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1. 发明申请

US20090239791A1 PHARMACEUTICAL COMPOSITION CONTAINING LIPOPHILIC SUBSTANCE WHICH INHIBITS IL-2 PRODUCTION 审中-公开
标题翻译：含有抑制IL-2生产的脂质物质的药物组合物
公开(公告)号：US20090239791A1
公开(公告)日：2009-09-24
申请号：US12256851
申请日：2008-10-23
申请人： Takayuki Yoshida , Kiyo Nakanishi , Atsushi Maeda , Kazuhiro Sako , Yuki Kasashima , Hiromu Kondo , Tatsunobu Yoshioka , Yuuki Tsutsui
发明人： Takayuki Yoshida , Kiyo Nakanishi , Atsushi Maeda , Kazuhiro Sako , Yuki Kasashima , Hiromu Kondo , Tatsunobu Yoshioka , Yuuki Tsutsui
IPC分类号： A61K38/13 , A61K31/436 , A61K31/343
CPC分类号： A61K9/08 , A61K31/343 , A61K31/365 , A61K31/436 , A61K38/13 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/44
摘要： A pharmaceutical composition comprising a lipophilic substance which inhibits IL-2 production, and a base capable of inhibiting blood exposure of the substance and delivering the substance to lymph following oral administration, is disclosed. The pharmaceutical composition can inhibit blood exposure of the substance to reduce its adverse effects, and can develop desired pharmacological effects.
摘要翻译：公开了一种药物组合物，其包含抑制IL-2产生的亲脂性物质，以及能够抑制物质的血液暴露并将其输送到口服给药后的淋巴液的碱。药物组合物可以抑制物质的血液暴露以减少其不利影响，并且可以产生所需的药理作用。

2. 发明申请

US20100136110A1 GRANULAR PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口腔管理的颗粒药物组合物
公开(公告)号：US20100136110A1
公开(公告)日：2010-06-03
申请号：US12568257
申请日：2009-09-28
申请人： Hiroaki Tasaki , Atsushi Maeda , Takeshi Yano , Kazuhiro Sako
发明人： Hiroaki Tasaki , Atsushi Maeda , Takeshi Yano , Kazuhiro Sako
IPC分类号： A61K9/20 , A61K9/16
CPC分类号： A61K9/0056
摘要： A granular pharmaceutical composition for oral administration, wherein a drug-containing particle is coated with a coating comprising a methyl methacrylate-butyl methacrylate-dimethylaminoethyl methacrylate copolymer and a water-soluble polymer is disclosed.
摘要翻译：公开了一种用于口服给药的粒状药物组合物，其中含有药物的颗粒用包含甲基丙烯酸甲酯 - 甲基丙烯酸丁酯 - 甲基丙烯酸二甲氨基乙酯共聚物和水溶性聚合物的涂层涂覆。

3. 发明授权

US09050249B2 Oral pharmaceutical compositions in timed-release particle form and fast-disintegrating tablets containing this composition 有权
标题翻译：定时释放颗粒形式的口服药物组合物和含有该组合物的快速崩解片剂
公开(公告)号：US09050249B2
公开(公告)日：2015-06-09
申请号：US11119460
申请日：2005-04-28
申请人： Takayuki Yoshida , Hiroaki Tasaki , Masataka Katsuma , Atsushi Maeda
发明人： Takayuki Yoshida , Hiroaki Tasaki , Masataka Katsuma , Atsushi Maeda
IPC分类号： A61K9/16 , A61K31/135 , A61K47/02 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/24 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/40 , A61K47/42 , A61K9/00 , A61K9/20 , A61K9/50
CPC分类号： A61K9/0056 , A61K9/2077 , A61K9/2081 , A61K9/2095 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5078 , A61K31/135
摘要： The present invention relates to an oral pharmaceutical composition in particle form, which comprises particles that contain a drug at the core of the pharmaceutical composition in particle form; a middle layer that contains two types of water-soluble components, an insolubilizer and an insolubilizing substance; and an outer layer for controlling water penetration that contains a water-insoluble substance. The present invention makes it possible to provide a pharmaceutical composition in particle form for oral use with which initial drug release is suppressed, the drug is quickly released thereafter, and lag time can be controlled as needed, and fast-disintegrating tablets containing this composition.
摘要翻译：本发明涉及一种颗粒形式的口服药物组合物，其包含以粒子形式含有药物组合物核心的药物的颗粒; 含有两种水溶性组分的中间层，不溶物和不溶物质; 以及用于控制含水不溶性物质的水渗透的外层。本发明使得可以提供一种用于口服使用的颗粒形式的药物组合物，其中抑制初始药物释放，此后快速释放药物，并且可以根据需要控制滞后时间，以及含有该组合物的快速崩解片剂。

4. 发明申请

US20050287211A1 Oral pharmaceutical compositions in timed-release particle form and fast-disintegrating tablets containing this composition 有权
标题翻译：定时释放颗粒形式的口服药物组合物和含有该组合物的快速崩解片剂
公开(公告)号：US20050287211A1
公开(公告)日：2005-12-29
申请号：US11119460
申请日：2005-04-28
申请人： Takayuki Yoshida , Hiroaki Tasaki , Masataka Katsuma , Atsushi Maeda
发明人： Takayuki Yoshida , Hiroaki Tasaki , Masataka Katsuma , Atsushi Maeda
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K9/26 , A61K9/50 , A61K31/135 , A61K47/02 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/24 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/40 , A61K47/42
CPC分类号： A61K9/0056 , A61K9/2077 , A61K9/2081 , A61K9/2095 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5078 , A61K31/135
摘要： The present invention relates to an oral pharmaceutical composition in particle form, which comprises particles that contain a drug at the core of the pharmaceutical composition in particle form; a middle layer that contains two types of water-soluble components, an insolubilizer and an insolubilizing substance; and an outer layer for controlling water penetration that contains a water-insoluble substance. The present invention makes it possible to provide a pharmaceutical composition in particle form for oral use with which initial drug release is suppressed, the drug is quickly released thereafter, and lag time can be controlled as needed, and fast-disintegrating tablets containing this composition.
摘要翻译：本发明涉及一种颗粒形式的口服药物组合物，其包含以粒子形式含有药物组合物核心的药物的颗粒; 含有两种水溶性组分的中间层，不溶物和不溶物质; 以及用于控制含水不溶性物质的水渗透的外层。本发明使得可以提供一种用于口服使用的颗粒形式的药物组合物，其中抑制初始药物释放，此后快速释放药物，并且可以根据需要控制滞后时间，以及含有该组合物的快速崩解片剂。

5. 发明授权

US09062734B2 Shock absorber and vehicle using the same 有权
标题翻译：减震器和车辆使用相同
公开(公告)号：US09062734B2
公开(公告)日：2015-06-23
申请号：US13775454
申请日：2013-02-25
申请人： Mikio Yamashita , Atsushi Maeda
发明人： Mikio Yamashita , Atsushi Maeda
IPC分类号： F16F11/00 , F16F7/09 , F16F9/512
CPC分类号： F16F7/09 , F16F9/5126
摘要： A shock absorber includes a first and a second passage configured to flow a working fluid out of one chamber by movement of a piston, a first damping force generation mechanism installed at the first passage and configured to generate a damping force, a housing having at least a partial passage of the second passage formed therein, a free piston movably installed in the housing and configured to partition the second passage into an upstream side and a downstream side, and a spring member disposed in the housing and configured to hole the free piston at a neutral position, wherein a second damping force generation mechanism including a friction member installed at an inner side of the cylinder with respect to the sealing member and constituted by an annular elastic rubber section in sliding contact with the piston rod and an annular base section to which the elastic rubber section is fixed and a communication passage configured to reduce a pressure difference between both sides in an axial direction of the friction member is provided.
摘要翻译：减震器包括第一和第二通道，第一通道和第二通道构造成通过活塞的运动将工作流体流出一个室，第一阻尼力产生机构，安装在第一通道处并被构造成产生阻尼力，壳体至少具有形成在其中的第二通道的部分通道，可移动地安装在壳体中并被构造成将第二通道分隔成上游侧和下游侧的自由活塞，以及设置在壳体中并构造成将自由活塞孔中空位置，其中第二阻尼力产生机构包括摩擦构件，所述摩擦构件相对于所述密封构件安装在所述气缸的内侧，并且由与所述活塞杆滑动接触的环形弹性橡胶区段构成，所述弹性橡胶部分被固定，并且连通通道被构造成减小斧头两侧之间的压力差提供摩擦构件的方向。

6. 发明申请

US20120248670A1 SHOCK ABSORBER 有权
标题翻译：减震器
公开(公告)号：US20120248670A1
公开(公告)日：2012-10-04
申请号：US13423698
申请日：2012-03-19
申请人： Mikio Yamashita , Fumiyuki Yamaoka , Masaru Kouyama , Atsushi Maeda
发明人： Mikio Yamashita , Fumiyuki Yamaoka , Masaru Kouyama , Atsushi Maeda
IPC分类号： B60G15/06 , F16F13/00
CPC分类号： F16F9/49 , F16F9/19 , F16F9/516 , F16F9/585
摘要： A shock absorber includes first passages configured to communicate two chambers to flow a working fluid therebetween by movement of a piston, and a second passage configured to communicate with one chamber of the two chambers. The first passages have damping valves configured to suppress a flow of the working fluid generated by movement of the piston to generate a damping force. The second passage has a variable orifice having an area adjusted by an elastic member when a piston rod moves in an extension direction, a pressure chamber installed in series with the variable orifice, and a free piston configured to vary a volume of the pressure chamber by movement of the piston.
摘要翻译：减震器包括第一通道，第一通道构造成通过活塞的运动而连通两个腔室以使工作流体在其间流动;以及第二通道，其构造成与两个腔室的一个室连通。第一通道具有阻尼阀，其构造成抑制由活塞的运动产生的工作流体的流动以产生阻尼力。第二通道具有可变孔口，当活塞杆沿延伸方向移动时具有由弹性构件调节的面积，与可变孔串联安装的压力室，以及被配置为通过以下方式改变压力室的体积的自由活塞活塞的运动。

7. 发明申请

US20120037965A1 SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：半导体器件及其制造方法
公开(公告)号：US20120037965A1
公开(公告)日：2012-02-16
申请号：US13281454
申请日：2011-10-26
申请人： Yusuke Terada , Shigeya Toyokawa , Atsushi Maeda
发明人： Yusuke Terada , Shigeya Toyokawa , Atsushi Maeda
IPC分类号： H01L29/78
CPC分类号： H01L21/02274 , G02F1/13306 , G02F1/133345 , G02F1/134309 , G02F1/13439 , G02F1/136286 , G02F1/1368 , G02F2001/133302 , G02F2001/136295 , H01L21/31051 , H01L21/76224 , H01L21/76229 , H01L21/76837 , H01L21/76895 , H01L21/823456 , H01L21/823462 , H01L21/823475 , H01L21/823481 , H01L23/50 , H01L23/53295 , H01L23/535 , H01L27/088 , H01L27/124 , H01L29/0653 , H01L29/66477 , H01L29/6675 , H01L29/78 , H01L29/7836 , H01L2924/0002 , H01L2924/00
摘要： In an LCD driver, in a high voltage resistant MISFET, end portions of a gate electrode run onto electric field relaxing insulation regions. Wires to become source wires or drain wires are formed on an interlayer insulation film of the first layer over the high voltage resistant MISFET. At this moment, when a distance from an interface between a semiconductor substrate and a gate insulation film to an upper portion of the gate electrode is defined as “a”, and a distance from the upper portion of the gate electrode to an upper portion of the interlayer insulation film on which the wires are formed is defined as “b”, a relation of a>b is established. In such a high voltage resistant MISFET structured in this manner, the wires are arranged so as not to be overlapped planarly with the gate electrode of the high voltage resistant MISFET.
摘要翻译：在LCD驱动器中，在高耐压MISFET中，栅电极的端部运行到电场松弛绝缘区域上。在高电压MISFET的第一层的层间绝缘膜上形成用于成为源极线或漏极线的电线。此时，当从半导体衬底和栅极绝缘膜之间的界面到栅电极的上部的距离定义为“a”，并且从栅电极的上部到上部的距离其上形成有导线的层间绝缘膜被定义为“b”，建立a> b的关系。在以这种方式构成的这种高耐压MISFET中，布线布置成不与高电压MISFET的栅电极平面地重叠。

8. 发明授权

US07863353B2 Paving resin composition, paving asphalt composition, and method for producing paving asphalt composition 有权
标题翻译：摊铺树脂组合物，铺路沥青组合物及铺路沥青组合物的制造方法
公开(公告)号：US07863353B2
公开(公告)日：2011-01-04
申请号：US10546607
申请日：2004-02-24
申请人： Toshiyuki Hakata , Atsushi Maeda , Ryoma Masui
发明人： Toshiyuki Hakata , Atsushi Maeda , Ryoma Masui
IPC分类号： C08L95/00
CPC分类号： E01C7/30 , C08L23/0853 , C08L95/00 , C08L2666/02
摘要： Disclosed is a paving resin composition which comprises a thermoplastic resin in small lumps, containing 30 to 70% by weight of an ethylene-vinyl acetate copolymer having a vinyl acetate content of 20 to 45% by weight and a melting temperature of 40 to 100° C. The paving resin composition of the present invention is melted within a short time, excellent in wettability and adhesion property to aggregates, and capable of providing a paved face excellent in durability free from problems of deformation during summer and cracking during winter. Moreover, the paving resin composition of the present invention can be thrown directly to a mixer without being passed through a measurement apparatus and accordingly, washing work of the measurement apparatus or pipes is made unnecessary and the workability is thus significantly increased.
摘要翻译：公开了一种铺路树脂组合物，其包含小块状的热塑性树脂，其含有30〜70重量％的乙酸乙烯酯含量为20〜45重量％，熔融温度为40〜100℃的乙烯 - 乙酸乙烯酯共聚物 C.本发明的铺路树脂组合物在短时间内熔化，润湿性和聚集体的粘合性优异，并且能够提供耐候性优异的耐候性，并且在冬季期间不会出现夏季变形和冬季的龟裂。此外，本发明的铺路树脂组合物可以直接投入混合器而不通过测量装置，因此，不需要测量装置或管道的洗涤工作，从而显着提高了可加工性。

9. 发明申请

US20090194379A1 Fluid-pressure shock absorber 有权
标题翻译：流体压力减震器
公开(公告)号：US20090194379A1
公开(公告)日：2009-08-06
申请号：US12320507
申请日：2009-01-28
申请人： Atsushi Maeda
发明人： Atsushi Maeda
IPC分类号： F16F9/10
CPC分类号： F16F9/58
摘要： A fluid-pressure shock absorber comprising: an external cylinder with an open portion provided at one end thereof, a piston rod, a tip of which projects from the open portion of the external cylinder; a rod guide, wherein the open portion of the external cylinder is closed with caulking works so as to make a caulking portion, and further comprising: an annular bump cap coaxially arranged relative to the external cylinder; a cap holder arranged on a side of the tip of the piston rod relative to the rod guide so as to retain the bump cap, wherein an end portion on the rod guide side of the bump cap is abutted to the caulking portion, and a clearance in an axial direction is formed between an end portion of the cap holder on a side towards the tip of the piston rod and the bump cap.
摘要翻译：一种流体压力减震器，包括：外筒，其一端设有开口部，活塞杆，其顶端从所述外筒的开口部突出; 杆引导件，其中外筒的开口部分用铆接工具封闭以形成铆接部分，并且还包括：相对于外筒同轴布置的环形凸块盖; 帽座，其相对于所述杆导向件设置在所述活塞杆的所述前端的一侧，以便保持所述凸起盖，其中，所述凸块盖的所述杆引导侧上的端部抵靠所述铆接部，并且间隙在轴向方向上形成在盖保持件的朝向活塞杆的顶端的一侧的端部与凸块盖之间。

10. 发明申请

US20070202168A1 COMPOSITION COMPRISES SUSTAINED-RELEASE FINE PARTICLES AND MANUFACTURING METHOD THEREOF 失效
标题翻译：组合物包含持续释放的细颗粒及其制造方法
公开(公告)号：US20070202168A1
公开(公告)日：2007-08-30
申请号：US11743616
申请日：2007-05-02
申请人： Tatsuki Shinoda , Atsushi Maeda , Naoki Itou , Takao Mizumoto , Shigeru Yamazaki , Yuuki Takaishi
发明人： Tatsuki Shinoda , Atsushi Maeda , Naoki Itou , Takao Mizumoto , Shigeru Yamazaki , Yuuki Takaishi
IPC分类号： A61K9/26
CPC分类号： A61K9/2081 , A61K9/0056 , A61K9/2018 , A61K9/5026 , A61K31/18
摘要： The present invention relates to a composition comprising sustained-release fine particles, characterized in that it contains sustained-release fine particles that can be used in quick-disintegrating tablets in the buccal cavity, one or more fillers selected from the group consisting of sugars or sugar alcohols, and one or more binders for quick-disintegrating tablets in the buccal cavity selected from the group consisting of sugars of high moldability and water-soluble polymer substances, and in that the sustained-release fine particles are granulated with filler and binder for quick-disintegrating tablets in the buccal cavity, and a manufacturing method thereof.
摘要翻译：本发明涉及包含持续释放微粒的组合物，其特征在于其含有可用于颊腔中快速崩解片剂的缓释微粒，一种或多种选自以下的填料：糖或糖醇和一种或多种选自高成型性糖和水溶性聚合物物质的颊腔中的快速崩解片的粘合剂，并且缓释微粒用填料和粘合剂造粒，颊腔中的快速崩解片及其制造方法。

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