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1. 发明申请

WO2013075902A1 DIGITAL MICROFLUIDICS SYSTEM WITH DISPOSABLE CARTRIDGES 审中-公开
标题翻译：具有可拆卸盒的数字微流控系统
公开(公告)号：WO2013075902A1
公开(公告)日：2013-05-30
申请号：PCT/EP2012/070985
申请日：2012-10-23
申请人： TECAN TRADING AG , BJÖRNSON, Torleif , FEIGLIN, Marc, N. , KOPF-SILL, Anne, R. , FRANKLIN, Michael, Benjamin , LEE, Travis , WANG, Kailiang
发明人： BJÖRNSON, Torleif , FEIGLIN, Marc, N. , KOPF-SILL, Anne, R. , FRANKLIN, Michael, Benjamin , LEE, Travis , WANG, Kailiang
IPC分类号： B01L3/00
CPC分类号： B01L3/502792 , B01L3/502715 , B01L3/505 , B01L2200/027 , B01L2200/0673 , B01L2300/043 , B01L2300/044 , B01L2300/089 , B01L2300/123 , B01L2400/0427
摘要： A digital microfluidics system (1) for manipulating samples in liquid droplets within disposable cartridges (2) is disclosed. The disposable cartridges (2) comprise a bottom layer (3), a top layer (4), and a gap (6) between the bottom and top layers (3,4). The digital microfluidics system (1) comprises a base unit (7) with at least one cartridge accommodation site (8); at least one electrode array (9) that comprises a number of individual electrodes (10); at least one cover plate (12) located at the cartridge accommodation site(s) (8); and a central control unit (14) for controlling the selection of the individual electrodes (10) of the electrode array(s) (9) and for providing these electrodes (10) with individual voltage pulses for manipulating liquid droplets within said cartridges (2) by electrowetting. The at least one cover plate (12) of the digital microfluidics system (1) further comprises an electrically conductive material (15) that extends substantially parallel to the electrode array (9) of the cartridge accommodation site (8) the at least one cover plate (12) is assigned to. The electrically conductive material (15) of the cover plate (12) is not connected to a source of a distinct electrical potential during manipulating samples in liquid droplets (23). Also disclosed are a selection of disposable cartridges (2) and a method for manipulating samples in liquid droplets (23) that adhere to a hydrophobic surface (17).
摘要翻译：公开了一种用于在一次性盒（2）内操作液滴中的样品的数字微流体系统（1）。一次性盒（2）包括底层（3），顶层（4）和底层（3,4）之间的间隙（6）。数字微流体系统（1）包括具有至少一个筒容纳部位（8）的基部单元（7）。包括多个单独电极（10）的至少一个电极阵列（9）。至少一个位于所述药筒容纳部位（8）的盖板（12）; 以及用于控制电极阵列（9）的各个电极（10）的选择并且为这些电极（10）提供用于操纵所述盒（2）内的液滴的各个电压脉冲的中央控制单元（14））通过电润湿。数字微流体系统（1）的至少一个盖板（12）还包括基本上平行于墨盒容纳部位（8）的电极阵列（9）延伸的导电材料（15），所述至少一个盖板（12）被分配给。在操作液滴（23）中的样品时，盖板（12）的导电材料（15）不连接到不同电位的源。还公开了一次性盒（2）的选择和用于操纵粘附到疏水表面（17）的液滴（23）中的样品的方法。

2. 发明申请

WO2014114500A1 OPTICAL MEASURING APPARATUS AND METHOD FOR THE ANALYSIS OF SAMPLES CONTAINED IN LIQUID DROPS 审中-公开
标题翻译：光学测量装置及液体液体样品分析方法
公开(公告)号：WO2014114500A1
公开(公告)日：2014-07-31
申请号：PCT/EP2014/050301
申请日：2014-01-09
申请人： TECAN TRADING AG
发明人： BJÖRNSON, Torleif , GEIGES, Thomas
IPC分类号： G01N21/01 , G01N21/17 , G01N21/33 , G01N21/64 , G01N15/02 , B01L3/02
CPC分类号： G01N21/17 , B01L3/021 , B01L3/0241 , G01N15/0227 , G01N21/01 , G01N21/03 , G01N21/33 , G01N21/49 , G01N21/645 , G01N2015/0038 , G01N2015/0693 , G01N2021/0314 , G01N2021/035 , G01N2021/8564 , G01N2035/1046 , Y10T436/11 , Y10T436/119163 , Y10T436/143333 , Y10T436/2575
摘要： An optical measuring apparatus (1) is configured for the analysis of samples contained in liquid drops (2) provided by a liquid handling system (3) that comprises at least one liquid handling tip (4). The optical measuring apparatus (1) comprises a light source (8) for irradiating the liquid drop (2); a detector (10) for measuring sample light (11); an optics system (43) with first optical elements (18) for transmit- ting irradiation light (9), and a processor (13) for accepting and processing the measurement signals (12). The liquid drop (2) is suspended at the liquid handling orifice (6) of the liquid handling tip (4) in a position where the liquid drop (2) is penetrated by a first optical axis (14) defined by the light source (8) and the first optical elements (18). The liquid drop (2) is physically touched only by the liquid handling tip (4) of the liquid handling system (3) and the liquid sample (30) inside the liquid handling tip (4). The optical measuring apparatus (1) comprises means for the mutual adaption of the size and position of the liquid drop (2) with respect to the first optical elements (18) of the optics system (43). An optical measuring method of analyzing samples contained in liquid drops (2) that are provided by liquid handling systems (3) and that are examined using the optical measuring apparatus (1) is disclosed as well.
摘要翻译：光学测量装置（1）被配置用于分析由液体处理系统（3）提供的液滴（2）中包含的包含至少一个液体处理尖端（4）的样品。光学测量装置（1）包括用于照射液滴（2）的光源（8）。用于测量样品光（11）的检测器（10）; 具有用于发射照射光（9）的第一光学元件（18）和用于接收和处理测量信号（12）的处理器（13）的光学系统（43）。液滴（2）悬挂在液体处理尖端（4）的液体处理孔（6）处，在液滴（2）被由光源限定的第一光轴（14）穿透的位置 8）和第一光学元件（18）。液滴（2）仅通过液体处理系统（3）的液体处理尖端（4）和液体处理尖端（4）内的液体样品（30）物理地接触。光学测量装置（1）包括用于相对于光学系统（43）的第一光学元件（18）相互适应液滴（2）的尺寸和位置的装置。还公开了一种分析由液体处理系统（3）提供并使用光学测量装置（1）检查的液滴（2）中包含的样品的光学测量方法。

3. 发明授权

EP2948756B1 OPTICAL MEASURING APPARATUS AND METHOD FOR THE ANALYSIS OF SAMPLES CONTAINED IN LIQUID DROPS 有权转让
公开(公告)号：EP2948756B1
公开(公告)日：2019-06-05
申请号：EP14700270.3
申请日：2014-01-09
申请人： Tecan Trading AG
发明人： BJÖRNSON, Torleif , GEIGES, Thomas
IPC分类号： B01L3/02 , G01N21/03 , G01N21/49 , G01N21/64 , G01N15/06 , G01N15/00

4. 发明公开

EP2782674A1 DIGITAL MICROFLUIDICS SYSTEM WITH DISPOSABLE CARTRIDGES 有权
标题翻译：一次性盒数字微流体
公开(公告)号：EP2782674A1
公开(公告)日：2014-10-01
申请号：EP12784525.3
申请日：2012-10-23
申请人： Tecan Trading AG
发明人： BJÖRNSON, Torleif , FEIGLIN, Marc N. , KOPF-SILL, Anne R. , FRANKLIN, Michael Benjamin , LEE, Travis , WANG, Kailiang
IPC分类号： B01L3/00
CPC分类号： B01L3/502792 , B01L3/502715 , B01L3/505 , B01L2200/027 , B01L2200/0673 , B01L2300/043 , B01L2300/044 , B01L2300/089 , B01L2300/123 , B01L2400/0427
摘要： A digital microfluidics system manipulates samples in liquid droplets within disposable cartridges and has disposable cartridges each with a bottom layer, a top layer and a gap therebetween. A base unit with cartridge accommodation sites and at least one electrode array with electrodes works with a cover plate at the sites and a control unit for controlling selection of the electrodes and for providing them with voltage pulses for manipulating liquid droplets within the cartridges by electrowetting. The cover plate has an electrically conductive material that extends parallel to the array. A selection of disposable cartridges and a method for manipulating samples in liquid droplets that adhere to a hydrophobic surface can be used with the system.

5. 发明授权

EP1669762B1 Pipetting apparatus with integrated liquid level and/or gas bubble detection 有权转让
标题翻译：具有集成的传感器移液装置用于检测液面和膀胱
公开(公告)号：EP1669762B1
公开(公告)日：2007-10-17
申请号：EP05110328.1
申请日：2005-11-04
申请人： Tecan Trading AG
发明人： BJÖRNSON, Torleif , LIEBHARD, Robert , ZUPPIGER, Adi , HEERKLOTZ, Dirk
IPC分类号： G01N35/10 , G01N1/00
CPC分类号： G01N35/1009 , G01F23/185 , Y10T436/119163 , Y10T436/2575

6. 发明公开

EP2948756A1 OPTICAL MEASURING APPARATUS AND METHOD FOR THE ANALYSIS OF SAMPLES CONTAINED IN LIQUID DROPS 有权转让
标题翻译： OPTISCHE MESSVORRICHTUNG UND VERFAHREN ZUR ANALYZE VON PROBEN在FLÜSSIGTROPFEN
公开(公告)号：EP2948756A1
公开(公告)日：2015-12-02
申请号：EP14700270.3
申请日：2014-01-09
申请人： Tecan Trading AG
发明人： BJÖRNSON, Torleif , GEIGES, Thomas
IPC分类号： G01N21/01 , G01N21/17 , G01N21/33 , G01N21/64 , G01N15/02 , B01L3/02
CPC分类号： G01N21/17 , B01L3/021 , B01L3/0241 , G01N15/0227 , G01N21/01 , G01N21/03 , G01N21/33 , G01N21/49 , G01N21/645 , G01N2015/0038 , G01N2015/0693 , G01N2021/0314 , G01N2021/035 , G01N2021/8564 , G01N2035/1046 , Y10T436/11 , Y10T436/119163 , Y10T436/143333 , Y10T436/2575
摘要： An optical measuring apparatus and method for analysis of samples contained in liquid drops provided by a liquid handling system has a liquid handling tip. A light source irradiates the liquid drop; a detector measures sample light; and an optics system with first optical elements transmits irradiation light, and a processor processes the measurement signals. The liquid drop is suspended at the liquid handling orifice of the liquid handling tip in a position where the liquid drop is penetrated by a first optical axis defined by the light source and the first optical elements. The liquid drop is physically touched only by the liquid handling tip and the liquid sample inside the liquid handling tip. A mutual adaption of the size and position of the liquid drop with respect to the first optical elements is achieved.
摘要翻译：用于分析由液体处理系统提供的液滴中包含的样品的光学测量装置和方法具有液体处理尖端。光源照射液滴; 检测器测量样品光; 并且具有第一光学元件的光学系统透射照射光，并且处理器处理测量信号。液滴在液体处理尖端的液体处理孔处悬挂在液滴被由光源和第一光学元件限定的第一光轴穿透的位置处。液体液滴仅由液体处理尖端和液体处理尖端内的液体样品物理地接触。实现液滴相对于第一光学元件的尺寸和位置的相互适应。

7. 发明公开

EP1669762A1 Pipetting apparatus with integrated liquid level and/or gas bubble detection 有权转让
标题翻译：传感器zurFlüssigkeitspegel-和Blasendetektion
公开(公告)号：EP1669762A1
公开(公告)日：2006-06-14
申请号：EP05110328.1
申请日：2005-11-04
申请人： Tecan Trading AG
发明人： BJÖRNSON, Torleif , LIEBHARD, Robert , ZUPPIGER, Adi , HEERKLOTZ, Dirk
IPC分类号： G01N35/10 , G01N1/00
CPC分类号： G01N35/1009 , G01F23/185 , Y10T436/119163 , Y10T436/2575
摘要： A pipetting apparatus (1) comprises a fluidic space (7), to which a pressure transducer (11) with a pressure sensor (12) is attached with a gas filled space (15). The fluidic space (7) is defined by a pipette tip (2), a first tubing (5) that connects the pipette tip (2) to a pump (4), and an active part (6) of the pump (4). The pipetting apparatus (1) according to the present invention is characterized in that the pipetting apparatus (1) further comprises an impulse generating means (16,18,19) that is in operative contact with a column (10) of system liquid (8) inside the fluidic space (7). The impulse generating means (16,18,19) is designed to induce a vertical movement in this system liquid column (10), which results in a pressure variation in the gas filled space (15) that is pneumatically connected with the fluidic space (7). This pressure variation - as recorded with the pressure transducer (11) and as processed by a first data processing unit (13) during utilization of this pipetting apparatus - is taken as an indicator for the detection of penetration or of quitting of a surface (17) of a liquid, with an orifice (3) of the pipette tip (2), of which liquid an amount is to be aspirated and dispensed. This pressure variation is also taken as an indicator for the detection of the presence or the absence of gas bubbles in the system liquid (8) contained in the fluidic space (7) of this pipetting apparatus.
摘要翻译：移液装置（1）包括流体空间（7），具有压力传感器（12）的压力传感器（11）与气体填充空间（15）附接到该流体空间。流体空间（7）由移液管吸头（2），将移液管吸头（2）连接到泵（4）的第一管（5）和泵（4）的有源部分（6）。根据本发明的移液装置（1）的特征在于，移液装置（1）还包括与系统液体（8）的柱（10）有效接触的脉冲发生装置（16,18,19））在流体空间（7）内。脉冲发生装置（16,18,19）被设计成在该系统液柱（10）中引起垂直运动，这导致与流体空间气动连接的气体填充空间（15）中的压力变化（ 7）。作为压力传感器（11）记录并在利用该移液装置期间由第一数据处理单元（13）处理的压力变化被用作检测表面的穿透或退出的指示器（17 ），其具有移液器吸头（2）的孔口（3），液体的量将被吸入和分配。该压力变化也被用作检测包含在该移液装置的流体空间（7）中的系统液体（8）中是否存在气泡的指示器。

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