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1. 发明申请

US20080108141A1 DIAMINORHODAMINE DERIVATIVE 审中-公开
公开(公告)号：US20080108141A1
公开(公告)日：2008-05-08
申请号：US11757853
申请日：2007-06-04
申请人： Tetsuo NAGANO , Hirotatsu KOJIMA , Kazuya KIKUCHI
发明人： Tetsuo NAGANO , Hirotatsu KOJIMA , Kazuya KIKUCHI
IPC分类号： G01N33/00 , G01N37/00 , C07D519/00
CPC分类号： C07D405/04 , C07D311/90 , C07D491/20 , C07D493/10 , G01N21/6428 , G01N2021/6439 , Y10T436/10 , Y10T436/141111 , Y10T436/17 , Y10T436/177692 , Y10T436/179228
摘要： A compound represented by the following formula (I) or (II): wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X— represents an anion, and a reagent for measurement of nitric oxide which comprises said compound.
摘要翻译：由下式（I）或（II）表示的化合物：其中，在式（I）中，R 1，R 2，R 3， R 4和R 4独立地代表甲基或乙基; 在式（II）中，R 5，R 6，R 7和R 8独立地表示甲基或乙基，X-表示阴离子，和含有所述化合物的一氧化氮测定用试剂。

2. 发明申请

US20110038803A1 FLUORESCENT PROBE 失效
标题翻译：荧光探针
公开(公告)号：US20110038803A1
公开(公告)日：2011-02-17
申请号：US12911348
申请日：2010-10-25
申请人： Tetsuo NAGANO , Eita SASAKI , Hirotatsu KOJIMA , Tomoya HIRANO , Kazuya KIKUCHI
发明人： Tetsuo NAGANO , Eita SASAKI , Hirotatsu KOJIMA , Tomoya HIRANO , Kazuya KIKUCHI
IPC分类号： A61K49/00 , C07D403/10 , C07F3/06 , C07D403/14
CPC分类号： C09K11/06 , C07D209/08 , C07D209/12 , C07D249/18 , C09B23/0016 , C09B23/0025 , C09B23/0033 , C09B23/0066 , C09B23/086 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , G01N31/22 , G01N2021/6439 , Y02P20/55 , Y10S436/80 , Y10T436/141111
摘要： A fluorescent probe which specifically and efficiently traps nitrogen monoxide, zinc ion etc. to emit fluorescence is provided.A compound represented by the following general formula (I): [wherein R1 and R2 represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 to X4 represent hydrogen atom, an alkyl group, or a protective group for amino group, and m and n represent 0 or 1); R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R5 to R12 represent hydrogen atom, sulfo group, phospho group, a halogen atom, or a C1-6 alkyl group; R13 and R14 represent a C1-18 alkyl group; Z1 represents oxygen atom, sulfur atom, or —N(R15)— (wherein R15 represents hydrogen atom, or a C1-6 alkyl group); Y1 and Y2 represent —C(═O)—, —C(═S)—, or —C(R16)(R17) (wherein R16 and R17 represent a C1-6 alkyl group); and M− represents a counter ion in a number required for neutralizing the charge].
摘要翻译：提供了一种能够特异地有效捕获一氧化氮，锌离子等以发出荧光的荧光探针。由以下通式（I）表示的化合物：[其中R1和R2表示氢原子或由下式（A）表示的基团：（其中X1至X4表示氢原子，烷基或保护基氨基，m和n表示0或1）; R3和R4表示氢原子，C1-6烷基或C1-6烷氧基; R5至R12表示氢原子，磺基，磷基，卤素原子或C1-6烷基; R13和R14表示C1-18烷基; Z1表示氧原子，硫原子或-N（R15） - （其中R15表示氢原子或C1-6烷基）; Y1和Y2表示-C（= O） - ， - C（= S） - 或-C（R16）（R17）（其中R16和R17表示C1-6烷基）。和M-表示中和电荷所需数量的抗衡离子]。

3. 发明申请

US20110165085A1 TUMOR SELECTIVE FLUORESCENT STAINING AGENT 审中-公开
标题翻译：肿瘤选择性荧光染色剂
公开(公告)号：US20110165085A1
公开(公告)日：2011-07-07
申请号：US13018831
申请日：2011-02-01
申请人： Tetsuo NAGANO , Yasuteru URANO , Hirotatsu KOJIMA , Yuuta FUJIKAWA , Tetsuro TAKAMATSU , Yoshinori HARADA
发明人： Tetsuo NAGANO , Yasuteru URANO , Hirotatsu KOJIMA , Yuuta FUJIKAWA , Tetsuro TAKAMATSU , Yoshinori HARADA
IPC分类号： A61K49/00 , A61P43/00
CPC分类号： C07D493/10 , A61K49/0043 , A61K49/0052
摘要： A tumor cell or tumor tissue-selective fluorescent staining agent comprising a compound represented by the following general formula (I): wherein R1 and R2 independently represent a C1-C4 alkyl group which may be substituted, a C2-C4 alkenyl group which may be substituted, a C2-C4 alkynyl group which may be substituted, an aryl group which may be substituted, or a heteroaryl group which may be substituted.
摘要翻译：一种肿瘤细胞或肿瘤组织选择性荧光染色剂，其包含由以下通式（I）表示的化合物：其中R 1和R 2独立地表示可被取代的C 1 -C 4烷基，可以被取代的C 2 -C 4烯基可被取代的C2-C4炔基，可被取代的芳基或可被取代的杂芳基。

4. 发明申请

US20080261314A1 FLUORESCENT PROBE FOR ZINC 审中-公开
标题翻译：荧光探针
公开(公告)号：US20080261314A1
公开(公告)日：2008-10-23
申请号：US12058289
申请日：2008-03-28
申请人： Tetsuo NAGANO , Kazuya Kikuchi , Tomoya Hirano , Satoko Maruyama
发明人： Tetsuo NAGANO , Kazuya Kikuchi , Tomoya Hirano , Satoko Maruyama
IPC分类号： G01N33/20 , C07D413/14 , C07D401/14
CPC分类号： C07D405/14 , C07D413/14 , C09K11/06 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1088 , C09K2211/188 , G01N31/22
摘要： A compound represented by the following general formula (I) or a salt thereof: wherein R1 represents hydrogen atom, an alkyl group, an alkoxy group, or hydroxy group; R2 represents a group represented by the following formula (A): wherein X1 to X4 represent hydrogen atom, an alkyl group, or 2-pyridylmethyl group, and m and n represent 0 or 1; Y represents a single bond or —CO—; R3 represents a carboxy-substituted aryl group, a carboxy-substituted heteroaryl group, benzothiazol-2-yl group, or 5-oxo-2-thioxo-4-imidazolyzinylidenmethyl group], and a fluorescent probe for zinc which comprises said compound or a salt thereof.
摘要翻译：由下列通式（I）表示的化合物或其盐：其中R 1表示氢原子，烷基，烷氧基或羟基; R 2表示由下式（A）表示的基团：其中X 1至X 4表示氢原子，烷基或 2-吡啶基甲基，m和n表示0或1; Y表示单键或-CO-; R 3表示羧基取代的芳基，羧基取代的杂芳基，苯并噻唑-2-基或5-氧代-2-硫代-4-咪唑基亚乙烯基甲基]和荧光探针对于包含所述化合物或其盐的锌。

5. 发明申请

US20080188006A1 METHOD FOR MEASURING HYPOCHLORITE ION 审中-公开
标题翻译：测量高碘离子的方法
公开(公告)号：US20080188006A1
公开(公告)日：2008-08-07
申请号：US12099979
申请日：2008-04-09
申请人： Ken-ichi SETSUKINAI , Yasuteru URANO , Tetsuo NAGANO
发明人： Ken-ichi SETSUKINAI , Yasuteru URANO , Tetsuo NAGANO
IPC分类号： G01N33/00
CPC分类号： G01N21/6428 , G01N2021/7786 , Y10T436/14 , Y10T436/19 , Y10T436/196666 , Y10T436/200833
摘要： A method for measuring hypochlorite ion, which comprises the steps of. (A) reacting, with hypochlorite ion, a compound represented by the following general formula (I): wherein R1 represents a 2-carboxyphenyl group which may be substituted; R2 represents a phenyl group which is substituted with a substituted or unsubstituted amino group; X1 and X2 each independently represents either hydrogen atom or a halogen atom; or a salt thereof; and (B) measuring fluorescence of a dearylated compound generated in the aforementioned step (A) or a salt thereof.
摘要翻译：一种测定次氯酸根离子的方法，包括以下步骤。（A）与次氯酸根离子反应由以下通式（I）表示的化合物：其中R 1表示可被取代的2-羧基苯基; R 2代表被取代或未取代的氨基取代的苯基; X 1和X 2各自独立地表示氢原子或卤素原子; 或其盐; 和（B）测量在上述步骤（A）中产生的脱芳基化合物的荧光或其盐。

6. 发明申请

US20110033944A1 METHOD FOR MEASURING HYPOCHLORITE ION 审中-公开
标题翻译：测量高碘离子的方法
公开(公告)号：US20110033944A1
公开(公告)日：2011-02-10
申请号：US12910457
申请日：2010-10-22
申请人： Ken-ichi SETSUKINAI , Yasuteru URANO , Tetsuo NAGANO
发明人： Ken-ichi SETSUKINAI , Yasuteru URANO , Tetsuo NAGANO
IPC分类号： G01N21/76
CPC分类号： G01N21/6428 , G01N2021/7786 , Y10T436/14 , Y10T436/19 , Y10T436/196666 , Y10T436/200833
摘要： A method for measuring hypochlorite ion, which comprises the steps of:(A) reacting, with hypochlorite ion, a compound represented by the following general formula (I): wherein R1 represents a 2-carboxyphenyl group which may be substituted; R2 represents a phenyl group which is substituted with a substituted or unsubstituted amino group; X1 and X2 each independently represents either hydrogen atom or a halogen atom; or a salt thereof; and (B) measuring fluorescence of a dearylated compound generated in the aforementioned step (A) or a salt thereof.
摘要翻译：一种测定次氯酸根离子的方法，包括以下步骤：（A）与次氯酸根离子反应由以下通式（I）表示的化合物：其中R1表示可被取代的2-羧基苯基; R2表示被取代或未取代的氨基取代的苯基; X1和X2各自独立地表示氢原子或卤素原子; 或其盐; 和（B）测量在上述步骤（A）中产生的脱芳基化合物的荧光或其盐。

7. 发明申请

US20090118471A1 NOVEL COUMARIN DERIVATIVES 审中-公开
标题翻译：新型欧姆龙衍生物
公开(公告)号：US20090118471A1
公开(公告)日：2009-05-07
申请号：US12337327
申请日：2008-12-17
申请人： Tetsuo NAGANO , Yasuteru Urano , Takuji Shoda
发明人： Tetsuo NAGANO , Yasuteru Urano , Takuji Shoda
IPC分类号： C07K1/107 , C07D405/14
CPC分类号： C07D405/12 , C07D405/14
摘要： A compound represented by the following general formula (I) or a salt thereof [R1 represents hydrogen atom, or a C1-12 alkyl group; R2 represents a C1-12 alkyl group having one or more maleimide groups, an aryl group having two or more maleimide groups, a group represented by the formula (A): —(CH2)n—CO—N(R11)(R12) (R11 and R12 represent hydrogen atom, a C1-12 alkyl group, a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and n represents an integer of 1 to 6), or a group represented by the formula (B): —(CH2)m—NH—CO—R13 (R13 represents a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and m represents an integer of 1 to 6); R3 and R5 represent hydrogen atom, or a halogen atom; R4 represents hydroxyl group, a C1-12 acyloxy group, a C1-12 acyloxymethyloxy group, or an amino group], which is useful as a novel fluorescent labeling agent having a property of emitting intense fluorescence only after reacting with a thiol group.
摘要翻译：由以下通式（I）表示的化合物或其盐[R1表示氢原子或C1-12烷基; R2表示具有一个或多个马来酰亚胺基团的C1-12烷基，具有两个或更多个马来酰亚胺基团的芳基，由式（A）表示的基团： - （CH 2）n -CO-N（R 11）（R 12）（R11和R12表示氢原子，C1-12烷基，具有一个或多个马来酰亚胺基的C1-12烷基或具有一个或多个马来酰亚胺基团的芳基，n表示1至6的整数），或由式（B）表示的基团： - （CH 2）m -NH-CO-R 13（R 13表示具有一个或多个马来酰亚胺基团的C1-12烷基或具有一个或多个马来酰亚胺基团的芳基， m表示1〜6的整数）; R3和R5代表氢原子或卤原子; R 4表示羟基，C 1-12酰氧基，C 1-12酰氧基甲氧基或氨基]，其仅在与硫醇基反应后具有发射强荧光性质的新型荧光标记剂是有用的。

8. 发明申请

US20100120160A1 Fluorescent Probe 审中-公开
标题翻译：荧光探针
公开(公告)号：US20100120160A1
公开(公告)日：2010-05-13
申请号：US12688625
申请日：2010-01-15
申请人： Tetsuo NAGANO , Yu Gabe , Yasuteru Urano
发明人： Tetsuo NAGANO , Yu Gabe , Yasuteru Urano
IPC分类号： G01N33/00 , C07F5/02
CPC分类号： C07F5/022 , C09K11/06 , C09K2211/1055 , G01N31/22 , Y10T436/145555 , Y10T436/177692
摘要： A compound represented by the formula (I) wherein R1 and R2 represent amino groups that substitute at adjacent positions on the benzene ring, wherein one of the amino groups may have one alkyl group; R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, R9 and R8 independently represent a C1-6 alkyl group, R6 and R9 represent a carboxy-substituted C1-6 alkyl group, an alkoxycarbonyl-substituted C1-6 alkyl group, a sulfo-substituted C1-6 alkyl group, or an alkyl sulfonate-substituted C1-6 alkyl group, and R7 and R10 represent a C1-6 alkyl group, an aryl group, a C1-6 alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group, and an agent for measurement of nitrogen monoxide containing the compound. Said compound can give a fluorescent substance that is free from change in fluorescence intensity in a wide pH range.
摘要翻译：由式（I）表示的化合物，其中R 1和R 2表示在苯环上的相邻位置取代的氨基，其中一个氨基可以具有一个烷基; R3和R4表示氢原子，C1-6烷基或C1-6烷氧基，R9和R8独立地表示C1-6烷基，R6和R9表示羧基取代的C1-6烷基，烷氧基羰基取代的C 1-6烷基，磺基取代的C 1-6烷基或烷基磺酸酯取代的C 1-6烷基，R 7和R 10表示C 1-6烷基，芳基，C 1-6 烷氧基羰基，乙烯基，噻吩基或吡咯基，以及含有该化合物的一氧化氮测定用试剂。所述化合物可以产生在宽pH范围内没有荧光强度变化的荧光物质。

9. 发明申请

US20120178174A1 FLUORESCENT PROBE 有权
标题翻译：荧光探针
公开(公告)号：US20120178174A1
公开(公告)日：2012-07-12
申请号：US13425802
申请日：2012-03-21
申请人： Tetsuo NAGANO , Yu GABE , Yasuteru URANO
发明人： Tetsuo NAGANO , Yu GABE , Yasuteru URANO
IPC分类号： G01N21/64 , C07F5/02
CPC分类号： C07F5/022 , C09K11/06 , C09K2211/1055 , G01N31/22 , Y10T436/145555 , Y10T436/177692
摘要： A compound represented by the formula (I) wherein R1 and R2 represent amino groups that substitute at adjacent positions on the benzene ring, wherein one of the amino groups may have one alkyl group; R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, R5 and R8 independently represent a C1-6 alkyl group, R6 and R9 represent a carboxy-substituted C1-6 alkyl group, an alkoxycarbonyl-substituted C1-6 alkyl group, a sulfo-substituted C1-6 alkyl group, or an alkyl sulfonate-substituted C1-6 alkyl group, and R7 and R10 represent a C1-6 alkyl group, an aryl group, a C1-6 alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group, and an agent for measurement of nitrogen monoxide containing the compound. Said compound can give a fluorescent substance that is free from change in fluorescence intensity in a wide pH range.
摘要翻译：由式（I）表示的化合物，其中R 1和R 2表示在苯环上的相邻位置取代的氨基，其中一个氨基可以具有一个烷基; R3和R4表示氢原子，C1-6烷基或C1-6烷氧基，R5和R8独立地表示C1-6烷基，R6和R9表示羧基取代的C1-6烷基，烷氧基羰基取代的C 1-6烷基，磺基取代的C 1-6烷基或烷基磺酸酯取代的C 1-6烷基，R 7和R 10表示C 1-6烷基，芳基，C 1-6 烷氧基羰基，乙烯基，噻吩基或吡咯基，以及含有该化合物的一氧化氮测定用试剂。所述化合物可以产生在宽pH范围内没有荧光强度变化的荧光物质。

10. 发明申请

US20110098475A1 FLUORESCENT PROBES 审中-公开
标题翻译：荧光探针
公开(公告)号：US20110098475A1
公开(公告)日：2011-04-28
申请号：US12914525
申请日：2010-10-28
申请人： Tetsuo NAGANO , Yoko WADA , Yasuteru URANO
发明人： Tetsuo NAGANO , Yoko WADA , Yasuteru URANO
IPC分类号： C07D405/14 , C07D311/90 , C07D311/82
CPC分类号： C07D311/82 , C07D311/90 , C09B11/24
摘要： A fluorescent probe which is represented by the following formula (wherein R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species; R3 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R4 and R5 represent hydrogen atom, a halogen atom, or an alkyl group; R6 to R9 represent an alkyl group; R10 and R11 represent hydrogen atom, a halogen atom, or an alkyl group; M− represents a counter ion; and the combination of R1, R2, and R3 (1) imparts a substantially high electron density to the benzene ring to which they bond so that the compound can be substantially non-fluorescent before trapping proton, a metal ion, or an active oxygen species, and (2) substantially reduces electron density of the benzene ring to which they bond so that the compound after trapping proton, a metal ion, or an active oxygen species can be highly fluorescent after the trapping.
摘要翻译：由下式表示的荧光探针（其中R1和R2表示氢原子，或用于捕获质子的取代基，金属离子或活性氧类; R3表示除氢原子以外的一价取代基，羧基或磺基; R 4和R 5表示氢原子，卤原子或烷基; R 6至R 9表示烷基; R 10和R 11表示氢原子，卤素原子或烷基; M表示抗衡离子; 并且R 1，R 2和R 3（1）的组合赋予它们所键合的苯环基本上高的电子密度，使得化合物在捕获质子，金属离子或活性氧物质之前基本上不发生荧光，和（2）大大降低了它们键合的苯环的电子密度，使得捕获质子，金属离子或活性氧之后的化合物在捕获后可以是高度荧光的。

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