semiramis Ayral-Kaloustian , Thai Nguyen
IPC分类号： A61K31/505 , A61K31/506 , A61P35/00 , C07D239/42 , C07D239/48 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , A61K31/513 , C07D43/02
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D239/48 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof. More specifically, the present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及某些5-芳基嘧啶化合物或其药学上可接受的盐，以及含有所述化合物或其药学上可接受的盐的组合物，其中所述化合物是可用于治疗哺乳动物癌症的抗癌剂。本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，并进一步提供了治疗或预防表达多重耐药性（MDR）或耐多药耐药性的癌性肿瘤的方法在需要的哺乳动物中，所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。更具体地，本发明涉及通过促进微管聚合来治疗或抑制有需要的哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，其包括向所述哺乳动物施用有效量的所述化合物和药学上可接受的盐其中。

10. 发明授权

US06658526B2 Network attached virtual data storage subsystem 有权
标题翻译：网络连接的虚拟数据存储子系统
公开(公告)号：US06658526B2
公开(公告)日：2003-12-02
申请号：US09421916
申请日：1999-10-20
申请人： Thai Nguyen , Robert M. Raymond , Michael L. Leonhardt
发明人： Thai Nguyen , Robert M. Raymond , Michael L. Leonhardt
IPC分类号： G06F1200
CPC分类号： G06F3/0613 , G06F3/0664 , G06F3/067 , G06F3/0686
摘要： This data storage subsystem creates multiple virtual storage devices on demand, which are available to any and all of the system's host data processors. The subsystem utilizes a plurality of tape devices and automated tape libraries with the tape devices connected to a plurality of data processors via a high-speed network. A set of software components, the Network Storage Manager (NSM) controls all system operations. Depending upon the requested storage performance, one or more tape devices are assigned to a virtual device. Data stripping across multiple tape devices allows the storage bandwidth of a virtual device to be changed on demand. The overall capacity and performance of the subsystem is scalable by adding or removing storage devices. The NSM system controller contains a plurality of software elements including: Resource Allocation, Resource Configuration, Resource Management, and Security Management modules. The use of a networked storage manager enables the storage devices to be managed as a pool and yet be attached directly to the network as individual resources. The NSM also provides the mechanism for the enterprise management to control tape device allocation and configuration as well as other functions, such as tape cartridge movement, data migration and data security.
摘要翻译：该数据存储子系统根据需要创建多个虚拟存储设备，可用于任何和所有系统的主机数据处理器。子系统利用多个磁带设备和自动磁带库，磁带设备经由高速网络连接到多个数据处理器。一组软件组件，网络存储管理器（NSM）控制所有系统操作。根据请求的存储性能，将一个或多个磁带设备分配给虚拟设备。跨多个磁带设备的数据剥离允许虚拟设备的存储带宽根据需求进行更改。通过添加或删除存储设备可以扩展子系统的整体容量和性能。 NSM系统控制器包含多个软件元素，包括：资源分配，资源配置，资源管理和安全管理模块。使用网络存储管理器可以将存储设备作为池进行管理，并将其作为个别资源直接连接到网络。 NSM还提供了企业管理控制磁带设备分配和配置以及其他功能（如磁带盒移动，数据迁移和数据安全性）的机制。

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