专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08394376B2 Therapeutic agents for alzheimer's disease and cancer 有权
公开(公告)号：US08394376B2
公开(公告)日：2013-03-12
申请号：US12962019
申请日：2010-12-07
申请人： Takeshi Iwatsubo , Tatsuhiko Kodama , Takao Hamakubo , Taisuke Tomita , Ikuo Hayashi , Yasuomi Urano , Hiroko Iwanari , Masao Ohkuchi
发明人： Takeshi Iwatsubo , Tatsuhiko Kodama , Takao Hamakubo , Taisuke Tomita , Ikuo Hayashi , Yasuomi Urano , Hiroko Iwanari , Masao Ohkuchi
IPC分类号： A61K39/395
CPC分类号： G01N33/6896 , A61K2039/505 , C07K16/40 , C07K2317/73 , C07K2317/76 , G01N33/574 , G01N2333/948 , G01N2500/02
摘要： To provide a therapeutic drug for Alzheimer's disease and/or a cancer. The therapeutic drug for Alzheimer's disease and/or a cancer contains an anti-nicastrin antibody, a derivative of the antibody, or a fragment of the antibody or the derivative.

2. 发明授权

US08398981B2 Therapeutic agents for alzheimer's disease and cancer 有权
标题翻译：阿尔茨海默病和癌症的治疗剂
公开(公告)号：US08398981B2
公开(公告)日：2013-03-19
申请号：US13276501
申请日：2011-10-19
申请人： Takeshi Iwatsubo , Tatsuhiko Kodama , Takao Hamakubo , Taisuke Tomita , Ikuo Hayashi , Yasuomi Urano , Hiroko Iwanari , Masao Ohkuchi
发明人： Takeshi Iwatsubo , Tatsuhiko Kodama , Takao Hamakubo , Taisuke Tomita , Ikuo Hayashi , Yasuomi Urano , Hiroko Iwanari , Masao Ohkuchi
IPC分类号： A61K39/395
CPC分类号： G01N33/6896 , A61K2039/505 , C07K16/40 , C07K2317/73 , C07K2317/76 , G01N33/574 , G01N2333/948 , G01N2500/02
摘要： To provide a therapeutic drug for Alzheimer's disease and/or a cancer. The therapeutic drug for Alzheimer's disease and/or a cancer contains an anti-nicastrin antibody, a derivative of the antibody, or a fragment of the antibody or the derivative.
摘要翻译：为阿尔茨海默病和/或癌症提供治疗药物。用于阿尔茨海默氏病和/或癌症的治疗药物含有抗 - 尼卡星抗体，抗体衍生物或抗体或其衍生物的片段。

3. 发明申请

US20110165179A1 THERAPEUTIC AGENTS FOR ALZHEIMER'S DISEASE AND CANCER 有权
标题翻译：阿尔茨海默病和癌症的治疗药物
公开(公告)号：US20110165179A1
公开(公告)日：2011-07-07
申请号：US12962019
申请日：2010-12-07
申请人： Takeshi IWATSUBO , Tatsuhiko Kodama , Takao Hamakubo , Taisuke Tomita , Ikuo Hayashi , Yasuomi Urano , Hiroko Iwanari , Masao Ohkuchi
发明人： Takeshi IWATSUBO , Tatsuhiko Kodama , Takao Hamakubo , Taisuke Tomita , Ikuo Hayashi , Yasuomi Urano , Hiroko Iwanari , Masao Ohkuchi
IPC分类号： A61K39/395 , A61P25/28 , A61P35/00 , A61P35/02
CPC分类号： G01N33/6896 , A61K2039/505 , C07K16/40 , C07K2317/73 , C07K2317/76 , G01N33/574 , G01N2333/948 , G01N2500/02
摘要： To provide a therapeutic drug for Alzheimer's disease and/or a cancer.The therapeutic drug for Alzheimer's disease and/or a cancer contains an anti-nicastrin antibody, a derivative of the antibody, or a fragment of the antibody or the derivative.
摘要翻译：为阿尔茨海默病和/或癌症提供治疗药物。用于阿尔茨海默氏病和/或癌症的治疗药物含有抗 - 尼卡星抗体，抗体衍生物或抗体或其衍生物的片段。

4. 发明申请

US20090220524A1 THERAPEUTIC AGENTS FOR ALZHEIMER'S DISEASE AND CANCER 审中-公开
标题翻译：阿尔茨海默病和癌症的治疗药物
公开(公告)号：US20090220524A1
公开(公告)日：2009-09-03
申请号：US12298151
申请日：2007-04-23
申请人： Takeshi Iwatsubo , Tatsuhiko Kodama , Takao Hamakuob , Taisuke Tomita , Ikuo Hayashi , Yasuomi Urano , Hiroko Iwanari , Masao Ohkuchi
发明人： Takeshi Iwatsubo , Tatsuhiko Kodama , Takao Hamakuob , Taisuke Tomita , Ikuo Hayashi , Yasuomi Urano , Hiroko Iwanari , Masao Ohkuchi
IPC分类号： A61K39/395 , C07K16/18 , G01N33/573
CPC分类号： G01N33/6896 , A61K2039/505 , C07K16/40 , C07K2317/73 , C07K2317/76 , G01N33/574 , G01N2333/948 , G01N2500/02
摘要： To provide a therapeutic drug for Alzheimer's disease and/or a cancer.The therapeutic drug for Alzheimer's disease and/or a cancer contains an anti-nicastrin antibody, a derivative of the antibody, or a fragment of the antibody or the derivative.
摘要翻译：为阿尔茨海默病和/或癌症提供治疗药物。用于阿尔茨海默氏病和/或癌症的治疗药物含有抗 - 尼卡星抗体，抗体衍生物或抗体或其衍生物的片段。

5. 发明申请

US20080003623A1 Monitoring Agent for Seriousness of Hepatitis 审中-公开
标题翻译：监测肝炎严重程度
公开(公告)号：US20080003623A1
公开(公告)日：2008-01-03
申请号：US11575109
申请日：2005-10-03
申请人： Atsushi Nakajima , Hiroyuki Aburatani , Hiroko Iwanari , Masao Ohkuchi , Hirokazu Satoh
发明人： Atsushi Nakajima , Hiroyuki Aburatani , Hiroko Iwanari , Masao Ohkuchi , Hirokazu Satoh
IPC分类号： G01N33/53 , C07K16/18 , G01N33/563
CPC分类号： G01N33/57438 , G01N33/576 , G01N2800/085
摘要： The present invention relates to a method of monitoring seriousness of hepatitis, comprising measuring GPC3 using an antibody which recognizes an N-terminal region of GPC3. According to the present invention, seriousness of hepatitis, specifically, progression of hepatitis or cirrhosis toward hepatoma can be presumed.
摘要翻译：本发明涉及一种监测肝炎严重性的方法，包括使用识别GPC3的N末端区域的抗体测量GPC3。根据本发明，可以推测肝炎的严重性，特别是肝硬化对肝癌的发展。

6. 发明授权

US06867221B2 Cyclic amine compounds and pharmaceutical composition containing the same 失效
标题翻译：环胺化合物和含有其的药物组合物
公开(公告)号：US06867221B2
公开(公告)日：2005-03-15
申请号：US10191534
申请日：2002-07-10
申请人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Takeshi Doi , Yoshinori Kyotani , Masao Ohkuchi
发明人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Takeshi Doi , Yoshinori Kyotani , Masao Ohkuchi
IPC分类号： A61K31/4545 , A61P9/10 , A61P11/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D211/58 , C07D211/62 , C07D213/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14
CPC分类号： C07D401/06 , A61K31/4545 , C07D211/58 , C07D211/62 , C07D213/38 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14
摘要： A cyclic amine compound represented by the following general formula (1): wherein, R1, R2 and R3 each independently represent a hydrogen atom or an alkoxy group; W1 and W2 each independently represent N or CH; X represents O, NR4, CONR4 or NR4CO; R4 represents a hydrogen atom, or an alkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl group; and l, m and n each represents a number of 0 or 1, a salt thereof and a hydrate thereof are provided. These compounds have inhibitory effects on both cell adhesion and cell infiltration and are useful as anti-asthmatic agents, anti-allergic agents, anti-rheumatic agents, anti-arteriosclerotic agents, anti-inflammatory agents, anti-Sjogren's syndrome agents or the like.
摘要翻译：由以下通式（1）表示的环胺化合物：其中，R 1，R 2和R 3各自独立地表示氢原子或烷氧基; W 1和W 2均为氢原子，各自独立地表示N或CH; X表示O，NR 4，CONR 4或NR 4 CO; R 4表示氢原子或烷基，芳基，杂芳基，芳烷基或杂芳烷基; 和l，m和n各自表示0或1的数，其盐和其水合物。这些化合物对细胞粘附和细胞浸润都具有抑制作用，并且可用作抗哮喘剂，抗过敏剂，抗风湿剂，抗动脉硬化剂，抗炎剂，抗干燥素综合征剂等。

7. 发明授权

US06498169B1 Cyclic amine compounds and pharmaceutical composition containing the same 有权
标题翻译：环胺化合物和含有其的药物组合物
公开(公告)号：US06498169B1
公开(公告)日：2002-12-24
申请号：US09983928
申请日：2001-10-26
申请人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Takeshi Doi , Yoshinori Kyotani , Masao Ohkuchi
发明人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Takeshi Doi , Yoshinori Kyotani , Masao Ohkuchi
IPC分类号： A61K314545
CPC分类号： C07D401/06 , A61K31/4545 , C07D211/58 , C07D401/12 , C07D401/14 , C07D403/14
摘要： A cyclic amine compound represented by the following general formula (1): wherein, R1, R2 and R3 each independently represent a hydrogen atom or an alkoxy group; W1 an W2 each independently represent N or CH; X represents O, NR4, CONR4 or NR4CO; R4 each independently represents a hydrogen atom, or an alkyl, aryl, heteroaryl, aralkyl, or heteroalkyl group; and l, m and n each represents a number of 0 to 1, a salt thereof and a hydrate thereof are provided. These compounds have inhibitory effects on both cell adhesion and cell infiltration and are useful as anti-asthmatic agents, anti-allergic agents, anti-rheumatic agents, anti-arteriosclerotic agents, anti-inflammatory agents, anti-Sjogren's syndrome agents or the like.
摘要翻译：由以下通式（1）表示的环胺化合物：其中，R 1，R 2和R 3各自独立地表示氢原子或烷氧基; W 1，W 2各自独立地表示N或CH; X表示O，NR 4，CONR 4或 NR4CO; R4各自独立地表示氢原子，或烷基，芳基，杂芳基，芳烷基或杂烷基; 和l，m和n各自表示0至1的数，其盐和其水合物。这些化合物对细胞粘附和细胞浸润均具有抑制作用，可用作抗哮喘剂，抗过敏剂，抗风湿剂，抗动脉硬化剂，抗炎剂，抗干燥素综合征剂等。

8. 发明授权

US06605620B1 Cyclic amine compounds and pharmaceutical composition containing the same 有权
标题翻译：环胺化合物和含有其的药物组合物
公开(公告)号：US06605620B1
公开(公告)日：2003-08-12
申请号：US10107180
申请日：2002-03-28
申请人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Takeshi Doi , Yoshinori Kyotani , Masao Ohkuchi
发明人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Takeshi Doi , Yoshinori Kyotani , Masao Ohkuchi
IPC分类号： A61K314545
CPC分类号： C07D401/06 , C07D211/58 , C07D213/38 , C07D401/12 , C07D401/14
摘要： A cyclic amine compound by the following general formula (1): wherein, R1, R2 and R3 each independently represent a hydrogen atom or an alkoxy group W1 and W2 each independently represent N or CH; X represents O, NR4, CONR4 or NR4CO; R4 represents a hydrogen atom, or an alkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl group; and l, m and n each represents a number of 0 or 1, a salt thereof and a hydrate thereof are provided. These compounds have inhibitory effects on both cell adhesion and cell infiltration and are useful as anti-asthmatic agents, anti-allergic agents, anti-rheumatic agents, anti-arteriosclerotic agents, anti-inflammatory agents, anti-Sjogren's syndrome agents or the like.
摘要翻译：通式（1）表示的环状胺化合物：其中，R 1，R 2和R 3各自独立地表示氢原子或烷氧基，W 1和W 2各自独立地表示N或CH; X表示O，NR 4，CONR 4或NR 4 CO; R 4 表示氢原子，或烷基，芳基，杂芳基，芳烷基或杂芳烷基; 和l，m和n各自表示0或1的数，其盐和其水合物。这些化合物对细胞粘附和细胞浸润具有抑制作用，并且可用作抗哮喘药，抗过敏剂，抗风湿剂，抗动脉硬化剂，抗炎剂，抗干燥素综合征剂等。

9. 发明授权

US06395753B1 Cyclic amine compounds and pharmaceutical composition containing the same 有权
标题翻译：环胺化合物和含有其的药物组合物
公开(公告)号：US06395753B1
公开(公告)日：2002-05-28
申请号：US09941684
申请日：2001-08-30
申请人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Takeshi Doi , Yoshinori Kyotani , Masao Ohkuchi
发明人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Takeshi Doi , Yoshinori Kyotani , Masao Ohkuchi
IPC分类号： A61K314545
CPC分类号： C07D401/06 , A61K31/4545 , C07D211/58 , C07D401/12 , C07D401/14 , C07D403/14
摘要： A cyclic amine compound represented by the following general formula (1): wherein, R1, R2 and R3 each independently represent a hydrogen atom or an alkoxy group; W1 and W2 each independently represent N or CH; X represents O, NR4, CONR4 or NR4CO; R4 each independently represents a hydrogen atom, or an alkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl group; and l, m and n each represents a number of 0 or 1, a salt thereof and a hydrate thereof are provided. These compounds have inhibitory effects on both cell adhesion and cell infiltration and are useful as anti-asthmatic agents, anti-allergic agents, anti-rheumatic agents, anti-arteriosclerotic agents, anti-inflammatory agents, anti-Sjogren's syndrome agents or the like.
摘要翻译：由以下通式（1）表示的环胺化合物：其中，R1，R2和R3各自独立地表示氢原子或烷氧基; W1和W2各自独立地表示N或CH; X表示O，NR4，CONR4或 NR4CO; R4各自独立地表示氢原子，或烷基，芳基，杂芳基，芳烷基或杂芳烷基; 和l，m和n各自表示0或1的数，其盐和其水合物。这些化合物对细胞粘附和细胞浸润都具有抑制作用，并且可用作抗哮喘剂，抗过敏剂，抗风湿剂，抗动脉硬化剂，抗炎剂，抗干燥素综合征剂等。

10. 发明申请

US20060040986A1 Erythropoietin production accelerator 审中-公开
标题翻译：促红细胞生成素促进剂
公开(公告)号：US20060040986A1
公开(公告)日：2006-02-23
申请号：US10537407
申请日：2003-12-05
申请人： Shigehiko Imagawa , Takeshi Dol , Masahiro Tamura , Masao Ohkuchi
发明人： Shigehiko Imagawa , Takeshi Dol , Masahiro Tamura , Masao Ohkuchi
IPC分类号： A61K31/4545 , A61K31/444 , A61K31/4439 , A61K31/40 , C07D403/02 , C07D401/14
CPC分类号： A61K31/444 , A61K31/4468 , A61K31/4545 , C07D211/58 , C07D213/38 , C07D401/06 , C07D401/12 , C07D401/14
摘要： The present invention relates to a preventive or therapeutic agent for pathological conditions caused by reduced production of erythropoietin, or for anemia, or for chronic anemia, renal anemia, aplastic anemia, or pure red cell aplasia, the agent comprising, as an active ingredient, a cyclic amine compound represented by the following formula (1): wherein, R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group; W1 and W2 each independently represent N or CH; X represents O, NR4, CONR4 or NR4CO; R4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group; and l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof.
摘要翻译：本发明涉及由促红细胞生成素或贫血，贫血，慢性贫血，肾性贫血，再生障碍性贫血或纯红细胞发育不全引起的病理状况的预防或治疗剂，所述药物包含作为活性成分的，由下式（1）表示的环胺化合物：其中R 1，R 2和R 3各自独立地表示氢原子卤素原子或羟基，烷基，卤素取代的烷基，烷氧基，烷硫基，羧基，烷氧基羰基或烷酰基; W 1和W 2各自独立地表示N或CH; X表示O，NR 4，CONR 4或NR 4 CO; R 4各自表示氢原子或烷基，烯基，炔基，取代或未取代的芳基，取代或未取代的杂芳基，取代或未取代的芳烷基或取代或未取代的杂芳烷基; l，m和n各自表示0或1的数，或其盐或其溶剂合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式