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1. 发明授权

US07711416B1 Measurement of neural functionality using phase sensitive optical reflectometry 失效
标题翻译：使用相位敏感光学反射测量神经功能
公开(公告)号：US07711416B1
公开(公告)日：2010-05-04
申请号：US11136213
申请日：2005-05-24
申请人： Taner Akkin , Digant P. Dave , Thomas E. Milner , H. Grady Rylander, III
发明人： Taner Akkin , Digant P. Dave , Thomas E. Milner , H. Grady Rylander, III
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01N21/4795 , G01N2021/1782
摘要： Optical methods, devices, and systems for non-invasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflection coatings are not required. Transient neural surface displacement of less than 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
摘要翻译：公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。提供的方法，设备和系统可以采用相敏光学低相干反射计。此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。根据一些实施方案，不需要外源化学品或反射涂层。可以检测到振幅小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。它们也可用于检测各种药理学试剂的作用。

2. 发明申请

US20140171807A1 MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY 有权
标题翻译：使用相敏感光学相干反射测量法测量神经功能
公开(公告)号：US20140171807A1
公开(公告)日：2014-06-19
申请号：US13720563
申请日：2012-12-19
申请人： Taner Akkin , Thomas E. Milner , Digant P. Dave , H. Grady Rylander, III
发明人： Taner Akkin , Thomas E. Milner , Digant P. Dave , H. Grady Rylander, III
IPC分类号： A61B5/00 , A61N1/00 , A61N5/06
CPC分类号： A61B5/4041 , A61B5/0066 , A61B5/0075 , A61B5/0082 , A61B5/40 , A61B5/4029 , A61B5/6821 , A61B5/7225 , A61B5/7282 , A61N1/00 , A61N1/3605 , A61N5/0622
摘要： Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
摘要翻译：公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。提供的方法，设备和系统可以采用相敏光学低相干反射计。此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。根据一些实施方案，不需要外源化学品或反射离子涂层。可以检测到幅度小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。它们也可用于检测各种药理学试剂的作用。

3. 发明授权

US07177491B2 Fiber-based optical low coherence tomography 有权
标题翻译：基于光纤的光学低相干断层扫描
公开(公告)号：US07177491B2
公开(公告)日：2007-02-13
申请号：US10679952
申请日：2003-10-06
申请人： Digant P. Dave , Thomas E. Milner , Taner Akkin
发明人： Digant P. Dave , Thomas E. Milner , Taner Akkin
IPC分类号： G02B6/27 , G02B6/26 , G01J4/00 , G01B9/02
CPC分类号： G01P5/26 , A61B5/0066 , A61B5/0261 , G01B9/0201 , G01B9/02027 , G01B9/02045 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01N21/4795 , G01P5/001
摘要： Generally, and in one form of the present invention, is a polarization-maintaining fiber-based polarization sensitive optical low coherence reflectometer for depth resolved birefringence measurement. With the present invention, linear birefringence of a sample may be measured from data recorded in a single A-Scan. In addition, the present invention provides for the simultaneous measurement of retardation and orientation of birefringent axes, wherein measured retardation is insensitive to sample rotation in the plane perpendicular to ranging.
摘要翻译：通常，在本发明的一种形式中，是用于深度分辨双折射测量的基于偏振保持光纤的偏振敏感光学低相干反射计。利用本发明，可以从记录在单个A-Scan中的数据测量样品的线性双折射。此外，本发明提供了同时测量双折射轴的延迟和取向，其中测量的延迟对垂直于测距的平面中的样品旋转不敏感。

4. 发明授权

US08352022B2 Measurement of neural functionality using phase sensitive optical coherence reflectometry 有权
标题翻译：使用相敏光学相干反射测量神经功能
公开(公告)号：US08352022B2
公开(公告)日：2013-01-08
申请号：US12717735
申请日：2010-03-04
申请人： Taner Akkin , Thomas E. Milner , Digant P. Dave , H. Grady Rylander
发明人： Taner Akkin , Thomas E. Milner , Digant P. Dave , H. Grady Rylander
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01N21/4795 , G01N2021/1782
摘要： Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
摘要翻译：公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。提供的方法，设备和系统可以采用相敏光学低相干反射计。此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。根据一些实施方案，不需要外源化学品或反射离子涂层。可以检测到幅度小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。它们也可用于检测各种药理学试剂的作用。

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