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1. 发明授权

US5401469A Plastic optical biomaterials assay device 失效
标题翻译：塑料光学生物材料测定装置
公开(公告)号：US5401469A
公开(公告)日：1995-03-28
申请号：US238782
申请日：1994-05-06
申请人： Takeshi Kobayashi , Hiroyuki Honda , Ken-ichi Shimada
发明人： Takeshi Kobayashi , Hiroyuki Honda , Ken-ichi Shimada
IPC分类号： G01N33/533 , G01N33/543 , G01N33/58 , G01N21/64
CPC分类号： G01N33/54373 , G01N33/533 , G01N33/54353 , G01N33/582 , Y10S436/80 , Y10S436/805
摘要： A reagent for biomaterials assay of (fluorescent dye).sub.n --avidin--a compound having a plurality of reactive groups--a biomaterial, or a reagent in which avidin is bound to a compound having a plurality of reactive groups through biotin in the above, a plastic fiber optics necessary for utilizing this, an assaying device having a sensing portion utilizing this fiber optics and an assaying method of biomaterials by use of this reagent and device. The assay method can be used for an immunoassay of biomaterials such as antigens, antibodies, and enzymes contained in extremely minute amounts in blood or body fluid for medical diagnosis, and improves the detectable sensitivity to a great extent.
摘要翻译：（荧光染料）正离子交换蛋白 - 具有多个反应性基团的化合物 - 生物材料或其中抗生物素蛋白通过上述生物素与具有多个反应性基团的化合物结合的试剂的生物材料测定试剂，使用该材料所需的塑料光纤，具有利用该光纤的感测部分的测定装置和通过使用该试剂和装置的生物材料的测定方法。测定方法可用于生物材料的免疫测定，例如用于医学诊断的血液或体液中极少量含有的抗原，抗体和酶，并且在很大程度上提高了可检测的敏感性。

2. 发明授权

US6010867A Reagent for biomaterials assay, preparation method thereof, and assay method 失效
标题翻译：生物材料测定试剂，其制备方法和测定方法
公开(公告)号：US6010867A
公开(公告)日：2000-01-04
申请号：US867401
申请日：1997-06-02
申请人： Takeshi Kobayashi , Hiroyuki Honda , Ken-ichi Shimada
发明人： Takeshi Kobayashi , Hiroyuki Honda , Ken-ichi Shimada
IPC分类号： G01N33/533 , G01N33/543 , G01N33/58 , G01N33/53 , G01N33/552
CPC分类号： G01N33/533 , G01N33/54353 , G01N33/54373 , G01N33/582 , Y10S436/80 , Y10S530/813
摘要： The present invention relates to a reagent for biomaterials assay of (fluorescent dye).sub.n --avidin--a compound having a plurality of reactive groups--a biomaterial, or a reagent in which avidin is bound to a compound having a plurality of reactive groups through biotin in the above, a method for preparing it, a plastic fiber optics necessary for utilizing this, an assaying device having a sensing portion utilizing this fiber optics and an assaying method of biomaterials by use of this reagent and device. The assay method can be used for immunoassay of biomaterials such as antigens, enzymes contained in extremely minute amounts in blood or body fluid in medical diagnosis, and improves detectable sensitivity to a great extent.
摘要翻译：本发明涉及（荧光染料）正离子交换蛋白 - 具有多个反应性基团的化合物 - 生物材料或其中抗生物素蛋白通过生物素与具有多个反应性基团的化合物结合的试剂的生物材料测定试剂在上述中，其制备方法，利用该方法所需的塑料光纤，具有利用该光纤的感测部分的测定装置和使用该试剂和装置的生物材料的测定方法。该测定方法可用于免疫测定生物材料如抗原，在医学诊断中在血液或体液中极少量含有的酶，并在很大程度上改善可检测的敏感性。

3. 发明授权

US5449625A Optical fiber based fluorescent immunoassay apparatus 失效
标题翻译：基于光纤的荧光免疫测定仪
公开(公告)号：US5449625A
公开(公告)日：1995-09-12
申请号：US98394
申请日：1993-08-16
申请人： Takeshi Kobayashi , Shinji Iijima , Yasunori Sakai , Ken-ichi Shimada
发明人： Takeshi Kobayashi , Shinji Iijima , Yasunori Sakai , Ken-ichi Shimada
IPC分类号： G01N21/64 , G01N33/53 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54366 , G01N33/5302 , G01N33/582 , Y10S435/968 , Y10S435/969 , Y10S436/80 , Y10S436/807
摘要： The present invention relates to an apparatus for performing a fluoroimmunoassay, the apparatus comprising an excitation light source, a fluorescence detector, an optical fiber for an excitation light from the excitation light source to which an antigen or antibody is bound, and a spectroscope, in which the mentioned antigen or antibody is bound to an outgoing end surface of the optical fiber for the excitation light. In the apparatus the spectroscope is constructed so that it introduces the excitation light emitted from the excitation light source to a incident end surface of the optical fiber for the excitation light and introduces a fluorescence emitted from a fluorescence-labeled antibody or antigen which forms an immunological complex with the antigen or antibody to the fluorescence detector. In the apparatus the outgoing end surface of the optical fiber for the excitation light has a transmittance for the excitation light from the excitation light source. The invention also relates to a sensing chip which is used in the apparatus for performing a fluoroimmunoassay therewith.
摘要翻译： PCT No.PCT / JP92 / 01652 Sec。 371日期：1993年8月16日 102（e）日期1993年8月16日PCT提交1992年12月17日PCT公布。公开号WO93 / 13418 日期：1993年7月8日。本发明涉及一种用于进行荧光免疫测定的装置，该装置包括激发光源，荧光检测器，用于来自激发光源的激发光的光纤，抗原或抗体所述抗原或抗体结合到所述光纤的出射端表面用于激发光。在该装置中，分光镜被构造成使得从激发光源发射的激发光引入用于激发光的光纤的入射端面，并引入从形成免疫学的荧光标记的抗体或抗原发射的荧光与荧光检测器的抗原或抗体复合。在该装置中，用于激发光的光纤的出射端面对于来自激发光源的激发光具有透射率。本发明还涉及用于与其进行荧光免疫测定的装置中的感测芯片。

4. 发明授权

US5354574A Method for producing optical fiber having formyl groups on core surface thereof 失效
标题翻译：在其芯表面上具有甲酰基的光纤的制造方法
公开(公告)号：US5354574A
公开(公告)日：1994-10-11
申请号：US80615
申请日：1993-06-22
申请人： Takeshi Kobayashi , Shinji Iijima , Ken-ichi Shimada , Kazue Ohe , Yasunori Sakai
发明人： Takeshi Kobayashi , Shinji Iijima , Ken-ichi Shimada , Kazue Ohe , Yasunori Sakai
IPC分类号： G01N33/545 , G01N33/547 , B05D5/06
CPC分类号： G01N33/547 , G01N33/545
摘要： The present invention is directed to a method for producing an optical fiber having formyl groups on a core surface. In one embodiment, a plastic optical fiber having formyl groups on a core surface is obtained by immersing the core surface of the plastic optical fiber in a treating solution containing at least a 0.5 to 40 mM alkali metal hydroxide and a compound having formyl groups in water or lower alcohol solvent. In the other embodiment, a plastic optical fiber having formyl groups on a core surface is obtained by introducing a vic-diol group, a primary hydroxyl group or an alkenyl group on the core surface, and then oxidizing it. Turbidity on the core surface of the optical fiber thus obtained is minimized, thereby reducing the transmittance losses of light.
摘要翻译：本发明涉及一种在芯表面上制备具有甲酰基的光纤的方法。在一个实施方案中，通过将塑料光纤的芯表面浸渍在含有至少0.5至40mM碱金属氢氧化物和在水中具有甲酰基的化合物的处理溶液中来获得在芯表面上具有甲酰基的塑料光纤或低级醇溶剂。在另一实施方式中，通过在芯表面上引入邻二醇基，伯羟基或烯基，然后将其氧化来获得在芯表面上具有甲酰基的塑料光纤。由此获得的光纤的芯表面上的浊度最小化，从而降低光的透射率损失。

5. 发明授权

US06376052B1 Multilayer printed wiring board and its production process, resin composition for filling through-hole 有权
标题翻译：多层印刷线路板及其生产工艺，填充通孔的树脂组合物
公开(公告)号：US06376052B1
公开(公告)日：2002-04-23
申请号：US09556860
申请日：2000-04-21
申请人： Motoo Asai , Ken-ichi Shimada , Kouta Noda , Takashi Kariya , Hiroshi Segawa
发明人： Motoo Asai , Ken-ichi Shimada , Kouta Noda , Takashi Kariya , Hiroshi Segawa
IPC分类号： B32B300
CPC分类号： B32B3/00 , H05K3/0094 , H05K3/383 , H05K3/384 , H05K3/385 , H05K3/4069 , H05K3/4602 , H05K2201/0209 , H05K2201/0212 , H05K2201/0215 , H05K2201/0257 , H05K2201/0347 , H05K2201/09536 , H05K2201/09563 , H05K2201/0959 , H05K2201/096 , Y10S428/901 , Y10T428/24917
摘要： A multilayer printed wiring board is composed of a substrate provided with through-holes, and a wiring board formed on the substrate through the interposition of an interlaminar insulating resin layer, the through-holes having a roughened internal surface and being filled with a filler, an exposed part of the filler in the through-holes being covered with a through-hole-covering conductor layer, and a viahole formed just thereabove being connected to the through-hole-covering conductor layer. Without peeling between the through-holes and the filler, this wiring board has a satisfactory connection reliability between the through-holes and the internal layer circuit and provides a high density wiring.
摘要翻译：多层印刷布线板由设置有通孔的基板和通过插入层间绝缘树脂层而形成在基板上的布线板，所述通孔具有粗糙的内表面并填充有填料，通孔中的填充物的暴露部分被覆盖有通孔覆盖导体层，并且形成在其上方的通孔连接到通孔覆盖导体层。在通孔和填充物，该布线板在通孔和内层电路之间具有令人满意的连接可靠性，并且提供高密度布线。

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