专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07153972B2 Benzimidazole derivatives, their production and use 失效
标题翻译：苯并咪唑衍生物，其生产和使用
公开(公告)号：US07153972B2
公开(公告)日：2006-12-26
申请号：US10991861
申请日：2004-11-19
申请人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
发明人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
IPC分类号： C07D257/04
CPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/04 , C07D403/10 , C07D405/14
摘要： A method for producing a compound represented by the formula: wherein the ring A is a benzene ring which may be substituted in addition to the R′ group; R1 is hydrogen or an optionally substituted hydrocarbon residue; X is a direct bond or a spacer having an atomic length or two or less between the phenylene group and the phenyl group; Y is —O—, —S(O)m- or —N(R4)— wherein m is an integer of 0, 1 or 2 and R4 is hydrogen or an optionally substituted alkyl group; R′ is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or a group convertible thereinto; n is an integer of 1 or 2; or a salt thereof, which comprises deprotecting a compound represented by the formula: wherein R is triphenylmethyl, 2-tetrahydropyranyl, methoxymethyl or ethoxy methyl, the other symbols as defined above; or a salt thereof.
摘要翻译：一种制备由下式表示的化合物的方法：其中环A是除R'基之外可被取代的苯环; R 1是氢或任选取代的烃残基; X是在亚苯基和苯基之间具有原子长度或者两个或更少的直接键或间隔子; Y是-O - ， - S（O）m - 或-N（R 4） - ，其中m是0,1或2的整数，R 4是氢或任选取代的烷基; R'是羧基，其酯，其酰胺或能够形成阴离子的基团或可转化的基团; n为1或2的整数; 其包括使由下式表示的化合物脱保护：其中R是三苯甲基，2-四氢吡喃基，甲氧基甲基或乙氧基甲基，其它符号如上定义; 或其盐。

2. 发明申请

US20050131039A1 Benzimidazole derivatives, their production and use 失效
标题翻译：苯并咪唑衍生物，其生产和使用
公开(公告)号：US20050131039A1
公开(公告)日：2005-06-16
申请号：US10991861
申请日：2004-11-19
申请人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
发明人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
IPC分类号： A61P9/12 , C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/10 , A61K31/4184 , C07D43/02
CPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/04 , C07D403/10 , C07D405/14
摘要： A method for producing a compound represented by the formula: wherein the ring A is a benzene ring which may be substituted in addition to the R′ group; R1 is hydrogen or an optionally substituted hydrocarbon residue; X is a direct bond or a spacer having an atomic length or two or less between the phenylene group and the phenyl group; Y is —O—, —S(O)m- or —N(R4)— wherein m is an integer of 0, 1 or 2 and R4 is hydrogen or an optionally substituted alkyl group; R′ is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or a group convertible thereinto; n is an integer of 1 or 2; or a salt thereof, which comprises deprotecting a compound represented by the formula: wherein R is triphenylmethyl, 2-tetrahydropyranyl, methoxymethyl or ethoxy methyl, the other symbols as defined above; or a salt thereof.
摘要翻译：一种制备由下式表示的化合物的方法：其中环A是除R'基之外可被取代的苯环; R 1是氢或任选取代的烃残基; X是在亚苯基和苯基之间具有原子长度或者两个或更少的直接键或间隔子; Y是-O - ， - S（O）m - 或-N（R 4） - ，其中m是0,1或2的整数，R 4是氢或任选取代的烷基; R'是羧基，其酯，其酰胺或能够形成阴离子的基团或可转化的基团; n为1或2的整数; 其包括使由下式表示的化合物脱保护：其中R是三苯甲基，2-四氢吡喃基，甲氧基甲基或乙氧基甲基，其它符号如上定义; 或其盐。

3. 发明授权

US06355808B2 Benzimidazole compounds, their production and use 失效
标题翻译：苯并咪唑化合物，其生产和使用
公开(公告)号：US06355808B2
公开(公告)日：2002-03-12
申请号：US09817231
申请日：2001-03-27
申请人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
发明人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
IPC分类号： A61K314184
CPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/04 , C07D403/10 , C07D405/14
摘要： Benzimidazole derivatives of the formula (I): wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R′ group; R1 is hydrogen or an optionally substituted hydrocarbon residue; R2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R′ is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is —O—, —S(O)m— or —N(R4)— wherein m is an integer of 0, 1 or 2 and R4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin Π antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.
摘要翻译：式（I）的苯并咪唑衍生物：其中环A是可以任选地除R'基团之外的取代基的苯环; R1是氢或任选取代的烃残基; R2是能够形成阴离子或可转换的基团的基团; X是亚苯基和苯基之间的原子长度为2以下的直接键或间隔物; R'是羧基，其酯，其酰胺或能够形成阴离子或可转化成阴离子的基团; Y是-O - ， - S（O）m - 或-N（R4） - ，其中m是0,1或2的整数，R4是氢或任选取代的烷基; n为1或2的整数; 和其药学上可接受的盐具有有效的血管紧张素Π拮抗活性和抗高血压活性，因此可用作治疗循环系统疾病如高血压疾病，心脏病（例如高血压，心力衰竭，心肌梗塞等），中风，脑中风，肾炎等

4. 发明授权

US06232334B1 Benzimidazole derivatives, their production and use 失效
标题翻译：苯并咪唑衍生物，其生产和使用
公开(公告)号：US06232334B1
公开(公告)日：2001-05-15
申请号：US09376494
申请日：1999-08-18
申请人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
发明人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
IPC分类号： A61K314184
CPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/04 , C07D403/10 , C07D405/14
摘要： Benzimidazole derivatives of the formula (I): wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R′ group; R1 is hydrogen or an optionally substituted hydrocarbon residue; R2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R′ is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is —O—, —S(O)m— or —N(R4)— wherein m is an integer of 0, 1 or 2 and R4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases, strokes, cerebral apoplexy and nephritis.
摘要翻译：式（I）的苯并咪唑衍生物：其中环A是可以任选地除R'基团之外的取代基的苯环; R1是氢或任选取代的烃残基; R2是能够形成阴离子或可转换的基团的基团; X是亚苯基和苯基之间的原子长度为2以下的直接键或间隔物; R'是羧基，其酯，其酰胺或能够形成阴离子或可转化成阴离子的基团; Y是-O - ， - S（O）m - 或-N（R4） - ，其中m是0,1或2的整数，R4是氢或任选取代的烷基; n为1或2的整数; 其药学上可接受的盐具有有效的血管紧张素II拮抗活性和抗高血压活性，因此可用作治疗循环系统疾病如高血压疾病，心脏病，中风，脑中风和肾炎的治疗剂。

5. 发明申请

US20070259932A1 Benzimidazole derivatives, their production and use 失效
标题翻译：苯并咪唑衍生物，其生产和使用
公开(公告)号：US20070259932A1
公开(公告)日：2007-11-08
申请号：US11594982
申请日：2006-11-09
申请人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
发明人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
IPC分类号： A61K31/4184 , A61K31/41 , A61P13/12 , A61P9/04 , A61P9/12 , C07D257/04 , C07D403/10
CPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/04 , C07D403/10 , C07D405/14
摘要： Benzimidazole derivatives of the formula (I): wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R′ group; R1 is hydrogen or an optionally substituted hydrocarbon residue; R2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R′ is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is —O—, —S(O)m— or —N(R4)— wherein m is an integer of 0, 1 or 2 and R4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.
摘要翻译：式（I）的苯并咪唑衍生物：其中环A是可以任选地除R'基团之外的取代基的苯环; R 1是氢或任选取代的烃残基; R 2是能够形成阴离子或可转换的基团的基团; X是亚苯基和苯基之间的原子长度为2以下的直接键或间隔物; R'是羧基，其酯，其酰胺或能够形成阴离子或可转化成阴离子的基团; Y是-O - ， - S（O）m - 或-N（R 4） - ，其中m是0,1或2的整数，R 0 > 4是氢或任选取代的烷基; n为1或2的整数; 和其药学上可接受的盐具有有效的血管紧张素II拮抗活性和抗高血压活性，因此可用作治疗循环系统疾病如高血压疾病，心脏病（例如高血压，心力衰竭，心肌梗塞等），中风，脑中风，肾炎等

6. 发明授权

US06844443B2 Benzimidazole derivatives, their production and use 失效
标题翻译：苯并咪唑衍生物，其生产和使用
公开(公告)号：US06844443B2
公开(公告)日：2005-01-18
申请号：US10612984
申请日：2003-07-07
申请人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
发明人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
IPC分类号： A61P9/12 , C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/10 , C07D257/04
CPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/04 , C07D403/10 , C07D405/14
摘要： A method for producing a compound represented by the formula: wherein the ring A is a benzene ring which may be substituted in addition to the R′ group; R1 is hydrogen or an optionally substituted hydrocarbon residue; X is a direct bond or a spacer having an atomic length or two or less between the phenylene group and the phenyl group; Y is —O—, —S(O)m- or —N(R4)— wherein m is an integer of 0, 1 or 2 and R4 is hydrogen or an optionally substituted alkyl group; R′ is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or a group convertible thereinto; n is an integer of 1 or 2; or a salt thereof, which comprises deprotecting a compound represented by the formula: wherein R is triphenylmethyl, 2-tetrahydropyranyl, methoxymethyl or ethoxy methyl, the other symbols as defined above; or a salt thereof.
摘要翻译：一种制备由下式表示的化合物的方法：其中环A是除R'基之外可被取代的苯环; R 1是氢或任选取代的烃残基; X是在亚苯基和苯基之间具有原子长度或者两个或更少的直接键或间隔子; Y是-O - ， - S（O）m - 或-N（R 4） - ，其中m是0,1或2的整数，R 4是氢或任选取代的烷基; R'是羧基，其酯，其酰胺或能够形成阴离子的基团或可转化的基团; n为1或2的整数; 其包括使由下式表示的化合物脱保护：其中R是三苯甲基，2-四氢吡喃基，甲氧基甲基或乙氧基甲基，其它符号如上定义; 或其盐。

7. 发明授权

US5703110A Benzimidazole derivatives, their production and use 失效
标题翻译：苯并咪唑衍生物，其生产和使用
公开(公告)号：US5703110A
公开(公告)日：1997-12-30
申请号：US715100
申请日：1996-09-17
申请人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
发明人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
IPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/10 , A01N43/50 , A61K31/41 , C07D235/12
CPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/10
摘要： Benzimidazole derivatives of the formula (I): ##STR1## wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R.sup.1 is hydrogen or an optionally substituted hydrocarbon residue; R.sup.2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R' is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is --O--, --S(O).sub.m -- or --N(R.sup.4)-- wherein m is an integer of 0, 1 or 2 and R.sup.4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.
摘要翻译：式（I）的苯并咪唑衍生物：其中环A是可以任选地含有取代基的R'基团的苯环; R1是氢或任选取代的烃残基; R2是能够形成阴离子或可转换的基团的基团; X是亚苯基和苯基之间的原子长度为2以下的直接键或间隔物; R'是羧基，其酯，其酰胺或能够形成阴离子或可转化成阴离子的基团; Y是-O - ， - S（O）m - 或-N（R4） - ，其中m是0,1或2的整数，R4是氢或任选取代的烷基; n为1或2的整数; 和其药学上可接受的盐具有有效的血管紧张素II拮抗活性和抗高血压活性，因此可用作治疗循环系统疾病如高血压疾病，心脏病（例如高血压，心力衰竭，心肌梗塞等），中风，脑中风，肾炎等

8. 发明授权

US5328919A Pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl] benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof and compositions and method of pharmaceutical use thereof 失效
标题翻译： 2-乙氧基-1 - [[2' - （1H-四唑-5-基）联苯-4-基]苯并咪唑-7-羧酸酯或其药学上可接受的盐的新戊酰氧基甲基酯及其药物用途的组合物和方法
公开(公告)号：US5328919A
公开(公告)日：1994-07-12
申请号：US997703
申请日：1993-01-05
申请人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
发明人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
IPC分类号： A61K31/415 , C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/10 , C07D405/14 , C07P257/04 , A61K31/41
CPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/10 , C07D405/14
摘要： Pivaloyloxymethyl2-ethoxy-1-[['-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II antagonistic activity and antihypertensive activity, thus being a useful therapeutic agent for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy or nephritis.
摘要翻译：新戊酰氧基甲基2-乙氧基-1 - [[' - （1H-四唑-5-基）联苯-4-基]甲基]苯并咪唑-7-羧酸酯或其药学上可接受的盐具有有效的血管紧张素II拮抗活性和抗高血压活性，用于治疗循环系统疾病如高血压疾病，心脏病（例如高血压，心力衰竭，心肌梗死等），中风，脑中风或肾炎的有用治疗剂。

9. 发明授权

US07538133B2 Benzimidazole derivatives, their production and use 失效
标题翻译：苯并咪唑衍生物，其生产和使用
公开(公告)号：US07538133B2
公开(公告)日：2009-05-26
申请号：US11594982
申请日：2006-11-09
申请人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
发明人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/04 , C07D403/10 , C07D405/14
摘要： Benzimidazole derivatives of the formula (I): wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R′ group; R1 is hydrogen or an optionally substituted hydrocarbon residue; R2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R′ is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is —O—, —S(O)m— or —N(R4)— wherein m is an integer of 0, 1 or 2 and R4 is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.
摘要翻译：式（I）的苯并咪唑衍生物：其中环A是可以任选地除R'基团之外的取代基的苯环; R1是氢或任选取代的烃残基; R2是能够形成阴离子或可转换的基团的基团; X是亚苯基和苯基之间的原子长度为2以下的直接键或间隔物; R'是羧基，其酯，其酰胺或能够形成阴离子或可转化成阴离子的基团; Y是-O - ， - S（O）m - 或-N（R4） - ，其中m是0,1或2的整数，R4是氢或任选取代的烷基; n为1或2的整数; 和其药学上可接受的盐具有有效的血管紧张素II拮抗活性和抗高血压活性，因此可用作治疗循环系统疾病如高血压疾病，心脏病（例如高血压，心力衰竭，心肌梗塞等），中风，脑中风，肾炎等

10. 发明授权

US06608210B2 Benzimidazole derivatives, their production and use 失效
标题翻译：苯并咪唑衍生物，其生产和使用
公开(公告)号：US06608210B2
公开(公告)日：2003-08-19
申请号：US10046189
申请日：2002-01-16
申请人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
发明人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
IPC分类号： C07D25702
CPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/04 , C07D403/10 , C07D405/14
摘要： A method for producing a compound represented by the formula: wherein the ring A is a benzene ring which may be substituted in addition to the R′ group; R1 is hydrogen or an optionally substituted hydrocarbon residue; X is a direct bond or a spacer having an atomic length or two or less between the phenylene group and the phenyl group; Y is —O—, —S(O)m— or —N(R4)— wherein m is an integer of 0, 1 or 2 and R4 is hydrogen or an optionally substituted alkyl group; R′ is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or a group convertible thereinto; n is an integer of 1 or 2; or a salt thereof, which comprises deprotecting a compound represented by the formula: wherein R is triphenylmethyl, 2-tetrahydropyranyl, methoxymethyl or ethoxy methyl, the other symbols as defined above; or a salt thereof.
摘要翻译：一种制备由下式表示的化合物的方法：其中环A是除R'基之外可被取代的苯环; R1是氢或任选取代的烃残基; X是在亚苯基和苯基之间具有原子长度或者两个或更少的直接键或间隔子; Y是-O - ， - S（O）m - 或-N（R4） - ，其中m是0,1或2的整数，R4是氢或任选取代的烷基; R'是羧基，其酯，其酰胺或能够形成阴离子的基团或可转化的基团; n为1或2的整数; 其包括使由下式表示的化合物脱保护：其中R是三苯甲基，2-四氢吡喃基，甲氧基甲基或乙氧基甲基，其它符号如上定义; 或其盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式