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1. 发明授权

US06300364B1 Medicinal compositions with cholesterol-lowering effect 有权
标题翻译：具有降胆固醇作用的药物组合物
公开(公告)号：US06300364B1
公开(公告)日：2001-10-09
申请号：US09463334
申请日：2000-01-24
申请人： Teruhiko Shimokawa , Satomi Nishijima , Koyo Matsuda , Yuichi Iizumi , Seiichi Hashimoto
发明人： Teruhiko Shimokawa , Satomi Nishijima , Koyo Matsuda , Yuichi Iizumi , Seiichi Hashimoto
IPC分类号： A01N4338
CPC分类号： A61K31/192 , C07K14/705
摘要： Pharmaceutical compositions having a cholesterol-lowering effect which comprises as the active ingredient a compound having a PPAR (peroxisome proliferator-activated receptor)&dgr; activating effect or a PPAR&dgr;- and PPAR&ggr;-activating effect or a pharmaceutically acceptable salt thereof; pharmaceutical compositions wherein the cholesterol-lowering effect is an LDL-cholesterol-lowering effect; and a method for identifying a compound having a cholesterol-lowering effect characterized by measuring the PPAR&dgr;-activating effect or the PPAR&dgr;- and PPAR&ggr;-activating effect thereof. Means for Solution: It is found out that a compound exerting an excellent cholesterol-lowering effect on higher animals such as humans and ape has an effect of activating PPAR&dgr; or PPAR&dgr; and PPAR&ggr;. Also, a method for identifying a compound having an excellent cholesterol-lowering effect was found, wherein the desired compound can be quickly and efficiently screened from among a number of compounds by measuring the PPAR&dgr;-activating effect or the PPAR&dgr;- and PPAR&ggr;-activating effect.
摘要翻译：包含具有降胆固醇作用的药物组合物，其包含具有PPAR（过氧化物酶体增殖物激活受体）δ激活作用或PPARδ和PPARγ活化作用的化合物或其药学上可接受的盐作为活性成分; 药物组合物，其中所述降胆固醇作用是降低LDL-胆固醇的作用; 以及用于鉴定具有胆固醇降低作用的化合物的方法，其特征在于测量PPARδ激活作用或其PPARδ和PPARγ活化作用。解决方法：发现对高等动物如人和猿具有优异的降低胆固醇的作用的化合物具有激活PPARdta或PPARδ和PPARγ的作用。另外，发现了鉴定具有优异的降胆固醇降低作用的化合物的方法，通过测量PPARδ激活效应或PPARδ和PPARγ活化效应，可以从多种化合物中快速有效地筛选所需化合物。

2. 发明授权

US08073187B2 Speaker and speaker apparatus 有权
标题翻译：扬声器和扬声器设备
公开(公告)号：US08073187B2
公开(公告)日：2011-12-06
申请号：US12180000
申请日：2008-07-25
申请人： Seiichi Hashimoto , Junichi Fujimori
发明人： Seiichi Hashimoto , Junichi Fujimori
IPC分类号： H04R1/02
CPC分类号： H04R9/025 , H04R3/002 , H04R9/027 , H04R9/06 , H04R2209/041
摘要： A speaker capable of properly adjusting a spring characteristic with which a voice coil is driven and capable of being driven in large amplitude. When a position control coil wound around a bobbin is at a reference position, both ends of the coil cross a magnetic gap formed between external and internal yokes by a predetermined length and Lorentz forces acting on the front and rear ends are balanced. When the voice coil moves in either forward or rearward direction, lengths of the magnetic gap crossed by the front and rear ends of the control coil are different therebetween, and the vector sum of Lorentz forces acting on the position control coil is opposite in direction from the movement of the voice coil, whereby the voice coil is stably held at the reference position.
摘要翻译：能够适当地调节弹簧特性的扬声器，通过该弹簧特性，音圈被驱动并能够以大幅度驱动。当卷绕在线轴上的位置控制线圈处于基准位置时，线圈的两端与形成在外轭铁和内轭铁之间的磁隙交叉预定长度，并且作用在前端和后端的洛伦兹力平衡。当音圈向前或向后移动时，由控制线圈的前端和后端交叉的磁隙的长度不同，并且作用在位置控制线圈上的洛伦兹力的矢量和相反，音圈的移动，由此音圈稳定地保持在基准位置。

3. 发明授权

US06977157B2 Clock gene promoter 失效
标题翻译：时钟基因启动子
公开(公告)号：US06977157B2
公开(公告)日：2005-12-20
申请号：US10415489
申请日：2002-04-02
申请人： Tomohiro Takasugi , Wenbin Chen , Seiichi Hashimoto
发明人： Tomohiro Takasugi , Wenbin Chen , Seiichi Hashimoto
IPC分类号： C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/85 , C12Q1/02 , A01K67/027 , C07H21/04 , C12N5/00 , G01N33/00
CPC分类号： C12N15/85 , A01K2217/05 , C07K14/47 , C12N2830/00 , C12N2830/85 , G01N2500/00
摘要： The present invention discloses a Period2 gene promoter, a construct containing the promoter and a reporter gene, a cell containing the construct, a transgenic animal harboring the construct, and a method for screening a substance which controls expression or oscillatory expression of a biological clock gene. The screening method uses the above cell, a suprachiasmatic nucleus section or peripheral tissue of the above transgenic animal or the above transgenic animal.
摘要翻译：本发明公开了一种Period2基因启动子，含有该启动子和报告基因的构建体，含该构建体的细胞，携带该构建体的转基因动物以及用于筛选控制生物钟基因表达或振荡表达的物质的方法。筛选方法使用上述转基因动物或上述转基因动物的上述细胞，视交叉上核部分或外周组织。

4. 发明申请

US20060078883A1 Apparatus for forming molecular timetable and apparatus for estimating circadian clock 审中-公开
标题翻译：用于形成分子时间表的装置和用于估计昼夜节律钟的装置
公开(公告)号：US20060078883A1
公开(公告)日：2006-04-13
申请号：US10522735
申请日：2003-07-29
申请人： Hiroki Ueda , Seiichi Hashimoto
发明人： Hiroki Ueda , Seiichi Hashimoto
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G16B25/00
摘要： An apparatus 11 for estimating internal biological time of a biological individual on the basis of quantity data of a gene product as measured in a specimen sampled from the individual. The apparatus includes circadian oscillatory gene selection means for selecting circadian oscillatory genes whose time-course change in gene product quantity data as measured in standard specimens approximates a cosine curve having a predetermined period; circadian expression curve selection means for selecting, from among a plurality of cosine curves having different phases and sharing a specific period, a circadian expression curve which is similar to the pattern of time-course change in the expression product quantity of each of the above-selected circadian oscillatory genes; and registration means for registering information which identifies the selected circadian expression curve.
摘要翻译：一种用于基于从个人采样的样本中测量的基因产物的量数据来估计生物个体的内部生物学时间的装置11。该装置包括昼夜节律振荡基因选择装置，用于选择昼夜节律振荡基因，其在标准样本中测量的基因产物数量数据的时间过程变化近似具有预定周期的余弦曲线; 昼夜表达曲线选择装置，用于从具有不同相位并且共享特定周期的多个余弦曲线中选择类似于上述每个的表达产物量的时间 - 过程变化的模式的昼夜表达曲线，选择的昼夜节律振荡基因; 以及用于登记识别所选择的昼夜表达曲线的信息的登记装置。

5. 发明授权

US4351097A Hydraulic pliers for snap rings 失效
标题翻译：用于卡环的液压钳
公开(公告)号：US4351097A
公开(公告)日：1982-09-28
申请号：US162441
申请日：1980-06-24
申请人： Seiichi Hashimoto , Takaaki Aoki
发明人： Seiichi Hashimoto , Takaaki Aoki
IPC分类号： B25B7/00 , B25B7/12 , B25B27/20 , B23P19/04
CPC分类号： B25B7/12 , B25B27/205 , B25B7/126 , Y10T29/5363
摘要： Hydraulic pliers useful for mounting and dismounting snap rings (otherwise called C-shaped stop rings) of large nominal diameter. They comprise a hand-holdable plier main body having working fluid contained therein, a hydraulic piston mechanism contained in the plier main body and adapted to be moved by hydraulic forces exerted by manual pumping operation effected by gripping action applied from outside, and a working-pin opening and closing mechanism mounted on a plier head for operative connection to the hydraulic piston and adapted to be opened or closed in the same plane and at right angles to the directon of movement of the hydraulic piston as the latter advances. The hydraulic pliers do not require any accessory equipment and are handy to carry. Thus, they are designed to expand or contract snap rings of large diameter lightly and efficiently by their hydraulic force.
摘要翻译：液压钳可用于安装和拆卸公称直径大的卡环（称为C形止动环）。它们包括一个包含在其中的工作流体的可手握钳子主体，一个容纳在钳子主体中的液压活塞机构，并且适于由通过从外部施加的夹紧动作而进行的手动泵送操作而产生的液压力移动，销打开和关闭机构安装在钳子头上，用于与液压活塞操作连接，并且适于在同一平面中开启或关闭，并且与液压活塞的运动方向成直角。液压钳不需要任何附件设备，方便携带。因此，它们被设计成通过其液压力轻且有效地扩大或收缩大直径的卡环。

6. 发明申请

US20050262579A1 Novel clock gene promoter 审中-公开
标题翻译：新型时钟基因启动子
公开(公告)号：US20050262579A1
公开(公告)日：2005-11-24
申请号：US11176253
申请日：2005-07-08
申请人： Tomohiro Takasugi , Wenbin Chen , Seiichi Hashimoto
发明人： Tomohiro Takasugi , Wenbin Chen , Seiichi Hashimoto
IPC分类号： C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/85 , A01K67/027 , C07H21/04
CPC分类号： C12N15/85 , A01K2217/05 , C07K14/47 , C12N2830/00 , C12N2830/85 , G01N2500/00
摘要： The present invention discloses a Period2 gene promoter, a construct containing the promoter and a reporter gene, a cell containing the construct, a transgenic animal harboring the construct, and a method for screening a substance which controls expression or oscillatory expression of a biological clock gene. The screening method uses the above cell, a suprachiasmatic nucleus section or peripheral tissue of the above transgenic animal or the above transgenic animal.
摘要翻译：本发明公开了一种Period2基因启动子，含有该启动子和报告基因的构建体，含该构建体的细胞，携带该构建体的转基因动物以及用于筛选控制生物钟基因表达或振荡表达的物质的方法。筛选方法使用上述转基因动物或上述转基因动物的上述细胞，视交叉上核部分或外周组织。

7. 发明授权

US4532680A Double clip for office use 失效
标题翻译：用于办公室使用的双夹
公开(公告)号：US4532680A
公开(公告)日：1985-08-06
申请号：US515569
申请日：1983-07-20
申请人： Seiichi Hashimoto
发明人： Seiichi Hashimoto
IPC分类号： B42F1/02 , B42F21/00
CPC分类号： B42F1/02 , Y10T24/20 , Y10T24/202 , Y10T24/203 , Y10T24/205
摘要： The present invention relates to a double clip for office use comprising a clip main body of metal spring sheet bent into an isosceles triangular cross-section, and operating levers of metal wire tiltably and pivotally connected to the clip main body so as to open the apex against the spring force, wherein index caps of synthetic resin serving as knobs are removably fitted on the bent front ends of the levers, thereby providing the double clip itself with an index indicating function in connection with filing and subsequent withdrawal of documents to facilitate the handling of documents while using the index caps as knobs to open and close the clip main body without giving pain to the finger tips of the user.
摘要翻译：本发明涉及一种用于办公用途的双夹子，包括弯曲成等腰三角形横截面的金属弹簧片的夹主体和可倾斜地并可枢转地连接到夹主体的金属丝的操作杆，以便打开顶点针对弹簧力，其中用作旋钮的合成树脂的折叠盖可拆卸地安装在杠杆的弯曲前端上，从而为双夹具本身提供指示功能，与归档和随后取出文件相关联以便于处理的文档，同时使用索引帽作为旋钮来打开和关闭剪辑主体，而不会给用户的指尖造成痛苦。

8. 发明授权

US4425682A Clamp for hoses and the like 失效
标题翻译：软管夹等
公开(公告)号：US4425682A
公开(公告)日：1984-01-17
申请号：US499423
申请日：1983-06-03
申请人： Seiichi Hashimoto , Takaaki Aoki
发明人： Seiichi Hashimoto , Takaaki Aoki
IPC分类号： F16L33/02 , F16B2/08 , F16L33/03 , B65D63/04
CPC分类号： F16L33/03 , Y10T24/1457 , Y10T24/1463 , Y10T24/1484 , Y10T24/44872
摘要： A clamp useful for connecting fluid-conveying hoses and the like to couplings, valves and the like. The clamp is formed of a spring metal strip which has portions of its longitudinal parallel linear edges cut to provide a pair of parallel inclined linear edges such that the original constant width of the strip is gradually reduced toward the longitudinal opposite ends of the strip so that the width of the strip varies in proportion to the bending moment produced in the strip, with the thus narrowed opposite ends being bent in mutually opposed relation to provide operating knobs for forcibly spreading the ring diameter. The spring metal strip thus prepared is then wound into a ring of right circle, with the inclined linear edges abutting against each other along a given length, thereby ensuring uniform bending stress throughout the ring.
摘要翻译：用于将流体输送软管等连接到联轴器，阀等的夹具。夹具由弹簧金属带形成，其弹性金属带的纵向平行的线性边缘的部分被切割以提供一对平行的倾斜的线性边缘，使得带的原始恒定宽度朝向带的纵向相对端逐渐减小，使得条的宽度与条中产生的弯曲力矩成比例地变化，其中相应的相对端弯曲成相互相对的关系，以提供用于强制地扩展环直径的操作旋钮。然后将如此制备的弹簧金属带缠绕成右圆环，其中倾斜的线性边缘沿着给定的长度彼此抵靠，从而确保整个环上均匀的弯曲应力。

9. 发明授权

US4183280A C-shaped retaining ring 失效
标题翻译： C形保持环
公开(公告)号：US4183280A
公开(公告)日：1980-01-15
申请号：US884199
申请日：1978-03-07
申请人： Seiichi Hashimoto
发明人： Seiichi Hashimoto
IPC分类号： F16B21/18 , F16B21/00
CPC分类号： F16B21/186 , Y10S403/07
摘要： A C-shaped retaining ring having an open portion and at least two pairs of cutouts formed in the inner peripheral edge or outer peripheral edge of the ring and arranged symmetrically on the opposite sides of the open portion, the ring being uniform in its width and thickness circumferentially thereof. The cutouts are arranged at apexes of an equilateral polygon formed when the ring is loaded as installed on a shaft or in a bore. In addition, the cutouts are separately spaced apart along the peripheral edge of the ring and have a progressively increasing depth toward the open portion. The remaining width of the portion of the ring defining each of the cutouts satisfies the equation: ##EQU1## where b.sub.n is the remaining width, b is the width of the ring, .alpha. is the angle between the center line and the end face of the open portion, and .PSI. is the angle between the center line and the cutout.
摘要翻译： C形保持环，其具有形成在所述环的内周边缘或外周边缘中的开口部分和至少两对切口，并且对称地布置在所述开口部分的相对侧上，所述环的宽度均匀，圆周厚度。切口被布置在当环被安装在轴上或孔中时形成的等边多边形的顶点处。此外，切口沿着环的周边边缘分开间隔开，并且朝向打开部分逐渐增加深度。限定每个切口的环的部分的剩余宽度满足以下等式：其中bn是剩余宽度，b是环的宽度，α是中心线和端面之间的角度开口部分，PSI是中心线和切口之间的角度。

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