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1. 发明授权

US07040483B2 Packaging bag with weak sealed duct 失效
标题翻译：包装袋带弱密封管
公开(公告)号：US07040483B2
公开(公告)日：2006-05-09
申请号：US10207045
申请日：2002-07-30
申请人： Takeshi Inuzuka , Susumu Niwa , Takayuki Kotani
发明人： Takeshi Inuzuka , Susumu Niwa , Takayuki Kotani
IPC分类号： B65D25/08
CPC分类号： B65D75/5855 , B65D81/3266 , Y10S383/904 , Y10S383/906
摘要： A packaging material capable of having a desired sealing strength with ease and a packaging bag using such material are provided. A packaging material, which serves as either one of a first and a second packaging materials to be heat-sealed to each other, includes a sealing portion. This sealing portion is relatively weaker in sealing strength and composed of an applied area of a coating agent preventing the heat sealing and a non-applied area of the coating agent. The applied area and the non-applied area are changed in an area size from each other depending on the sealing strength required for the sealing portion.
摘要翻译：提供能够容易地具有期望的密封强度的包装材料和使用这种材料的包装袋。用作彼此热密封的第一和第二包装材料中的任一种的包装材料包括密封部分。该密封部分的密封强度相对较弱，并且由涂覆剂的涂覆区域组成，防止热封和涂覆剂的未涂覆区域。施加区域和非施加区域根据密封部分所需的密封强度彼此改变。

2. 发明授权

US5316826A Barrier packaging material for infusion solution 失效
标题翻译：用于输液的屏障包装材料
公开(公告)号：US5316826A
公开(公告)日：1994-05-31
申请号：US974358
申请日：1992-11-10
申请人： Takayuki Kotani , Takeshi Inuzuka
发明人： Takayuki Kotani , Takeshi Inuzuka
IPC分类号： A61J1/10 , B32B7/02 , B32B27/00 , B32B27/08 , B32B27/28 , B32B27/30 , B65D65/40 , B32B3/00
CPC分类号： B32B27/30 , Y10T428/1341 , Y10T428/24612 , Y10T428/2495 , Y10T428/24967 , Y10T428/24975 , Y10T428/31928
摘要： A barrier packaging material for an infusion solution including a base material, a polyethylene layer and an ethylene-vinyl acetate copolymer layer disposed on one surface side of the base material which have successively been extrusion-laminated on the base material, and a polyethylene layer and an ethylene-vinyl acetate copolymer layer disposed on the other surface side of the base material which have successively been extrusion-laminated on the base material, wherein the base material includes a co-extrusion film including an ethylene-vinyl alcohol copolymer layer, and a pair of polyethylene layers disposed on both surface sides of the ethylene-vinyl alcohol copolymer layer.
摘要翻译：一种用于输液的阻隔性包装材料，其包括基材，聚乙烯层和设置在基材的一个表面侧上的乙烯 - 乙酸乙烯酯共聚物层，所述基材，乙烯 - 乙酸乙烯酯共聚物层先后挤出层叠在基材上，设置在基材的另一面的乙烯 - 乙酸乙烯酯共聚物层，其先后挤出层叠在基材上，其中，基材包括包含乙烯 - 乙烯醇共聚物层的共挤出膜，和设置在乙烯 - 乙烯醇共聚物层的两个表面侧上的一对聚乙烯层。

3. 发明申请

US20090118694A1 FLUID-SUPPLEMENT BAG PACKAGE AND PROTECTIVE BAG 审中-公开
标题翻译：流体包装袋和保护袋
公开(公告)号：US20090118694A1
公开(公告)日：2009-05-07
申请号：US12224893
申请日：2007-03-08
申请人： Takeshi Inuzuka , Takayuki Kotani
发明人： Takeshi Inuzuka , Takayuki Kotani
IPC分类号： A61J1/10
CPC分类号： A61J1/00 , B32B7/10 , B32B27/32 , B32B27/36 , B65D75/38 , B65D75/5805
摘要： A fluid supplement bag package has a protective bag having a sealant layer that will not be fused to a fluid supplement bag. The fluid supplement bag can be easily taken out of the protective bag. The fluid supplement bag package includes a fluid supplement bag 2 formed by sealing a fluid supplement in a pouch, and a protective bag 3 sealing up the fluid supplement bag 2 therein. The pouch is formed from a polypropylene film, and the protective bag 3 has an outer layer 4 of a polyester resin, and a sealant layer 7 of a polypropylene resin containing an ultrahigh-molecular-weight polypropylene.
摘要翻译：流体补充袋包装具有保护袋，该保护袋具有不会与流体补充袋熔合的密封剂层。液体补充袋可以容易地从保护袋中取出。液体补充袋包装包括通过将袋中的液体补充物密封而形成的流体补充袋2和将流体补充袋2密封在其中的保护袋3。该袋由聚丙烯膜形成，保护袋3具有聚酯树脂的外层4和含有超高分子量聚丙烯的聚丙烯树脂的密封层7。

4. 发明授权

US06332711B1 Gusseted bag for medicinal or medical purposes formed of a plastic film laminate composed of a plurality of layers 有权
标题翻译：由多层构成的塑料薄膜叠层形成的用于药物或医疗用途的角撑袋
公开(公告)号：US06332711B1
公开(公告)日：2001-12-25
申请号：US09238592
申请日：1999-01-28
申请人： Takeshi Inuzuka , Susumu Niwa , Takayuki Kotani
发明人： Takeshi Inuzuka , Susumu Niwa , Takayuki Kotani
IPC分类号： B65D3310
CPC分类号： B65D31/10 , B65D31/02
摘要： A gusseted bag for medicinal or medical purposes comprises a gusseted bag body formed of a plastic film into a hollow shape; and a sealed portion formed at a bottom of the gusseted bag body. The plastic film is a laminate composed of a plurality of layers. The innermost layer of the plurality of layers essentially consists of polyethylene.
摘要翻译：用于医疗或医疗用途的角撑包包括由塑料膜形成中空形状的角撑袋体; 以及形成在该角撑体袋体的底部的密封部。塑料薄膜是由多层构成的层叠体。多个层的最内层基本上由聚乙烯组成。

5. 发明授权

US5132149A Barrier packaging material for infusion solution 失效
标题翻译：阻塞包装材料用于输液解决方案
公开(公告)号：US5132149A
公开(公告)日：1992-07-21
申请号：US635667
申请日：1990-12-28
申请人： Takayuki Kotani , Takeshi Inuzuka
发明人： Takayuki Kotani , Takeshi Inuzuka
IPC分类号： A61J1/14 , A61J1/10 , B32B7/02 , B32B27/08 , B32B27/28 , B32B27/30 , B65D65/40
CPC分类号： B32B27/30 , Y10T428/1341 , Y10T428/1383 , Y10T428/2495 , Y10T428/2826 , Y10T428/31913
摘要： A barrier packaging material for an infusion solution including an intermediate layer including an ethylene-vinyl alcohol copolymer, and co-extrusion layers including an ethylene-vinyl acetate copolymer which have respectively been dry-laminated on both sides of the intermediate layer, wherein the ethylene-vinyl acetate co-extrusion layer includes a middle layer having a vinyl acetate content of 15 to 25 wt. %, and an upper layer and a lower layer each having a vinyl acetate content of 5 to 9 wt. % respectively disposed on both sides of the middle layer.
摘要翻译：一种用于输液的屏障包装材料，包括包含乙烯 - 乙烯醇共聚物的中间层和包含乙烯 - 乙酸乙烯酯共聚物的共挤出层，它们分别在中间层的两侧进行干式层压，其中乙烯乙酸乙烯酯共挤出层包括乙酸乙烯酯含量为15〜25重量％的中间层。％，以及各自具有5至9重量％的乙酸乙烯酯含量的上层和下层。％分别设置在中间层的两侧。

6. 发明申请

US20060080073A1 Three-dimensional structural activity correlation method 审中-公开
标题翻译：三维结构活动相关法
公开(公告)号：US20060080073A1
公开(公告)日：2006-04-13
申请号：US10530550
申请日：2003-10-07
申请人： Takayuki Kotani , Kunihiko Higashiura
发明人： Takayuki Kotani , Kunihiko Higashiura
IPC分类号： G06G7/58
CPC分类号： G16C20/30 , G16C20/50 , G16C20/70
摘要： A three-dimensional quantitative structure-activity relationship method has process B1 of calculating the coordinates of the respective atoms contained in the plural molecules thus superposed in the virtual space, process B2 of calculating interatomic distances between each atom and other atoms and identifying the shortest interatomic distance among thus calculated interatomic distances and two atoms constituting the shortest interatomic distance; process B3 of deleting the two atoms having the shortest interatomic distance from the three-dimensional space and generating an atom which represents the two atoms in the weighted average coordinates of the two atoms to delete, when the shortest interatomic distance thus calculated is equal to or smaller than a predetermined threshold value; process B4 of returning to the second process B2 after the third process B3 and executing the second process B2 including the atoms formed during the third process B3; and process B5 of terminating the process B when the shortest interatomic distance thus calculated is exceeds the predetermined threshold. This method enables strikingly reducing the memory zone and amount of computation required for 3D QSAR analysis.
摘要翻译：三维定量结构 - 活动关系方法具有计算包含在虚拟空间中的多个分子中包含的各个原子的坐标的处理B1，计算每个原子与其它原子之间的原子间距离的处理B2，并且识别最短的原子间由此计算的原子间距离和构成最短原子间距离的两个原子之间的距离; 从三维空间中删除具有最短原子间距离的两个原子的过程B3，并产生一个表示两个原子的加权平均坐标中要删除的两个原子的原子，当这样计算的最短原子间距离等于或小于预定阈值; 在第三处理B3之后返回到第二处理B2并且执行包括在第三处理B3期间形成的原子的第二处理B2的处理B4; 以及当这样计算的最短原子间距离超过预定阈值时终止处理B的处理B5。该方法可显着减少3D QSAR分析所需的存储区和计算量。

7. 发明授权

US06782323B2 Method and program for evaluating molecular similarity 失效
标题翻译：评估分子相似性的方法和程序
公开(公告)号：US06782323B2
公开(公告)日：2004-08-24
申请号：US10133539
申请日：2002-04-25
申请人： Takayuki Kotani
发明人： Takayuki Kotani
IPC分类号： G01N3100
CPC分类号： G06F19/705
摘要： A molecular similarity evaluation method has steps of: (a) obtaining an upper threshold and a lower threshold from one of a value specific to an atom included in a first molecule, a value specific to an atom included in a second molecule of which correlation with respect to the atom in the first molecule is to be evaluated, or another value obtained from these values; (b) calculating the correlation between the atom in the first molecule and the atom in the second molecule, using the upper and lower thresholds; and (c) evaluating the similarity between the first and second molecules based on the correlation obtained in the step (b).
摘要翻译：分子相似性评价方法具有以下步骤：（a）从包含在第一分子中的原子的特定值的值中获得上限阈值和下限阈值，对与第一分子相关的第二分子中包含的原子的特异性值要评估第一分子中的原子，或从这些值获得的另一个值; （b）使用上限和下限计算第一分子中的原子与第二分子中的原子之间的相关性; 和（c）基于步骤（b）中获得的相关性来评估第一和第二分子之间的相似性。

8. 发明授权

US5912261A Carboxyalkyl heterocyclic derivatives 失效
标题翻译：羧甲基杂环衍生物
公开(公告)号：US5912261A
公开(公告)日：1999-06-15
申请号：US575023
申请日：1995-12-19
申请人： Takayuki Kotani , Kaoru Okamoto , Yasuhiro Nagaki
发明人： Takayuki Kotani , Kaoru Okamoto , Yasuhiro Nagaki
IPC分类号： C07D233/66 , C07D233/72 , C07D233/74 , C07D233/96 , C07D239/22 , C07D417/06 , A61K31/415 , C07D239/02
CPC分类号： C07D233/66 , C07D233/72 , C07D233/96 , C07D239/22 , C07D417/06
摘要： Carboxyalkyl heterocyclic derivatives, pharmaceutically acceptable salts thereof, and therapeutic agents containing said compounds as an effective component are useful pharmaceuticals for the treatment of diabetic complications such as diabetic neuropathy, diabetic cataracts and retinopathy, diabetic nephropathy, diabetic dermopathy, and other diabetic microangiopathy. The compounds of the present invention are represented by the following general formula (A): ##STR1## The compounds of the present invention exhibit excellent inhibitory action towards aldose reductase with a high enzyme selectivity. Accordingly, they are useful as drugs for the therapy and prevention of various types of diabetic complications without substantially inhibiting aldehyde reductase.
摘要翻译：含有所述化合物作为有效成分的羧甲基杂环衍生物，其药学上可接受的盐和治疗剂是用于治疗糖尿病性并发症如糖尿病性神经病，糖尿病性白内障和视网膜病变，糖尿病性肾病，糖尿病性皮肤病和其它糖尿病性微血管病变的有用药物。本发明化合物由下列通式（A）表示：本发明化合物对酶选择性高的醛糖还原酶表现出优异的抑制作用。因此，它们可用作治疗和预防各种类型的糖尿病并发症而不显着抑制醛还原酶的药物。

9. 发明授权

US5900426A Benzothiazole derivatives 失效
标题翻译：苯并噻唑衍生物
公开(公告)号：US5900426A
公开(公告)日：1999-05-04
申请号：US624746
申请日：1996-03-27
申请人： Hiroki Muramoto , Kiyoshi Fukuda , Taisuke Hasegawa , Kaoru Okamoto , Takayuki Kotani
发明人： Hiroki Muramoto , Kiyoshi Fukuda , Taisuke Hasegawa , Kaoru Okamoto , Takayuki Kotani
IPC分类号： C07D277/64 , A61K31/415
CPC分类号： C07D277/64
摘要： Benzothiazole derivatives, pharmaceutically acceptable salts thereof, and therapeutic agents containing said compounds as an effective component possess a lipid lowering activity and are useful pharmaceuticals for the treatment of hyperlipemia. The lipid lowering agents are of the formula: ##STR1## wherein R.sub.1 is halogen, trifluoromethyl, acetamido or --OX.sub.1 ; X.sub.1 is hydrogen, alkyl or acyl; R.sub.2 is hydrogen, halogen, alkyl, hydroxyalkyl, trifluoromethyl, nitro, amino which may be substituted with alkyl or acyl, carboxy which may be esterified with alkyl, or --OX.sub.2 ; X.sub.2 is hydrogen, alkyl, acyl, carboxyalkyl which may be esterified with alkyl; n is an integer from 1 to 3 denoting the number of substituents R.sub.2 ; and plural R.sub.2 may be the same or different when n is 2 or 3; with the proviso that R.sub.1 is a group other than halogen when R.sub.2 is hydrogen. The benzothiazole derivatives and their pharmaceutically acceptable salts significantly decrease cholesterol, triglyceride and low-density lipoprotein in blood.
摘要翻译：苯并噻唑衍生物，其药学上可接受的盐和含有所述化合物作为有效成分的治疗剂具有降脂活性，并且是用于治疗高脂血症的有用药物。降脂剂具有下式：其中R1是卤素，三氟甲基，乙酰氨基或-OX1; X1是氢，烷基或酰基; R 2是氢，卤素，烷基，羟基烷基，三氟甲基，硝基，可被烷基或酰基取代的氨基，可以被烷基或-OX 2酯化的羧基; X 2是可以被烷基酯化的氢，烷基，酰基，羧基烷基; n是1至3的整数，表示取代基R2的数目; 当n为2或3时，多个R2可以相同或不同; 条件是当R 2为氢时，R 1为卤素以外的基团。苯并噻唑衍生物及其药学上可接受的盐显着降低血液中的胆固醇，甘油三酯和低密度脂蛋白。

10. 发明授权

US5756171A Laminate film and method of producing the same 失效
标题翻译：层压膜及其制造方法
公开(公告)号：US5756171A
公开(公告)日：1998-05-26
申请号：US170737
申请日：1993-12-21
申请人： Yoshiji Moteki , Takayuki Kotani
发明人： Yoshiji Moteki , Takayuki Kotani
IPC分类号： B32B27/08 , B65D30/08 , B27N5/02
CPC分类号： B32B27/08 , B65D31/02 , Y10T428/1225 , Y10T428/1355 , Y10T428/1359 , Y10T428/1379 , Y10T428/31681 , Y10T428/31692 , Y10T428/31786 , Y10T428/31797
摘要： A laminate film having two olefin type films, a heat resistant film with a vapor deposition coat of aluminum oxide on each surface thereof and a heat adhesion resin layer for joining the olefin type films to the heat resistant film. Instead of the heat resistant film and the heat adhesion resin layer, an oriented film of ethylene-vinyl alcohol copolymer resin layer and a co-extrusion resin layer including a heat adhesion resin layer and an olefin type resin layer may be used. The heat adhesion resin layer is maintained in a heating state for a predetermined time when the laminate film is manufactured.
摘要翻译：具有两个烯烃型膜的层压膜，在其表面上具有氧化铝气相沉积涂层的耐热膜和用于将烯烃类膜粘合到耐热膜上的热粘合树脂层。可以使用乙烯 - 乙烯醇共聚物树脂层和包含热粘树脂层和烯烃类树脂层的共挤出树脂层的取向膜代替耐热膜和热粘合性树脂层。当制造层压膜时，热粘合树脂层保持加热状态一段预定时间。

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