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1. 发明申请

US20110015729A1 TRANSAPICAL DELIVERY SYSTEM FOR HEART VALVES 有权
公开(公告)号：US20110015729A1
公开(公告)日：2011-01-20
申请号：US12835555
申请日：2010-07-13
申请人： Teodoro S. Jimenez , Walter Lee , Mark Dehdashtian , Kristopher Yee
发明人： Teodoro S. Jimenez , Walter Lee , Mark Dehdashtian , Kristopher Yee
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61M25/0133 , A61M25/0136 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M2025/015
摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall while preserving good operating field stability. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.

2. 发明授权

US08439970B2 Transapical delivery system for heart valves 有权
公开(公告)号：US08439970B2
公开(公告)日：2013-05-14
申请号：US12835555
申请日：2010-07-13
申请人： Teodoro S. Jimenez , Walter Lee , Mark Dehdashtian , Kristopher Yee
发明人： Teodoro S. Jimenez , Walter Lee , Mark Dehdashtian , Kristopher Yee
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61M25/0133 , A61M25/0136 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M2025/015
摘要： A delivery system for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. A pre-dilation valvuloplasty procedure may also be utilized.

3. 发明授权

US08475522B2 Transapical delivery system for heart valves 有权
标题翻译：心脏瓣膜经皮递送系统
公开(公告)号：US08475522B2
公开(公告)日：2013-07-02
申请号：US12835546
申请日：2010-07-13
申请人： Teodoro S. Jimenez , Walter Lee , Mark Dehdashtian , Kristopher Yee
发明人： Teodoro S. Jimenez , Walter Lee , Mark Dehdashtian , Kristopher Yee
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61M25/0133 , A61M25/0136 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M2025/015
摘要： A delivery system for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. A pre-dilation valvuloplasty procedure may also be utilized.
摘要翻译：用于将假体心脏瓣膜递送至主动脉瓣环的输送系统。该系统包括具有其上的转向机构的输送导管，用于通过穿过其顶点进入左心室的导引器以顺行方式将球囊可扩张的假体心脏瓣膜递送至主动脉环。导引器可以具有比近端部分更软的远侧部分，以减少对心脏壁的创伤。输送导管包括刚好靠近远端气囊的偏转部分，以便于假体心脏瓣膜位于环形空间内的正确取向。导管手柄中的触发器可以联接到致动偏转段的偏转线，而手柄中的滑块控制阀推动器的缩回。还可以使用预扩张瓣膜成形术程序。

4. 发明申请

US20110015728A1 TRANSAPICAL DELIVERY SYSTEM FOR HEART VALVES 有权
标题翻译：用于心脏瓣膜的通用输送系统
公开(公告)号：US20110015728A1
公开(公告)日：2011-01-20
申请号：US12835546
申请日：2010-07-13
申请人： Teodoro S. Jimenez , Walter Lee , Mark Dehdashtian , Kristopher Yee
发明人： Teodoro S. Jimenez , Walter Lee , Mark Dehdashtian , Kristopher Yee
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61M25/0133 , A61M25/0136 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M2025/015
摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall while preserving good operating field stability. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.
摘要翻译：用于将假体心脏瓣膜递送到主动脉瓣环的输送系统和方法。该系统包括具有其上的转向机构的输送导管，用于通过穿过其顶点进入左心室的导引器以顺行方式将球囊可扩张的假体心脏瓣膜递送至主动脉环。导引器可以具有比近端部分更软的远侧部分，以减少对心脏壁的创伤，同时保持良好的操作场稳定性。输送导管包括刚好靠近远端气囊的偏转部分，以便于在主动脉瓣环内的正确取向中定位假体心脏瓣膜。导管手柄中的触发器可以联接到致动偏转段的偏转线，而手柄中的滑块控制阀推动器的缩回。假体心脏瓣膜可以安装在现有的钙化小叶上，并且还可以使用预扩张瓣膜成形术程序。

5. 发明授权

US09119716B2 Delivery systems for prosthetic heart valve 有权
标题翻译：假体心脏瓣膜输送系统
公开(公告)号：US09119716B2
公开(公告)日：2015-09-01
申请号：US13559395
申请日：2012-07-26
申请人： Walter Lee , Mark Dehdashtian , Teodoro S. Jimenez , Gilbert S. Leung , Bryan Janish , Michael G. Valdez , Tram Nguyen , Timothy C. Ulrich
发明人： Walter Lee , Mark Dehdashtian , Teodoro S. Jimenez , Gilbert S. Leung , Bryan Janish , Michael G. Valdez , Tram Nguyen , Timothy C. Ulrich
IPC分类号： A61F2/24 , A61F2/06 , A61F2/95 , A61F2/958 , A61M25/10
CPC分类号： A61F2/2433 , A61F2/958 , A61F2002/485 , A61F2002/9517 , A61F2002/9586 , A61F2250/0003 , A61F2250/0021 , A61M25/1002 , A61M25/10184 , A61M2025/1013 , A61M2025/1084
摘要： Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.
摘要翻译：本文描述的是从假体装置（例如假体心脏瓣膜）传递穿过身体并进入心脏以植入其中的系统和方法。与本文公开的递送系统一起递送的假体装置例如可以从安装在输送系统上的径向压缩状态径向展开，以便使用输送系统的可充气气囊进行植入。通过身体和心脏的示例性递送途径包括经股动脉途径，经皮途径和经主动脉途径等。

6. 发明申请

US20130030520A1 DELIVERY SYSTEMS FOR PROSTHETIC HEART VALVE 有权
公开(公告)号：US20130030520A1
公开(公告)日：2013-01-31
申请号：US13559395
申请日：2012-07-26
申请人： Walter Lee , Mark Dehdashtian , Teodoro S. Jimenez , Gilbert S. Leung , Bryan Janish , Michael G. Valdez , Tram Nguyen , Timothy C. Ulrich
发明人： Walter Lee , Mark Dehdashtian , Teodoro S. Jimenez , Gilbert S. Leung , Bryan Janish , Michael G. Valdez , Tram Nguyen , Timothy C. Ulrich
IPC分类号： A61F2/24
CPC分类号： A61F2/2433 , A61F2/958 , A61F2002/485 , A61F2002/9517 , A61F2002/9586 , A61F2250/0003 , A61F2250/0021 , A61M25/1002 , A61M25/10184 , A61M2025/1013 , A61M2025/1084
摘要： Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.

7. 发明申请

US20130116654A1 Aortic Occlusion Catheter 审中-公开
标题翻译：主动脉闭塞导管
公开(公告)号：US20130116654A1
公开(公告)日：2013-05-09
申请号：US13291920
申请日：2011-11-08
申请人： Mark Dehdashtian , Teodoro S. Jimenez, JR. , RB Hayes , Amanda Larsen , Edwin Schulting , Lex Boudewijn
发明人： Mark Dehdashtian , Teodoro S. Jimenez, JR. , RB Hayes , Amanda Larsen , Edwin Schulting , Lex Boudewijn
IPC分类号： A61M25/10
CPC分类号： A61M25/0032 , A61M25/0041 , A61M25/1002 , A61M2025/0003 , A61M2025/1052 , F04C2270/0421
摘要： An cardioplegic fluid delivery catheter includes an expandable member for occluding the ascending aorta of a patient. A length of the catheter allows the distal end to be within the ascending aorta while the proximal end extends from a peripheral artery. The delivery catheter has a multi-lumen construction with a primary lumen extending configured to allow a cardioplegic fluid to be delivered to the aorta. Secondary lumens provide for balloon inflation and aortic root pressure monitoring. The delivery catheter includes a shaft having a pre-determined curve profile at a distal end of the delivery catheter. The pre-determined curve profile generally corresponds to the curve of the bottom surface of the aortic arch. The shaft may be eccentric to the expandable member such that retraction of the shaft causes a distal tip to be parallel within the ascending aorta.
摘要翻译：心脏停搏液输送导管包括用于闭塞患者的升主动脉的可扩张构件。导管的长度允许远端在升主动脉内，而近端从外周动脉延伸。输送导管具有多腔结构，其中主腔延伸构造成允许将心脏停搏液输送到主动脉。次级流明提供气囊充气和主动脉根部压力监测。递送导管包括在输送导管的远端处具有预定曲线轮廓的轴。预先确定的曲线曲线通常对应于主动脉弓底面的曲线。轴可以偏心于可扩张构件，使得轴的缩回导致远端尖端在升主动脉内平行。

8. 发明授权

US06849088B2 Aorto uni-iliac graft 有权
标题翻译： Aorto髂骨移植
公开(公告)号：US06849088B2
公开(公告)日：2005-02-01
申请号：US10055787
申请日：2001-11-07
申请人： Mark Dehdashtian , Teodoro S. Jimenez, Jr.
发明人： Mark Dehdashtian , Teodoro S. Jimenez, Jr.
IPC分类号： A61F2/00 , A61F2/06 , A61F2/82
CPC分类号： A61F2/07 , A61F2/89 , A61F2/95 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/075 , A61F2002/826 , A61F2250/0098
摘要： A generally tubular intraluminal vascular graft having a linear shape that may be radially expanded from a compressed state to an expanded state within a body vessel is disclosed. The graft includes a plurality of stent portions which take the form of undulating filaments extending circumferentially along the tubular body and forming a generally ring-shaped configuration. The graft may further be equipped with a plurality of specifically-configured engagement members disposed on the outer surface of the graft which are configured to frictionally engage an inner wall of a vessel so as to inhibit longitudinal movement of the tubular body without piercing the vessel wall.
摘要翻译：公开了一种具有线性形状的通常管状的管腔内血管移植物，其可以在体内容器内从压缩状态径向膨胀至扩张状态。移植物包括多个支架部分，该支架部分呈沿着管状体沿周向延伸并形成大致环形构造的起伏细丝的形式。移植物还可以配备有设置在移植物的外表面上的多个具体构造的接合构件，其配置成摩擦地接合容器的内壁，以便阻止管状体的纵向移动而不刺穿血管壁。

9. 发明授权

US08764820B2 Transapical heart valve delivery system and method 有权
标题翻译：经心脏心脏瓣膜输送系统及方法
公开(公告)号：US08764820B2
公开(公告)日：2014-07-01
申请号：US11280063
申请日：2005-11-16
申请人： Mark Dehdashtian , Jane M. Olin
发明人： Mark Dehdashtian , Jane M. Olin
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/24 , A61F2/2412 , A61F2/2433 , A61F2002/9583 , A61F2220/0016
摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a balloon catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve through an introducer in an antegrade fashion to the aortic annulus. The balloon catheter passes through an introducer that accesses the left ventricle through its apex and a small incision in the chest wall. The balloon catheter includes a deflecting segment just proximal to the distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A slider in a deflection handle may be coupled to a deflection wire that actuates the deflecting segment. The method includes using two concentric rings of purse-string sutures around the puncture in the left ventricular apex to maintain a good seal around instruments passed therethrough. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.
摘要翻译：用于将假体心脏瓣膜递送到主动脉瓣环的输送系统和方法。该系统包括其上具有转向机构的气囊导管，用于将气球可扩张的假体心脏瓣膜以顺行方式通过导引器传送到主动脉环。气囊导管通过导引器，通过其顶点和左胸壁的小切口进入左心室。气囊导管包括刚好靠近远侧气囊的偏转区段，以便于将主动脉瓣环内的正确定位的假体心脏瓣膜定位。偏转手柄中的滑块可以联接到致动偏转段的偏转线。该方法包括在左心室顶端的穿刺周围使用两个同心环的钱包缝合线，以保持穿过其中的器械周围的良好密封。假体心脏瓣膜可以安装在现有的钙化小叶上，并且还可以使用预扩张瓣膜成形术程序。

10. 发明申请

US20070112422A1 Transapical heart valve delivery system and method 有权
标题翻译：经心脏心脏瓣膜输送系统及方法
公开(公告)号：US20070112422A1
公开(公告)日：2007-05-17
申请号：US11280063
申请日：2005-11-16
申请人： Mark Dehdashtian
发明人： Mark Dehdashtian
IPC分类号： A61F2/24 , A61M29/02
CPC分类号： A61F2/2436 , A61F2/24 , A61F2/2412 , A61F2/2433 , A61F2002/9583 , A61F2220/0016
摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a balloon catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve through an introducer in an antegrade fashion to the aortic annulus. The balloon catheter passes through an introducer that accesses the left ventricle through its apex and a small incision in the chest wall. The balloon catheter includes a deflecting segment just proximal to the distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A slider in a deflection handle may be coupled to a deflection wire that actuates the deflecting segment. The method includes using two concentric rings of purse-string sutures around the puncture in the left ventricular apex to maintain a good seal around instruments passed therethrough. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.
摘要翻译：用于将假体心脏瓣膜递送到主动脉瓣环的输送系统和方法。该系统包括其上具有转向机构的气囊导管，用于将气球可扩张的假体心脏瓣膜以顺行方式通过导引器传送到主动脉环。气囊导管通过导引器，通过其顶点和左胸壁的小切口进入左心室。气囊导管包括刚好靠近远侧气囊的偏转区段，以便于将主动脉瓣环内的正确定位的假体心脏瓣膜定位。偏转手柄中的滑块可以联接到致动偏转段的偏转线。该方法包括在左心室顶端的穿刺周围使用两个同心环的钱包缝合线，以保持穿过其中的器械周围的良好密封。假体心脏瓣膜可以安装在现有的钙化小叶上，并且还可以使用预扩张瓣膜成形术程序。

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