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1. 发明授权

US5876975A Trehalose phosphorylase its preparation and uses 失效
标题翻译：海藻糖磷酸酶的制备及用途
公开(公告)号：US5876975A
公开(公告)日：1999-03-02
申请号：US103509
申请日：1998-06-24
申请人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： A61K38/00 , C12N1/21 , C12N9/10 , C12N15/54 , C12P19/18 , C12P19/44 , C07K1/00 , C12P21/06
CPC分类号： C12N9/1051 , C12P19/18 , A61K38/00
摘要： A thermostable trehalose phosphorylase which is obtainable from microorganisms of the genus Thermoanaerobium and which hydrolyzes trehalose in the presence of an inorganic phosphoric acid to form D-glucose and .beta.-D-glucose-1-phosphoric acid. The trehalose phosphorylase can be also prepared by recombinant DNA technology. When the enzyme is allowed to contact with .beta.-D-glucose-1-phosphoric acid as a saccharide donor in the presence of other saccharides, glucosyl-transferred saccharides including glucosyl-D-galactoside, which are conventionally known but scarcely obtainable, can be produced on an industrial-scale and in a relatively-low cost.
摘要翻译：一种热稳定的海藻糖磷酸化酶，其可从Thermoanaerobium属的微生物获得，并且在无机磷酸存在下水解海藻糖以形成D-葡萄糖和β-D-葡萄糖-1-磷酸。海藻糖磷酸化酶也可以通过重组DNA技术制备。当酶在其他糖类存在下与β-D-葡萄糖-1-磷酸作为糖供体接触时，通常已知但几乎不可获得的包括葡糖基-D-半乳糖苷的葡糖基转移的糖可以是以工业规模生产，成本相对较低。

2. 发明授权

US5910436A Trehalose phosphorylase, its preparation and uses 失效
标题翻译：海藻糖磷酸化酶，其制备及用途
公开(公告)号：US5910436A
公开(公告)日：1999-06-08
申请号：US102644
申请日：1998-06-23
申请人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： A61K38/00 , C12N1/21 , C12N9/10 , C12N15/54 , C12P19/18 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/1051 , C12P19/18 , A61K38/00
摘要： A thermostable trehalose phosphorylase which is obtainable from microorganisms of the genus Thermoanaerobium and which hydrolyzes trehalose in the presence of an inorganic phosphoric acid to form D-glucose and .beta.-D-glucose-1-phosphoric acid. The trehalose phosphorylase can be also prepared by recombinant DNA technology. When the enzyme is allowed to contact with .beta.-D-glucose-1-phosphoric acid as a saccharide donor in the presence of other saccharides, glucosyl-transferred saccharides including glucosyl-D-galactoside, which are conventionally known but scarcely obtainable, can be produced on an industrial-scale and in a relatively-low cost.
摘要翻译：一种热稳定的海藻糖磷酸化酶，其可从Thermoanaerobium属的微生物获得，并且在无机磷酸存在下水解海藻糖以形成D-葡萄糖和β-D-葡萄糖-1-磷酸。海藻糖磷酸化酶也可以通过重组DNA技术制备。当酶在其他糖类存在下与β-D-葡萄糖-1-磷酸作为糖供体接触时，通常已知但几乎不可获得的包括葡糖基-D-半乳糖苷的葡糖基转移的糖可以是以工业规模生产，成本相对较低。

3. 发明授权

US5993889A Trehalose phosphorylase, its preparation and use 有权
标题翻译：海藻糖磷酸酶，其制备和用途
公开(公告)号：US5993889A
公开(公告)日：1999-11-30
申请号：US218032
申请日：1998-12-22
申请人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： A61K38/00 , C12N9/10 , C12P19/18 , A61K7/00 , A23G3/00 , A23L1/09 , A23L1/28
CPC分类号： C12N9/1051 , C12P19/18 , A61K38/00
摘要： A thermostable trehalose phosphorylase which is obtainable from microorganisms of the genus Thermoanaerobium and which hydrolyzes trehalose in the presence of an inorganic phosphoric acid to form D-glucose and .beta.-D-glucose-1-phosphoric acid. The trehalose phosphorylase can be also prepared by recombinant DNA technology. When the enzyme is allowed to contact with .beta.-D-glucose-1-phosphoric acid as a saccharide donor in the presence of other saccharides, glucosyl-transferred saccharides including glucosyl-D-galactoside, which are conventionally known but scarcely obtainable, can be produced on an industrial-scale and in a relatively-low cost.
摘要翻译：一种热稳定的海藻糖磷酸化酶，其可从Thermoanaerobium属的微生物获得，并且在无机磷酸存在下水解海藻糖以形成D-葡萄糖和β-D-葡萄糖-1-磷酸。海藻糖磷酸化酶也可以通过重组DNA技术制备。当酶在其他糖类存在下与β-D-葡萄糖-1-磷酸作为糖供体接触时，通常已知但几乎不可获得的包括葡糖基-D-半乳糖苷的葡糖基转移的糖可以是以工业规模生产，成本相对较低。

4. 发明授权

US5843748A Trehalose phosphorylase its preparation and uses 失效
公开(公告)号：US5843748A
公开(公告)日：1998-12-01
申请号：US966389
申请日：1997-11-07
申请人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： A61K38/00 , C12N1/21 , C12N9/10 , C12N15/54 , C12P19/18 , C07H21/04 , C07K1/00 , C12P21/06
CPC分类号： C12N9/1051 , C12P19/18 , A61K38/00
摘要： A thermostable trehalose phosphorylase which is obtainable from microorganisms of the genus Thermoanaerobium and which hydrolyzes trehalose in the presence of an inorganic phosphoric acid to form D-glucose and .beta.-D-glucose-1-phosphoric acid. The trehalose phosphorylase can be also prepared by recombinant DNA technology. When the enzyme is allowed to contact with .beta.-D-glucose-1-phosphoric acid as a saccharide donor in the presence of other saccharides, glucosyl-transferred saccharides including glucosyl-D-galactoside, which are conventionally known but scarcely obtainable, can be produced on an industrial-scale and in a relatively-low cost.

5. 发明授权

US5714368A Thermostable non-reducing saccharide-forming enzyme its production and uses 失效
标题翻译：热稳定性非还原性糖形成酶其生产和用途
公开(公告)号：US5714368A
公开(公告)日：1998-02-03
申请号：US466434
申请日：1995-06-06
申请人： Tetsuya Nakada , Hiroto Chaen , Toshiyuki Sugimoto , Toshio Miyake
发明人： Tetsuya Nakada , Hiroto Chaen , Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： A23L7/10 , A23L27/00 , C12N9/24 , C12P19/14 , C12N9/26 , C12N9/10 , C12N9/14
CPC分类号： C12P19/14 , C12N9/2428 , C12Y302/01003
摘要： Disclosed are novel thermostable non-reducing saccharides-forming enzyme, its preparation and uses. The enzyme is obtainable from the culture of microorganisms such as Sulfolobus acidocaldarius (ATCC 33909 and ATCC 49426) and Sulfolobus solfataricus (ATCC 35091 and ATCC 35092), and capable of forming non-reducing saccharides having a trehalose structure as an end unit when allowed to act on reducing partial starch hydrolysates at a temperature of over 55.degree. C. Glucoamylase and .alpha.-glucosidase readily yield trehalose when allowed to act on the non-reducing saccharides. These non-reducing saccharides and trehalose are extensively useful in food products, cosmetics and pharmaceuticals.
摘要翻译：公开了新型热稳定性非还原性糖形成酶，其制备和用途。该酶可以从微生物的培养物获得，例如硫酸亚硫酸杆菌（ATCC 33909和ATCC 49426）和溶血糠鱼（Sulfolobus solfataricus）（ATCC 35091和ATCC 35092），并且能够形成具有海藻糖结构的非还原性糖作为终端单元在超过55℃的温度下还原部分淀粉水解产物起作用。当允许作用于非还原糖时，葡糖淀粉酶和α-葡糖苷酶容易产生海藻糖。这些非还原性糖和海藻糖广泛用于食品，化妆品和药物。

6. 发明授权

US06140487A DNA encoding kojibiose phosphorylase obtainable from thermoanaerobium, ' its preparation and uses 有权
标题翻译：编码由热酵母获得的曲霉糖磷酸化酶的DNA，其制备和用途
公开(公告)号：US06140487A
公开(公告)日：2000-10-31
申请号：US188404
申请日：1998-11-10
申请人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： A61K8/60 , A61K38/00 , A61Q11/00 , A61Q17/04 , A61Q19/02 , C12N1/21 , C12N9/10 , C12N15/54 , C12P19/18 , C07H21/04 , C12N9/12
CPC分类号： A61K8/60 , A61Q11/00 , A61Q17/04 , A61Q19/02 , C12N9/1051 , C12P19/18 , A61K38/00
摘要： A kojibiose phosphorylase which hydrolyzes kojibiose in the presence of an inorganic phosphoric acid to form D-glucose and .beta.-D-glucose-1-phosphoric acid, forms kojibiose and an inorganic phosphoric acid from .beta.-D-glucose-1-phosphoric acid, and catalyzes the transfer reaction of glucosyl group to other saccharides using .beta.-D-glucose-1-phosphoric acid as a saccharide donor. The enzyme is obtainable from natural sources such as microorganisms of the genus Thermoanaerobium, and obtainable by recombinant technology.
摘要翻译：在无机磷酸存在下水解曲霉糖以形成D-葡萄糖和β-D-葡萄糖-1-磷酸的曲霉糖磷酸化酶，从β-D-葡萄糖-1-磷酸形成曲酸和无机磷酸，并使用β-D-葡萄糖-1-磷酸作为糖供体催化葡糖基转移到其他糖类上。该酶可从天然来源例如Thermoanaerobium属的微生物获得，可通过重组技术获得。

7. 发明授权

US06204377B1 Kojibiose phosphorylase glucosyl-saccharides produced by transglycosylation 有权
标题翻译：通过转糖基化产生的糖基二糖磷酸化葡糖基糖
公开(公告)号：US06204377B1
公开(公告)日：2001-03-20
申请号：US09281259
申请日：1999-03-30
申请人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： C07H100
CPC分类号： A61K8/60 , A61K38/00 , A61Q11/00 , A61Q17/04 , A61Q19/02 , C12N9/1051 , C12P19/18
摘要： A kojibiose phosphorylase which hydrolyzes kojibiose in the presence of an inorganic phosphoric acid to form D-glucose and &bgr;-D-glucose-1-phosphoric acid, forms kojibiose and an inorganic phosphoric acid from &bgr;-D-glucose-1-phosphoric acid, and catalyzes the transfer reaction of glucosyl group to other saccharides using &bgr;-D-glucose-1-phosphoric acid as a saccharide donor. The enzyme is obtainable from natural sources such as microorganisms of the genus Thermoanaerobium, and obtainable by recombinant technology. Kojibiose phosphorylase is used to transfer glucose from glucose-1-phosphate to acceptor saccharides to produce &agr;-D-glucosyl-1(1→5)-L-sorbose, kojibiosylglucose, kojibiosylglucoside and kojibiosylfructoside.
摘要翻译：在无机磷酸存在下水解曲霉糖以形成D-葡萄糖和β-D-葡萄糖-1-磷酸的曲霉糖磷酸化酶，从β-D-葡萄糖-1-磷酸形成曲酸和无机磷酸，并使用β-D-葡萄糖-1-磷酸作为糖供体催化葡糖基转移至其他糖类。该酶可从天然来源例如Thermoanaerobium属的微生物获得，可通过重组技术获得。葡萄糖磷酸化酶用于将葡萄糖从葡萄糖-1-磷酸转移到受体糖以产生α-D-葡糖基-1（1-> 5）-L-山梨糖，茉莉基糖基葡萄糖，猕猴糖基葡萄糖苷和猕猴桃糖苷果糖苷。

8. 发明授权

US5965412A Kojibiose phosphorylase obtainable from Thermoanaerobium brockii, its preparation and uses 失效
标题翻译：可从Thermoanaerobium brockii获得的赤藓糖磷酸化酶，其制备和用途
公开(公告)号：US5965412A
公开(公告)日：1999-10-12
申请号：US966388
申请日：1997-11-07
申请人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： A61K8/60 , A61K38/00 , A61Q11/00 , A61Q17/04 , A61Q19/02 , C12N1/21 , C12N9/10 , C12N15/54 , C12P19/18 , C12P19/12 , C12N9/12
CPC分类号： A61K8/60 , A61Q11/00 , A61Q17/04 , A61Q19/02 , C12N9/1051 , C12P19/18 , A61K38/00
摘要： A kojibiose phosphorylase which hydrolyzes kojibiose in the presence of an inorganic phosphoric acid to form .beta.-glucose and .beta.-D-glucose-1-phosphoric acid, forms kojibiose and an inorganic phosphoric acid from .beta.-D-glucose-1-phosphoric acid, and catalyzes the transfer reaction of glucosyl group to other saccharides using .beta.-D-glucose-1-phosphoric acid as a saccharide donor. The enzyme is obtainable from Thermoanaerobium brockii and obtainable by recombinant technology.
摘要翻译：在无机磷酸存在下水解曲霉糖以形成β-葡萄糖和β-D-葡萄糖-1-磷酸的曲曲糖磷酸化酶，从β-D-葡萄糖-1-磷酸形成曲酸和无机磷酸，并使用β-D-葡萄糖-1-磷酸作为糖供体催化葡糖基转移到其他糖类上。该酶可从Thermoanaerobium brockii获得并可通过重组技术获得。

9. 发明授权

US6066477A Method of producing glucosylated saccharides with kojibiose phosphorylase 有权
标题翻译：用曲霉糖磷酸化酶生产葡糖基化糖的方法
公开(公告)号：US6066477A
公开(公告)日：2000-05-23
申请号：US188403
申请日：1998-11-10
申请人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： A61K8/60 , A61K38/00 , A61Q11/00 , A61Q17/04 , A61Q19/02 , C12N1/21 , C12N9/10 , C12N15/54 , C12P19/18 , C12P19/44 , C12P19/00
CPC分类号： A61K8/60 , A61Q11/00 , A61Q17/04 , A61Q19/02 , C12N9/1051 , C12P19/18 , A61K38/00
摘要： A kojibiose phosphorylase which hydrolyzes kojibiose in the presence of an inorganic phosphoric acid to form D-glucose and .beta.-D-glucose-1-phosphoric acid, forms kojibiose and an inorganic phosphoric acid from .beta.-D-glucose-1-phosphoric acid, and catalyzes the transfer reaction of glucosyl group to other saccharides using .beta.-D-glucose-1-phosphoric acid as a saccharide donor. The enzyme is obtainable from natural sources such as microorganisms of the genus Thermoanaerobium, and obtainable by recombinant technology.
摘要翻译：在无机磷酸存在下水解曲霉糖以形成D-葡萄糖和β-D-葡萄糖-1-磷酸的曲霉糖磷酸化酶，从β-D-葡萄糖-1-磷酸形成曲酸和无机磷酸，并使用β-D-葡萄糖-1-磷酸作为糖供体催化葡糖基转移到其他糖类上。该酶可从天然来源例如Thermoanaerobium属的微生物获得，可通过重组技术获得。

10. 发明授权

US08008058B2 Ketose 3-epimerase, its preparation and uses 有权
标题翻译：酮基3-差向异构酶，其制备和用途
公开(公告)号：US08008058B2
公开(公告)日：2011-08-30
申请号：US12093902
申请日：2006-11-06
申请人： Kazuhiko Maruta , Kozo Yamamoto , Tomoyuki Nishimoto , Hiroto Chaen , Tetsuya Nakada
发明人： Kazuhiko Maruta , Kozo Yamamoto , Tomoyuki Nishimoto , Hiroto Chaen , Tetsuya Nakada
IPC分类号： C12N9/90 , C07K14/00 , C12P19/24 , C12P21/00
CPC分类号： C12N9/90 , C12P19/02
摘要： An object of the present invention is to provide a novel ketose 3-epimerase, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and a process for producing a ketose by using the enzyme. The present invention solves the above objects by providing a ketose 3-epimerase which is obtainable from a microorganism of the genus Rhizobium, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and a process for converting D- or L-ketohexose into corresponding D- or L-ketohexose by epimerizing the hydroxyl group at the C-3 position of the D- or L-ketohexose; and D- or L-ketopentose into corresponding D- or L-ketopentose by epimerizing the hydroxyl group at the C-3 position of the D- or L-ketopentose; by using the enzyme.
摘要翻译：本发明的目的是提供一种新的酮糖3-差向异构酶，其制备方法，编码该酶的DNA，重组DNA和包含该DNA的转化体，以及使用该酶制备酮糖酮的方法。本发明通过提供可从根瘤菌属微生物获得的酮糖3-差向异构酶，其制备方法，编码该酶的DNA，重组DNA和包含该DNA的转化体，解决上述目的，以及方法通过使D-或L-酮基己糖的C-3位的羟基差向异构化将D-或L-酮己糖转化为相应的D-或L-己酮; 和D-或L-酮戊糖转化成相应的D-或L-酮戊糖，通过差异化D-或L-酮戊糖的C-3位的羟基; 通过使用酶。

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