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    • 3. 发明申请
    • PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID
    • 生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法
    • US20140178943A9
    • 2014-06-26
    • US13980223
    • 2012-03-07
    • Takashi ShibuyaSeisuke IzawaTomoyuki NishimotoShigeharu FukudaToshio Miyake
    • Takashi ShibuyaSeisuke IzawaTomoyuki NishimotoShigeharu FukudaToshio Miyake
    • C12P19/18
    • A61K31/7048A61K9/16C07H17/04C12P19/18C12P19/60C12Y204/01019
    • The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
    • 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法,即使当抗坏血酸2-葡萄糖苷的产率不达到35重量%时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法,其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液,然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27%的溶液,纯化得到的溶液,将抗坏血酸2-葡萄糖苷含量提高至86重量%以上,将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法,收集沉淀的无水结晶抗坏血酸2-葡萄糖苷,并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。
    • 4. 发明申请
    • PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID
    • 生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法
    • US20130295618A1
    • 2013-11-07
    • US13980223
    • 2012-03-07
    • Takashi ShibuyaSeisuke IzawaTomoyuki NishimotoShigeharu FukudaToshio Miyake
    • Takashi ShibuyaSeisuke IzawaTomoyuki NishimotoShigeharu FukudaToshio Miyake
    • C12P19/18
    • A61K31/7048A61K9/16C07H17/04C12P19/18C12P19/60C12Y204/01019
    • The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
    • 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法,即使当抗坏血酸2-葡萄糖苷的产率不达到35重量%时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法,其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液,然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27%的溶液,纯化得到的溶液,将抗坏血酸2-葡萄糖苷含量提高至86重量%以上,将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法,收集沉淀的无水结晶抗坏血酸2-葡萄糖苷,并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。
    • 7. 发明申请
    • Method for transferring a glucosyl residue
    • 转移葡糖基残基的方法
    • US20070154996A1
    • 2007-07-05
    • US10587711
    • 2005-01-27
    • Tomoyuki NishimotoMichio KubotaShigeharu FukudaToshio Miyake
    • Tomoyuki NishimotoMichio KubotaShigeharu FukudaToshio Miyake
    • C12P19/04
    • C12P19/18C12P19/44
    • An object of the present invention is to provide novel methods for forming glucosyl-transferred polyalcohols, glucosyl-transferred glucuronic acid, and glucosyl-transferred derivatives of glucose whose C-6 hydroxyl group bound to a saccharide by using an enzymatic reaction. The present invention solves the above object by providing a method for transferring a glucosyl residue to polyalcohols, glucuronic acid and/or derivatives of glucose whose C-6 hydroxyl group bound to a saccharide, comprising a step of: allowing a trehalose phosphorylase to act on a saccharide containing glucose as a component sugar and one or more polyalcohols selected from the group consisting of inositol, ribitol, erythritol, and glycerol; glucuronic acid and/or a salt thereof; and/or one or more derivatives of glucose whose C-6 hydroxyl group bound to a saccharide selected from the group consisting of isomaltose, gentiobiose, melibiose, isomaltotriose, and isopanose.
    • 本发明的目的是提供通过酶促反应形成C-6羟基与糖结合的葡萄糖转移的多元醇,葡糖基转移的葡萄糖醛酸和葡萄糖转移的葡萄糖转移衍生物的新方法。 本发明通过提供一种将葡糖基残基转移到多糖,葡糖醛酸和/或其C-6羟基与糖结合的葡萄糖的衍生物的方法,包括以下步骤:使海藻糖磷酸化酶作用于 含有葡萄糖作为组分糖和一种或多种选自肌醇,核糖醇,赤藓糖醇和甘油的多元醇的糖; 葡萄糖醛酸和/或其盐; 和/或一种或多种C-6羟基结合于选自异麦芽糖,龙胆糖,蜜二糖,异麦芽三糖和异丙糖的糖的葡萄糖衍生物。