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1. 发明申请

US20110273955A1 LIQUID MIXING DEVICE 审中-公开
标题翻译：液体混合装置
公开(公告)号：US20110273955A1
公开(公告)日：2011-11-10
申请号：US13107581
申请日：2011-05-13
申请人： Takehiko Matsumura , Yoshihiko Uchino
发明人： Takehiko Matsumura , Yoshihiko Uchino
IPC分类号： G05D11/02 , B01F3/08
CPC分类号： B01F5/0685 , B01F3/0807 , B01F5/0688 , B01F5/0689 , B01F13/1027 , B01F2215/0088 , C10L1/328 , F23K5/12
摘要： Provided is a liquid mixing device capable of mixing together two or more kinds of liquids successively in an accurate ratio. The liquid mixing device includes: a first supply system for supplying a first liquid; a second supply system for supplying a second liquid; and a liquid mixing system that receives supply of the first liquid and second liquid from the first supply system and the second supply system, respectively, in which: the first supply system communicates to the liquid mixing system through a first flow rate regulation unit having a first path sectional area; the second supply system is connected to the liquid mixing system through a second flow rate regulation unit having a second path sectional area; and the first liquid in an amount corresponding to the first path sectional area and the second liquid in an amount corresponding to the second path sectional area are allowed to flow into the liquid mixing system, respectively, by making an inside pressure of the liquid mixing system negative.
摘要翻译：本发明提供一种液体混合装置，能够以两种或更多种液体连续地将其精确地混合在一起。液体混合装置包括：用于供应第一液体的第一供应系统; 用于供应第二液体的第二供应系统; 以及液体混合系统，其分别接收来自第一供应系统和第二供应系统的第一液体和第二液体的供应，其中：第一供应系统通过第一流量调节单元与液体混合系统连通，所述第一流量调节单元具有第一路径截面积; 第二供应系统通过具有第二路径截面积的第二流量调节单元连接到液体混合系统; 并且分别通过使液体混合系统的内部压力分别将与第一路径截面面积相对应的量的第一液体和对应于第二路径截面面积的量分别流入液体混合系统负。

2. 发明申请

US20090299265A1 Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same 审中-公开
标题翻译：具有形状记忆分离器和使用其的离子电渗装置的离子电渗电极组件
公开(公告)号：US20090299265A1
公开(公告)日：2009-12-03
申请号：US11992672
申请日：2006-10-02
申请人： Akihiko Tanioka , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Akihiko Tanioka , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/044 , A61N1/0448
摘要： An electrode assembly for iontophoresis including an electrode coupled to an electric power source device having a same polarity as that of the ionic drug in the electrode assembly, an electrolyte solution holding portion holding an electrolyte solution by being impregnated with the electrolyte solution, the electrolyte solution holding portion being placed adjacent to the electrode, a first ion exchange membrane operable to substantially pass ions having a polarity that is same as a polarity of the ionic drug and substantially block ions having a polarity that is opposite the polarity of the ionic drug, the first ion exchange membrane being placed adjacent to the electrolyte solution holding portion, a drug solution holding portion holding the ionic drug by being impregnated with the ionic drug, the drug solution holding portion being placed adjacent to the first ion exchange membrane, a second ion exchange membrane operable to substantially pass ions having a polarity that is opposite the polarity of the ionic drug and substantially block ions having a polarity that is the same as the polarity of the ionic drug, the second ion exchange membrane being placed adjacent to the drug solution holding portion, and a shape-memory separator capable of being transformed between a first and a second configuration to respectively allow passage of a substance and blocking of the substance, the shape-memory separator placed adjacent to at least one surface of the first ion exchange membrane.
摘要翻译：一种用于离子电渗疗法的电极组件，其包括与电极组件中的离子药物极性相同的电源装置的电极，通过浸渍电解质溶液保持电解质溶液的电解液保持部分，保持部分被放置成与电极相邻，第一离子交换膜可操作以基本上通过具有与离子药物的极性相同的极性的离子，并且基本上阻挡具有与离子药物的极性相反的极性的离子，第一离子交换膜与电解质溶液保持部相邻配置，通过浸渍离子性药物而保持离子性药物的药液保持部，药液保持部与第一离子交换膜相邻配置，第二离子交换膜可操作以基本上通过具有相反极性的离子 e离子药物的极性，并且基本上阻挡具有与离子药物的极性相同的极性的离子，第二离子交换膜邻近药物溶液保持部分放置，以及形状记忆分离器，其能够在第一和第二构型之间转换以分别允许物质的通过和物质的阻塞，所述形状记忆隔离物与第一离子交换膜的至少一个表面相邻放置。

3. 发明申请

US20090221951A1 IONTOPHORESIS DEVICE AND ELECTRIC POWER SOURCE FOR AN IONTOPHORESIS DEVICE 审中-公开
标题翻译：静电装置和电源的静电装置
公开(公告)号：US20090221951A1
公开(公告)日：2009-09-03
申请号：US12066362
申请日：2006-09-13
申请人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A drug may be administered in accordance with a daily living pattern of a patient and/or a circadian rhythm of the drug.An iontophoresis device includes a working electrode assembly and a non-working electrode assembly for administering a drug by iontophoresis and an electric power source connected to the working electrode assembly and the non-working electrode assembly. Current control circuitry programmably controls a current that flows to each of the electrode assemblies according to a set pattern, and the drug is released based at least in part on the current.
摘要翻译：可以根据患者的日常生活方式和/或药物的昼夜节律来施用药物。离子电渗装置包括工作电极组件和用于通过离子电渗疗法给药的非工作电极组件和连接到工作电极组件和非工作电极组件的电源。电流控制电路可编程地控制根据设定模式流向每个电极组件的电流，并且至少部分地基于电流释放药物。

4. 发明申请

US20090005721A1 PACKAGED IONTOPHORESIS SYSTEM 审中-公开
标题翻译：包装IOPOPHORESIS系统
公开(公告)号：US20090005721A1
公开(公告)日：2009-01-01
申请号：US12135901
申请日：2008-06-09
申请人： Mizuo Nakayama , Takehiko Matsumura , Tsutomu Shibata , Akihiro Ryuka
发明人： Mizuo Nakayama , Takehiko Matsumura , Tsutomu Shibata , Akihiro Ryuka
IPC分类号： A61N1/30
CPC分类号： B65D75/58 , A61N1/303
摘要： Provided is a packaged iontophoresis system 15 including: an iontophoresis system 10 including an apparatus body 50 for transdermally delivering an ionized drug by iontophoresis, and a connection part 70 extended from the apparatus body 50 and connected to the apparatus body 50 and a power source 60, the power source 60 supplying power to the apparatus body 50; a package material 80 hermetically packaging the apparatus body 50 and a portion of the connection part 70, by at least a part thereof being welded to the connection part 70; and a cutting guide 400 guiding a cutting line of the package material 80 so that the part of the package material 80 welded to the connection part 70 remains at the connection part 70 when the package material 80 is opened.
摘要翻译：提供了一种封装的离子电渗系统15，其包括：离子电渗系统10，其包括用于通过离子电渗法透皮地递送离子化药物的装置主体50;以及从装置主体50延伸并连接到装置主体50的连接部70和电源60 向设备主体50供电的电源60; 包装材料80将装置主体50和连接部70的一部分密封地包封，其至少一部分被焊接到连接部70; 以及导向包装材料80的切割线的切割引导件400，使得当包装材料80打开时，焊接到连接部70的包装材料80的一部分保留在连接部70。

5. 发明申请

US20070071807A1 CAPSULE-TYPE DRUG-RELEASING DEVICE AND CAPSULE-TYPE DRUG-RELEASING DEVICE SYSTEM 审中-公开
标题翻译：胶囊型药物释放装置和胶囊型药物释放装置系统
公开(公告)号：US20070071807A1
公开(公告)日：2007-03-29
申请号：US11536194
申请日：2006-09-28
申请人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
发明人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
IPC分类号： A61N1/00 , A61K9/48
CPC分类号： A61K9/0009 , A61K9/0097 , A61K9/48
摘要： A capsule-type drug-releasing device is capable of freely controlling the release and stoppage of a drug and causing neither the back flow of contents of a stomach, an intestine, or the like nor clogging with the contents. A capsule-type drug-releasing device may include: a capsule-shaped casing; a cation exchange membrane arranged on the surface of the casing; a drug solution holding portion arranged inside the casing and on the inner side of the cation exchange membrane; an anion exchange membrane arranged on the inner side of the drug solution holding portion; an electrolyte solution holding portion arranged on the inner side of the anion exchange membrane; an electrode arranged on the inner side of the electrolyte solution holding portion; an electric power source connected to the electrode; a control portion capable of controlling energization from the electric power source to the electrode; and a transceiver portion causing the control portion to receive a signal from the outside of an organism.
摘要翻译：胶囊型药物释放装置能够自由地控制药物的释放和停止，并且不会引起胃，肠等的内容物的反流，也不会堵塞内容物。胶囊型药物释放装置可以包括：胶囊型壳体; 设置在所述壳体的表面上的阳离子交换膜; 药液保持部，其配置在所述壳体内部和所述阳离子交换膜的内侧; 阴离子交换膜，其设置在药液保持部的内侧; 设置在阴离子交换膜的内侧的电解液保持部，设置在所述电解液保持部的内侧的电极; 连接到电极的电源; 控制部，其能够控制从所述电源向所述电极的通电; 以及使得所述控制部分从生物体的外部接收信号的收发器部分。

6. 发明申请

US20070066930A1 Iontophoresis device and method of producing the same 审中-公开
标题翻译：离子电渗疗法装置及其制造方法
公开(公告)号：US20070066930A1
公开(公告)日：2007-03-22
申请号：US11471973
申请日：2006-06-20
申请人： Akihiko Tanioka , Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
发明人： Akihiko Tanioka , Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
IPC分类号： A61N1/30 , A61L33/00 , B32B18/00
CPC分类号： A61N1/0444 , A61N1/044 , A61N1/0448
摘要： An iontophoresis device and method of producing the same may reduce material loss during the course of production of a conventional iontophoresis device, and may allow for easy automation of production processes and increases in production scale. The iontophoresis device may be used for administering drug ions of a first polarity generated by dissociation of a drug to a living body, and may comprise: a first conductive layer formed on a surface of a first substrate; a drug layer made of a drug coating containing the drug, the drug layer being laminated on the first conductive layer; and a first ion exchange layer made of an ion exchange coating containing an ion exchange resin having an exchange group introduced thereto, the ion exchange group having a counter ion to the first polarity ions, the first ion exchange layer being laminated on the drug layer.
摘要翻译：离子电渗装置及其制造方法可以在常规离子电渗装置的制造过程中减少材料损失，并且可以容易地实现生产方法的自动化和生产规模的增加。离子电渗装置可以用于施用通过将药物解离为活体而产生的第一极性的药物离子，并且可以包括：形成在第一基底的表面上的第一导电层; 由含有药物的药物涂层制成的药物层，所述药物层被层压在所述第一导电层上; 以及第一离子交换层，其由含有引入了交换基团的离子交换树脂的离子交换涂层构成，所述离子交换基团与所述第一极性离子具有抗衡离子，所述第一离子交换层层叠在所述药物层上。

7. 发明申请

US20070048362A1 General purpose electrolyte solution composition for iontophoresis 审中-公开
标题翻译：用于离子电渗疗法的通用电解质溶液组合物
公开(公告)号：US20070048362A1
公开(公告)日：2007-03-01
申请号：US11512756
申请日：2006-08-29
申请人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30 , A61F13/00
CPC分类号： A61N1/30 , A61N1/0436 , A61N1/044 , A61N1/0444 , A61N1/325
摘要： A single electrolyte solution composition may be used in an anode side and in a cathode side of an iontophoresis device. The electrolyte solution may include a compound having an oxidation-reduction potential lower than that of water, the compound including, in combination, both a component that is likely to be relatively reduced and a component that is likely to be relatively oxidized.
摘要翻译：单个电解质溶液组合物可用于离子电渗装置的阳极侧和阴极侧。电解质溶液可以包括具有低于水的氧化还原电位的化合物，所述化合物组合包括可能相对减少的组分和可能相对氧化的组分。

8. 发明申请

US20120090222A1 FUEL MANUFACTURING METHOD 审中-公开
标题翻译：燃料制造方法
公开(公告)号：US20120090222A1
公开(公告)日：2012-04-19
申请号：US13259037
申请日：2009-03-25
申请人： Takehiko Matsumura , Noritaka Hirose , Takako Izumi
发明人： Takehiko Matsumura , Noritaka Hirose , Takako Izumi
IPC分类号： C10L1/02
CPC分类号： C10L1/02 , C10G2300/1014 , C10G2300/1018 , C10G2300/805 , Y02E50/30 , Y02P30/20
摘要： The objective is to obtain fuel having high combustion calorie and superior handleability from a crude glycerin or a fatty acid mixture that have been discarded as industrial waste products. Disclosed is a fuel comprising a water-insolublized fatty acid substance obtained by water-insolubilizing a fatty acid that is contained in a crude glycerin or fatty acid mixtures that are produced as by-products in the process of producing a biofuel from an animal/plant-derived fat/oil. The water-insolublized fatty acid substance is preferably a water-insoluble fatty acid salt, particularly preferably a salt of a fatty acid with a divalent or trivalent metal ion.
摘要翻译：目的是获得作为工业废弃物被丢弃的粗甘油或脂肪酸混合物获得具有高燃烧热量和优异操作性的燃料。公开了一种燃料，其包含水不溶性脂肪酸物质，所述脂肪酸物质通过水分不溶于粗制甘油或脂肪酸混合物中所含的脂肪酸，所述粗甘油或脂肪酸混合物在从动物/植物生产生物燃料的过程中作为副产物生产得到的脂肪/油。水不溶性脂肪酸物质优选为水不溶性脂肪酸盐，特别优选为具有二价或三价金属离子的脂肪酸的盐。

9. 发明授权

US07660626B2 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US07660626B2
公开(公告)日：2010-02-09
申请号：US11195364
申请日：2005-08-02
申请人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
发明人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
摘要翻译：本发明提供了具有药物高效给药的离子电渗疗法装置。一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。

10. 发明申请

US20100030128A1 IONTOPHORESIS DEVICE 审中-公开
标题翻译： IONTOPHORESIS设备
公开(公告)号：US20100030128A1
公开(公告)日：2010-02-04
申请号：US12065851
申请日：2006-09-01
申请人： Kazuma Mitsuguchi , Mitsugu Yamauchi , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Kazuma Mitsuguchi , Mitsugu Yamauchi , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/303
摘要： The transport efficiency of a drug using an iontophoresis device is increased using a negative pressure device.The iontophoresis device includes a working electrode assembly and a non-working electrode assembly for administering drug by iontophoresis. Each of the working electrode assembly and the non-working electrode assembly includes an adhesive surface configured to adhere to a biological interface. A DC electric power source is connected to the working electrode assembly and the non-working electrode assembly. The iontophoresis device further includes a negative pressure device integral with at least one of the working electrode assembly and the non-working electrode assembly and configured to maintain a negative pressure between the at least one of the working electrode assembly and the non-working electrode assembly and the biological interface.
摘要翻译：使用离子渗透装置的药物的输送效率使用负压装置增加。离子电渗装置包括工作电极组件和用于通过离子电渗疗法给药的非工作电极组件。工作电极组件和非工作电极组件中的每一个包括被配置为粘附到生物界面的粘合表面。直流电源连接到工作电极组件和非工作电极组件。离子电渗装置还包括与至少一个工作电极组件和非工作电极组件成一体的负压装置，并且构造成在工作电极组件和非工作电极组件中的至少一个之间保持负压和生物界面。

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