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    • 7. 发明申请
    • Piperidine compound and process for preparing the same
    • 哌啶化合物及其制备方法
    • US20070112029A1
    • 2007-05-17
    • US10581045
    • 2004-11-26
    • Masami TakahashiTsutomu MiyakeTakeshi YamanakaHidetoshi AsaiRikako Kono
    • Masami TakahashiTsutomu MiyakeTakeshi YamanakaHidetoshi AsaiRikako Kono
    • A61K31/445C07D211/56
    • C07D211/38C07D211/46C07D211/54C07D211/58
    • Disclosed are a novel piperidine compound represented by the general formula [I] below which has an excellent tachykinin receptor antagonizing activity and pharmacologically acceptable salts thereof. [I] In the formula, ring A represents an optionally substituted benzene ring; ring B represents an optionally substituted benzene ring; R1 represents an optionally substituted hydroxyl group, a thiol group having a substituent, a sulfonyl group having a substituent, or a group represented by the following formula [II]: wherein R11 represents a carbonyl group having a substituent or a sulfonyl group having a substituent and R12 represents a hydrogen atom or an optionally substituted alkyl group; R2 represents a hydrogen atom or the like; Z represents an oxygen atom or a group represented by —N(R3)— wherein R3 represents an optionally substituted alkyl group or the like; R4a represents an optionally substituted alkyl group; and R4b represents an optionally substituted alkyl group.
    • 公开了由下述通式[I]表示的新型哌啶化合物,其具有优异的速激肽受体拮抗活性及其药理学上可接受的盐。 式中,环A表示任选取代的苯环; 环B表示任选取代的苯环; R 1表示任选取代的羟基,具有取代基的硫醇基,具有取代基的磺酰基或由下式[II]表示的基团:其中R 11, SUP>表示具有取代基的羰基或具有取代基的磺酰基,R 12表示氢原子或任选取代的烷基; R 2表示氢原子等; Z表示氧原子或由-N(R 3 O 3)表示的基团,其中R 3表示任选取代的烷基等; R 4a表示任选取代的烷基; R 4b表示任选取代的烷基。