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1. 发明申请

US20070053939A1 Biguanide drug-containing jelly preparation 审中-公开
标题翻译：双胍药物含果冻制剂
公开(公告)号：US20070053939A1
公开(公告)日：2007-03-08
申请号：US10576209
申请日：2004-10-15
申请人： Hideakira Yokoyama , Akihiko Hirata , Hidetoshi Hamamoto , Masaki Ishibashi , Keiko Yamasaki , Takeru Fujii
发明人： Hideakira Yokoyama , Akihiko Hirata , Hidetoshi Hamamoto , Masaki Ishibashi , Keiko Yamasaki , Takeru Fujii
IPC分类号： A61K31/155 , A61K9/00
CPC分类号： A61K47/02 , A61K9/0056 , A61K31/155 , A61K47/36
摘要： The invention provides a biguanide drug-containing jelly preparation of which discomfort upon administration is decreased by the control of its harshness or bitterness. In addition, the preparation has stability and excellent ability for releasing a drug in the digestive tract. The biguanide drug-containing jelly preparation of the invention is characterized by comprising a biguanide drug, an inorganic acid, and a water-soluble polymer. The jelly preparation of the invention is excellent in both stability and ability for releasing a drug, which are usually incompatible characters, particularly by the action of the inorganic acid.
摘要翻译：本发明提供了一种含双胍类药物的果冻制剂，其通过控制其粗糙度或苦味来降低给药后的不适。另外，该制剂具有在消化道中释放药物的稳定性和极好的能力。本发明的双胍药物凝胶制剂的特征在于包含双胍药物，无机酸和水溶性聚合物。本发明的果冻制剂在稳定性和释放药物的能力方面都是优异的，这通常是不相容的特征，特别是通过无机酸的作用。

2. 发明授权

US06827939B2 Peptide having an affinity for gp120 失效
标题翻译：对gp120具有亲和力的肽
公开(公告)号：US06827939B2
公开(公告)日：2004-12-07
申请号：US09757655
申请日：2001-01-11
申请人： Takeru Fujii , Hideakira Yokoyama , Hidetoshi Hamamoto
发明人： Takeru Fujii , Hideakira Yokoyama , Hidetoshi Hamamoto
IPC分类号： A61K3912
CPC分类号： C07K7/06 , A61K38/00 , C07K14/005 , C12N2740/16122
摘要： The peptide in this invention is a peptide having affinity to gp120 represented by H-A1-A2-A3-A4-A5-R (SEQ ID No. 1) Formula (1) (in the formula, H means hydrogen, A1 is aspartic acid, lysine, valine, glutamic acid, glycine, asparagine, or tyrosine residue, A2 is valine, aspartic acid, tryptophan, lysine, phenylalanine, isoleucine, leucine, or tyrosine residue, A3 is lysine, valine, aspartic acid, arginine, alanine, or tryptophan residue, A4 is alanine, tryptophan, or glycine residue, A5 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, methionine, asparagine, glutamine, histidine, lysine, arginine, phenylalanine, tryptophan, proline, or tyrosine residue, R is OH derived from carboxyl group or NH2 derived from acid amide group).
摘要翻译：本发明中的肽是对gp120具有亲和性的肽（式中，H表示氢，A1为天冬氨酸，赖氨酸，缬氨酸，谷氨酸，甘氨酸，天冬酰胺或酪氨酸残基，A2为缬氨酸，天冬氨酸， A3是赖氨酸，缬氨酸，天冬氨酸，精氨酸，丙氨酸或色氨酸残基，A4是丙氨酸，色氨酸或甘氨酸残基，A5是甘氨酸，丙氨酸，缬氨酸，亮氨酸，异亮氨酸，丝氨酸，苏氨酸，甲硫氨酸，天冬酰胺，谷氨酰胺，组氨酸，赖氨酸，精氨酸，苯丙氨酸，色氨酸，脯氨酸或酪氨酸残基，R是衍生自羧基的OH或衍生自酰胺基的NH2）。

3. 发明授权

US08323693B2 External preparation for wounds 失效
标题翻译：伤口的外部准备
公开(公告)号：US08323693B2
公开(公告)日：2012-12-04
申请号：US10507522
申请日：2003-03-12
申请人： Hidetoshi Hamamoto , Keiko Yamasaki , Hideakira Yokoyama , Akihiko Hirata , Takeru Fujii
发明人： Hidetoshi Hamamoto , Keiko Yamasaki , Hideakira Yokoyama , Akihiko Hirata , Takeru Fujii
IPC分类号： A61K9/14
CPC分类号： A61L26/008 , A61L15/60 , A61L26/0014 , A61L26/0066 , A61L2300/106 , A61L2300/404 , C08L33/02
摘要： There is provided an external preparation for wounds which has novel usability in treating skin damages accompanied by a large amount of exudation such as bedsores, skin ulcers, and burns, and yet has such advantages as observed in conventional medicines having been employed in treating these wounds. The external preparation for wounds comprises a water-soluble polymer and a crosslinking agent, and has powdery/granular or ointment form. After absorbing an exudation, the preparation undergoes phase transition from a sol to a gel by the action of ingredient of the preparation, and thus exhibits actions of adsorbing and eliminating necrotic tissues, and protecting the wounded parts. Subsequently, it can continuously absorb the exudation. After being used, it can be easily separated substantially as a mass, thereby exhibiting high therapeutic effects and usability.
摘要翻译：本发明提供了一种伤口外用制剂，其在治疗伴有大量渗出物如褥疮，皮肤溃疡和烧伤的皮肤损伤方面具有新颖的可用性，但具有在用于治疗这些伤口的常规药物中观察到的优点。用于伤口的外用制剂包括水溶性聚合物和交联剂，并且具有粉末/颗粒或软膏形式。在吸收渗出物后，制剂通过制剂成分的作用从溶胶到凝胶发生相变，从而显示出吸附和消除坏死组织并保护受伤部位的作用。随后，它可以连续吸收渗出物。使用后，可以容易地分散为质量，从而表现出高的治疗效果和可用性。

4. 发明申请

US20050118269A1 External preparation for wounds 失效
标题翻译：伤口的外部准备
公开(公告)号：US20050118269A1
公开(公告)日：2005-06-02
申请号：US10507522
申请日：2003-03-12
申请人： Hidetoshi Hamamoto , Keiko Yamasaki , Hideakira Yokoyama , Akihiro Hirata , Takeru Fujii
发明人： Hidetoshi Hamamoto , Keiko Yamasaki , Hideakira Yokoyama , Akihiro Hirata , Takeru Fujii
IPC分类号： A61L15/60 , A61L26/00 , A61K9/14
CPC分类号： A61L26/008 , A61L15/60 , A61L26/0014 , A61L26/0066 , A61L2300/106 , A61L2300/404 , C08L33/02
摘要： There is provided an external preparation for wounds which has novel usability in treating skin damages accompanied by a large amount of exudation such as bedsores, skin ulcers, and burns, and yet has such advantages as observed in conventional medicines having been employed in treating these wounds. The external preparation for wounds comprises a water-soluble polymer and a crosslinking agent, and has powdery/granular or ointment form. After absorbing an exudation, the preparation undergoes phase transition from a sol to a gel by the action of ingredient of the preparation, and thus exhibits actions of adsorbing and eliminating necrotic tissues, and protecting the wounded parts. Subsequently, it can continuously absorb the exudation. After being used, it can be easily separated substantially as a mass, thereby exhibiting high therapeutic effects and usability.
摘要翻译：本发明提供了一种伤口外用制剂，其在治疗伴有大量渗出物如褥疮，皮肤溃疡和烧伤的皮肤损伤方面具有新颖的可用性，但具有在用于治疗这些伤口的常规药物中观察到的优点。用于伤口的外用制剂包括水溶性聚合物和交联剂，并且具有粉末/颗粒或软膏形式。在吸收渗出物后，制剂通过制剂成分的作用从溶胶到凝胶发生相变，从而显示出吸附和消除坏死组织并保护受伤部位的作用。随后，它可以连续吸收渗出物。使用后，可以容易地分散为质量，从而表现出高的治疗效果和可用性。

5. 发明申请

US20050004040A1 Peptide having an affinity for gp120 失效
标题翻译：对gp120具有亲和力的肽
公开(公告)号：US20050004040A1
公开(公告)日：2005-01-06
申请号：US10909310
申请日：2004-08-03
申请人： Takeru Fujii , Hideakira Yokoyama , Hidetoshi Hamamoto
发明人： Takeru Fujii , Hideakira Yokoyama , Hidetoshi Hamamoto
IPC分类号： A61K39/12 , A61K38/00 , A61P31/18 , C07K7/00 , C07K7/06 , C07K14/16 , G01N33/569 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00 , C07K14/005 , C12N2740/16122
摘要： The peptide in this invention is a peptide having affinity to gp120 represented by Formula (1): H-A1-A2-A3-A4-A5-R (in the formula, H means hydrogen, A1 is aspartic acid, lysine, valine, glutamic acid, glycine, asparagine, or tyrosine residue, A2 is valine, aspartic acid, tryptophan, lysine, phenylalanine, isoleucine, leucine, or tyrosine residue, A3 is lysine, valine, aspartic acid, arginine, alanine, or tryptophan residue, A4 is alanine, tryptophan, or glycine residue, A5 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, methionine, asparagine, glutamine, histidine, lysine, arginine, phenylalanine, tryptophan, proline, or tyrosine residue, R is OH derived from carboxyl group or NH2 derived from acid amide group). The above peptide has an affinity to gp120 of the HIV envelope protein and is superior in stability.
摘要翻译：本发明的肽是与式（1）表示的gp120具有亲和性的肽：H-A1-A2-A3-A4-A5-R（式中，H表示氢，A1为天冬氨酸，赖氨酸，缬氨酸，谷氨酸，甘氨酸，天冬酰胺或酪氨酸残基，A2是缬氨酸，天冬氨酸，色氨酸，赖氨酸，苯丙氨酸，异亮氨酸，亮氨酸或酪氨酸残基，A3是赖氨酸，缬氨酸，天冬氨酸，精氨酸，丙氨酸或色氨酸残基，A4 是丙氨酸，色氨酸或甘氨酸残基，A5是甘氨酸，丙氨酸，缬氨酸，亮氨酸，异亮氨酸，丝氨酸，苏氨酸，甲硫氨酸，天冬酰胺，谷氨酰胺，组氨酸，赖氨酸，精氨酸，苯丙氨酸，色氨酸，脯氨酸或酪氨酸残基，衍生自羧基或衍生自酰胺基团的NH 2）。上述肽对HIV包膜蛋白的gp120具有亲和力，并且稳定性优异。

6. 发明授权

US6060254A Reagent for examining agglutination of virus and kit for virus examination 失效
标题翻译：用于检查病毒凝集的试剂和用于病毒检查的试剂盒
公开(公告)号：US6060254A
公开(公告)日：2000-05-09
申请号：US011748
申请日：1998-04-21
申请人： Takeru Fujii , Hideakira Yokoyama , Hidetoshi Hamamoto
发明人： Takeru Fujii , Hideakira Yokoyama , Hidetoshi Hamamoto
IPC分类号： C12Q1/70 , G01N33/569 , G01N33/576 , G01N33/53 , C07K1/00 , C07K16/00 , C12P21/08
CPC分类号： G01N33/56988 , G01N33/5767 , Y10S435/81 , Y10S530/81 , Y10S977/802 , Y10S977/92 , Y10S977/959
摘要： A viral agglutination test agent and a virus test kit containing the agent, which can directly and sensitively detect viruses in blood without using the anti-viral antibody formed in the blood of patients with viral infections.
摘要翻译： PCT No.PCT / JP96 / 02304 Sec。 371日期：1998年4月21日 102（e）日期1998年4月21日PCT 1996年8月16日PCT公布。公开号WO97 / 07400 日期1997年2月27日一种病毒凝集试验剂和含有该试剂的病毒试验试剂盒，其可以直接且灵敏地检测血液中的病毒，而不使用病毒感染患者血液中形成的抗病毒抗体。

7. 发明授权

US07291337B2 Peptide having an affinity for gp120 失效
标题翻译：对gp120具有亲和力的肽
公开(公告)号：US07291337B2
公开(公告)日：2007-11-06
申请号：US10909310
申请日：2004-08-03
申请人： Takeru Fujii , Hideakira Yokoyama , Hidetoshi Hamamoto
发明人： Takeru Fujii , Hideakira Yokoyama , Hidetoshi Hamamoto
IPC分类号： A61K39/15
CPC分类号： C07K7/06 , A61K38/00 , C07K14/005 , C12N2740/16122
摘要： The peptide in this invention is a peptide having affinity to gp120 represented by Formula (1): H-A1-A2-A3-A4-A5-R(SEQ ID No. 1) (in the formula, H means hydrogen, A1 is aspartic acid, lysine, valine, glutamic acid, glycine, asparagine, or tyrosine residue, A2 is valine, aspartic acid, tryptophan, lysine, phenylalanine, isoleucine, leucine, or tyrosine residue, A3 is lysine, valine, aspartic acid, arginine, alanine, or tryptophan residue, A4 is alanine, tryptophan, or glycine residue, A5 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, methionine, asparagine, glutamine, histidine, lysine, arginine, phenylalanine, tryptophan, proline, or tyrosine residue, R is OH derived from carboxyl group or NH2 derived from acid amide group). The above peptide has an affinity to gp120 of the HIV envelope protein and is superior in stability.
摘要翻译：本发明中的肽是对由式（1）表示的gp120具有亲和性的肽：H-A1-A2-A3-A4-A5-R（SEQ ID No.1）（式中，H表示氢，A1为天冬氨酸，赖氨酸，缬氨酸，谷氨酸，甘氨酸，天冬酰胺或酪氨酸残基，A2是缬氨酸，天冬氨酸，色氨酸，赖氨酸，苯丙氨酸，异亮氨酸，亮氨酸或酪氨酸残基，A3是赖氨酸，缬氨酸，天冬氨酸，精氨酸，丙氨酸或色氨酸残基，A4是丙氨酸，色氨酸或甘氨酸残基，A5是甘氨酸，丙氨酸，缬氨酸，亮氨酸，异亮氨酸，丝氨酸，苏氨酸，甲硫氨酸，天冬酰胺，谷氨酰胺，组氨酸，赖氨酸，精氨酸，苯丙氨酸，色氨酸，或酪氨酸残基，R为衍生自酰胺基团的羧基或NH 2的OH）。上述肽对HIV包膜蛋白的gp120具有亲和力，并且稳定性优异。

8. 发明申请

US20050089577A1 Liquid matrix undergoing phase transfer in vivo and liquid oral preparations 审中-公开
标题翻译：液体基质在体内进行相转移和液体口服制剂
公开(公告)号：US20050089577A1
公开(公告)日：2005-04-28
申请号：US10506512
申请日：2003-03-03
申请人： Hideakira Yokoyama , Akihiko Hirata , Hidetoshi Hamamoto , Keiko Yamasaki , Takeru Fujii
发明人： Hideakira Yokoyama , Akihiko Hirata , Hidetoshi Hamamoto , Keiko Yamasaki , Takeru Fujii
IPC分类号： A61K9/00 , A61K31/43 , A61K31/496 , A61K31/545 , A61K31/65 , A61K31/7048 , A61K47/04 , A61K9/14
CPC分类号： A61K9/0095 , A61K31/43 , A61K31/496 , A61K31/545 , A61K31/65 , A61K31/7048
摘要： It is intended to provide a liquid matrix for medicinal use in which medicine can be easily solubilized, dispersed or suspended and which can be easily swallowed because of being liquid, has favorable working properties in sterilization and so on and a high stability, also exhibits an effect of masking bitterness, and gels in vivo so as to control the release speed of the medicine, and liquid oral preparations using the same. Namely, a liquid matrix which is a liquid assistant for facilitating swallowing medicine characterized in comprising a water-soluble polymer gelling under acidic conditions, and the breaking stress of the gel is about 3.00×103 N/m2 or more. Liquid oral preparations have favorable slow release properties even though being a liquid.
摘要翻译：本发明提供一种医药用液体基质，其中药物易于溶解，分散或悬浮，并且由于液体容易吞咽，在消毒等中具有良好的加工性能和高稳定性，还表现出掩蔽苦味的效果和体内凝胶，以控制药物的释放速度，以及使用其的液体口服制剂。即，作为促进吞咽药物的液体助剂的液体基质，其特征在于在酸性条件下含有水溶性聚合物胶凝，凝胶的断裂应力为约3.00×10 3 N / SUP> 2以上。液体口服制剂即使是液体也具有良好的缓释特性。

9. 发明授权

US07235257B1 Drugs for relieving hemicrania comprising 1-menthol and essential oils 有权
标题翻译：用于缓解含有1-薄荷醇和精油的血红素的药物
公开(公告)号：US07235257B1
公开(公告)日：2007-06-26
申请号：US09890552
申请日：1999-12-14
申请人： Hideakira Yokoyama , Hidetoshi Hamamoto
发明人： Hideakira Yokoyama , Hidetoshi Hamamoto
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61K9/7061 , A61K9/06 , A61K31/045 , Y10S514/947 , Y10S514/953
摘要： This invention relates to external drugs for dermal application which have a migraine-alleviating effect, in more detail ointments and patches comprising in mixing l-menthol and an essential oil into a base containing a hydrophilic high-molecular weight compound, a polyhydric alcohol and water.
摘要翻译：本发明涉及具有偏头痛减轻作用的皮肤外用药物，更详细地涉及将1-薄荷醇和精油混合到含有亲水性高分子量化合物，多元醇和水的基质中的软膏和贴剂。

10. 发明授权

US09750924B2 Adhesive patching aid for microneedle adhesive skin patch 有权
公开(公告)号：US09750924B2
公开(公告)日：2017-09-05
申请号：US13574496
申请日：2011-01-20
申请人： Katsunori Kobayashi , Hidetoshi Hamamoto
发明人： Katsunori Kobayashi , Hidetoshi Hamamoto
IPC分类号： A61M5/32 , A61M37/00 , A61M25/02
CPC分类号： A61M37/0015 , A61M2025/0253 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： The invention provides an applicator that holds a microneedle to facilitate puncture of the skin and includes an assisting tool as a supporting base to set the microneedle and an adhesive sheet such as a tape and the like, on the side face of the assisting tool to enable close adhesion of the microneedle puncturing the skin.

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