专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4617314A Benzofuran- and benzopyran-carboxamide derivatives 失效
标题翻译：苯并呋喃和苯并吡喃 - 甲酰胺衍生物
公开(公告)号：US4617314A
公开(公告)日：1986-10-14
申请号：US591363
申请日：1984-03-20
申请人： Tetsuya Tahara , Kiyoharu Hayano , Michihide Setoguchi , Takemi Fukuda
发明人： Tetsuya Tahara , Kiyoharu Hayano , Michihide Setoguchi , Takemi Fukuda
IPC分类号： A61K31/335 , A61K31/34 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4025 , A61K31/443 , A61K31/445 , A61K31/535 , A61P1/08 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , C07D307/79 , C07D311/58 , C07D405/12
CPC分类号： C07D307/79 , C07D405/12
摘要： Benzofuran- and benzopyran-carboxamide derivatives of the formula: ##STR1## wherein l is 1 or 2; X is hydrogen atom, amino group or halogen atom; Y is --S(O).sub.m --R.sup.3 wherein R.sup.3 is lower alkyl group and m is 0, 1 or 2, or ##STR2## wherein R.sup.4 and R.sup.5 are the same or different and are each hydrogen atom or lower alkyl group; R.sup.1 is hydrogen atom, lower alkyl group, arylthiomethyl group, halogenomethyl group or ##STR3## wherein R.sup.6 and R.sup.7 are the same or different and are each hydrogen atom or lower alkyl group or R.sup.6 and R.sup.7 together with the adjacent nitrogen atom form a hetrocycle; R.sup.2 is hydrogen atom or lower alkyl group; and Z is ##STR4## wherein p is 2 or 3, R.sup.8 and R.sup.9 are the same or different and are each lower alkyl group or R.sup.8 and R.sup.9 together with the adjacent nitrogen atom form a heterocycle, or ##STR5## wherein q is 0 or 1, n is 1 or 2, R.sup.10 is lower alkyl group, lower alkenyl group, lower alkinyl group, aralkyl group or cycloalkyl group and R.sup.11 is hydrogen atom or lower alkyl group, their physiologically acceptable salts or their optical isomers, and a method of preparing same. These compounds are useful as psychotropic and antipsychotic agents.
摘要翻译：苯并呋喃和苯并吡喃 - 甲酰胺衍生物，其结构式如下：其中l为1或2; X是氢原子，氨基或卤素原子; Y是-S（O）m -R 3，其中R 3是低级烷基，m是0,1或2，或者其中R 4和R 5相同或不同，各自为氢原子或低级烷基; R 1是氢原子，低级烷基，芳基硫代甲基，卤代甲基或者其中R 6和R 7相同或不同，各自为氢原子或低级烷基，或者R 6和R 7与相邻的氮原子一起形成杂环; R2是氢原子或低级烷基; 并且Z为，其中p为2或3，R8和R9相同或不同，为低级烷基或R8和R9与相邻的氮原子一起形成杂环，或者其中q为0或 1，n为1或2，R 10为低级烷基，低级烯基，低级炔基，芳烷基或环烷基，R 11为氢原子或低级烷基，其生理学上可接受的盐或其旋光异构体，准备相同这些化合物可用作精神药物和抗精神病药。

2. 发明授权

US4414216A Tetrahydrofuran compounds and analogs thereof 失效
标题翻译：四氢呋喃化合物及其类似物
公开(公告)号：US4414216A
公开(公告)日：1983-11-08
申请号：US390433
申请日：1982-06-21
申请人： Takeshi Kawakita , Yasuaki Chihara , Takemi Fukuda , Michihide Setoguchi , Tetsuya Tahara
发明人： Takeshi Kawakita , Yasuaki Chihara , Takemi Fukuda , Michihide Setoguchi , Tetsuya Tahara
IPC分类号： C07D405/06 , A61K31/443 , A61K31/445 , A61K31/495 , A61P1/00 , A61P25/26 , C07C29/147 , C07C33/30 , C07D307/10 , C07D307/12 , C07D307/33 , C07D405/14 , C07D471/04 , C07D471/10 , C07D471/20 , C07D513/20 , A61K31/505
CPC分类号： C07D307/33 , C07C29/147 , C07C33/30 , C07D307/10 , C07D307/12 , C07D471/10
摘要： There are disclosed tetrahydrofuran compounds and analogs thereof of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein X is oxygen or sulfur, R.sup.1 and R.sup.2 are each hydrogen, halogen, lower alkyl or lower alkoxy, and Am is a group of the formula: ##STR2## wherein Z is oxygen or sulfur, R.sup.3 is hydrogen or halogen, R.sup.4 is hydrogen, lower alkyl or phenyl which may be substituted by 1 to 3 substituents at any position(s) on the phenyl nucleus, each substituent being independently selected from halogen, lower alkyl and lower alkoxy, and R.sup.5 is hydrogen or lower alkyl. Such compounds are useful as neuroleptics.
摘要翻译：公开了具有下式的四氢呋喃化合物及其类似物：其中X是氧或硫，R 1和R 2各自是氢，卤素，低级烷基或低级烷氧基，并且Am是一个基团其中Z是氧或硫，R 3是氢或卤素，R 4是氢，低级烷基或苯基，其可以被1至3个取代基取代在任何位置上苯基核，每个取代基独立地选自卤素，低级烷基和低级烷氧基，R 5是氢或低级烷基。这些化合物可用作精神安定药。

3. 发明授权

US4616009A Neuroleptic indole-3-carboxamide derivatives 失效
标题翻译：神经性吲哚-3-甲酰胺衍生物
公开(公告)号：US4616009A
公开(公告)日：1986-10-07
申请号：US679437
申请日：1984-12-07
申请人： Tetsuya Tahara , Takemi Fukuda , Michihide Setoguchi
发明人： Tetsuya Tahara , Takemi Fukuda , Michihide Setoguchi
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/4427 , A61K31/445 , A61K31/55 , A61P1/04 , A61P1/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D209/42 , C07D401/12 , C07D403/12
CPC分类号： C07D401/12 , C07D209/42 , C07D403/12 , Y10S47/01
摘要： Indole-3-carboxamide derivatives of the formula: ##STR1## inclusive of pharmaceutically acceptable acid addition salt and/or hydrate forms thereof, wherein R.sup.1 is hydrogen, C.sub.1-4 alkyl, phenyl which may be optionally substituted by halogen on the benzene ring or phenyl-C.sub.1-4 alkyl which may be optionally substituted by halogen on the benzene ring; R.sup.2 is hydrogen or C.sub.1-4 alkyl; R.sup.3 is hydrogen, halogen, C.sub.1-4 alkyl, hydroxy or C.sub.1-4 alkoxy; R.sup.4 is hydrogen, C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, allyl or benzyl which may be optionally substituted by halogen on the benzene ring or by methyl on the .alpha.-carbon; R.sup.5 is hydrogen or C.sub.1-4 alkyl; m is 0 or 1; and n is an integer of 1 to 3, are useful as neuroleptic and anxiolytic drugs, and for the prevention and treatment of psychosomatic disturbances.
摘要翻译：下式的吲哚-3-甲酰胺衍生物：包括其药学上可接受的酸加成盐和/或其水合物形式，其中R 1是氢，C 1-4烷基，可任意被苯环上的卤素取代的苯基或苯基-C 1-4烷基，其可任选被苯环上的卤素取代; R2是氢或C1-4烷基; R3是氢，卤素，C1-4烷基，羟基或C1-4烷氧基; R4是氢，C1-4烷基，C3-7环烷基，烯丙基或苄基，它们可以任选地被苯环上的卤素取代，或在α-碳上被甲基取代; R5是氢或C1-4烷基; m为0或1; n为1〜3的整数，可用作抗精神病药和抗焦虑药，用于预防和治疗心身障碍。

4. 发明授权

US4397853A Isoxazole derivatives 失效
标题翻译：异恶唑衍生物
公开(公告)号：US4397853A
公开(公告)日：1983-08-09
申请号：US253930
申请日：1981-04-14
申请人： Takeshi Kawakita , Tomio Muro , Michihide Setoguchi
发明人： Takeshi Kawakita , Tomio Muro , Michihide Setoguchi
IPC分类号： A61K31/415 , A61K31/42 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5377 , A61P1/08 , A61P25/00 , A61P25/04 , A61P25/26 , A61P29/00 , C07D261/04 , C07D413/04 , C07D413/06 , C07D413/14 , C07D471/04 , C07D471/10 , C07D471/20
CPC分类号： C07D471/04 , C07D261/04 , C07D471/10
摘要： Isoxazole derivatives represented by the formula ##STR1## wherein Ar, R.sup.1, R.sup.2 and Am are as defined in the specification, or salts thereof. These compounds are useful as drugs such as psychotropic agent, antiemetic agent, etc.
摘要翻译： PCT No.PCT / JP80 / 00286 Sec。 371日期1981年7月28日 102（e）日期1981年4月14日PCT提交1980年11月25日PCT公布。第WO81 / 01554号公报日期：1981年6月11日。由式表示的异唑衍生物，其中Ar，R 1，R 2和Am如说明书中所定义，或其盐。这些化合物可用作药物如精神药物，止吐剂等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式