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1. 发明申请

US20060287684A1 METHOD AND APPARATUS FOR INITIATING AND DELIVERING CARDIAC PROTECTION PACING 有权
标题翻译：用于启动和输送心脏保护剂的方法和装置
公开(公告)号：US20060287684A1
公开(公告)日：2006-12-21
申请号：US11382849
申请日：2006-05-11
申请人： Tamara Baynham , Julio Spinelli , Frits Prinzen , Richard Cornelussen , Ward Vanagt
发明人： Tamara Baynham , Julio Spinelli , Frits Prinzen , Richard Cornelussen , Ward Vanagt
IPC分类号： A61N1/00
CPC分类号： A61N1/36557 , A61B5/026 , A61N1/3621 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates a cardiac protection pacing sequence in response to the detection of the onset of an ischemic event, such that a pacing concurrent conditioning therapy is applied during the detected ischemic event.
摘要翻译：起搏系统提供心脏保护起搏，以保护心脏免受与缺血事件相关的损伤。起搏系统检测缺血事件，并作为响应启动一个或多个心脏保护起搏序列，每个起搏序列包括替代起搏和非起搏期。在一个实施方案中，响应于检测到缺血事件的发作，起搏系统引发心脏保护起搏序列，使得在检测到的缺血事件期间应用起搏并发调节疗法。

2. 发明申请

US20060259088A1 Method and apparatus for delivering pacing pulses using a coronary stent 审中-公开
公开(公告)号：US20060259088A1
公开(公告)日：2006-11-16
申请号：US11129058
申请日：2005-05-13
申请人： Joseph Pastore , Andrew Kramer , Julio Spinelli , Rodney Salo , Tamara Baynham , Jeffrey Ross , Frits Prinzen , Ward Vanagt , Richard Cornelussen
发明人： Joseph Pastore , Andrew Kramer , Julio Spinelli , Rodney Salo , Tamara Baynham , Jeffrey Ross , Frits Prinzen , Ward Vanagt , Richard Cornelussen
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/3627 , A61N1/36557 , A61N1/37205 , A61N1/3787 , A61N2001/0585
摘要： An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.

3. 发明申请

US20070021789A1 INTERMITTENT STRESS AUGMENTATION PACING FOR CARDIOPROTECTIVE EFFECT 有权
标题翻译：间歇性应激补充剂对保护作用的影响
公开(公告)号：US20070021789A1
公开(公告)日：2007-01-25
申请号：US11458286
申请日：2006-07-18
申请人： Joseph Pastore , Julio Spinelli , Frits Prinzen , Richard Cornelussen , Ward Vanagt
发明人： Joseph Pastore , Julio Spinelli , Frits Prinzen , Richard Cornelussen , Ward Vanagt
IPC分类号： A61N1/00
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译：公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。

4. 发明申请

US20080027495A1 INTERMITTENT STRESS AUGMENTATION PACING FOR CARDIOPROTECTIVE EFFECT 有权
标题翻译：间歇性应激补充剂对保护作用的影响
公开(公告)号：US20080027495A1
公开(公告)日：2008-01-31
申请号：US11868767
申请日：2007-10-08
申请人： Frits Prinzen , Richard Cornelussen , Ward Vanagt , Joseph Pastore , Julio Spinelli
发明人： Frits Prinzen , Richard Cornelussen , Ward Vanagt , Joseph Pastore , Julio Spinelli
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译：公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。

5. 发明申请

US20060149326A1 Intermittent stress augmentation pacing for cardioprotective effect 有权
标题翻译：间歇性应激增加起搏心脏保护作用
公开(公告)号：US20060149326A1
公开(公告)日：2006-07-06
申请号：US11030575
申请日：2005-01-06
申请人： Frits Prinzen , Richard Cornelussen , Ward Vanagt , Joseph Pastore , Julio Spinelli
发明人： Frits Prinzen , Richard Cornelussen , Ward Vanagt , Joseph Pastore , Julio Spinelli
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译：公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。

6. 发明申请

US20070260284A1 MYOCARDIUM CONDITIONING USING MYOCARDIAL AND PARASYMPATHETIC STIMULATION 失效
公开(公告)号：US20070260284A1
公开(公告)日：2007-11-08
申请号：US11381211
申请日：2006-05-02
申请人： Joseph Pastore , Tamara Baynham , Andrew Kramer , Julio Spinelli , Jeffrey Ross , Rodney Salo
发明人： Joseph Pastore , Tamara Baynham , Andrew Kramer , Julio Spinelli , Jeffrey Ross , Rodney Salo
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，脉冲发生器和控制器。神经刺激器适于产生神经刺激信号。脉冲发生器适用于产生起搏信号以提供心肌起搏。控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。本文提供了其它方面和实施例。

7. 发明申请

US20070054871A1 Method and apparatus for device controlled gene expression for cardiac protection 有权
标题翻译：心脏保护装置控制基因表达的方法和装置
公开(公告)号：US20070054871A1
公开(公告)日：2007-03-08
申请号：US11220397
申请日：2005-09-06
申请人： Joseph Pastore , Jeffrey Ross , Tamara Baynham , Rodney Salo , Andrew Kramer , Julio Spinelli
发明人： Joseph Pastore , Jeffrey Ross , Tamara Baynham , Rodney Salo , Andrew Kramer , Julio Spinelli
IPC分类号： A61K48/00 , A61N1/00
CPC分类号： A61N1/3627 , A61K48/0083 , A61N1/36514
摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.
摘要翻译：基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。基因调控信号直接或间接调控基因产物的基因表达。

8. 发明申请

US20070118177A1 Neural stimulation therapy system for atherosclerotic plaques 失效
标题翻译：动脉粥样硬化斑块神经刺激治疗系统
公开(公告)号：US20070118177A1
公开(公告)日：2007-05-24
申请号：US11284370
申请日：2005-11-21
申请人： Imad Libbus , Julio Spinelli , Tamara Baynham
发明人： Imad Libbus , Julio Spinelli , Tamara Baynham
IPC分类号： A61N1/36
CPC分类号： A61N1/056 , A61N1/0556 , A61N1/36014 , A61N1/36114 , A61N1/36135 , A61N1/362
摘要： A neural stimulation therapy system for atherosclerotic plaques is provided. One aspect of this disclosure relates to a medical device for applying neural stimulation therapy for atherosclerotic plaques. The device includes a neural stimulator adapted to deliver an electrical signal through at least one electrode to an autonomic neural target. The device also includes a controller to control the neural stimulator to provide a therapy for atherosclerotic plaques. The device is external to a human body in an embodiment, and includes an implantable medical device (IMD) in various embodiments. According to an embodiment, the device includes a neural stimulation lead connected to the neural stimulator. The neural stimulator delivers electrical signals with waveform parameters based on sensed arterial blockage levels, according to various embodiments. Other aspects and embodiments are provided herein.
摘要翻译：提供了一种用于动脉粥样硬化斑块的神经刺激治疗系统。本公开的一个方面涉及用于对动脉粥样硬化斑块施加神经刺激疗法的医疗装置。该装置包括适于将电信号通过至少一个电极输送到自主神经靶的神经刺激器。该装置还包括控制器以控制神经刺激器以提供动脉粥样硬化斑块的治疗。在一个实施例中，该装置在人体外部，并且在各种实施例中包括可植入医疗装置（IMD）。根据实施例，该装置包括连接到神经刺激器的神经刺激引线。根据各种实施例，神经刺激器基于感测的动脉阻塞水平递送具有波形参数的电信号。本文提供了其它方面和实施例。

9. 发明申请

US20110071588A1 CARDIAC PACING USING ADJUSTABLE ATRIO-VENTRICULAR DELAYS 有权
标题翻译：使用可调节ATRIO-VENTRICULAR延迟的心脏瓣膜
公开(公告)号：US20110071588A1
公开(公告)日：2011-03-24
申请号：US12955218
申请日：2010-11-29
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1/365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

10. 发明申请

US20080114410A1 CLOSED LOOP IMPEDANCE-BASED CARDIAC RESYNCHRONIZATION THERAPY SYSTEMS, DEVICES, AND METHODS 有权
标题翻译：基于闭环阻塞的心脏再生治疗系统，装置和方法
公开(公告)号：US20080114410A1
公开(公告)日：2008-05-15
申请号：US12016830
申请日：2008-01-18
申请人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
发明人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

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