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1. 发明授权

US09193695B2 1, 2, 4-triazolone derivative and use thereof as an antagonist on the arginine-vasopressin 1B receptor 有权
标题翻译： 1,2,4-三唑酮衍生物及其作为精氨酸 - 加压素1B受体拮抗剂的用途
公开(公告)号：US09193695B2
公开(公告)日：2015-11-24
申请号：US13824174
申请日：2011-09-30
申请人： Takeshi Kuwada , Mitsukane Yoshinaga , Tomoko Ishizaka , Daisuke Wakasugi , Shin-ichi Shirokawa , Nobutaka Hattori , Youichi Shimazaki , Naoki Miyakoshi
发明人： Takeshi Kuwada , Mitsukane Yoshinaga , Tomoko Ishizaka , Daisuke Wakasugi , Shin-ichi Shirokawa , Nobutaka Hattori , Youichi Shimazaki , Naoki Miyakoshi
IPC分类号： C07D265/30 , C07D249/12 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/12 , C07D413/10 , C07D413/14 , C07D451/06 , C07D491/08 , C07D491/107 , C07D498/08
CPC分类号： C07D249/12 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/12 , C07D413/10 , C07D413/14 , C07D451/06 , C07D491/08 , C07D491/107 , C07D498/08
摘要： The present invention provides a 1,2,4-triazolone derivative represented by Formula (1A) having an antagonistic activity on the arginine-vasopressin 1b receptor or a pharmaceutically acceptable salt thereof and provides a pharmaceutical composition comprising the compound or the salt as an active ingredient, in particular, a therapeutic or preventive agent exhibiting favorable pharmacokinetics in a disease such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, or alopecia.
摘要翻译：本发明提供对精氨酸 - 加压素1b受体或其药学上可接受的盐具有拮抗作用的由式（1A）表示的1,2,4-三唑酮衍生物，并提供包含该化合物或其盐作为活性物质的药物组合物成分，特别是在疾病如情绪障碍，焦虑障碍，精神分裂症，阿尔茨海默病，帕金森病，亨廷顿舞蹈病，进食障碍，高血压，胃肠道疾病，药物成瘾，癫痫，脑梗死等疾病中表现出有利的药代动力学的治疗或预防药物，脑缺血，脑水肿，头部损伤，炎症，免疫相关疾病或脱发。

2. 发明申请

US20130197217A1 1, 2, 4-TRIAZOLONE DERIVATIVE 有权
标题翻译： 1，2，4-TRIAZOLONE DERIVATIVE
公开(公告)号：US20130197217A1
公开(公告)日：2013-08-01
申请号：US13824174
申请日：2011-09-30
申请人： Takeshi Kuwada , Mitsukane Yoshinaga , Tomoko Ishizaka , Daisuke Wakasugi , Shin-ichi Shirokawa , Nobutaka Hattori , Youichi Shimazaki , Naoki Miyakoshi
发明人： Takeshi Kuwada , Mitsukane Yoshinaga , Tomoko Ishizaka , Daisuke Wakasugi , Shin-ichi Shirokawa , Nobutaka Hattori , Youichi Shimazaki , Naoki Miyakoshi
IPC分类号： C07D249/12 , C07D403/10 , C07D401/10 , C07D401/04 , C07D451/06 , C07D413/10 , C07D491/107 , C07D498/08
CPC分类号： C07D249/12 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/12 , C07D413/10 , C07D413/14 , C07D451/06 , C07D491/08 , C07D491/107 , C07D498/08
摘要： The present invention provides a 1,2,4-triazolone derivative represented by Formula (1A) having an antagonistic activity on the arginine-vasopressin 1b receptor or a pharmaceutically acceptable salt thereof and provides a pharmaceutical composition comprising the compound or the salt as an active ingredient, in particular, a therapeutic or preventive agent exhibiting favorable pharmacokinetics in a disease such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, or alopecia.
摘要翻译：本发明提供对精氨酸 - 加压素1b受体或其药学上可接受的盐具有拮抗作用的由式（1A）表示的1,2,4-三唑酮衍生物，并提供包含该化合物或其盐作为活性物质的药物组合物成分，特别是在疾病如情绪障碍，焦虑障碍，精神分裂症，阿尔茨海默病，帕金森病，亨廷顿舞蹈病，进食障碍，高血压，胃肠道疾病，药物成瘾，癫痫，脑梗死等疾病中表现出有利的药代动力学的治疗或预防药物，脑缺血，脑水肿，头部损伤，炎症，免疫相关疾病或脱发。

3. 发明申请

US20060273485A1 Golf ball manufacturing method 失效
标题翻译：高尔夫球制造方法
公开(公告)号：US20060273485A1
公开(公告)日：2006-12-07
申请号：US11144006
申请日：2005-06-03
申请人： Hiroshi Higuchi , Naoki Miyakoshi , Akira Kimura , Toru Ogawana
发明人： Hiroshi Higuchi , Naoki Miyakoshi , Akira Kimura , Toru Ogawana
IPC分类号： B29C45/14
CPC分类号： B29C45/0055 , B29C45/14073 , B29C2045/0058 , B29L2031/54 , B29L2031/545
摘要： The invention provides a method of manufacturing golf balls composed of a core and one or more cover layer which encloses the core, at least one cover layer being a thin layer having a thickness of 1.0 mm or less. The thin layer is formed to a desired thickness on a surface of a core or spherical body by holding within a mold cavity the core or a spherical body composed of the core enclosed by a cover layer and injecting a synthetic resin material into a space defined by a surface of the core or spherical body and an inner face of the mold cavity so as to form a cover layer on the surface of the core or spherical body, then grinding the resulting cover layer to a thickness of at least 0.1 mm with a specific type of grinder. Golf balls obtained in this way can be provided with a good sphericity even when the cover is formed to a very small thickness.
摘要翻译：本发明提供一种制造高尔夫球的方法，该球由芯体和一个或多个包覆芯体的覆盖层组成，至少一个覆盖层是厚度为1.0mm或更小的薄层。在芯体或球体的表面上，通过在芯腔内保持芯体或由被覆盖层包围的芯构成的球体或将合成树脂材料注入由芯或球体的表面和模腔的内表面，以在芯或球体的表面上形成覆盖层，然后用特定的方法将所得到的覆盖层研磨至至少0.1mm的厚度研磨机类型即使盖形成为非常小的厚度，也可以以这种方式获得的高尔夫球具有良好的球形度。

4. 发明授权

US08764582B2 Multi-piece solid golf ball 有权
标题翻译：多件式固体高尔夫球
公开(公告)号：US08764582B2
公开(公告)日：2014-07-01
申请号：US11652529
申请日：2007-01-12
申请人： Hiroshi Higuchi , Naoki Miyakoshi , Akira Kimura , Toru Ogawana
发明人： Hiroshi Higuchi , Naoki Miyakoshi , Akira Kimura , Toru Ogawana
IPC分类号： A63B37/06
CPC分类号： A63B37/0043 , A63B37/0018 , A63B37/0019 , A63B37/002 , A63B37/0045 , A63B37/0062 , A63B37/0063 , A63B37/0064 , A63B37/0076
摘要： A multi-piece solid golf ball has a solid core, an envelope layer that encloses the solid core, an intermediate layer that encloses the envelope layer, and a cover that encloses the intermediate layer and has a plurality of dimples on a surface thereof. The diameter of the solid core, the center hardness, surface hardness and hardness difference between the center and surface of the solid core, the thickness and surface hardness of the envelope layer, and the thickness and surface hardness of the intermediate layer are each optimized within specific ranges. Moreover, the intermediate layer is formed so as to be harder than the envelope layer and the cover. In addition, the thickness and surface hardness of the cover, and the combined thickness of the envelope layer, intermediate layer and cover are each optimized within specific ranges.
摘要翻译：多片固体高尔夫球具有实芯，包围实心芯的包络层，围绕包层的中间层，以及包围中间层并在其表面上具有多个凹坑的盖。实心芯的直径，实芯的中心和表面之间的中心硬度，表面硬度和硬度差，包层的厚度和表面硬度以及中间层的厚度和表面硬度各自在具体范围。此外，中间层形成为比包层和盖更硬。此外，盖的厚度和表面硬度以及包层，中间层和盖的组合厚度各自在特定范围内进行优化。

5. 发明申请

US20120243161A1 ELECTRONIC DEVICE 审中-公开
标题翻译：电子设备
公开(公告)号：US20120243161A1
公开(公告)日：2012-09-27
申请号：US13486465
申请日：2012-06-01
申请人： Yusuke Mizuno , Naoki Miyakoshi , Shinya Matsushita
发明人： Yusuke Mizuno , Naoki Miyakoshi , Shinya Matsushita
IPC分类号： G06F1/16 , H05K5/03
CPC分类号： G11B33/027 , G06F1/1616 , G06F1/1633 , G06F1/1658 , G06F1/169 , G06F3/03547 , G06F3/0362 , G06F3/0485
摘要： An electronic device includes a housing including an installing part having an opening, an electronic component installed in the installing part and including a first side surface and a second side surface, an attachment component fastened to the electronic component and configured to fix the first side surface to the housing, and a cover component detachably attached to the opening and configured to cover the opening. The cover component includes an elastic member configured to exert force to the vicinity of the second side surface.
摘要翻译：一种电子设备，包括：壳体，包括具有开口的安装部，安装在所述安装部中的电子部件，包括第一侧面和第二侧面;固定在所述电子部件上的安装部，以及可拆卸地附接到所述开口并构造成覆盖所述开口的盖部件。盖部件包括构造成向第二侧表面附近施加力的弹性部件。

6. 发明申请

US20070111823A1 Multi-piece solid golf ball 有权
公开(公告)号：US20070111823A1
公开(公告)日：2007-05-17
申请号：US11652529
申请日：2007-01-12
申请人： Hiroshi Higuchi , Naoki Miyakoshi , Akira Kimura , Toru Ogawana
发明人： Hiroshi Higuchi , Naoki Miyakoshi , Akira Kimura , Toru Ogawana
IPC分类号： A63B37/04 , A63B37/14 , A63B37/12
CPC分类号： A63B37/0043 , A63B37/0018 , A63B37/0019 , A63B37/002 , A63B37/0045 , A63B37/0062 , A63B37/0063 , A63B37/0064 , A63B37/0076
摘要： A multi-piece solid golf ball has a solid core, an envelope layer that encloses the solid core, an intermediate layer that encloses the envelope layer, and a cover that encloses the intermediate layer and has a plurality of dimples on a surface thereof. The diameter of the solid core, the center hardness, surface hardness and hardness difference between the center and surface of the solid core, the thickness and surface hardness of the envelope layer, and the thickness and surface hardness of the intermediate layer are each optimized within specific ranges. Moreover, the intermediate layer is formed so as to be harder than the envelope layer and the cover. In addition, the thickness and surface hardness of the cover, and the combined thickness of the envelope layer, intermediate layer and cover are each optimized within specific ranges. This golf ball is more advantageous than prior-art golf balls because it reduces the spin rate of the ball on full shots taken with a driver and increases the carry of the ball, in addition to which it provides a good performance on approach shots.

7. 发明授权

US08461182B2 7-piperidinoalkyl-3, 4-Dihydroquinolone derivative 失效
标题翻译： 7-哌啶子基烷基-3,4-二氢喹诺酮衍生物
公开(公告)号：US08461182B2
公开(公告)日：2013-06-11
申请号：US13122281
申请日：2009-09-30
申请人： Kosuke Kanuma , Naoki Miyakoshi , Madoka Kawamura , Tsuyoshi Shibata
发明人： Kosuke Kanuma , Naoki Miyakoshi , Madoka Kawamura , Tsuyoshi Shibata
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D401/06 , C07D401/14
摘要： PROBLEMTo provide a novel compound, a pharmaceutically acceptable salt or a hydrate thereof useful for preventing or treating for depression, anxiety disorders (such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, obsessive-compulsive disorder or social anxiety disorder), attention deficit disorder, mania, manic-depressive illness, schizophrenia, mood disorders, stress, sleep disorders, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, cardiovascular diseases, hypertension, dyslipidemia, myocardial infarction, movement disorder (such as Parkinson's disease, epilepsy, convulsion or tremor), drug abuse, drug addiction or sexual dysfunction, based on a melanin-concentrating hormone receptor (MCH receptor) antagonistic action.SOLUTIONA compound, a pharmaceutically acceptable salt or a hydrate thereof represented by the formula (I).
摘要翻译：提供用于预防或治疗抑郁症，焦虑症（例如广泛性焦虑症，创伤后应激障碍，恐慌症，强迫症或社会焦虑症）的新型化合物，其药学上可接受的盐或水合物，注意力缺陷障碍，躁狂症，躁狂抑郁症，精神分裂症，情绪障碍，压力，睡眠障碍，攻击，记忆障碍，认知障碍，痴呆，遗忘症，del妄，肥胖，进食障碍，食欲障碍，食欲过盛，贪食症，基于黑色素浓度激素受体（MCH受体）拮抗作用的心血管疾病，高血压，血脂异常，心肌梗塞，运动障碍（例如帕金森病，癫痫，惊厥或震颤），药物滥用，药物成瘾或性功能障碍。解决方案由式（I）表示的化合物，其药学上可接受的盐或其水合物。

8. 发明申请

US20110178304A1 7-PIPERIDINOALKYL-3, 4-DIHYDROQUINOLONE DERIVATIVE 失效
标题翻译： 7-哌啶二醇-3,4-二氢喹啉酮衍生物
公开(公告)号：US20110178304A1
公开(公告)日：2011-07-21
申请号：US13122281
申请日：2009-09-30
申请人： Kosuke Kanuma , Naoki Miyakoshi , Madoka Kawamura , Tsuyoshi Shibata
发明人： Kosuke Kanuma , Naoki Miyakoshi , Madoka Kawamura , Tsuyoshi Shibata
IPC分类号： C07D401/10
CPC分类号： C07D401/06 , C07D401/14
摘要： Problem To provide a novel compound, a pharmaceutically acceptable salt or a hydrate thereof useful for preventing or treating for depression, anxiety disorders (such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, obsessive-compulsive disorder or social anxiety disorder), attention deficit disorder, mania, manic-depressive illness, schizophrenia, mood disorders, stress, sleep disorders, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, cardiovascular diseases, hypertension, dyslipidemia, myocardial infarction, movement disorder (such as Parkinson's disease, epilepsy, convulsion or tremor), drug abuse, drug addiction or sexual dysfunction, based on a melanin-concentrating hormone receptor (MCH receptor) antagonistic action.Solution A compound, a pharmaceutically acceptable salt or a hydrate thereof represented by the formula (I).
摘要翻译：问题提供用于预防或治疗抑郁症，焦虑症（例如广泛性焦虑症，创伤后应激障碍，恐慌症，强迫症或社会焦虑症）的新型化合物，其药学上可接受的盐或水合物，注意力缺陷障碍，躁狂症，躁狂抑郁症，精神分裂症，情绪障碍，压力，睡眠障碍，攻击，记忆障碍，认知障碍，痴呆，遗忘症，del妄，肥胖，进食障碍，食欲障碍，食欲过盛，贪食症，基于黑色素浓度激素受体（MCH受体）拮抗作用的心血管疾病，高血压，血脂异常，心肌梗塞，运动障碍（例如帕金森病，癫痫，惊厥或震颤），药物滥用，药物成瘾或性功能障碍。溶液由式（I）表示的化合物，其药学上可接受的盐或其水合物。

9. 发明授权

US07727437B2 Golf ball manufacturing method 失效
标题翻译：高尔夫球制造方法
公开(公告)号：US07727437B2
公开(公告)日：2010-06-01
申请号：US11144006
申请日：2005-06-03
申请人： Hiroshi Higuchi , Naoki Miyakoshi , Akira Kimura , Toru Ogawana
发明人： Hiroshi Higuchi , Naoki Miyakoshi , Akira Kimura , Toru Ogawana
IPC分类号： B29C59/00 , B24B5/20
CPC分类号： B29C45/0055 , B29C45/14073 , B29C2045/0058 , B29L2031/54 , B29L2031/545
摘要： The invention provides a method of manufacturing golf balls composed of a core and one or more cover layer which encloses the core, at least one cover layer being a thin layer having a thickness of 1.0 mm or less. The thin layer is formed to a desired thickness on a surface of a core or spherical body by holding within a mold cavity the core or a spherical body composed of the core enclosed by a cover layer and injecting a synthetic resin material into a space defined by a surface of the core or spherical body and an inner face of the mold cavity so as to form a cover layer on the surface of the core or spherical body, then grinding the resulting cover layer to a thickness of at least 0.1 mm with a specific type of grinder. Golf balls obtained in this way can be provided with a good sphericity even when the cover is formed to a very small thickness.
摘要翻译：本发明提供一种制造高尔夫球的方法，该球由芯体和一个或多个包覆芯体的覆盖层组成，至少一个覆盖层是厚度为1.0mm或更小的薄层。在芯体或球体的表面上，通过在芯腔内保持芯体或由被覆盖层包围的芯构成的球体或将合成树脂材料注入由芯或球体的表面和模腔的内表面，以在芯或球体的表面上形成覆盖层，然后用特定的方法将所得到的覆盖层研磨至至少0.1mm的厚度研磨机类型即使盖形成为非常小的厚度，也可以以这种方式获得的高尔夫球具有良好的球形度。

10. 发明申请

US20090154086A1 Casing structure and electronic device 审中-公开
标题翻译：外壳结构和电子设备
公开(公告)号：US20090154086A1
公开(公告)日：2009-06-18
申请号：US12285786
申请日：2008-10-14
申请人： Masaki Ishikawa , Naoki Miyakoshi
发明人： Masaki Ishikawa , Naoki Miyakoshi
IPC分类号： G06F1/16
CPC分类号： G06F1/1601 , G06F1/181
摘要： The casing structure includes a first frame having a top surface section; a second frame having a top surface section and a bent section that is bent on the top surface section at a location where the the second frame abuts the first frame; and a hinge mounted over the top surface section of the first frame including the location and the top surface section of the second part. The hinge secures an LCD to the second frame.
摘要翻译：壳体结构包括具有顶表面部分的第一框架; 第二框架，具有顶表面部分和弯曲部分，所述弯曲部分在所述第二框架邻接所述第一框架的位置处在所述顶表面部分上弯曲; 以及安装在第一框架的顶表面部分上的铰链，包括第二部分的位置和顶表面部分。铰链将LCD固定到第二个框架。

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