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1. 发明授权

US5955371A Apparatus for inhibiting glycolysis in blood samples 失效
标题翻译：用于抑制血液样品中糖酵解的装置
公开(公告)号：US5955371A
公开(公告)日：1999-09-21
申请号：US969628
申请日：1997-11-13
申请人： Tatsuhiko Ikeda , Ajit N. Dastane , Robert Losada
发明人： Tatsuhiko Ikeda , Ajit N. Dastane , Robert Losada
IPC分类号： G01N33/48 , A61B5/15 , A61J3/00 , B01L3/14 , C12Q1/56 , G01N33/50
CPC分类号： B01L3/5082 , A61B5/15003 , A61B5/150351 , A61B5/150755 , A61B5/153 , A61B5/154 , C12Q1/56 , G01N2400/40 , Y10T436/108331 , Y10T436/2525
摘要： A blood collection device comprising formed additive particles. The additive particles are an improvement over available additive formulations that are powder blended in that the components of the additive particles of the present invention are in each formed particle. The formed additive particles comprise a fluoride salt and an ethylenediaminetetraacetate salt or a heparin salt to consistently minimize glycolysis and coagulation of a blood specimen with low hemolysis.
摘要翻译：一种采血装置，包括形成的添加剂颗粒。添加剂颗粒是相对于粉末混合的可用添加剂制剂的改进，因为本发明的添加剂颗粒的组分在每个形成的颗粒中。所形成的添加剂颗粒包括氟化物盐和乙二胺四乙酸盐或肝素盐，以一致地最小化具有低溶血性的血液标本的糖酵解和凝结。

2. 发明申请

US20050139547A1 Plasma on demand tube 有权
标题翻译：等离子按需管
公开(公告)号：US20050139547A1
公开(公告)日：2005-06-30
申请号：US11015949
申请日：2004-12-17
申请人： Dimitrios Manoussakis , Robert Losada
发明人： Dimitrios Manoussakis , Robert Losada
IPC分类号： B01L3/00 , B01L3/14 , G01N33/49 , B65D39/00
CPC分类号： B01L3/5635 , B01L3/5082 , B01L2300/0681 , B01L2400/049 , G01N33/491
摘要： A device for separating plasma from whole blood is provided having an evacuated primary collection chamber capable of fluid communication through a porous filter to an evacuated secondary collection chamber. An agglutinating agent is provided within the primary collection chamber so as to aggregate blood cells within a whole blood sample. The porous filter has a pore size which is small enough to capture the aggregated blood cells therein, yet large enough to permit plasma to transfer therethrough under pressures associated with conventional evacuated blood collection tubes. The primary and secondary collection chambers may be provided in separate containers or tubes, with transfer occurring therebetween through a transfer device including the porous filter therein.
摘要翻译：提供了一种用于从全血中分离血浆的装置，其具有能够通过多孔过滤器与抽空的二次收集室流体连通的抽真空的主收集室。在主收集室内提供凝集剂，以便聚集全血样品中的血细胞。多孔过滤器具有足够小的孔径以捕获其中的聚集血细胞，但足够大以允许血浆在与常规抽空采血管相关联的压力下转运。初级和次级收集室可以设置在分开的容器或管中，其中通过包括其中的多孔过滤器的转移装置在其间进行转移。

3. 发明授权

US06803022B2 Device and method for separating components of a fluid sample 有权
标题翻译：用于分离流体样品组分的装置和方法
公开(公告)号：US06803022B2
公开(公告)日：2004-10-12
申请号：US09727282
申请日：2000-11-30
申请人： Paul C. DiCesare , Jeffrey R. Radziunas , Robert Losada , Fu-Chung Lin
发明人： Paul C. DiCesare , Jeffrey R. Radziunas , Robert Losada , Fu-Chung Lin
IPC分类号： B01L1100
CPC分类号： B01L3/50215
摘要： A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising a deformable bellows, a ballast mounted to the lower end of the bellows, and a float is engageable with an upper end of the bellows. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the ballast to move toward the bottom of the tube and causes an elongation and narrowing of the bellows. The separator then moves down the tube and stabilizes in a position between the separated phases of the fluid sample. Termination of the centrifugal load enables the bellows to return to its original condition in sealing engagement with the walls of the tube. The dense formed phase of the fluid sample will lie between the separator and the bottom of the tube, while less dense liquid phase of the fluid sample will be the separator.
摘要翻译：用于分离流体样品的较重和较轻馏分的装置和方法。该装置包括多个构件，其包括容器中的容器和复合元件。复合元件是分离器，其包括可变形的波纹管，安装在波纹管的下端的压载物，浮子可与波纹管的上端接合。将流体样品输送到容器，并且该装置进行离心，由此离心负载使压载物朝向管的底部移动并引起波纹管的伸长和变窄。然后，分离器向下移动管并稳定在流体样品的分离相之间的位置。离心负载的终止使得波纹管能够恢复到与管的壁密封接合的其初始状态。流体样品的致密成形阶段将位于分离器和管的底部之间，而流体样品的较不致密的液相将是分离器。

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