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1. 发明申请

US20100016354A1 NOVEL OXADIAZOLE DERIVATIVES AND THIADIAZOLE DERIVATIVES HAVING NEOVASCULARIZATION INHIBITORY ACTIVITY 失效
标题翻译：新型氧化氮衍生物和具有新鲜血液活性抑制活性的噻唑衍生物
公开(公告)号：US20100016354A1
公开(公告)日：2010-01-21
申请号：US12449159
申请日：2008-01-29
申请人： Takahiro Honda , Koushi Fujisawa , Hiroyuki Aono , Masakazu Ban
发明人： Takahiro Honda , Koushi Fujisawa , Hiroyuki Aono , Masakazu Ban
IPC分类号： A61K31/4725 , C07D413/12 , A61K31/4439 , C07D413/14 , A61K31/444 , A61P35/00 , A61P3/10 , A61P19/02
CPC分类号： C07D285/135 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to Compounds represented by the formula (I) or salts thereof. In the formula (I), the ring A represents a benzene ring, a thiophene ring, or a pyridine ring; Ra represents a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group; the ring B represents a pyridine ring, a pyrimidine ring, or a quinoline ring; the ring C represents a benzene ring; a pyridine ring, a quinoline ring, or an isoquinoline ring; X and Y, the same or different, represent an oxygen atom or a sulfur atom, with the proviso that the case X is a sulfur atom and Y is an oxygen atom be excluded; R1 represents a hydrogen atom, a halogen atom, an amino group, a cycloalkylamino group, an alkylcarbonylamino group, an alkyloxycarbonylamino group, an alkylaminocarbonyl group, or a non-aromatic heterocyclic group; and R2 and R2′, the same or different, represent a hydrogen atom, a halogen atom, an alkyl group, a halogeno-alkyl group, or a halogeno-alkoxy group.
摘要翻译：本发明涉及由式（I）表示的化合物或其盐。在式（I）中，环A表示苯环，噻吩环或吡啶环; Ra表示氢原子，卤素原子，烷基或烷氧基; 环B表示吡啶环，嘧啶环或喹啉环; 环C表示苯环; 吡啶环，喹啉环或异喹啉环; X和Y相同或不同，表示氧原子或硫原子，条件是情况X为硫原子，Y为氧原子排除; R1表示氢原子，卤素原子，氨基，环烷基氨基，烷基羰基氨基，烷氧基羰基氨基，烷基氨基羰基或非芳香族杂环基; 和R2和R2'相同或不同，表示氢原子，卤素原子，烷基，卤代烷基或卤代 - 烷氧基。

2. 发明授权

US08063034B2 Oxadiazole derivatives and thiadiazole derivatives having neovascularization inhibitory activity 失效
标题翻译：具有新血管形成抑制活性的恶二唑衍生物和噻二唑衍生物
公开(公告)号：US08063034B2
公开(公告)日：2011-11-22
申请号：US12449159
申请日：2008-01-29
申请人： Takahiro Honda , Koushi Fujisawa , Hiroyuki Aono , Masakazu Ban
发明人： Takahiro Honda , Koushi Fujisawa , Hiroyuki Aono , Masakazu Ban
IPC分类号： A61K31/397 , A61K31/4245 , C07D271/07 , C07D413/08
CPC分类号： C07D285/135 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to Compounds represented by the formula (I) or salts thereof. In the formula (I), the ring A represents a benzene ring, a thiophene ring, or a pyridine ring; Ra represents a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group; the ring B represents a pyridine ring, a pyrimidine ring, or a quinoline ring; the ring C represents a benzene ring; a pyridine ring, a quinoline ring, or an isoquinoline ring; X and Y, the same or different, represent an oxygen atom or a sulfur atom, with the proviso that the case X is a sulfur atom and Y is an oxygen atom be excluded; R1 represents a hydrogen atom, a halogen atom, an amino group, a cycloalkylamino group, an alkylcarbonylamino group, an alkyloxycarbonylamino group, an alkylaminocarbonyl group, or a non-aromatic heterocyclic group; and R2 and R2′, the same or different, represent a hydrogen atom, a halogen atom, an alkyl group, a halogeno-alkyl group, or a halogeno-alkoxy group.
摘要翻译：本发明涉及由式（I）表示的化合物或其盐。在式（I）中，环A表示苯环，噻吩环或吡啶环; Ra表示氢原子，卤素原子，烷基或烷氧基; 环B表示吡啶环，嘧啶环或喹啉环; 环C表示苯环; 吡啶环，喹啉环或异喹啉环; X和Y相同或不同，表示氧原子或硫原子，条件是情况X为硫原子，Y为氧原子排除; R1表示氢原子，卤素原子，氨基，环烷基氨基，烷基羰基氨基，烷氧基羰基氨基，烷基氨基羰基或非芳香族杂环基; 和R2和R2'相同或不同，表示氢原子，卤素原子，烷基，卤代烷基或卤代 - 烷氧基。

3. 发明授权

US08518973B2 Compounds having 4-pyridylalkylthio group as a substituent 有权
标题翻译：具有4-吡啶基烷硫基作为取代基的化合物
公开(公告)号：US08518973B2
公开(公告)日：2013-08-27
申请号：US13449921
申请日：2012-04-18
申请人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
发明人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
IPC分类号： C07D401/12 , A61K31/44
CPC分类号： C07D401/12 , C07D213/32 , C07D401/14
摘要： A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring; B is an alkylene; R1 and R2 are hydrogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R1 and R2 join together to form a heterocycle; X and Y are hydrogen, halogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro; p is 0, 1 or 2; and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.
摘要翻译：具有下式[I]的化合物或其药学上可接受的盐：其中A是任选与环烷烃环稠合的芳族五元杂环; B是亚烷基; R 1和R 2是氢，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，杂环，氨基，烷基氨基，芳基氨基或酰基，或R 1和R 2连接在一起形成杂环; X和Y是氢，卤素，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，巯基，烷硫基，芳硫基，羧基，羧基的酯，羧基的酰胺，氰基或硝基; p为0,1或2; q为0或1.该化合物可用于治疗涉及血管生成或增加血管通透性的疾病。

4. 发明授权

US07534802B2 Compounds having 4-pyridylalkylthio group as substituent 有权
标题翻译：具有4-吡啶基烷硫基作为取代基的化合物
公开(公告)号：US07534802B2
公开(公告)日：2009-05-19
申请号：US10548283
申请日：2004-03-05
申请人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
发明人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
IPC分类号： C07D401/14 , A61K31/444
CPC分类号： C07D401/12 , C07D213/32 , C07D401/14
摘要： A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a pharmaceutical. Compound represented by the following general formula [I] or salts thereof are useful as therapeutic agents for diseases in which angiogenesis or augmentation of vascular permeability is involved. In the formula, ring “A” is a benzene ring or an aromatic five- or six-memberd heterocycle which can be fused with a cycloalkane ring, “B” is alkylene, R1 and R2, the same or different, are H, OH, substituted or unsubstituted alkoxy and the like, X and Y, the same or different, are group(s) selected from H, halogen, OH, substituted or unsubstituted alkoxy and the like respectively, p is 0, 1 or 2, and q is 0 or 1.
摘要翻译：本发明的目的是提供一种新颖的具有4-吡啶基烷硫基作为取代基的五元或六元杂环衍生物或其盐，其可用作药物。由以下通式[I]表示的化合物或其盐可用作涉及血管生成或增加血管通透性的疾病的治疗剂。在该式中，环“A”是可以与环烷烃环稠合的苯环或芳族五元或六元杂环，“B”是亚烷基，R 1和R 2相同或不同，是H，OH 取代或未取代的烷氧基等，X和Y相同或不同，分别为选自H，卤素，OH，取代或未取代的烷氧基等的基团，p为0,1或2，q为0,1或2，q为是0或1。

5. 发明授权

US08207194B2 Compounds having a 4-pyridylalkylthio group as a substituent 有权
标题翻译：具有4-吡啶基烷硫基作为取代基的化合物
公开(公告)号：US08207194B2
公开(公告)日：2012-06-26
申请号：US12381290
申请日：2009-03-10
申请人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
发明人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
IPC分类号： A61K31/47 , C07D401/02 , C07D213/02
CPC分类号： C07D401/12 , C07D213/32 , C07D401/14
摘要： A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is benzene or an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring; B is an alkylene; R1 and R2 are hydrogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R1 and R2 join together to form a heterocycle; X and Y are hydrogen, halogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro; p is 0, 1 or 2; and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.
摘要翻译：具有下式[I]的化合物或其药学上可接受的盐：其中A是任选与环烷烃环稠合的苯或芳族五元杂环; B是亚烷基; R 1和R 2是氢，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，杂环，氨基，烷基氨基，芳基氨基或酰基，或R 1和R 2连接在一起形成杂环; X和Y是氢，卤素，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，巯基，烷硫基，芳硫基，羧基，羧基的酯，羧基的酰胺，氰基或硝基; p为0,1或2; q为0或1.该化合物可用于治疗涉及血管生成或增加血管通透性的疾病。

6. 发明申请

US20090286786A1 Compounds having a 4-pyridylalkylthio group as a substituent 有权
标题翻译：具有4-吡啶基烷硫基作为取代基的化合物
公开(公告)号：US20090286786A1
公开(公告)日：2009-11-19
申请号：US12381290
申请日：2009-03-10
申请人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
发明人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/4709 , A61K31/444 , A61K31/4436 , A61K31/44 , C07D413/12 , C07D401/12 , C07D409/12 , C07D405/12 , C07D211/70 , A61K31/443
CPC分类号： C07D401/12 , C07D213/32 , C07D401/14
摘要： A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is benzene or an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring; B is an alkylene; R1 and R2 are hydrogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R1 and R2 join together to form a heterocycle; X and Y are hydrogen, halogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro; p is 0, 1 or 2; and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.
摘要翻译：具有下式[I]的化合物或其药学上可接受的盐：其中A是任选与环烷烃环稠合的苯或芳族五元杂环; B是亚烷基; R 1和R 2是氢，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，杂环，氨基，烷基氨基，芳基氨基或酰基，或R 1和R 2连接在一起形成杂环; X和Y是氢，卤素，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，巯基，烷硫基，芳硫基，羧基，羧基的酯，羧基的酰胺，氰基或硝基; p为0,1或2; q为0或1.该化合物可用于治疗涉及血管生成或增加血管通透性的疾病。

7. 发明申请

US20120202817A1 COMPOUNDS HAVING 4-PYRIDYLALKYLTHIO GROUP AS A SUBSTITUENT 有权
标题翻译：具有4-PYRIDYLALKYLTHIO组的化合物作为替代物
公开(公告)号：US20120202817A1
公开(公告)日：2012-08-09
申请号：US13449921
申请日：2012-04-18
申请人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
发明人： Takahiro Honda , Hisashi Tajima , Yoshimasa Sasabuchi , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Masakazu Ban
IPC分类号： A61K31/4409 , C07D409/12 , A61K31/4436 , C07D401/12 , A61K31/4709 , C07D413/14 , A61K31/5377 , C07D409/14 , A61K31/4545 , A61K31/4439 , C07D405/12 , A61K31/443 , A61P35/00 , A61P29/00 , A61P27/02 , A61P17/06 , A61P9/10 , C07D213/56
CPC分类号： C07D401/12 , C07D213/32 , C07D401/14
摘要： A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring; B is an alkylene; R1 and R2 are hydrogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R1 and R2 join together to form a heterocycle; X and Y are hydrogen, halogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro; p is 0, 1 or 2; and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.
摘要翻译：具有下式[I]的化合物或其药学上可接受的盐：其中A是任选与环烷烃环稠合的芳族五元杂环; B是亚烷基; R 1和R 2是氢，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，杂环，氨基，烷基氨基，芳基氨基或酰基，或R 1和R 2连接在一起形成杂环; X和Y是氢，卤素，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，巯基，烷硫基，芳硫基，羧基，羧基的酯，羧基的酰胺，氰基或硝基; p为0,1或2; q为0或1.该化合物可用于治疗涉及血管生成或增加血管通透性的疾病。

8. 发明授权

US09023572B2 Method for producing toner for developing electrostatic image and apparatus for producing resin particles 有权
标题翻译：用于生产静电图像显影用调色剂的方法和用于制备树脂颗粒的装置
公开(公告)号：US09023572B2
公开(公告)日：2015-05-05
申请号：US12784906
申请日：2010-05-21
申请人： Takahiro Honda , Yohichiroh Watanabe , Yasutada Shitara , Yoshihiro Norikane
发明人： Takahiro Honda , Yohichiroh Watanabe , Yasutada Shitara , Yoshihiro Norikane
IPC分类号： G03G9/08 , B01J19/06 , B01J4/00 , C08J3/12 , G03G9/16 , G03G9/18
CPC分类号： B01J19/06 , B01J4/002 , B01J4/007 , B01J2219/00123 , C08J3/122 , G03G9/0804 , G03G9/16 , G03G9/18
摘要： A method for producing resin particles, including ejecting a liquid containing at least a resin in the form of droplets from a droplet ejecting unit having a plurality of holes provided in a part of a flow channel for feeding the liquid containing at least a resin, and drying and solidifying the ejected droplets so as to obtain the resin particles, while the ejected droplets are transported by a primary transport air flow flowing in the direction in which the droplets are ejected, wherein the ejected droplets are further transported by a secondary transport air flow which transports the ejected droplets in a different direction from a direction in which the primary transport air flow flows, and wherein a smaller angle of angles formed between a velocity vector of the primary transport air flow and a velocity vector of the secondary transport air flow is less than 120 degrees.
摘要翻译：一种树脂颗粒的制造方法，其特征在于，包括从具有设置在至少含有树脂的液体的流路的一部分的具有多个孔的液滴喷射单元的液滴喷射单元喷出至少含有液滴形式的液体的液体，干燥并固化喷出的液滴，以便获得树脂颗粒，同时喷射的液滴通过沿着喷射液滴的方向流动的初级输送空气流输送，其中喷射的液滴通过二次输送空气流进一步输送其沿着与一次输送空气流动的方向不同的方向输送喷射的液滴，并且其中在一次输送空气流的速度矢量与二次输送空气流的速度矢量之间形成的较小的角度角为小于120度。

9. 发明申请

US20150104739A1 TONER, DEVELOPER, AND IMAGE FORMING APPARATUS 审中-公开
标题翻译：调色剂，开发商和图像形成装置
公开(公告)号：US20150104739A1
公开(公告)日：2015-04-16
申请号：US14384490
申请日：2013-03-07
申请人： Tsuneyasu Nagatomo , Satoshi Kojima , Syouko Satoh , Kiwako Hirohara , Osamu Uchinokura , Junichi Awamura , Satoshi Ogawa , Takahiro Honda
发明人： Tsuneyasu Nagatomo , Satoshi Kojima , Syouko Satoh , Kiwako Hirohara , Osamu Uchinokura , Junichi Awamura , Satoshi Ogawa , Takahiro Honda
IPC分类号： G03G9/00
CPC分类号： G03G9/08755 , G03G9/0804 , G03G9/0819 , G03G9/08797 , G03G9/09716 , G03G9/09725
摘要： A toner, containing: toner base particles; and an external additive, the toner base particles each including a binder resin and a releasing agent, wherein the external additive includes non-spherical coalesced particles in each of which primary particles are coalesced together, and wherein the coalesced particles satisfy the following formula (1): Nx/1,000×100≦30% where Nx is a number of the primary particles present alone relative to 1,000 of the coalesced particles, as observed under a scanning electron microscope after stirring 0.5 g of the coalesced particles and 49.5 g of a carrier placed in a 50 mL bottle for 10 minutes by means of a mixing and stirring device at 67 Hz.
摘要翻译：调色剂，含有：调色剂基础颗粒; 和外部添加剂，所述调色剂基础颗粒各自包含粘合剂树脂和脱模剂，其中所述外部添加剂包括其中一次颗粒聚结在一起的非球形聚结颗粒，并且其中所述聚结颗粒满足下式（1 ）：Nx / 1,000×100＆nlE; 30％其中Nx是相对于1000个聚结颗粒单独存在的一次颗粒数，如在扫描电子显微镜下观察到的，搅拌0.5g聚结颗粒和49.5g载体通过67Hz的混合搅拌装置置于50mL瓶中10分钟。

10. 发明授权

US08948631B2 Image forming apparatus and density adjusting method 有权
标题翻译：图像形成装置和密度调节方法
公开(公告)号：US08948631B2
公开(公告)日：2015-02-03
申请号：US13091188
申请日：2011-04-21
申请人： Takahiro Honda
发明人： Takahiro Honda
IPC分类号： G03G15/00 , G03G15/01
CPC分类号： G03G15/0178 , G03G15/0131 , G03G15/0194 , G03G15/5058 , G03G2215/00059
摘要： An image forming apparatus has a memory, an image forming unit, an intermediate transfer member, a density detector, a background density measurer, a test patch controlling unit and a density correcting unit. The density detector detects the density of the intermediate transfer member. The background density measurer stores background density, in the memory in correspondence with position information on the intermediate transfer member at a predetermined timing before a calibration for adjusting image formation density. The test patch controlling unit causes the image forming unit to form a test patch, on the intermediate transfer member while the intermediate transfer member is driven at a predetermined speed. The density correcting unit executes the calibration to adjust image formation density according to a difference between the background density stored in the memory when executing the calibration and corresponding to the position and density of the test patch.
摘要翻译：图像形成装置具有存储器，图像形成单元，中间转印构件，浓度检测器，背景浓度测量器，测试块控制单元和浓度校正单元。密度检测器检测中间转印部件的密度。背景浓度测量器在调整图像形成密度的校准之前的预定定时将与中间转印部件上的位置信息相对应的记录体中的背景浓度存储。测试片控制单元使图像形成单元在中间转印构件上以预定速度驱动中间转印构件时形成测试片。密度校正单元执行校准，以在执行校准时根据存储在存储器中的背景浓度之间的差异来调整图像形成密度，并且与测试贴片的位置和密度相对应。

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