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1. 发明授权

US4740534A Surgical adhesive 失效
标题翻译：手术胶
公开(公告)号：US4740534A
公开(公告)日：1988-04-26
申请号：US898710
申请日：1986-08-21
申请人： Takehisa Matsuda , Hiroo Iwata , Tetsuo Itoh
发明人： Takehisa Matsuda , Hiroo Iwata , Tetsuo Itoh
IPC分类号： A61L24/04 , A61L27/18 , C08G18/10 , C09J175/08
CPC分类号： C09J175/08 , A61L24/046 , A61L27/18 , C08G18/10 , Y10S528/904
摘要： Elastomeric or flexible surgical adhesives, comprising [A] NCO-terminated hydrophilic urethane prepolymer derived from hydrophilic polyether polyol of higher oxyethylene content, or combination of [A] with [B] unsaturated cyano compound containing cyano group attached to a carbon atom constituting the polymerizable double bond, are used for bonding of tissues, with rapid cure rate and sufficient bonding power.
摘要翻译：弹性体或柔性手术粘合剂，包含衍生自具有较高氧化乙烯含量的亲水性聚醚多元醇的[A] NCO封端的亲水性氨基甲酸酯预聚物，或[A]与[B]含氰基的不饱和氰基化合物的组合，双键，用于粘合组织，具有快速固化速度和足够的粘合力。

2. 发明授权

US4806614A Surgical adhesive 失效
标题翻译：手术胶
公开(公告)号：US4806614A
公开(公告)日：1989-02-21
申请号：US124259
申请日：1987-11-23
申请人： Takehisa Matsuda , Hiroo Iwata , Tetsuo Itoh
发明人： Takehisa Matsuda , Hiroo Iwata , Tetsuo Itoh
IPC分类号： A61L24/04 , A61L27/18 , C08G18/10 , C09J175/08 , C08G75/00
CPC分类号： C09J175/08 , A61L24/046 , A61L27/18 , C08G18/10 , Y10S528/904
摘要： Elastomeric or flexible surgical adhesives, comprising [A] NCO-terminated hydrophilic urethane prepolymer derived from hydrophilic polyether polyol of higher oxyethylene content, or combination of [A] with [B] unsaturated cyano compound containing cyano group attached to a carbon atom constituting the polymerizable double bond, are used for bonding of tissues, with rapid cure rate and sufficient bonding power.
摘要翻译：弹性体或柔性手术粘合剂，包含衍生自具有较高氧化乙烯含量的亲水性聚醚多元醇的[A] NCO封端的亲水性氨基甲酸酯预聚物，或[A]与[B]含氰基的不饱和氰基化合物的组合，双键，用于粘合组织，具有快速固化速度和足够的粘合力。

3. 发明授权

US4944746A Method of and apparatus for separating a balloon in a balloon catheter 失效
标题翻译：球囊导管中球囊分离方法及装置
公开(公告)号：US4944746A
公开(公告)日：1990-07-31
申请号：US322923
申请日：1989-03-14
申请人： Hiroo Iwata , Sen Yamagata , Waro Taki , Takehisa Matsuda , Haruhiko Kikuchi , Yasuhiro Yonekawa , Yasuhiro Goto
发明人： Hiroo Iwata , Sen Yamagata , Waro Taki , Takehisa Matsuda , Haruhiko Kikuchi , Yasuhiro Yonekawa , Yasuhiro Goto
IPC分类号： A61M25/00 , A61B17/12
CPC分类号： A61B17/12109 , A61B17/12136 , A61M2025/1054
摘要： An apparatus for separating a balloon from a catheter member of a balloon is capable of melting and breaking a heat-meltable connecting member through which the balloon is connected to the catheter body by causing an electric current to flow between at least a pair of electrodes arranged on or in the vicinity of the connecting member. The apparatus has impedance measuring means for measuring the impedance of an electrode circuit including a pair of electrodes and lead lines connected to the electrodes, and judging means for comparing the measured value of the impedance with a predetermined reference range and capable of producing an abnormal signal when the measured value of the impedance does not fall within the predetermined reference range. The apparatus enables the operator to judge whether the electrode circuit is in safe condition, before changing the balloon with a settable liquid and to charge a settable liquid into the balloon only when the safe condition of the electrode circuit is confirmed, so that the balloon after the setting of the liquid can be separated from the catheter body without fail, thus eliminating any risk for the catheter body to dangerously remain in the living body.
摘要翻译：用于从球囊的导管构件分离球囊的装置能够熔化和破坏可热熔连接构件，气球通过该热连接构件连接到导管主体，通过使电流在布置的至少一对电极之间流动在连接构件上或附近。该装置具有用于测量电极电路的阻抗的阻抗测量装置，该电极电路包括一对连接到电极的电极和引线，以及判断装置，用于将阻抗的测量值与预定的参考范围进行比较，并且能够产生异常信号当阻抗的测量值不在预定参考范围内时。该设备使得操作者能够在电极回路处于安全状态之前，在用可固化液体改变球囊之前，仅在电极回路的安全状态被确认之后才将可固定液体充入球囊中，液体的设置可以不导通地与导管体分离，从而消除导管体危险地残留在生物体中的任何风险。

4. 发明授权

US5173301A Surgical adhesive 失效
标题翻译：手术粘合剂
公开(公告)号：US5173301A
公开(公告)日：1992-12-22
申请号：US799322
申请日：1991-11-27
申请人： Tetsuo Itoh , Takehisa Matsuda
发明人： Tetsuo Itoh , Takehisa Matsuda
IPC分类号： A61L24/00 , A61L24/04 , C08G18/10 , C08G18/12 , C08G18/40 , C08G18/42 , C08G18/46 , C08G18/77 , C09J175/00 , C09J175/06 , C09J175/08
CPC分类号： C09J175/06 , A61L24/046 , C08G18/10 , C08G18/12 , C08G18/4018 , C08G18/42 , C08G18/425 , C08G18/4252 , C08G18/4607 , C08G18/773 , Y10S528/904 , Y10S528/905
摘要： Surgical adhesives, comprising an NCO-terminated hydrophilic urethane prepolymer derived from an organic polyisocyanate and a polyol component comprising a polyester polyol derived from an electron-attracting group-containing dicarboxylic acid, such as 2-ketoglutaric acid, are capable of being easily hydrolyzed within a living body after a certain period of time.

5. 发明授权

US4994542A Surgical adhesive 失效
标题翻译：手术胶
公开(公告)号：US4994542A
公开(公告)日：1991-02-19
申请号：US320054
申请日：1989-03-07
申请人： Takehisa Matsuda , Teruo Takakura , Tetsuo Itoh
发明人： Takehisa Matsuda , Teruo Takakura , Tetsuo Itoh
IPC分类号： A61B17/00 , A61L24/00 , C08F283/00 , C08G18/10 , C08G18/48 , C08G18/66 , C08G18/77 , C09J175/08
CPC分类号： C09J175/08 , A61L24/0073 , C08F283/00 , C08G18/10 , C08G18/4833 , C08G18/4837 , C08G18/6674 , C08G18/773 , Y10S528/904
摘要： Elastomeric or flexible surgical adhesives, comprising (i) a NCO-terminated hydrophilic urethane prepolymer derived from a fluorine-containing polyisocyanate and a hydrophilic polyether polyol of higher oxyethylene content, or a combinatioin of (i) with (ii) an unsaturated cyano compound containing a cyano group directly bonded to a polymerizable double bond, exhibit low toxicity, may be safely used for bonding of tissues and possess a rapid cure rate and sufficient bonding power.

6. 发明授权

US5486547A Surgical adhesive sheet, surgical instruments and methods of using the same 失效
公开(公告)号：US5486547A
公开(公告)日：1996-01-23
申请号：US335341
申请日：1994-11-03
申请人： Takehisa Matsuda , Tetsuo Itoh , Tohru Tani
发明人： Takehisa Matsuda , Tetsuo Itoh , Tohru Tani
IPC分类号： A61B17/00 , A61B17/11 , A61F2/00 , A61F2/06 , A61F13/00 , A61F13/02 , A61F13/15 , A61F13/20 , A61F13/36 , A61L31/10 , A61L15/26 , C08L75/04 , C08L75/08
CPC分类号： A61F2/06 , A61B17/00491 , A61B17/11 , A61F13/00012 , A61F13/0209 , A61F13/0226 , A61L31/10 , A61B17/1114 , A61B2017/1107 , A61B2017/1125 , A61F13/023 , A61F13/0273 , A61F13/15252 , A61F13/551 , A61F2/0063 , A61F2013/00463 , A61F2013/00472 , A61F2013/00489 , A61F2013/00519 , A61F2013/00604 , A61F2013/00659 , A61F2013/00719 , A61F2013/0091 , A61F2013/00927 , Y10S528/905 , Y10T428/31554 , Y10T428/31562 , Y10T428/31576 , Y10T428/3158 , Y10T428/31587 , Y10T428/31591 , Y10T428/31598
摘要： A sheet material, coated with a surgical adhesive comprising an NCO-terminated urethane prepolymer, is used for bonding of tissues, with improved handleability.Surgical instruments, comprising a non-adherent material towards an NCO-terminated urethane prepolymer, are used for application of surgical adhesive. Such instruments, comprising a rod tapered so that the tip can be partly inserted into blood vessel, are suitable for anastomosis of blood vessel.

7. 发明授权

US5457141A Surgical adhesive sheet, surgical instruments and methods of using the same 失效
标题翻译：手术胶片，手术器械及使用方法
公开(公告)号：US5457141A
公开(公告)日：1995-10-10
申请号：US127477
申请日：1993-09-28
申请人： Takehisa Matsuda , Tetsuo Itoh , Tohru Tani
发明人： Takehisa Matsuda , Tetsuo Itoh , Tohru Tani
IPC分类号： A61B17/00 , A61B17/11 , A61F2/00 , A61F2/06 , A61F13/00 , A61F13/02 , A61F13/15 , A61F13/20 , A61F13/36 , A61L31/10 , C08G18/06
CPC分类号： A61F2/06 , A61B17/00491 , A61B17/11 , A61F13/00012 , A61F13/0209 , A61F13/0226 , A61L31/10 , A61B17/1114 , A61B2017/1107 , A61B2017/1125 , A61F13/023 , A61F13/0273 , A61F13/15252 , A61F13/551 , A61F2/0063 , A61F2013/00463 , A61F2013/00472 , A61F2013/00489 , A61F2013/00519 , A61F2013/00604 , A61F2013/00659 , A61F2013/00719 , A61F2013/0091 , A61F2013/00927 , Y10S528/905 , Y10T428/31554 , Y10T428/31562 , Y10T428/31576 , Y10T428/3158 , Y10T428/31587 , Y10T428/31591 , Y10T428/31598
摘要： A sheet material, coated with a surgical adhesive comprising an NCO-terminated urethane prepolymer, is used for bonding of tissues, with improved handleability.Surgical instruments, comprising a non-adherent material towards an NCO-terminated urethane prepolymer, are used for application of surgical adhesive. Such instruments, comprising a rod tapered so that the tip can be partly inserted into blood vessel, are suitable for anastomosis of blood vessel.
摘要翻译：用包含NCO封端的氨基甲酸酯预聚物的手术粘合剂涂覆的片材用于粘合组织，具有改进的可操作性。用于外用粘合剂的外科手术器械包括朝向NCO封端的氨基甲酸酯预聚物的非粘着材料。这种仪器包括一个锥形的杆，使得尖端部分地插入血管中，适用于血管的吻合。

8. 发明申请

US20050131192A1 Polymer and process for producing polymer 审中-公开
标题翻译：聚合物和生产聚合物的方法
公开(公告)号：US20050131192A1
公开(公告)日：2005-06-16
申请号：US10499331
申请日：2002-10-30
申请人： Takehisa Matsuda , Tetsuo Itoh , Tatsuya Ohsumi
发明人： Takehisa Matsuda , Tetsuo Itoh , Tatsuya Ohsumi
IPC分类号： A61L24/04 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/77 , C08L71/02 , C09J175/04 , C08G18/00
CPC分类号： C09J175/04 , A61L24/04 , A61L24/046 , C08G18/10 , C08G18/4837 , C08G18/5015 , C08G18/5021 , C08G18/5072 , C08G18/773 , C08L71/02 , C08L75/04 , C08G18/302
摘要： The object of the present invention is to provide a polymer best suited for use as a medical adhesive excellent in wet adhesion strength (water-resistant adhesive strength). In the present invention, a polymer capable of forming a cured film and useful as a medical adhesive, which has a viscosity at 37° C. of 0.5 to 2,000 Pa·s and shows a saturated water absorption of 0.2 to 5 ml/g, is used. The above-mentioned polymer preferably shows an initial water absorption rate of 0.01 to 0.5 ml/g·min, the wet elongation percentage of the cured film is preferably 100 to 1,500%, and the wet 100% modulus of the cured film is preferably 0.01 to 10 MPa. Additionally, it is preferable that the above-mentioned polymer contains oxyethylene groups and in which the oxyethylene group content is 30 to 100% by weight based on the weight of the polymer.
摘要翻译：本发明的目的是提供一种最适合用作湿粘合强度（耐水粘合强度）优异的医用粘合剂的聚合物。在本发明中，能够形成固化膜并用作医用粘合剂的聚合物在37℃下的粘度为0.5〜2,000Pa·s，饱和吸水倍数为0.2〜5ml / g，用来。上述聚合物优选初始吸水率为0.01〜0.5ml / g·min，固化膜的湿延伸率优选为100〜1500％，固化膜的湿100％模量优选为0.01 至10MPa。此外，上述聚合物优选含有氧化乙烯基，其中氧乙烯基含量相对于聚合物的重量为30〜100重量％。

9. 发明授权

US5763504A Photcurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof 失效
标题翻译：光电性糖胺聚糖衍生物，交联糖胺聚糖及其生产方法
公开(公告)号：US5763504A
公开(公告)日：1998-06-09
申请号：US476236
申请日：1995-06-07
申请人： Takehisa Matsuda , Minoo J. Moghaddam , Katsukiyo Sakurai
发明人： Takehisa Matsuda , Minoo J. Moghaddam , Katsukiyo Sakurai
IPC分类号： A61K47/36 , A61K31/715 , A61K31/726 , A61K31/727 , A61K31/737 , A61K47/48 , A61L27/00 , A61L27/20 , A61L31/04 , A61L33/00 , A61L33/08 , A61L33/10 , A61P43/00 , C08B37/00 , C08B37/08 , C08B37/10 , C08F251/00 , C08L5/00 , C08L5/08 , C08L5/10 , C08L51/02 , C08G64/00 , A61K9/50 , C08G69/08 , C08G73/10
CPC分类号： B82Y5/00 , A61K47/48961 , A61L27/20 , A61L31/042 , A61L33/08 , C08B37/0063
摘要： Photocurable glycosaminoglycan (GAG) derivatives and crosslinked glycosaminoglycans, which are highly safe and biocompatible, a method of preparing such photocurable GAG derivatives readily moldable by casting using a solvent when desired, by which method unreacted substances causative of adverse effects can be readily eliminated, and a method of producing the crosslinked GAGs and medical materials based on the photocurable GAG derivatives or crosslinked GAGs are provided. The photocurable GAG derivatives comprise a glycosaminoglycan and a photoreactive compound bound thereto and can be produced, for example, by subjecting hydroxyl or carboxyl groups of the glycosaminoglycan to esterification reaction or amidation reaction, respectively, with the photoreactive compound. The crosslinked GAGs are derived from the photocurable GAG derivatives by intermolecular crosslinking of the photoreactive compound bound thereto.
摘要翻译：可光固化的糖胺聚糖（GAG）衍生物和交联的糖胺聚糖，其是高度安全和生物相容的，制备这种可光固化的GAG衍生物的方法，其易于通过在需要时使用溶剂浇铸而成型，由此可以容易地消除引起不利影响的未反应物质，以及提供了基于可光固化的GAG衍生物或交联的GAG生产交联的GAG和医疗材料的方法。可光固化的GAG衍生物包含糖胺聚糖和结合到其上的光反应性化合物，并且可以例如通过使糖胺聚糖的羟基或羧基与光反应性化合物分别进行酯化反应或酰胺化反应来制备。交联的GAG通过与其结合的光反应性化合物的分子间交联衍生自可光固化的GAG衍生物。

10. 发明授权

US5192301A Closing plug of a defect for medical use and a closing plug device utilizing it 失效
标题翻译：关闭医疗用途的缺陷和使用其的闭合插管装置
公开(公告)号：US5192301A
公开(公告)日：1993-03-09
申请号：US754163
申请日：1991-09-03
申请人： Tetsuro Kamiya , Shigeyuki Echigo , Takehisa Matsuda , Ryuichiro Yoda , Nobuko Satoh
发明人： Tetsuro Kamiya , Shigeyuki Echigo , Takehisa Matsuda , Ryuichiro Yoda , Nobuko Satoh
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/00 , A61F2/01
CPC分类号： A61B17/0057 , A61B2017/00579 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B90/39 , A61F2002/3008 , A61F2250/0098
摘要： The closing plug and the closing plug device are used for closing a body defect percutaneously. During the insertion into the defect, the closing plug can be deformed to a smaller size to facilitate the insertion operation and recovered to its original larger shape after it is fitted to the defect, to thereby close the defect. The closing plug device facilitates the insertion of the closing plug into the defect. The closing plug has a flange or an enlarged portion at least at one end thereof and is made of a shape memory polymer having a shape recovery temperature in the range of 20.degree. C. to 70.degree. C. The closing plug device comprises a closing plug, a catheter and a guide wire or a pushing wire to aid in insertion of the closing plug to a defect.
摘要翻译：关闭塞子和闭塞装置用于经皮闭合身体缺陷。在插入缺陷期间，封闭塞可以变形为更小的尺寸以便于插入操作，并且在闭合塞被装配到缺陷之后恢复到其原始较大的形状，从而闭合缺陷。闭合塞装置便于将闭塞塞插入到缺陷中。封闭塞至少在其一端具有凸缘或扩大部分，并且由形状恢复温度在20℃至70℃范围内的形状记忆聚合物制成。封闭塞装置包括封闭塞，导管和引导线或推动线，以帮助将闭塞塞插入缺陷。

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