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1. 发明申请

US20090242804A1 METHOD FOR FLUORESCENCE ANALYSIS AND FLUORESCENCE ANALYZER 有权
标题翻译：荧光分析和荧光分析仪的方法
公开(公告)号：US20090242804A1
公开(公告)日：2009-10-01
申请号：US12400321
申请日：2009-03-09
申请人： Takayuki OBARA , Satoshi Takahashi , Akira Maekawa , Takuya Matsui , Nobutaka Kumazaki
发明人： Takayuki OBARA , Satoshi Takahashi , Akira Maekawa , Takuya Matsui , Nobutaka Kumazaki
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , G01N21/15 , G01N21/274 , G01N21/6452
摘要： The present invention aims at reducing background noise derived from a substance that is present in the vicinity of a target substance such as a DNA and protein and attached to the surface of a substrate without an effect on a fluorescent dye labeling the target substance. The substrate that has a probe and is capable of interacting with the target substance is irradiated with noise removing light such that an evanescent field is generated on the surface of the substrate. A target substance and a foreign particle, which are non-specifically stuck to the surface of the substrate, are decomposed by the evanescent field generated by the irradiation with the noise removing light. The evanescent field present near the surface of the substrate has almost no effect on the probe. It is possible to reduce the background noise derived from the substance that is present in the vicinity of the target substance and attached to the surface of the substrate and suppress effects on the probe and the target substance interacting with the probe.
摘要翻译：本发明旨在减少由存在于目标物质（例如DNA和蛋白质）附近的物质衍生的背景噪声，并附着于基材表面，而不影响标记目标物质的荧光染料。具有探针并且能够与目标物质相互作用的基板被消除噪声的光照射，使得在基板的表面上产生ev逝场。非特异性地粘附在基板表面上的目标物质和外来粒子被消除噪声的光照射产生的ev逝场分解。在衬底表面附近存在的消逝场对探针几乎没有影响。可以减少由存在于目标物质附近并附着于基板表面的物质导致的背景噪声，并抑制与探针相互作用的探针和目标物质的影响。

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