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1. 发明授权

US6063904A Method for producing ectoprotein of hepatitis C virus 失效
标题翻译：生产丙型肝炎病毒蛋白的方法
公开(公告)号：US6063904A
公开(公告)日：2000-05-16
申请号：US127829
申请日：1998-08-03
申请人： Tatsuo Miyamura , Izumu Saito , Yoshiharu Matsuura , Yoshikazu Honda , Makoto Seki
发明人： Tatsuo Miyamura , Izumu Saito , Yoshiharu Matsuura , Yoshikazu Honda , Makoto Seki
IPC分类号： C12N15/09 , A61K39/00 , C07K14/18 , C12N15/51 , C12P21/02 , C12R1/91 , C07K14/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , C12N2770/36122
摘要： A method for extracellularly producing an ectoprotein of hepatitis C virus comprises the steps of cultivating a transformant which is transformed with an expression vector containing a DNA fragment coding for the ectoprotein of hepatitis C virus and recovering the ectoprotein of hepatitis C virus extracellularly produced by the transformant. The protein originated from the E1 region prepared by the method can be used as a material for preparing a vaccine for preventing HCV infection. In addition, a diagnostic agent containing the protein is useful for the detection of an HCV antibody or the confirmation of the presence thereof in sera or the like. In other words, the protein of the present invention permits the diagnosis of C type hepatitis in high specificity and sensitivity.
摘要翻译：一种细胞外产生丙型肝炎病毒的蛋白质的方法包括以下步骤：培养转化体，该转化体用含有编码丙型肝炎病毒蛋白的DNA片段的表达载体转化，并回收由转化体细胞外产生的丙型肝炎病毒的蛋白质。起源于通过该方法制备的E1区域的蛋白质可以用作制备用于预防HCV感染的疫苗的材料。此外，含有蛋白质的诊断剂可用于HCV抗体的检测或其在血清等中的确认。换句话说，本发明的蛋白质能够以高特异性和灵敏度诊断C型肝炎。

2. 发明授权

US5830691A Method of producing ectoprotein of hepatitis C virus 失效
标题翻译：生产丙型肝炎病毒蛋白的方法
公开(公告)号：US5830691A
公开(公告)日：1998-11-03
申请号：US636883
申请日：1996-04-24
申请人： Tatsuo Miyamura , Izumu Saito , Yoshiharu Matsuura , Yoshikazu Honda , Makoto Seki
发明人： Tatsuo Miyamura , Izumu Saito , Yoshiharu Matsuura , Yoshikazu Honda , Makoto Seki
IPC分类号： C12N15/09 , A61K39/00 , C07K14/18 , C12N15/51 , C12P21/02 , C12R1/91 , C12P21/06 , C07H19/00 , C07K1/00 , C12N5/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , C12N2770/36122
摘要： A method for extracellularly producing an ectoprotein of hepatitis C virus comprises the steps of cultivating a transformant which is transformed with an expression vector containing a DNA fragment coding for the ectoprotein of hepatitis C virus and recovering the ectoprotein of hepatitis C virus extracellularly produced by the transformant. The protein originated from the E1 region prepared by the method can be used as a material for preparing a vaccine for preventing HCV infection. In addition, a diagnostic agent containing the protein is useful for the detection of an HCV antibody or the confirmation of the presence thereof in sera or the like. In other words, the protein of the present invention permits the diagnosis of C type hepatitis in high specificity and sensitivity.
摘要翻译：一种细胞外产生丙型肝炎病毒的蛋白质的方法包括以下步骤：培养转化体，该转化体用含有编码丙型肝炎病毒蛋白的DNA片段的表达载体转化，并回收由转化体细胞外产生的丙型肝炎病毒的蛋白质。起源于通过该方法制备的E1区域的蛋白质可以用作制备用于预防HCV感染的疫苗的材料。此外，含有蛋白质的诊断剂可用于HCV抗体的检测或其在血清等中的确认。换句话说，本发明的蛋白质能够以高特异性和灵敏度诊断C型肝炎。

3. 发明授权

US5789544A Method for producing ectoprotein of hepatitis C virus 失效
公开(公告)号：US5789544A
公开(公告)日：1998-08-04
申请号：US462195
申请日：1995-06-05
申请人： Tatsuo Miyamura , Izumu Saito , Yoshiharu Matsuura , Yoshikazu Honda , Makoto Seki
发明人： Tatsuo Miyamura , Izumu Saito , Yoshiharu Matsuura , Yoshikazu Honda , Makoto Seki
IPC分类号： C12N15/09 , A61K39/00 , C07K14/18 , C12N15/51 , C12P21/02 , C12R1/91 , C07K14/005
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , C12N2770/36122
摘要： A method for extracellularly producing an ectoprotein of hepatitis C virus comprises the steps of cultivating a transformant which is transformed with an expression vector containing a DNA fragment coding for the ectoprotein of hepatitis C virus and recovering the ectoprotein of hepatitis C virus extracellularly produced by the transformant. The protein originated from the E1 region prepared by the method can be used as a material for preparing a vaccine for preventing HCV infection. In addition, a diagnostic agent containing the protein is useful for the detection of an HCV antibody or the confirmation of the presence thereof in sera or the like. In other words, the protein of the present invention permits the diagnosis of C type hepatitis in high specificity and sensitivity.

4. 发明授权

US07101551B2 Remedies for hepatitis C 有权
标题翻译：丙型肝炎的补救措施
公开(公告)号：US07101551B2
公开(公告)日：2006-09-05
申请号：US10203754
申请日：2001-02-13
申请人： Seima Itami , Tatsurou Shibui , Makoto Seki , Yoshihisa Yotsumoto , Yoshiharu Matsuura , Tatsuo Miyamura
发明人： Seima Itami , Tatsurou Shibui , Makoto Seki , Yoshihisa Yotsumoto , Yoshiharu Matsuura , Tatsuo Miyamura
IPC分类号： A61K39/42 , C12P21/08 , G01N33/53 , C12Q21/08 , A61K39/12 , C12P21/04
CPC分类号： A61K31/737 , A61K2039/505 , C07K16/109 , C07K2317/21 , C07K2317/622
摘要： The present invention provides a substance which inhibits the binding between E2/NS1 protein of hepatitis C virus and a cell infectious with hepatitis C virus, a cell expressing CD81, or CD81. The present invention can provide a novel medicament which has an anti-viral effects such as an inhibitory action against HCV infection.
摘要翻译：本发明提供抑制丙型肝炎病毒的E2 / NS1蛋白与感染丙型肝炎病毒的细胞，表达CD81或CD81的细胞的结合的物质。本发明可以提供具有抗HCV感染的抑制作用的抗病毒作用的新型药物。

5. 发明授权

US08690449B2 Wheel bearing apparatus 有权
标题翻译：车轮轴承装置
公开(公告)号：US08690449B2
公开(公告)日：2014-04-08
申请号：US13826666
申请日：2013-03-14
申请人： Makoto Seki , Tomoko Baba
发明人： Makoto Seki , Tomoko Baba
IPC分类号： F16C33/78
CPC分类号： B60B27/0005 , B60B7/0013 , B60B27/0068 , B60B27/0073 , B60B2900/211 , B60B2900/212 , B60B2900/5112 , B60B2900/5114 , F16C19/186 , F16C33/723 , F16C33/768 , F16C33/783 , F16C41/007 , F16C2240/40 , F16C2240/60 , F16C2326/02 , G01D5/24442
摘要： A wheel bearing apparatus has a protecting cover formed from non-magnetic material with a substantially dish-shaped configuration. A cylindrical fitting portion is adapted to be press-fit onto the inner circumference of the inner-side end of the outer member. A disc-shaped shielding portion extends radially inward from the fitting portion, via a radially tapered portion. A bottom portion extends from the shielding portion, via a stepped portion. A flat relief portion is formed between the radially tapered portion and the shielding portion. The relief portion is parallel with the shielding portion. The relief portion is set slightly back from the shielding portion toward the radially tapered portion. An elastic member is integrally adhered to the outer circumference of the radially tapered portion. The elastic member elastically contacts with the inner circumference of the inner-side end of the outer member.
摘要翻译：车轮轴承装置具有由非磁性材料形成的具有基本盘形构造的保护盖。圆筒形装配部分适于压配合到外部构件的内侧端部的内周上。盘状遮蔽部分经由径向锥形部分从配合部分径向向内延伸。底部部分从屏蔽部分经由阶梯部分延伸。在径向渐缩部分和屏蔽部分之间形成平坦的释放部分。释放部分与屏蔽部分平行。释放部分从遮蔽部分朝向径向渐缩部分稍微设置。弹性构件一体地粘合到径向锥形部分的外周。弹性构件与外部构件的内侧端部的内周弹性接触。

6. 发明申请

US20100120908A1 EYE DROP PREPARATION COMPRISING LATANOPROST 审中-公开
标题翻译：包括LATANOPROST在内的眼药水制剂
公开(公告)号：US20100120908A1
公开(公告)日：2010-05-13
申请号：US12526349
申请日：2008-02-07
申请人： Takahito Kimura , Joshu Watanabe , Minoru Kobayashi , Makoto Seki , Takao Shimatani , Chiharu Takagi
发明人： Takahito Kimura , Joshu Watanabe , Minoru Kobayashi , Makoto Seki , Takao Shimatani , Chiharu Takagi
IPC分类号： A61K31/216 , A61P27/06
CPC分类号： A61K31/215 , A61K9/0048 , A61K31/5575 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26
摘要： Disclosed is an eye drop preparation comprising latanoprost, which is characterized in that the degradation of latanoprost in water can be prevented, the adsorption of latanoprost onto a plastic container can be prevented, and therefore the decrease in the latanoprost content can be prevented satisfactorily. The eye drop preparation comprises an eye drop composition comprising the following components (A)-(B) and packed in a plastic container: (A) latanoprost; and (B) a nonionic surfactant.
摘要翻译：本发明公开了一种包括拉坦前列素的滴眼剂制剂，其特征在于可以防止水中拉坦前列素的降解，可以防止拉坦前列素吸附在塑料容器上，因此可以令人满意地防止拉坦前列素含量的降低。眼药水制剂包含滴眼剂组合物，其包含以下组分（A） - （B）并包装在塑料容器中：（A）拉坦前列素; 和（B）非离子表面活性剂。

7. 发明授权

US09283797B2 Sheet processing apparatus and image forming system 有权
标题翻译：片材处理设备和成像系统
公开(公告)号：US09283797B2
公开(公告)日：2016-03-15
申请号：US14449282
申请日：2014-08-01
申请人： Yusuke Tanaka , Atsushi Kuriyama , Makoto Seki , Yuta Kiyao
发明人： Yusuke Tanaka , Atsushi Kuriyama , Makoto Seki , Yuta Kiyao
IPC分类号： B42B5/00 , B65H37/04 , B42F3/00 , B65H31/30 , B31F5/02 , B42B4/00 , B42C1/12 , G03G15/00
CPC分类号： B42B5/00 , B31F5/02 , B42B4/00 , B42C1/12 , B42F3/00 , B65H31/3081 , B65H31/36 , B65H37/04 , B65H2220/09 , B65H2301/4213 , B65H2301/4382 , B65H2301/43828 , B65H2301/51616 , B65H2403/46 , B65H2404/1521 , B65H2404/65 , B65H2404/692 , B65H2404/693 , B65H2405/211 , B65H2408/121 , B65H2511/13 , B65H2511/20 , B65H2511/30 , B65H2511/414 , B65H2511/416 , B65H2701/176 , B65H2801/27 , G03G15/6544 , G03G2215/00852 , B65H2220/02 , B65H2220/11 , B65H2220/01
摘要： A sheet processing apparatus includes: a sheet conveying unit that conveys a sheet; a sheet stacking member on a placing surface of which the sheet conveyed by the sheet conveying unit is stacked; an edge aligning unit that aligns edges of sheets in a sheet conveying direction on the sheet stacking member; a first binding unit that binds the sheets aligned by the edge aligning unit using a binding member; and a second binding unit that binds the sheets aligned by the edge aligning unit without using a binding member. The sheet processing apparatus selects either of the first binding unit and the second binding unit and performs binding processing on the sheets. The first binding unit and the second binding unit are integrally constructed.
摘要翻译：片材处理设备包括：片材输送单元，其传送片材; 在纸张输送单元输送的纸张的载置面上堆叠纸张堆叠部件; 边缘对齐单元，其将片材在片材输送方向上的边缘对准在片材堆叠构件上; 第一装订单元，其使用结合构件将由所述边缘对齐单元对准的所述纸张结合; 以及第二装订单元，其结合由所述边缘对准单元排列的所述纸张，而不使用装订构件。片材处理装置选择第一装订单元和第二装订单元中的任一个，并对纸张执行装订处理。第一装订单元和第二装订单元是一体构成的。

8. 发明申请

US20100152261A1 NOVEL NITROGEN-CONTAINING HETEROCYCLIC COMPOUND 审中-公开
标题翻译：含有氮的杂环化合物
公开(公告)号：US20100152261A1
公开(公告)日：2010-06-17
申请号：US11996922
申请日：2006-07-25
申请人： Hideyuki Aizawa , Makoto Seki , Jun-ichi Endoh , Minoru Tanaka , Naoto Fujie , Osamu Sakuma , Takao Kamahori
发明人： Hideyuki Aizawa , Makoto Seki , Jun-ichi Endoh , Minoru Tanaka , Naoto Fujie , Osamu Sakuma , Takao Kamahori
IPC分类号： A61K31/4196 , A61K31/4164 , C07D249/08 , C07D233/66 , C07D233/56 , A61P9/00 , A61P1/00 , A61P11/00 , A61P13/00 , A61P25/00
CPC分类号： C07D233/56 , C07D233/18 , C07D233/60 , C07D233/61 , C07D249/08 , C07D407/06
摘要： A nitrogen-containing heterocyclic derivative represented by the following general formula (I), or a hydrate or solvate thereof, which has a selective antagonistic action on the muscarinic M3 receptor and causes reduced cardiac side effect and thus is safe, and has superior pharmacological efficacy and prolonged action even by inhalation administration, and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.
摘要翻译：由以下通式（I）表示的含氮杂环衍生物或其水合物或溶剂化物，其对毒蕈碱性M3受体具有选择性拮抗作用并引起心脏副作用降低，因此是安全的，并且具有优异的药理功效以及甚至通过吸入给药延长的作用，以及包含该化合物和药学上可接受的载体的药物组合物。

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