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1. 发明申请

US20120156193A1 Antibodies That Specifically Bind to A Beta Oligomers and Use Thereof 有权
标题翻译：特异性结合β-低聚物及其用途的抗体
公开(公告)号：US20120156193A1
公开(公告)日：2012-06-21
申请号：US13389228
申请日：2010-08-05
申请人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
发明人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
IPC分类号： A61K39/395 , A61P25/28 , G01N33/566 , C07K16/18
CPC分类号： C07K16/18 , C07K2317/56 , C07K2317/565 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the anti-bodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译：本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。证明抗体可用作阿尔茨海默氏病的诊断/治疗单克隆抗体。

2. 发明授权

US09090679B2 Antibodies that specifically bind to A beta oligomers and use thereof 有权
标题翻译：特异性结合Aβ寡聚体的抗体及其用途
公开(公告)号：US09090679B2
公开(公告)日：2015-07-28
申请号：US13264671
申请日：2010-04-16
申请人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
发明人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
IPC分类号： C07K16/00 , C07K16/18 , G01N33/68
CPC分类号： C07K16/18 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译：本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。

3. 发明申请

US20120177664A1 Antibodies That Specifically Bind to A Beta Oligomers and Use Thereof 有权
标题翻译：特异性结合β-低聚物及其用途的抗体
公开(公告)号：US20120177664A1
公开(公告)日：2012-07-12
申请号：US13389229
申请日：2010-08-05
申请人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
发明人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
IPC分类号： A61K39/395 , A61P25/00 , A61P25/28 , C07K16/18 , G01N33/566
CPC分类号： G01N33/6896 , C07K16/18 , C07K2317/33 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译：本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。

4. 发明申请

US20120082667A1 Antibodies That Specifically Bind To A Beta Oligomers And Use Thereof 有权
标题翻译：特异性结合β-低聚物及其用途的抗体
公开(公告)号：US20120082667A1
公开(公告)日：2012-04-05
申请号：US13264671
申请日：2010-04-16
申请人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
发明人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii , Naofumi Takamatsu
IPC分类号： A61K39/395 , A61P25/00 , A61P25/28 , C07K16/18 , G01N33/566
CPC分类号： C07K16/18 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译：本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。

5. 发明授权

US08858949B2 Antibodies that specifically bind to a beta oligomers and use thereof 有权
标题翻译：特异性结合β-低聚物的抗体及其用途
公开(公告)号：US08858949B2
公开(公告)日：2014-10-14
申请号：US13389229
申请日：2010-08-05
申请人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
发明人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
IPC分类号： A61K39/395 , G01N33/566 , G01N33/68 , C07K16/18
CPC分类号： G01N33/6896 , C07K16/18 , C07K2317/33 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译：本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。证明该抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。

6. 发明授权

US08613924B2 Antibodies that specifically bind to A beta oligomers and use thereof 有权
标题翻译：特异性结合Aβ寡聚体的抗体及其用途
公开(公告)号：US08613924B2
公开(公告)日：2013-12-24
申请号：US13389228
申请日：2010-08-05
申请人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
发明人： Tatsuki Yokoseki , Yasuhide Okamoto , Makoto Umeda , Naofumi Takamatsu , Toshiyuki Ito , Yukiho Imai , Shinobu Fujii
IPC分类号： A61K39/395 , G01N33/53 , C07K16/18 , C12P21/08
CPC分类号： C07K16/18 , C07K2317/56 , C07K2317/565 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the anti-bodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
摘要翻译：本发明人成功地生产了仅针对可溶性Aβ寡聚体特异性但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。证明抗体可用作阿尔茨海默病的诊断/治疗单克隆抗体。

7. 发明申请

US20140096643A1 MOLTEN STEEL DESULFURIZATION METHOD, MOLTEN STEEL SECONDARY REFINING METHOD, AND MOLTEN STEEL MANUFACTURING METHOD 审中-公开
标题翻译：钼钢脱硫方法，钢铁二次精炼方法和钢铁制造方法
公开(公告)号：US20140096643A1
公开(公告)日：2014-04-10
申请号：US14123688
申请日：2012-08-08
申请人： Satoshi Kinoshiro , Toshiyuki Ito , Ryo Kawabata , Toshiro Ishige , Kyoko Fujimoto , Masao Inose
发明人： Satoshi Kinoshiro , Toshiyuki Ito , Ryo Kawabata , Toshiro Ishige , Kyoko Fujimoto , Masao Inose
IPC分类号： C21C7/064
CPC分类号： C21C7/0645 , C21C1/02 , C21C7/0006 , C21C7/0037 , C21C7/0075 , C21C7/0087 , C21C7/06 , C21C7/064 , C21C7/10 , C21C2007/0093 , C21C2300/08 , F27D19/00 , F27D21/00 , G01N21/64 , G01N21/645 , G01N33/0042 , Y02A50/248
摘要： There are provided a method for desulfurizing molten steel, characterized in that a sample taken out from molten steel after the tapping from a converter or during the secondary refining is analyzed rapidly in a high accuracy by a method comprising a high frequency induction heating step wherein the sample is combusted and oxidized under the high frequency induction heating in a pure oxygen atmosphere to convert S in the sample into SO2 and an analyzing step wherein SO2-containing gas produced in the high frequency induction heating step is analyzed through an ultraviolet fluorescence method to quantify S concentration of the sample, whereby S concentration of molten steel after the tapping from the converter can be controlled in a high accuracy to prevent failure of S concentration and also desulfurization time in the secondary refining can be shortened and the amount of the desulfurizer or the like used can be reduced, and a method of manufacturing molten steel by using such a method.
摘要翻译：提供了一种用于钢水脱硫的方法，其特征在于，通过包括高频感应加热步骤的方法，以高精度快速地分析从转炉中或在二次精炼过程中从钢水中取出的样品，其中，样品在纯氧气氛中在高频感应加热下燃烧和氧化，将样品中的S转化成SO2，分析步骤，其中通过紫外荧光法分析在高频感应加热步骤中产生的含SO 2的气体，以量化 S浓度，可以高精度地控制从转炉出料后的钢水的S浓度，以防止S浓度的降低，并且可以缩短二次精炼中的脱硫时间，并且脱硫剂或可以减少使用的方法，以及使用这种方法制造钢水的方法。

8. 发明申请

US20120216867A1 FULLERENE DERIVATIVES 审中-公开
标题翻译：富勒烯衍生物
公开(公告)号：US20120216867A1
公开(公告)日：2012-08-30
申请号：US13504278
申请日：2010-10-25
申请人： Toshiyuki Ito , Yasunori Uetani
发明人： Toshiyuki Ito , Yasunori Uetani
IPC分类号： H01L51/46 , H01B1/12 , B82Y30/00 , B82Y99/00
CPC分类号： C07D487/04 , C07D209/56 , Y02E10/549
摘要： A fullerene derivative having two or more structures represented by the formula (1) can increase light absorption in a long wavelength range when used for an organic photovoltaic cell. In the formula (1), C1 and C2 represent carbon atoms constituting the fullerene skeleton. m represents an integer from 1 to 6, and n represents an integer from 1 to 4. p represents an integer of 0 or more, and R represents a monovalent organic group. Q represents a single bond, an arylene group, or a divalent heterocyclic group. When m is plurally present, these m may be the same or different from each other.
摘要翻译：具有式（1）表示的两种以上结构的富勒烯衍生物可以在用于有机光伏电池时增加长波长范围的光吸收。在式（1）中，C1和C2表示构成富勒烯骨架的碳原子。 m表示1〜6的整数，n表示1〜4的整数。p表示0以上的整数，R表示1价的有机基团。 Q表示单键，亚芳基或二价杂环基。当m多重存在时，这些m可以相同或不同。

9. 发明授权

US08249278B2 Audio signal processing system 有权
标题翻译：音频信号处理系统
公开(公告)号：US08249278B2
公开(公告)日：2012-08-21
申请号：US11825019
申请日：2007-07-03
申请人： Toshiyuki Ito , Makoto Hiroi
发明人： Toshiyuki Ito , Makoto Hiroi
IPC分类号： H04B1/00
CPC分类号： H04B1/202
摘要： In an audio signal processing system, a plurality of audio signal processing apparatuses are previously linked to form a zone, and logically defined as devices belonging to a zone, and further the devices are grouped into a plurality of device groups within the zone. Each of the audio signal processing apparatuses includes a device group table that registers information specifying controls which are performed in respective audio signal processing apparatuses belonging to a device group in case that a group control command is given for collectively controlling the device group, and a master table that registers information specifying controls which are performed in respective device groups included in the zone in case that a zone control command is given for collectively controlling the zone. Both the collective control of the zone and the collective control of the device group are performed.
摘要翻译：在音频信号处理系统中，多个音频信号处理装置预先链接形成区域，并且逻辑地定义为属于区域的设备，并且还将该设备分组成该区域内的多个设备组。每个音频信号处理装置包括：设备组表，其在给出用于集体控制设备组的组控制命令的情况下，登记在属于设备组的各个音频信号处理设备中执行的指定控制的信息，以及主设备表格，其指定在区域控制命令被用于集中控制该区域的情况下指定在该区域中包括的各个设备组中执行的控制的信息。执行区域的集体控制和设备组的集体控制。

10. 发明授权

US07616104B2 Notification controller, notification control method and notification information transmitter 有权
标题翻译：通知控制器，通知控制方法和通知信息发送器
公开(公告)号：US07616104B2
公开(公告)日：2009-11-10
申请号：US11806466
申请日：2007-05-31
申请人： Tetsuya Hara , Hirotane Ikeda , Toshiyuki Ito , Kousuke Hara , Hirotoshi Iwasaki
发明人： Tetsuya Hara , Hirotane Ikeda , Toshiyuki Ito , Kousuke Hara , Hirotoshi Iwasaki
IPC分类号： B60Q1/00
CPC分类号： B60K35/00 , B60K2350/108
摘要： A notification controller allows a notification apparatus to perform notification in accordance with input of notification request information from a notification information transmitter. The notification controller determines whether or not the notification request information supplied from the notification information transmitter can be disabled from provision in accordance with a user operation. When the information supplied is determined to be disabled from provision in accordance with a user operation, the notification controller prompts a user to determine whether or not to stop the notification. The notification controller disables the notification when confirming that the user issues an instruction to stop the notification.
摘要翻译：通知控制器允许通知装置根据来自通知信息发送器的通知请求信息的输入来执行通知。通知控制器根据用户操作确定是否可以禁止从通知信息发送器提供的通知请求信息。当所提供的信息被确定为根据用户操作禁止提供时，通知控制器提示用户确定是否停止通知。当确认用户发出停止通知的指令时，通知控制器禁止通知。

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